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  1. Article: Fly infestation in Karachi, a cause of the rapid rise in enteric illnesses.

    Azim, Dua / Nasim, Sundus / Kumar, Sohail

    JPMA. The Journal of the Pakistan Medical Association

    2020  Volume 70, Issue 7, Page(s) 1307–1308

    Language English
    Publishing date 2020-09-21
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.5455/JPMA.65118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Congenital thrombotic thrombocytopenic purpura masquerading as vitamin B12 deficiency.

    Nanjiani, Deedar / Kumar, Sohail / Sharma, Nitik / Nasim, Sundus / Azim, Dua / Parkash, Oam

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

    2023  Volume 62, Issue 5, Page(s) 103728

    Abstract: Introduction: Congenital thrombotic thrombocytopenic purpura (CTTP), also called Upshaw-Schulman syndrome (USS), is a rare autosomal recessive disorder resulting from the deficiency of the ADAMTS13. CTTP is characterized by the formation of platelet- ... ...

    Abstract Introduction: Congenital thrombotic thrombocytopenic purpura (CTTP), also called Upshaw-Schulman syndrome (USS), is a rare autosomal recessive disorder resulting from the deficiency of the ADAMTS13. CTTP is characterized by the formation of platelet-rich thrombi in small vessels of multiple organs, resulting in thrombocytopenia and microangiopathic hemolytic anemia, eventually leading to organ failure.
    Case report: We present a case of an 11-month-old male infant with CTTP lacking classic features of the disease. Instead, his clinical picture portrayed vitamin B12 deficiency, leading to misdiagnosis and subsequent treatment delay.
    Conclusion: This case led to the conclusion that congenital TTP should be suspected in case of vitamin B12 deficiency if the child does not respond to the vitamin B12 replacement therapy. We also emphasize that management for CTTP should be started at its earliest in case of increased clinical suspicion to avoid worse outcomes, especially in countries lacking rapid availability of enzyme assay.
    MeSH term(s) Humans ; Infant ; Male ; ADAMTS13 Protein ; Anemia, Hemolytic ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/therapy ; Vitamin B 12 ; Vitamin B 12 Deficiency/diagnosis
    Chemical Substances ADAMTS13 Protein (EC 3.4.24.87) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2023.103728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Music Therapy for Depression in Pakistan

    Dua Azim / Sohail Kumar / Sundus Nasim

    Liaquat National Journal of Primary Care, Vol 3, Iss 1, Pp 54-

    A Novel Approach

    2021  Volume 54

    Abstract: Respected Editor, Depression is a widely prevalent and debilitating mood disorder affecting 44% of Pakistan’s entire population, with women affected twice as much as men [1]. It is characterized by persistent low mood, lack of interest, fatigability, ... ...

    Abstract Respected Editor, Depression is a widely prevalent and debilitating mood disorder affecting 44% of Pakistan’s entire population, with women affected twice as much as men [1]. It is characterized by persistent low mood, lack of interest, fatigability, worthlessness, and recurrent thoughts of suicide. At present, pharmacotherapy and psychotherapy are considered as gold standard modalities for treating depression. However, these therapies have shown reduction, but not absolute remission‎ [2]. Moreover, poor adherence to the aforementioned treatments due to side‐effects from medication and stigma attached to pursuing talking therapy suggests that alternative approaches need to be implemented urgently, either alone or in conjunction with traditional therapy. Music therapy is defined as a non-pharmacological means of treating depression using music or its elements to ameliorate the functioning of individuals with various somatic and psychological illnesses [3]. Evidence shows that music therapy has previously been used in a variety of ways as a part of a therapeutic regimen for people with depression and, thus, needs to be investigated further as a potential treatment option. Several studies including, a meta-analysis [4] and a Cochrane systemic review [5], identified that music therapy combined with treatment, as usual, is associated with improvement in mood and functional abilities that go beyond those found with standard care alone. Music therapy also appears to be a bettertolerated treatment option, as indicated by low drop-out rates as compared to those receiving conventional psychotherapy and pharmacotherapy. Along with major depressive disorder, individual music therapy also proved to be beneficial for people suffering from other mental illnesses such as anxiety accompanying depression, social anxiety, postpartum depression, dementia, and schizophrenia [6]. Music therapy uses a diverse variety of techniques. However, they can be classified broadly as 'Active', where people perform, improvise, or write music, ...
    Keywords Medicine (General) ; R5-920
    Subject code 780
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Liaquat National Hospital and Medical College
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Media on the frontline against mental health implications of COVID-19 in Pakistan.

    Azim, Dua / Nasim, Sundus / Kumar, Sohail / Hussain, Azhar / Jaipal, Minaheel

    Asian journal of psychiatry

    2020  Volume 54, Page(s) 102342

    MeSH term(s) COVID-19/psychology ; Health Communication ; Humans ; Mass Media ; Mental Health ; Pakistan ; Physical Distancing ; Social Media
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2020.102342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Corticosteroid use for 2019-nCoV infection: A double-edged sword.

    Nasim, Sundus / Kumar, Sohail / Azim, Dua / Ashraf, Zehra / Azeem, Qiraat

    Infection control and hospital epidemiology

    2020  Volume 41, Issue 10, Page(s) 1244–1245

    MeSH term(s) Adrenal Cortex Hormones ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Lung Injury ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Adrenal Cortex Hormones
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2020.165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Dwindling blood reserves: An ominous downside of COVID-19 pandemic.

    Kumar, Sohail / Azim, Dua / Nasim, Sundus / Hashmi, Shariq Haider

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

    2020  Volume 59, Issue 5, Page(s) 102818

    MeSH term(s) Altruism ; Blood Banks ; Blood Donors ; Blood Transfusion ; COVID-19/epidemiology ; COVID-19/transmission ; Hospitals ; Humans ; Pandemics ; SARS-CoV-2/physiology
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country England
    Document type Letter
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2020.102818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Chylomicron Retention Disease in A Male Infant: A Rare Case from Pakistan.

