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Article ; Online: A prospective review of the health-promoting potential of Jing Si Herbal Tea.

Ho, Tsung-Jung / Ahmed, Tanvir / Shibu, Marthandam Asokan / Lin, Yu-Jung / Shih, Cheng Yen / Lin, Pi-Yu / Ling, Shinn-Zong / Chiang, Chien-Yi / Kuo, Wei-Wen / Huang, Chih-Yang

Tzu chi medical journal

2024 Volume 36, Issue 1, Page(s) 1–22

Abstract: ... Jing Si Herbal Tea (JSHT)," has been reported recently for their health-promoting effects in improving ...

Abstract	Traditional Chinese medicine (TCM) has gained considerable attention over the past few years for its multicomponent, multitarget, and multi-pathway approach to treating different diseases. Studies have shown that TCMs as adjuvant therapy along with conventional treatment may benefit in safely treating various disorders. However, investigations on finding effective herbal combinations are ongoing. A novel TCM formula, "Jing Si Herbal Tea (JSHT)," has been reported recently for their health-promoting effects in improving overall body and mental health. JSHT is a combination of eight herbs recognized in Chinese herbal pharmacopoeia for their anti-viral, anti-aging, and anti-cancer properties as well as protective effects against cardiovascular, metabolic, neural, digestive, and genitourinary diseases. Thus, to better understand the beneficial effects of the ingredients of JSHT on health, this review intends to summarize the preclinical and clinical studies of the ingredients of JSHT on human health and diseases, and possible therapeutic effects with the related mode of actions and future prospects for their application in complementary therapies.
Language	English
Publishing date	2024-01-12
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2452925-4
ISSN	2223-8956 ; 2223-8956
ISSN (online)	2223-8956
ISSN	2223-8956
DOI	10.4103/tcmj.tcmj_194_23
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Article ; Online: Recuperative herbal formula Jing Si maintains vasculature permeability balance, regulates inflammation and assuages concomitants of "Long-Covid".

Chiang, Chien-Yi / Lin, Yu-Jung / Weng, Wen-Tsan / Lin, Heng-Dao / Lu, Cheng-You / Chen, Wan-Jing / Shih, Cheng Yen / Lin, Pi-Yu / Lin, Shinn-Zong / Ho, Tsung-Jung / Shibu, Marthandam Asokan / Huang, Chih-Yang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 163, Page(s) 114752

Abstract: ... the therapeutic effects of Jing Si herbal tea (JSHT) against COVID-19 infection and associated long-term effects ...

Abstract	Coronavirus disease 2019 (COVID-19) is a worldwide health threat that has long-term effects on the patients and there is currently no efficient cure prescribed for the treatment and the prolonging effects. Traditional Chinese medicines (TCMs) have been reported to exert therapeutic effect against COVID-19. In this study, the therapeutic effects of Jing Si herbal tea (JSHT) against COVID-19 infection and associated long-term effects were evaluated in different in vitro and in vivo models. The anti-inflammatory effects of JSHT were studied in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and in Omicron pseudotyped virus-induced acute lung injury model. The effect of JSHT on cellular stress was determined in HK-2 proximal tubular cells and H9c2 cardiomyoblasts. The therapeutic benefits of JSHT on anhedonia and depression symptoms associated with long COVID were evaluated in mice models for unpredictable chronic mild stress (UCMS). JSHT inhibited the NF-ƙB activities, and significantly reduced LPS-induced expression of TNFα, COX-2, NLRP3 inflammasome, and HMGB1. JSHT was also found to significantly suppress the production of NO by reducing iNOS expression in LPS-stimulated RAW 264.7 cells. Further, the protective effects of JSHT on lung tissue were confirmed based on mitigation of lung injury, repression in TMRRSS2 and HMGB-1 expression and reduction of cytokine storm in the Omicron pseudotyped virus-induced acute lung injury model. JSHT treatment in UCMS models also relieved chronic stress and combated depression symptoms. The results therefore show that JSHT attenuates the cytokine storm by repressing NF-κB cascades and provides the protective functions against symptoms associated with long COVID-19 infection.
MeSH term(s)	Mice ; Humans ; Animals ; Post-Acute COVID-19 Syndrome ; Lipopolysaccharides/adverse effects ; Cytokine Release Syndrome ; Cytokines/metabolism ; COVID-19 ; Inflammation/drug therapy ; Inflammation/metabolism ; Acute Lung Injury/metabolism ; NF-kappa B/metabolism
Chemical Substances	Lipopolysaccharides ; Cytokines ; NF-kappa B
Language	English
Publishing date	2023-04-26
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114752
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Article ; Online: Protective effects of Jing-Si-herbal-tea in inflammatory cytokines-induced cell injury on normal human lung fibroblast

Wang, Chien-Hao / Yang, Jai-Sing / Chen, Chao-Jung / Su, San-Hua / Yu, Hsin-Yuan / Juan, Yu-Ning / Chiu, Yu-Jen / Ho, Tsung-Jung

Tzu chi medical journal

2024 Volume 36, Issue 2, Page(s) 152–165

Abstract: Objectives: The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were ...

