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Article ; Online: Einführung in die Nierenpathologie.

Büttner-Herold, Maike / Amann, Kerstin

Pathologie (Heidelberg, Germany)

2024

Abstract: In recent decades, nephropathology has developed worldwide as a subspeciality of pathology, which requires special methodological and technical equipment to process the material and specific clinical and pathological expertise to interpret the findings. ... ...

Title translation	Introduction to renal pathology.
Abstract	In recent decades, nephropathology has developed worldwide as a subspeciality of pathology, which requires special methodological and technical equipment to process the material and specific clinical and pathological expertise to interpret the findings. These special requirements mean that nephropathology is not available at all pathology institutes, but is carried out on a large scale in a few highly specialised centres. The history of nephropathology, or in a narrower sense the specialised histopathological examination of kidney biopsies, began in 1958 with the first use or performance of a kidney biopsy [1]. It thus replaced the practice of urinalysis, which had been common since the Middle Ages, as a diagnostic tool for kidney diseases. Specialised techniques such as immunofluorescence or immunohistology but also electron microscopy are required to assess specific renal changes, for which the examination of renal biopsies is one of the few remaining routine applications today. In Germany and German-speaking countries, the discipline developed thanks to the work of outstanding people in the field of pathology who were primarily involved in this discipline and had the necessary technical and human resources in their laboratories to ensure that these biopsies could be analysed.
Language	German
Publishing date	2024-03-21
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ISSN	2731-7196
ISSN (online)	2731-7196
DOI	10.1007/s00292-024-01310-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nephropathologie infektiöser Erkrankungen.

Büttner-Herold, Maike / Amann, Kerstin / Velden, Joachim

Pathologie (Heidelberg, Germany)

2024

Abstract: Infections can affect the kidney via different pathways. Urinary tract infections can directly involve the renal tissue by spreading along pre-existing canalicular structures. Such an ascending infection can manifest as a highly active and purulent or ... ...

Title translation	Nephropathology of infectious disease.
Abstract	Infections can affect the kidney via different pathways. Urinary tract infections can directly involve the renal tissue by spreading along pre-existing canalicular structures. Such an ascending infection can manifest as a highly active and purulent or even abscessing interstitial nephritis or as a chronic-fibrosing process in recurrent pyelonephritis. Viral infections can also use the canalicular route as in polyomavirus nephropathy or spread via the blood stream in a hematogenous manner as in the case of cytomegalovirus or hantavirus infections. Likewise, bacterial infections can reach the kidney via the blood in the case of systemic infection. Another large group of nephropathies taking place as a sequel of infections includes infection-related glomerulonephritides (IRGN), which are mediated by a series of immunological mechanisms. These IRGN can be subdivided according to their temporal association with the infectious process, occurring either after the infection has healed (postinfectious) or accompanying the ongoing infectious process (parainfectious). The latter, in particular, is of increasing importance in the daily practice of nephropathologists, especially in older patients. A number of other glomerulonephritis forms, i.e., membranous or membranoproliferative forms, can occur as a consequence of infection. In addition, infections can trigger nephropathies, such as thrombotic microangiopathy. The present article gives an overview of morphologic changes in renal parenchyma that take place as a consequence of infectious processes, with particular focus on IRGN.
Language	German
Publishing date	2024-04-10
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ISSN	2731-7196
ISSN (online)	2731-7196
DOI	10.1007/s00292-024-01322-9
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Article ; Online: Macrophage subpopulations in pediatric patients with lupus nephritis and other inflammatory diseases affecting the kidney.

Sandersfeld, Mira / Büttner-Herold, Maike / Ferrazzi, Fulvia / Amann, Kerstin / Benz, Kerstin / Daniel, Christoph

Arthritis research & therapy

2024 Volume 26, Issue 1, Page(s) 46

Abstract: Background: Macrophages play an important role in the pathogenesis of lupus nephritis (LN), but less is known about macrophage subtypes in pediatric LN. Here we compared renal inflammation in LN with other inflammatory pediatric kidney diseases and ... ...

