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  1. Article: MedTech Forum 2021 (April 20-22, 2021 - Virtual Meeting).

    Colina, M

    Drugs of today (Barcelona, Spain : 1998)

    2020  Volume 57, Issue 6, Page(s) 401–405

    Abstract: The MedTech Forum 2021 was an online event at which participants from the field of medical devices, diagnostics and digital health openly shared their views on the latest trends, challenges and opportunities currently being faced. The event enticed ... ...

    Abstract The MedTech Forum 2021 was an online event at which participants from the field of medical devices, diagnostics and digital health openly shared their views on the latest trends, challenges and opportunities currently being faced. The event enticed representatives from around 30 companies from the healthcare sector, as well as those from competent authorities, notified bodies, healthcare providers, academia and patients. Parallel sessions distributed across 3 days enabled the audience to interact with the speakers through a live-chat platform. Various sessions covering health data space, digitalization and interoperability were held in a forum and were a highlight of the meeting due to the potential of health data for the improvement of patient management and healthcare systems. Hot topics included the imminent application of the Medical Device Regulation (MDR) in May 2021 and the application of the In Vitro Diagnostic Device Regulation (IVDR) by May 2022. European competitiveness in the healthcare sector, learnings from the COVID-19 crisis and how to make legislation more friendly with innovations were also topics widely discussed during the event. This report provides a summary of sessions on health digitalization, the application of the new European regulations and lessons learnt from COVID-19.
    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2020-12-07
    Publishing country Spain
    Document type Journal Article
    ISSN 1699-3993
    ISSN 1699-3993
    DOI 10.1358/dot.2021.57.6.3317239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Antibiotics in SAPHO syndrome: Comment on the article by Terui et al.

    Colina, Matteo / Khodeir, Micheline

    The Journal of dermatology

    2023  Volume 51, Issue 1, Page(s) e25

    MeSH term(s) Humans ; Acquired Hyperostosis Syndrome/diagnosis ; Acquired Hyperostosis Syndrome/drug therapy ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16937
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  3. Article ; Online: Experimental warming promotes CO

    Colina, Maite / Meerhoff, Mariana / Cabrera-Lamanna, Lucía / Kosten, Sarian

    The Science of the total environment

    2024  Volume 920, Page(s) 171029

    Abstract: Shallow freshwaters can exchange large amounts of carbon dioxide ( ... ...

    Abstract Shallow freshwaters can exchange large amounts of carbon dioxide (CO
    MeSH term(s) Animals ; Ecosystem ; Carbon Dioxide ; Lakes ; Cyanobacteria ; Phytoplankton ; Biomass ; Eutrophication ; Zooplankton
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2024-02-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171029
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  4. Article ; Online: 68Ga-FAPI-04 PET/CT in Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome.

    Khodeir, Micheline / Poerio, Antonio / Colina, Matteo

    Clinical nuclear medicine

    2023  

    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000005005
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  5. Article ; Online: Comment on "SAPHO Syndrome: Imaging Findings of Vertebral Involvement".

    Colina, M

    AJNR. American journal of neuroradiology

    2016  Volume 37, Issue 10, Page(s) E65–E66

    Language English
    Publishing date 2016-08-04
    Publishing country United States
    Document type Letter
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A4912
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  6. Article ; Online: Designing surface exposed sites on Bacillus subtilis lipase A for spin-labeling and hydration studies.

    Jaufer, Afnan M / Bouhadana, Adam / Kharrazizadeh, Amir / Zhou, Mingwei / Colina, Coray M / Fanucci, Gail E

    Biophysical chemistry

    2024  Volume 308, Page(s) 107203

    Abstract: Spin-labeling with electron paramagnetic resonance spectroscopy (EPR) is a facile method for interrogating macromolecular flexibility, conformational changes, accessibility, and hydration. Within we present a computationally based approach for the ... ...