Abstract	Objectives: The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were investigated in cellular damage mediated by pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, on normal human lung fibroblast by multiomic platform analysis. Materials and methods: The Results: In Conclusion: The findings from our research indicate that JSHT holds promise as a therapeutic agent, potentially offering advantageous outcomes in treating virus infections through various mechanisms. Furthermore, the primary bioactive components in JSHT justify extended research in antiviral drug development, especially in the context of addressing coronavirus.
Language	English
Publishing date	2024-03-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2452925-4
ISSN	2223-8956 ; 2223-8956
ISSN (online)	2223-8956
ISSN	2223-8956
DOI	10.4103/tcmj.tcmj_267_23
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Article ; Online: Integrating satellite and reanalysis precipitation products for SWAT hydrological simulation in the Jing River Basin, China.

Zhang, Yangkai / Gao, Yang / Xu, Liujia / Liu, Zhengguang / Wu, Lei

Environmental science and pollution research international

2024 Volume 31, Issue 13, Page(s) 20534–20555

Abstract: In hydrological studies, satellite and reanalysis precipitation products are increasingly being used to supplement gauge observation data. This study designed the composite simulation index (COSI), considering two factors: F1 (data accuracy assessment) ... ...

Abstract	In hydrological studies, satellite and reanalysis precipitation products are increasingly being used to supplement gauge observation data. This study designed the composite simulation index (COSI), considering two factors: F1 (data accuracy assessment) and F2 (hydrological simulation performance), to compare the performance of the latest satellite-based and reanalysis-based precipitation products (IMERG, ERA5, ERA5-Land), the prior precipitation products (TRMM, CMADS), and the multi-source weighted-ensemble precipitation (MSWEP). The Soil and Water Assessment Tool (SWAT) model was then applied to compare and analyze the hydrological simulation performance of four preferred products using three data fusion methods including simple model averaging, variance-based weighted averaging, and the latest quantile-based Bayesian model averaging (QBMA). The results can be summarized as follows: (1) Reanalysis products are superior to satellite-based products in terms of F1. However, the satellite-based precipitation products exhibit less BIAS and relatively higher F2, while the MSWEP has relatively high performance on both F1 and F2. (2) Among reanalysis-based precipitation products, CMADS has the best COSI value of 0.53. Although ERA5-Land shows good performance for individual parameters, the comprehensive assessment reveals that ERA5 outperforms ERA5-Land in terms of both F1 and F2. (3) IMERG and TRMM exhibit similar spatiotemporal patterns and similar F1, but IMERG is superior in F2. (4) QBMA outperformed traditional methods in F2, improving the NS coefficient of SWAT model from 0.74 to 0.85. These findings provide a useful reference for analyzing the strengths and limitations of satellite-based and reanalysis precipitation products, and also provide valuable ideas for the combined application of multi-source precipitation products in hydrological studies.
MeSH term(s)	Soil ; Rivers ; Bayes Theorem ; Hydrology ; China
Chemical Substances	Soil
Language	English
Publishing date	2024-02-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32482-z
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Article ; Online: Identification of nitrate sources in the Jing River using dual stable isotopes, Northwest China.

Hu, Jing / Pan, Mengyan / Han, Tianhao / Zhuang, Zhi / Cao, Yunning / Yang, Kaili / Li, Yuliang / Liu, Weiguo

Environmental science and pollution research international

2021 Volume 28, Issue 48, Page(s) 68633–68641

Abstract: ... Nitrate ( ... ...

Abstract	Nitrate (NO
MeSH term(s)	Bayes Theorem ; China ; Environmental Monitoring ; Nitrates/analysis ; Nitrogen Isotopes/analysis ; Rivers ; Water Pollutants, Chemical/analysis
Chemical Substances	Nitrates ; Nitrogen Isotopes ; Water Pollutants, Chemical
Language	English
Publishing date	2021-07-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-15380-6
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Article ; Online: Pen Yan Jing Tablets Alleviates Pelvic Inflammatory Disease by Inhibiting Akt/NF-κB Pathway.