Abstract	Background: Macrophages play an important role in the pathogenesis of lupus nephritis (LN), but less is known about macrophage subtypes in pediatric LN. Here we compared renal inflammation in LN with other inflammatory pediatric kidney diseases and assessed whether inflammation correlates with clinical parameters. Methods: Using immunofluorescence microscopy, we analyzed renal biopsies from 20 pediatric patients with lupus nephritis (ISN/RPS classes II-V) and pediatric controls with other inflammatory kidney diseases for infiltration with M1-like (CD68 + /CD206 - , CD68 + /CD163 -), M2a-like (CD206 + /CD68 +), and M2c-like macrophages (CD163 + /CD68 +) as well as CD3 + T-cells, CD20 + B-cells, and MPO + neutrophilic granulocytes. In addition, the correlation of macrophage infiltration with clinical parameters at the time of renal biopsy, e.g., eGFR and serum urea, was investigated. Macrophage subpopulations were compared with data from a former study of adult LN patients. Results: The frequency of different macrophage subtypes in biopsies of pediatric LN was dependent on ISN/RPS class and showed the most pronounced M1-like macrophage infiltration in patients with LN class IV, whereas M2c-like macrophages were most abundant in class III and IV. Interestingly, on average, only half as many macrophages were found in renal biopsies of pediatric LN compared to adult patients with LN. The distribution of frequencies of macrophage subpopulations, however, was different for CD68 + CD206 + (M2a-like) but comparable for CD68 + CD163 - (M1-like) CD68 + CD163 + (M2c-like) cells in pediatric and adult patients. Compared to other inflammatory kidney diseases in children, fewer macrophages and other inflammatory cells were found in kidney biopsies of LN. Depending on the disease, the frequency of individual immune cell types varied, but we were unable to confirm disease-specific inflammatory signatures in our study due to the small number of pediatric cases. Worsened renal function, measured as elevated serum urea and decreased eGFR, correlated particularly strongly with the number of CD68 + /CD163 - M1-like macrophages and CD20 + B cells in pediatric inflammatory kidney disease. Conclusion: Although M1-like macrophages play a greater role in pediatric LN patients than in adult LN patients, M2-like macrophages appear to be key players and are more abundant in other pediatric inflammatory kidney diseases compared to LN.
MeSH term(s)	Adult ; Humans ; Child ; Lupus Nephritis/metabolism ; Kidney/pathology ; Macrophages/metabolism ; Inflammation/pathology ; Urea/metabolism
Chemical Substances	Urea (8W8T17847W)
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-024-03281-1
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Zs.A 5490: Show issues

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Article ; Online: Künstliche Intelligenz in der Nierentransplantationspathologie.

Bülow, Roman David / Lan, Yu-Chia / Amann, Kerstin / Boor, Peter

Pathologie (Heidelberg, Germany)

2024

Abstract: Background: Artificial intelligence (AI) systems have showed promising results in digital pathology, including digital nephropathology and specifically also kidney transplant pathology.: Aim: Summarize the current state of research and limitations in ...

Title translation	Artificial intelligence in kidney transplant pathology.
Abstract	Background: Artificial intelligence (AI) systems have showed promising results in digital pathology, including digital nephropathology and specifically also kidney transplant pathology. Aim: Summarize the current state of research and limitations in the field of AI in kidney transplant pathology diagnostics and provide a future outlook. Materials and methods: Literature search in PubMed and Web of Science using the search terms "deep learning", "transplant", and "kidney". Based on these results and studies cited in the identified literature, a selection was made of studies that have a histopathological focus and use AI to improve kidney transplant diagnostics. Results and conclusion: Many studies have already made important contributions, particularly to the automation of the quantification of some histopathological lesions in nephropathology. This likely can be extended to automatically quantify all relevant lesions for a kidney transplant, such as Banff lesions. Important limitations and challenges exist in the collection of representative data sets and the updates of Banff classification, making large-scale studies challenging. The already positive study results make future AI support in kidney transplant pathology appear likely.
Language	German
Publishing date	2024-04-10
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ISSN	2731-7196
ISSN (online)	2731-7196
DOI	10.1007/s00292-024-01324-7
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Article ; Online: Grundlagen der Nierenpathologie für Pathologen – Teil 2 : Nichtentzündliche Veränderungen.

