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  1. Article ; Online: Medical Students' Perceptions and an Anatomy Teacher's Personal Experience Using an e-Learning Platform for Tutorials During the Covid-19 Crisis.

    Srinivasan, Dinesh Kumar

    Anatomical sciences education

    2020  Volume 13, Issue 3, Page(s) 318–319

    MeSH term(s) Anatomy/education ; Betacoronavirus ; COVID-19 ; Computer-Assisted Instruction/methods ; Computer-Assisted Instruction/trends ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Education, Distance/methods ; Education, Distance/organization & administration ; Education, Distance/trends ; Education, Medical ; Educational Measurement ; Faculty, Medical/psychology ; Humans ; Learning ; Pandemics/prevention & control ; Perception ; Personal Satisfaction ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Singapore/epidemiology ; Students, Medical/psychology ; Surveys and Questionnaires/statistics & numerical data
    Keywords covid19
    Language English
    Publishing date 2020-05-13
    Publishing country United States
    Document type Letter
    ZDB-ID 2483491-9
    ISSN 1935-9780 ; 1935-9772
    ISSN (online) 1935-9780
    ISSN 1935-9772
    DOI 10.1002/ase.1970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6787: Show issues Location:
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  2. Article: Assessment of dental age estimation using dentinal translucency in ground sections of single rooted teeth: a digital image analysis.

    Durand, Abelene Maria / Narayan, Madhu / Karthik, Raghavendhar / Krishnan, Rajkumar / Srinivasan, Narasimhan / Kumar, Dinesh

    Anatomy & cell biology

    2024  

    Abstract: Human dentition is unique to individuals and helps in identification of individuals in forensic odontology. This study proposes to study the manually ground sections of single rooted teeth using digital methods for dental age estimation. To assess the ... ...

    Abstract Human dentition is unique to individuals and helps in identification of individuals in forensic odontology. This study proposes to study the manually ground sections of single rooted teeth using digital methods for dental age estimation. To assess the dentinal translucency from the scanned digital images of manually ground section of teeth using commercially available image edition software. Corroborating the root dentinal translucency length and region of interest (ROI) of translucency zone in pixels (as a marker of dental age) with the chronological age of the subject, as stratified by different age groups. Twenty single-rooted extracted teeth from 20 patients each from 6 groups divided as per age. Manual sectioning of the teeth followed by scanning the sections was done. Root area in pixels and ROI of translucency zone were measured. From the observed values, translucency length percentage (TLP) and percentage of ROI in pixels (TPP) was calculated and tabulated. Pearson's correlation coefficients were obtained for age with TLP and TPP. Positive correlation existed between age and TLP and also between age and TPP. With the obtained data, multilinear regression equations for specific age groups based on 10-year intervals were derived. By a step-down analysis method, age was estimated with an average error of around ±7.9 years. This study gives a novel method for age-estimation that can be applied in real-time forensic sciences.
    Language English
    Publishing date 2024-03-29
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2590173-4
    ISSN 2093-3673 ; 2093-3665
    ISSN (online) 2093-3673
    ISSN 2093-3665
    DOI 10.5115/acb.23.270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Medical Students' Perceptions and an Anatomy Teacher's Personal Experience Using an e-Learning Platform for Tutorials During the Covid-19 Crisis

    Srinivasan, Dinesh Kumar

    Anat Sci Educ

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #197785
    Database COVID19

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  4. Article ; Online: Medical Students' Perceptions and an Anatomy Teacher's Personal Experience Using an e‐Learning Platform for Tutorials During the Covid‐19 Crisis

    Srinivasan, Dinesh Kumar

    Anatomical Sciences Education

    2020  Volume 13, Issue 3, Page(s) 318–319

    Keywords Anatomy ; Embryology ; Histology ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2483491-9
    ISSN 1935-9780 ; 1935-9772
    ISSN (online) 1935-9780
    ISSN 1935-9772
    DOI 10.1002/ase.1970
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6787: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article ; Online: Zinc solubilization and organic acid production by the entomopathogenic fungus, Metarhizium pingshaense sheds light on its key ecological role in the environment.

    Senthil Kumar, C M / D'Silva, Sharon / Praveena, R / Kaprakkaden, Anees / Athira Krishnan, L R / Balaji Rajkumar, M / Srinivasan, V / Dinesh, R

    The Science of the total environment

    2024  Volume 923, Page(s) 171348

    Abstract: We report for the first-time higher zinc (Zn) solubilization efficiency and plant growth promotion by an entomopathogenic fungus (EPF), Metarhizium pingshaense IISR-EPF-14, which was earlier isolated from Conogethes punctiferalis, a pest of global ... ...

    Abstract We report for the first-time higher zinc (Zn) solubilization efficiency and plant growth promotion by an entomopathogenic fungus (EPF), Metarhizium pingshaense IISR-EPF-14, which was earlier isolated from Conogethes punctiferalis, a pest of global importance. The Zn solubilizing efficiency of the fungus varied depending on the type of insoluble source of Zn used, which was observed to be 1.6 times higher in Zn
    MeSH term(s) Zinc ; Zinc Oxide ; Formates ; Fungi ; Soil Microbiology ; Metarhizium
    Chemical Substances Zinc (J41CSQ7QDS) ; Zinc Oxide (SOI2LOH54Z) ; Formates
    Language English
    Publishing date 2024-03-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Soil polluted with nano ZnO reveals unstable bacterial communities and decoupling of taxonomic and functional diversities.