Tang, Ping / Ding, Qi / Lin, Juan / Yang, Xinrong / Wang, Yiting / Liu, Fangle / Zheng, Yuying / Lin, Liuqing / Wang, Deqin / Lin, Baoqin

International journal of medical sciences

2023 Volume 20, Issue 11, Page(s) 1386–1398

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Humans ; Female ; Rats ; Animals ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; NF-KappaB Inhibitor alpha/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Pelvic Inflammatory Disease/drug therapy ; Lipopolysaccharides/pharmacology ; Interleukin-6 ; Intercellular Adhesion Molecule-1/metabolism ; Vascular Cell Adhesion Molecule-1/metabolism ; Vascular Cell Adhesion Molecule-1/pharmacology ; Cyclooxygenase 2/metabolism
Chemical Substances	NF-kappa B ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; NF-KappaB Inhibitor alpha (139874-52-5) ; Tumor Necrosis Factor-alpha ; Lipopolysaccharides ; Interleukin-6 ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Vascular Cell Adhesion Molecule-1 ; Cyclooxygenase 2 (EC 1.14.99.1)
Language	English
Publishing date	2023-09-04
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.87433
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Article ; Online: Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses.

Shao, Hao-Tian / Gao, Liang / Li, Hao-Tian / Zhang, Mei / Chen, Jun-Cheng / Duan, Ming-Hui / Li, Ze-En / Dai, Yan / Li, Xing-Ping / Yang, Fan

Poultry science

2023 Volume 102, Issue 8, Page(s) 102761

Abstract: ... enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ...

Abstract	Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used in an extra-label manner in commercial laying hens for the treatment of foot lesions, which are a common issue in this species. The present study aimed to determine the depletion profiles of meloxicam in eggs with multiple oral administration under 2 different dosing regimens and to further recommend reasonable withdrawal intervals (WDIs). Meloxicam (1 mg/kg) was administered orally to laying hens under 2 dosing schedules: 10 doses at 24-h intervals and 15 doses at 12-h intervals. Eggs were collected daily after the first dosing, and meloxicam concentrations in both yolk and white were determined by a high-performance liquid chromatography (HPLC) method. The weight ratio of white to yolk in the whole egg was 1.54 (the mean of 20 eggs with repeated tests), and this value combined with the meloxicam concentrations in white and yolk were used to calculate the drug concentrations in whole eggs. Meloxicam was quickly eliminated from egg white, and its concentrations could only be quantified at 2 time points during the elimination phase. The elimination half-lives in yolk and whole egg were 3.07 ± 1.00 and 2.98 ± 0.88 d, respectively, after 10 repeated doses. And the corresponding elimination half-lives were 2.30 ± 0.83 and 2.18 ± 0.67 d, respectively, after repeated 15 doses. Considering the time when meloxicam was not detectable in eggs with the time of ovum development and maturation, a withdrawal interval (WDI) was suggested as 17 d for both dosing schedules. The current results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ensure animal-derived food safety.
MeSH term(s)	Animals ; Female ; Meloxicam/analysis ; Egg Yolk/chemistry ; Chickens ; Drug Residues/analysis ; Ovum/chemistry ; Administration, Oral ; Eggs/analysis
Chemical Substances	Meloxicam (VG2QF83CGL)
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102761
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Article ; Online: Human adipose-derived stem cells preconditioned with a novel herbal formulation Jing Shi attenuate doxorubicin-induced cardiac damage.

Hsieh, Dennis Jine-Yuan / Tsai, Bruce Chi-Kang / Barik, Parthasarathi / Shibu, Marthandam Asokan / Kuo, Chia-Hua / Kuo, Wei-Wen / Lin, Pi-Yu / Shih, Cheng-Yen / Lin, Shinn-Zong / Ho, Tsung-Jung / Huang, Chih-Yang

Aging

2023 Volume 15, Issue 17, Page(s) 9167–9181

Abstract: ... with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin ...