Gaspert, Ariana / Büttner-Herold, Maike / Amann, Kerstin

Pathologie (Heidelberg, Germany)

2023 Volume 44, Issue 4, Page(s) 261–274

Abstract: The evaluation of kidney biopsies for specific renal diseases or kidney transplant biopsies is mainly restricted to specialized centers. Lesions in nonneoplastic renal tissue in partial nephrectomies or nephrectomies due to renal tumors, especially ... ...

Title translation	Basic nephropathology for pathologists-part 2 : Non-inflammatory lesions.
Abstract	The evaluation of kidney biopsies for specific renal diseases or kidney transplant biopsies is mainly restricted to specialized centers. Lesions in nonneoplastic renal tissue in partial nephrectomies or nephrectomies due to renal tumors, especially noninflammatory, ischemic, vascular changes or diabetic nephropathy can be of greater prognostic significance than the tumor itself in patients with a localized tumor and good tumor-associated survival. In this part of basic nephropathology for pathologists, the most common noninflammatory lesions of the vascular, glomerular and tubulo-interstitial compartment are discussed.
MeSH term(s)	Humans ; Kidney/surgery ; Pathologists ; Diabetic Nephropathies/diagnosis ; Kidney Neoplasms/surgery ; Kidney Glomerulus/pathology
Language	German
Publishing date	2023-06-27
Publishing country	Germany
Document type	English Abstract ; Journal Article
ISSN	2731-7196
ISSN (online)	2731-7196
DOI	10.1007/s00292-023-01204-6
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Article ; Online: Tubulointerstitielle Nephritis und Hantavirus-Infektion.

Plappert, David / Kraft, Leonie / Amann, Kerstin / Latus, Jörg

Deutsche medizinische Wochenschrift (1946)

2023 Volume 148, Issue 23, Page(s) 1525–1535

Abstract: Acute interstitial nephritis (AIN) is a cause of acute kidney injury and characterized by an inflammation of the tubulointerstitial space, leading to a decline in kidney function. Multiple etiologies can cause AIN including medications, autoimmune ... ...

Title translation	Acute interstitial nephritis and hantavirus infection.
Abstract	Acute interstitial nephritis (AIN) is a cause of acute kidney injury and characterized by an inflammation of the tubulointerstitial space, leading to a decline in kidney function. Multiple etiologies can cause AIN including medications, autoimmune diseases and infections. A multiplicity of drugs is associated with AIN, while antibiotics (especially beta-lactams), proton-pump inhibitors (PPI) and non-steroidal anti-inflammatory agents (NSAIDs) are the most common. The pathognomonic triad of exanthema, fever and eosinophilia is rarely present in AIN patients. Treatment of medication-associated AIN is based upon the discontinuation of the provoking drug. Glucocorticoids can be considered in severe cases.Nephropathia epidemica (NE) is a disease caused by an infection with the Puumula-virus (PUUV) in northern and central Europe. Small rodents (mostly mice) are the host of the virus accountable for a rising number of infections during spring and summer. It is causing a syndrome consisting of AIN, fever and often thrombocytopenia. There is a good chance of complete recovery of kidney function following NE.
MeSH term(s)	Humans ; Animals ; Mice ; Nephritis, Interstitial/complications ; Acute Kidney Injury/etiology ; Acute Kidney Injury/chemically induced ; Anti-Bacterial Agents/therapeutic use ; Fever ; Hantavirus Infections/diagnosis ; Hantavirus Infections/complications
Chemical Substances	Anti-Bacterial Agents
Language	German
Publishing date	2023-11-10
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	200446-x
ISSN	1439-4413 ; 0012-0472
ISSN (online)	1439-4413
ISSN	0012-0472
DOI	10.1055/a-1950-7419
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Ua VI Zs.60: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Do ANCAs make the difference in lupus nephritis?