    Abstract Spin-labeling with electron paramagnetic resonance spectroscopy (EPR) is a facile method for interrogating macromolecular flexibility, conformational changes, accessibility, and hydration. Within we present a computationally based approach for the rational selection of reporter sites in Bacillus subtilis lipase A (BSLA) for substitution to cysteine residues with subsequent modification with a spin-label that are expected to not significantly perturb the wild-type structure, dynamics, or enzymatic function. Experimental circular dichroism spectroscopy, Michaelis-Menten kinetic parameters and EPR spectroscopy data validate the success of this approach to computationally select reporter sites for future magnetic resonance investigations of hydration and hydration changes induced by polymer conjugation, tethering, immobilization, or amino acid substitution in BSLA. Analysis of molecular dynamic simulations of the impact of substitutions on the secondary structure agree well with experimental findings. We propose that this computationally guided approach for choosing spin-labeled EPR reporter sites, which evaluates relative surface accessibility coupled with hydrogen bonding occupancy of amino acids to the catalytic pocket via atomistic simulations, should be readily transferable to other macromolecular systems of interest including selecting sites for paramagnetic relaxation enhancement NMR studies, other spin-labeling EPR studies or any method requiring a tagging method where it is desirable to not alter enzyme stability or activity.
    MeSH term(s) Bacillus subtilis ; Lipase ; Electron Spin Resonance Spectroscopy/methods ; Spin Labels ; Magnetic Resonance Spectroscopy
    Chemical Substances Lipase (EC 3.1.1.3) ; Spin Labels
    Language English
    Publishing date 2024-02-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 185052-0
    ISSN 1873-4200 ; 0301-4622
    ISSN (online) 1873-4200
    ISSN 0301-4622
    DOI 10.1016/j.bpc.2024.107203
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    Zs.A 1147: Show issues Location:
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  7. Article ; Online: Standardized In-harness Ultrasound Protocol Improves Success Rate of Brace Treatment for Dislocated Hips.

    Pargas-Colina, Carlos D / Allred, Caleb M / Gupta, Apeksha / Blumberg, Todd J

    Journal of pediatric orthopedics

    2024  

    Abstract: Objective: Infant hip dislocations benefit from early detection and treatment for optimal outcomes. Prior studies have identified that there remains wide variability in the success rate of bracing between institutions. Although there are standardized ... ...

    Abstract Objective: Infant hip dislocations benefit from early detection and treatment for optimal outcomes. Prior studies have identified that there remains wide variability in the success rate of bracing between institutions. Although there are standardized methods to screen infants for hip dysplasia, there are no clear guidelines regarding how to image a child being treated for a hip dislocation with a Pavlik harness. As a result, there is substantial variability in how treatment success or failure is monitored between and within institutions. The goal of our study is to determine whether a standardized in-harness imaging protocol improves outcomes and the likelihood of successful treatment for dislocated hips being treated with the Pavlik harness.
    Methods: All patients with hip dislocations and pretreatment ultrasound (US) were included from July 2018 to July 2022. A new institutional US protocol was implemented in July 2020, during which standardized in-harness imaging was obtained for patients with hip dislocations. Patients treated before the implementation of standardized in-harness imaging were categorized as nonstandardized and after implementation as a standardized group. Outcomes were compared between standardized and nonstandardized groups. P<0.05 determined the statistical significance.
    Results: One hundred twenty-eight hips met the inclusion criteria (n = 97 patients). The mean age at diagnosis was 41.6 ± 23.4 days and was predominantly female (85.6%). There was no significant difference between the patients' demographics and baseline clinical characteristics between the standardized and nonstandardized groups. Pavlik harness success rate was significantly higher in the standardized group (85% vs 60%, P= 0.0024). Twenty-eight hips in the nonstandardized group remained dislocated and were indicated for surgical treatment, whereas only 8 hips remained dislocated in the standardized group and necessitated closed or open reduction.
    Conclusions: Standardization of in-harness imaging for patients undergoing treatment for developmental hip dislocations can significantly improve the Pavlik harness success rate. These findings emphasize the importance of obtaining images with the hip in flexion and abduction to prevent inadvertent stress during US evaluation for hips that have not yet stabilized, which may lead to premature cessation of the Pavlik harness.
    Level of evidence: Level III.
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604642-3
    ISSN 1539-2570 ; 0271-6798
    ISSN (online) 1539-2570
    ISSN 0271-6798
    DOI 10.1097/BPO.0000000000002690
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  8. Article ; Online: Temperature Effects in Flexible Adsorption Processes for Amorphous Microporous Polymers.

    Morgan, Wesley J / Anstine, Dylan M / Colina, Coray M

    The journal of physical chemistry. B

    2022  Volume 126, Issue 33, Page(s) 6354–6365

    Abstract: A collection of atomistic molecular simulations is reported that illustrate the impact of adsorption temperature on species uptake and adsorbate-induced structural rearrangement for amorphous polymers of intrinsic microporosity. Temperature-sensitive ... ...