Abstract	Pathological cardiac hypertrophy is a considerable contributor to global disease burden. Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since antiquity. Enhancing stem cell-mediated recovery through CHM represents a promising approach for protection against doxorubicin (Dox)-induced cardiac hypertrophy. Herein, we investigated whether human adipose-derived stem cells (hADSCs) preconditioned with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin-induced cardiac damage. The effect of JS on hADSC viability and migration capacity was determined via MTT and migration assays, respectively. Co-culture of hADSC or JS-preconditioned hADSCs with H9c2 cells was analyzed with immunoblot, flow cytometry, TUNEL staining, LC3B staining, F-actin staining, and MitoSOX staining. The
MeSH term(s)	Humans ; Animals ; Rats ; Rats, Sprague-Dawley ; Heart ; Stem Cells ; Doxorubicin/toxicity ; Cardiomegaly
Chemical Substances	Doxorubicin (80168379AG)
Language	English
Publishing date	2023-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205026
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Article ; Online: Traditional Chinese medicines (TCMs) with varied meridians (Gui-Jing) differentially alleviate the adverse impact of Coptis chinensis on gut microbiota.

Yang, Yanan / Su, Wenquan / Zang, Chenchen / Tan, Yinfeng / Zhang, Yong / Zhou, Zhi / Lu, Weiying / Wu, Shengxian / Zhang, Xiaopo / Wu, Chongming

Journal of ethnopharmacology

2023 Volume 307, Page(s) 116256

Abstract: Ethnopharmacological relevance: The meridian (GuiJing) theory is a unique theory of traditional Chinese medicine (TCM) which has been guiding the clinical practice of TCM for thousands of years, but physiological foundation of TCM's meridian remains to ... ...

Abstract	Ethnopharmacological relevance: The meridian (GuiJing) theory is a unique theory of traditional Chinese medicine (TCM) which has been guiding the clinical practice of TCM for thousands of years, but physiological foundation of TCM's meridian remains to be clarified. Recent investigations have marked gut microbiota as a key mediator for the pharmacological effects of various TCMs. However, most studies focus on the response of gut microbes to a single drug or formula, the interactive effects of different drugs on gut microbiota are scarcely investigated. Aim of the study: In this work, we evaluated the co-regulatory effects of different TCMs on gut microbiota when they were individually combined with Coptis chinensis (HL), and assessed the relationship between gut microbiota and the GuiJing of TCMs. Materials and methods: Normal C57BL/6 mice were gavaged with HL extract for 14 days to disrupt the gut microbial community. Simultaneously, animals were treated with different TCMs which all possess antimicrobial activity but belong to different meridians. The gut microbiota was analyzed by full-length 16S rRNA gene amplicon sequencing to get a thorough bacterial profile at the species level. Results: Administration of HL dramatically disrupted the gut microbiota and decreased the alpha diversity. Co-administration of different TCMs alleviated the adverse impact of HL on gut microbiota in a meridian-dependent manner. TCMs belonging to Shaoyin meridian moderately shifted the gut microbiota, while TCMs belonging to Taiyin and especially Jueyin meridians remarkably recovered the gut microbial community to the normal status. Decreased Firmicutes (Clostridia and Bacilli) and Actinobacteria (Bifidobacteriales) and increased Proteobacteria (Enterobacteriaceae) were main features of HL-induced gut dysbiosis. TCMs belonging to Shaoyin, Taiyin and Jueyin meridians gradually reversed the abundance of these bacteria to their normal levels. Simultaneously, the promoting effect of HL on beneficial bacteria such as Akkermansia muciniphila and Blautia coccoides was substantially preserved when co-administration of these TCMs, suggesting that co-treatment with these TCMs may reduce the toxicity of HL without deteriorating its beneficial effects. Conclusion: Combination of special TCMs may alleviate the adverse effect of HL on gut microbiota while preserving its beneficial actions. Gut microbiota may be a potential biological indicator of the meridian of TCMs.
MeSH term(s)	Animals ; Mice ; Medicine, Chinese Traditional ; Meridians ; Gastrointestinal Microbiome ; Drugs, Chinese Herbal/pharmacology ; Coptis chinensis ; RNA, Ribosomal, 16S ; Mice, Inbred C57BL ; Bacteria
Chemical Substances	Drugs, Chinese Herbal ; RNA, Ribosomal, 16S
Language	English
Publishing date	2023-02-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116256
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Article ; Online: Correction: Comparative effectiveness of aerobic exercise versus Yi Jin Jing on ovarian function in young overweight/obese women with polycystic ovary syndrome: study protocol for a randomized controlled trial.

Zhao, Jing / Ketlhoafetse, Antonnette / Liu, Xiangyun / Cao, Yang

Trials

2022 Volume 23, Issue 1, Page(s) 564

Language	English
Publishing date	2022-07-15
Publishing country	England
Document type	Published Erratum
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-022-06547-8
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