Article ; Online: Cardiac involvement in patients with rheumatic disorders: Data of the RHEU-M(A)R study.
International journal of cardiology
2016 Volume 224, Page(s) 37–49
Abstract: Background: The diagnosis of cardiac involvement in rheumatic disorders is challenging due to its varying clinical presentation. Since clinical consequences range from immediate treatment changes to adverse long-term outcome, individual risk ... ...
| Abstract | Background: The diagnosis of cardiac involvement in rheumatic disorders is challenging due to its varying clinical presentation. Since clinical consequences range from immediate treatment changes to adverse long-term outcome, individual risk stratification is of great clinical interest. Primary aim was to evaluate the prevalence of cardiac involvement in patients with different rheumatic disorders using late gadolinium enhancement-cardiac magnetic resonance imaging (LGE-CMR). In addition, we sought to investigate if different rheumatic disorders would demonstrate different LGE patterns. Methods: Two-hundred-ninety-seven patients with rheumatic disorders were included and underwent LGE-CMR for work-up of cardiac involvement, which was defined by the presence of LGE in the myocardium. Patients were divided into five subgroups: 1) ANCA-associated vasculitis, 2) non-ANCA-associated vasculitis, 3) connective tissue disorders, 4) arthritis, and 5) sarcoidosis. Results: Mean ejection fraction in the overall population was 65%, with a mean age of 55yrs. Prevalence of cardiac involvement in the five subgroups were as follows: 54% in the ANCA-associated vasculitis group, 22% in the non-ANCA-associated vasculitis group, 14% in the group with connective tissue disorders, 21% in the arthritis group, and 24% in sarcoid patients. Each of the five subgroups demonstrated a distinct pattern of LGE. Conclusion: There is a wide range in the prevalence of cardiac involvement in different rheumatic disorders (54%-14%). Different groups of rheumatic disorders demonstrate different patterns of LGE. Condensed abstract: Primary aim of the study was to evaluate the presence of cardiac involvement in patients with different rheumatic disorders using LGE-CMR. In addition, we sought to investigate if different rheumatic disorders would reveal different LGE patterns. In our 297 patients, the highest prevalence of cardiac involvement was found in patients with ANCA-associated vasculitis (54%), whereas the lowest prevalence was demonstrated in patients with connective tissue disorders (14%). Furthermore, different groups of rheumatic disorders demonstrate distinct patterns of LGE. |
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| MeSH term(s) | Adult ; Aged ; Cardiovascular Diseases/diagnostic imaging ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/physiopathology ; Electrocardiography/trends ; Female ; Humans ; Magnetic Resonance Imaging, Cine/trends ; Male ; Middle Aged ; Rheumatic Diseases/diagnostic imaging ; Rheumatic Diseases/epidemiology ; Rheumatic Diseases/physiopathology ; Statistics as Topic/trends |
| Language | English |
| Publishing date | 2016-12-01 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Multicenter Study |
| ZDB-ID | 779519-1 |
| ISSN | 1874-1754 ; 0167-5273 |
| ISSN (online) | 1874-1754 |
| ISSN | 0167-5273 |
| DOI | 10.1016/j.ijcard.2016.08.298 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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