    Abstract A collection of atomistic molecular simulations is reported that illustrate the impact of adsorption temperature on species uptake and adsorbate-induced structural rearrangement for amorphous polymers of intrinsic microporosity. Temperature-sensitive structural rearrangement is evaluated by contrasting two methods: standard grand canonical Monte Carlo simulations using a rigid framework approximation and a combined Monte Carlo/molecular dynamics approach that fully incorporates framework flexibility. We report single-component gas phase adsorption isotherms for CH
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c04543
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  9. Article ; Online: Forty-Eight-Month Monitoring of Disease Activity in Patients with Long-Standing Rheumatoid Arthritis Treated with TNF-α Inhibitors: Time for Clinical Outcome Prediction and Biosimilar vs Biologic Originator Performance.

    Colina, Matteo / Khodeir, Micheline / Rimondini, Roberto / Valentini, Marco / Campomori, Federica / Corvaglia, Stefania / Campana, Gabriele

    Clinical drug investigation

    2024  Volume 44, Issue 3, Page(s) 141–148

    Abstract: Background and objectives: Long-term treatment of patients with rheumatoid arthritis with tumor necrosis factor-α inhibitors leads to initial changes in disease activity that can predict a late treatment response. This observational and retrospective ... ...

    Abstract Background and objectives: Long-term treatment of patients with rheumatoid arthritis with tumor necrosis factor-α inhibitors leads to initial changes in disease activity that can predict a late treatment response. This observational and retrospective study aimed to determine when it is possible to foresee the response to therapy in the case of long-standing rheumatoid arthritis comparing also the efficacy of the original biologics with their biosimilars.
    Methods: A total of 1598 patients were recruited and treated with the original biologics, adalimumab and etanercept, or with biosimilars. Patients were monitored over a period of 48 months and disease activity scores (28-Joint Disease Activity Score, Simplified Disease Activity Index, and Clinical Disease Activity Index) were measured every 6 months.
    Results: No differences in disease activity levels were observed in etanercept versus biosimilars (GP2015/SB4) and adalimumab versus biosimilar (GP2017) patient groups. All scores significantly decreased in all treatments during the first 18 months of therapy, and after 24 months reached a minimum that lasted up to 48 months.
    Conclusions: We conclude that biosimilars of adalimumab and etanercept have equivalent effectiveness over a long period of time compared to their originator drugs, and also that the levels of disease activity after 6 months of tumor necrosis factor-α inhibitors (originator drugs and biosimilars) might predict the response to therapy at 4 years in patients with long-standing rheumatoid arthritis.
    MeSH term(s) Humans ; Etanercept/therapeutic use ; Tumor Necrosis Factor-alpha ; Adalimumab/therapeutic use ; Antirheumatic Agents ; Biosimilar Pharmaceuticals ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Retrospective Studies ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Treatment Outcome ; Infliximab
    Chemical Substances Etanercept (OP401G7OJC) ; Tumor Necrosis Factor-alpha ; Adalimumab (FYS6T7F842) ; Antirheumatic Agents ; Biosimilar Pharmaceuticals ; Tumor Necrosis Factor Inhibitors ; Infliximab (B72HH48FLU)
    Language English
    Publishing date 2024-01-31
    Publishing country New Zealand
    Document type Observational Study ; Journal Article
    ZDB-ID 1220136-4
    ISSN 1179-1918 ; 0114-2402 ; 1173-2563
    ISSN (online) 1179-1918
    ISSN 0114-2402 ; 1173-2563
    DOI 10.1007/s40261-024-01341-7
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    Zs.A 2807: Show issues Location:
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  10. Article: Surveillance of

    Hernandez-Colina, Arturo / Seechurn, Nicola / Costa, Taiana / Lopez, Javier / Baylis, Matthew / Hesson, Jenny C

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e26477

    Abstract: The emergence of several zoonotic mosquito-borne pathogens in Europe, including West Nile virus, Sindbis virus and Usutu virus, has emphasised the importance of consistent surveillance. Considerable fieldwork effort is usually needed to detect low- ... ...

    Abstract The emergence of several zoonotic mosquito-borne pathogens in Europe, including West Nile virus, Sindbis virus and Usutu virus, has emphasised the importance of consistent surveillance. Considerable fieldwork effort is usually needed to detect low-prevalence pathogens in mosquitoes and screening vertebrate hosts and reservoirs is rarely done simultaneously with mosquito sampling. Zoological gardens offer an opportunity for the surveillance of pathogens, mosquitoes, hosts, and reservoirs concurrently; thus, the aim of this study was undertaking integrated surveillance for mosquito-borne pathogens of wild birds and mosquitoes in Chester Zoo (Cheshire) in the United Kingdom. Mosquitoes were collected in September 2020 and tested for zoonotic bird-hosted arboviruses (i.e., West Nile virus, Usutu virus and Sindbis virus) using RT-qPCRs. Of the 3316 mosquitoes trapped, 98% were identified as
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26477
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