    Kumar, Sohail / Nanjiani, Deedar / Tahir, Faryal / Azim, Dua / Parkash, Oam

    Cureus

    2020  Volume 12, Issue 3, Page(s) e7184

    Abstract: Chylomicron retention disease (CMRD), also known as Anderson's disease, is an autosomal recessive condition with a genetic mutation in the secretion associated Ras related GTPase 1B (SAR1B) gene, a protein coding gene. CMRD classically manifests as ... ...

    Abstract Chylomicron retention disease (CMRD), also known as Anderson's disease, is an autosomal recessive condition with a genetic mutation in the secretion associated Ras related GTPase 1B (SAR1B) gene, a protein coding gene. CMRD classically manifests as steatorrhea, vomiting, failure to thrive or abdominal bloating shortly after birth or in childhood. Here, we report a rare case of a 50-day-old male infant who was, at first, overseen as a case of acute gastroenteritis with sepsis owing to the non-specific symptoms i.e. multiple episodes of loose stools with a low-grade fever and failure to thrive, and was managed accordingly. However, the symptoms did not resolve; moreover, the clinical condition deteriorated. Later, lipid profile, clinical presentation and pathological features led to a presumptive diagnosis of CMRD. Our patient showed significant improvement when treated with a trial of medium- and short-chain fatty acids. We conclude that, in resource-restricted countries, a therapeutic trial with the dietary changes is essential to not only prevent the devastating complication but also support the diagnosis.
    Language English
    Publishing date 2020-03-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.7184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Retrorectal Epidermal Inclusion Cyst: An Incidental Finding During Cesarean Section.

    Nasim, Sundus / Kumar, Sohail / Azim, Dua / Rai, Lajpat / Saeed, Summaya

    Cureus

    2020  Volume 12, Issue 11, Page(s) e11300

    Abstract: An epidermal inclusion cyst is a benign lesion, frequently observed throughout the body. However, its presence in the retrorectal region is a rare occurrence. With a higher incidence in women and non-specific symptoms, these cysts are mostly an ... ...

    Abstract An epidermal inclusion cyst is a benign lesion, frequently observed throughout the body. However, its presence in the retrorectal region is a rare occurrence. With a higher incidence in women and non-specific symptoms, these cysts are mostly an incidental finding. Here, we report a case of a 33-year-old female presenting with complaints of abdominal pain and sensation of incomplete and painful defecation. The patient's history revealed that a large pelvic cyst was found incidentally during her first cesarean section (CS) owing to an arrest in labor. A presumptive diagnosis of rectal duplication cyst was made based on digital rectal exam (DRE), computed tomography (CT), and magnetic resonance imaging (MRI) findings. For cyst removal, the patient underwent a midline laparotomy. A postoperative biopsy led to the confirmed diagnosis of the retrorectal epidermal inclusion cyst. On follow-up, our patient showed a smooth recovery without any complications. We conclude that when dealing with a pregnant woman with a pelvic mass, developmental cysts should always be kept in mind. Timely diagnosis and management of a retrorectal mass is essential for effective treatment and to prevent subsequent complications.
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.11300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Neurological Consequences of 2019-nCoV Infection: A Comprehensive Literature Review.

    Azim, Dua / Nasim, Sundus / Kumar, Sohail / Hussain, Azhar / Patel, Sundip

    Cureus

    2020  Volume 12, Issue 6, Page(s) e8790

    Abstract: First identified in November 2019 in Hubei Province, the coronavirus disease of 2019 (COVID-19) caused by SARS-CoV-2 soon spread worldwide to become a global health pandemic. The COVID-19 preferentially damages the respiratory system that produces ... ...

    Abstract First identified in November 2019 in Hubei Province, the coronavirus disease of 2019 (COVID-19) caused by SARS-CoV-2 soon spread worldwide to become a global health pandemic. The COVID-19 preferentially damages the respiratory system that produces symptoms such as fever, cough, and shortness of breath. However, the infection often tends to disseminate to involve various organ systems. Recent evidence indicates that SARS-CoV-2 can cause significant neurological damage and resultant neurological symptoms and complications. Here, we provide a comprehensive and thorough review of original articles, case reports, and case series to delineate the possible mechanisms of nervous system invasion and damage by SARS-CoV-2 and subsequent consequences. We divided the neurological manifestations into three categories: (1) Central Nervous System involvement, (2) Peripheral Nervous System manifestations, and (3) Skeletal Muscle Injury. Headache and dizziness were found to be the most prevalent symptoms followed by impaired consciousness. Among the symptoms indicating peripheral nervous system invasion, anosmia and dysgeusia were commonly reported. Skeletal muscle injury predominantly presents as myalgia. In addition, encephalitis, myelitis, cerebrovascular disease, Guillain-Barre syndrome, and Miller Fischer syndrome were among the commonly noted complications. We also emphasized the association of pre-existing comorbidities with neurological manifestations. The aim of this review is to provide a deeper understanding of the potential neurological implications to help neurologists have a high index of clinical suspicion allowing them to manage the patient appropriately.
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.8790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Tocilizumab for COVID-19: a real 'miracle drug'?

    Nasim, Sundus / Hashmi, Shariq Haider / Azim, Dua / Kumar, Sohail / Nasim, Jasia

    Infectious diseases (London, England)

    2020  Volume 52, Issue 9, Page(s) 681–682

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Disease Progression ; Humans ; Pandemics ; Pneumonia, Viral ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Keywords covid19
    Language English
    Publishing date 2020-06-17
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2020.1780307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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