Amann, Kerstin

Kidney international

2017 Volume 92, Issue 5, Page(s) 1048–1050

Abstract: There has been much debate as to whether the distinction between lupus nephritis class IV-S and class IV-G is clinically relevant and whether antineutrophil cytoplasmic antibodies are pathomechanistically involved because they have been associated with ... ...

Abstract	There has been much debate as to whether the distinction between lupus nephritis class IV-S and class IV-G is clinically relevant and whether antineutrophil cytoplasmic antibodies are pathomechanistically involved because they have been associated with the more necrotic and pauci-inflammatory phenotype of lupus nephritis that is more often seen in class IV-S. Recent data show that antineutrophil cytoplasmic antibody positivity indeed influences the histological pattern of lupus nephritis and is associated with worse baseline renal function and more active lupus serology.
MeSH term(s)	Antibodies, Antineutrophil Cytoplasmic ; Humans ; Lupus Nephritis ; Necrosis
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2017.07.011
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Zs.A 797: Show issues

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Book ; Online ; Thesis: Das renale Carnosin-Carnosinase-System in der Entwicklung der diabetischen Nephropathie

Kühlwein, Stephanie [Verfasser] / Amann, Kerstin [Akademischer Betreuer] / Daniel, Christoph [Gutachter]

2023

Author's details	Stephanie Kühlwein ; Gutachter: Christoph Daniel ; Betreuer: Kerstin Amann
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Publishing place	Erlangen
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Analyse der Versorgungssituation bei Epiphyseolysis capitis femoris (ECF) in Deutschland.

Amann, Elea / Schwarze, Michael / Noll, Yvonne / Windhagen, Henning / Radtke, Kerstin

Orthopadie (Heidelberg, Germany)

2023 Volume 53, Issue 1, Page(s) 11–22

Abstract: Introduction: The treatment concept for slipped capital femoral epiphysis is still controversial. According to studies, there is currently no recommendation for a universal approach. Therefore, the aim of this study is to analyze the care reality of ... ...

Title translation	Evaluation of care for slipped capital femoral epiphysis (SCFE) in Germany.
Abstract	Introduction: The treatment concept for slipped capital femoral epiphysis is still controversial. According to studies, there is currently no recommendation for a universal approach. Therefore, the aim of this study is to analyze the care reality of children with ECF in Germany. Methods: The evaluation of the study is performed based on a questionnaire sent to physicians tending to ECF in 2021. Data is compared to the literature. Results: 36 of 47 questionnaires sent out were included. Overall, no significant difference in ECF care was proven in terms of annual caseload or the size of hospital. Conclusion: A high variance in operative SCFE treatment is reported. According to current literature, the modified Dunn procedure is considered the best therapeutic option to date, especially for patients with severe or chronic ECF. However, compared with alternative care options, this is not feasible in every hospital due to its complicating and challenging nature. Central registration, minimum volume regulation, and expansion of continuing education measures can contribute to optimization.
MeSH term(s)	Child ; Humans ; Slipped Capital Femoral Epiphyses/diagnostic imaging ; Treatment Outcome ; Retrospective Studies ; Germany ; Severity of Illness Index
Language	German
Publishing date	2023-11-14
Publishing country	Germany
Document type	English Abstract ; Journal Article
ISSN	2731-7153
ISSN (online)	2731-7153
DOI	10.1007/s00132-023-04455-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Aktuelle Aspekte der Nephropathologie

Amann, Kerstin

Dialyse aktuell

2017 Volume 21, Issue 03, Page(s) 128–128

Language	German
Publishing date	2017-04-01
Publisher	© Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2146225-2
ISSN	1860-3300 ; 1434-0704
ISSN (online)	1860-3300
ISSN	1434-0704
DOI	10.1055/s-0043-106572
Database	Thieme publisher's database

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Zs.A 6979: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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