    Dinesh, R / Sreena, C P / Sheeja, T E / Kumar, I P Vijesh / Praveena, R / Charles, Sona / Srinivasan, V / Jayarajan, K / Sajith, V / Subila, K P / Haritha, P

    The Science of the total environment

    2023  Volume 889, Page(s) 164285

    Abstract: Due to relentless production and disposal of nano zinc oxide (nZnO), it has become critical to comprehend the serious risks large-scale accumulation of nZnO pose to bacterial communities in soil. The primary objective was to evaluate the changes in ... ...

    Abstract Due to relentless production and disposal of nano zinc oxide (nZnO), it has become critical to comprehend the serious risks large-scale accumulation of nZnO pose to bacterial communities in soil. The primary objective was to evaluate the changes in bacterial community structure and associated functional pathways through predictive metagenomic profiling and subsequent validation through Quantitative Realtime PCR in soil spiked with nZnO (0, 50, 200, 500 and 1000 mg Zn kg
    MeSH term(s) Soil/chemistry ; Zinc Oxide/toxicity ; Bacteria ; Acidobacteria ; Firmicutes ; Soil Microbiology
    Chemical Substances Soil ; Zinc Oxide (SOI2LOH54Z)
    Language English
    Publishing date 2023-05-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.164285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Maternal Diabetes Deregulates the Expression of Mecp2 via miR-26b-5p in Mouse Embryonic Neural Stem Cells.

    Shyamasundar, Sukanya / Ramya, Seshadri / Kandilya, Deepika / Srinivasan, Dinesh Kumar / Bay, Boon Huat / Ansari, Suraiya Anjum / Dheen, S Thameem

    Cells

    2023  Volume 12, Issue 11

    Abstract: Maternal diabetes has been associated with a greater risk of neurodevelopmental disorders in offspring. It has been established that hyperglycemia alters the expression of genes and microRNAs (miRNAs) regulating the fate of neural stem cells (NSCs) ... ...

    Abstract Maternal diabetes has been associated with a greater risk of neurodevelopmental disorders in offspring. It has been established that hyperglycemia alters the expression of genes and microRNAs (miRNAs) regulating the fate of neural stem cells (NSCs) during brain development. In this study, the expression of methyl-CpG-binding protein-2 (Mecp2), a global chromatin organizer and a crucial regulator of synaptic proteins, was analyzed in NSCs obtained from the forebrain of embryos of diabetic mice. Mecp2 was significantly downregulated in NSCs derived from embryos of diabetic mice when compared to controls. miRNA target prediction revealed that the miR-26 family could regulate the expression of Mecp2, and further validation confirmed that Mecp2 is a target of miR-26b-5p. Knockdown of Mecp2 or overexpression of miR-26b-5p altered the expression of tau protein and other synaptic proteins, suggesting that miR-26b-5p alters neurite outgrowth and synaptogenesis via Mecp2. This study revealed that maternal diabetes upregulates the expression of miR-26b-5p in NSCs, resulting in downregulation of its target, Mecp2, which in turn perturbs neurite outgrowth and expression of synaptic proteins. Overall, hyperglycemia dysregulates synaptogenesis that may manifest as neurodevelopmental disorders in offspring from diabetic pregnancy.
    MeSH term(s) Pregnancy ; Female ; Animals ; Mice ; Diabetes Mellitus, Experimental/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neural Stem Cells/metabolism ; Neurogenesis/genetics ; Hyperglycemia/genetics ; Methyl-CpG-Binding Protein 2/genetics
    Chemical Substances MicroRNAs ; Mecp2 protein, mouse ; Methyl-CpG-Binding Protein 2
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12111516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Maternal Diabetes Deregulates the Expression of Mecp2 via miR-26b-5p in Mouse Embryonic Neural Stem Cells

    Sukanya Shyamasundar / Seshadri Ramya / Deepika Kandilya / Dinesh Kumar Srinivasan / Boon Huat Bay / Suraiya Anjum Ansari / S Thameem Dheen

    Cells, Vol 12, Iss 1516, p

    2023  Volume 1516

    Abstract: Maternal diabetes has been associated with a greater risk of neurodevelopmental disorders in offspring. It has been established that hyperglycemia alters the expression of genes and microRNAs (miRNAs) regulating the fate of neural stem cells (NSCs) ... ...

    Abstract Maternal diabetes has been associated with a greater risk of neurodevelopmental disorders in offspring. It has been established that hyperglycemia alters the expression of genes and microRNAs (miRNAs) regulating the fate of neural stem cells (NSCs) during brain development. In this study, the expression of methyl-CpG-binding protein-2 (Mecp2), a global chromatin organizer and a crucial regulator of synaptic proteins, was analyzed in NSCs obtained from the forebrain of embryos of diabetic mice. Mecp2 was significantly downregulated in NSCs derived from embryos of diabetic mice when compared to controls. miRNA target prediction revealed that the miR-26 family could regulate the expression of Mecp2, and further validation confirmed that Mecp2 is a target of miR-26b-5p. Knockdown of Mecp2 or overexpression of miR-26b-5p altered the expression of tau protein and other synaptic proteins, suggesting that miR-26b-5p alters neurite outgrowth and synaptogenesis via Mecp2. This study revealed that maternal diabetes upregulates the expression of miR-26b-5p in NSCs, resulting in downregulation of its target, Mecp2, which in turn perturbs neurite outgrowth and expression of synaptic proteins. Overall, hyperglycemia dysregulates synaptogenesis that may manifest as neurodevelopmental disorders in offspring from diabetic pregnancy.
    Keywords maternal hyperglycemia ; microRNA ; synapse ; neurodevelopmental disorders ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing.

    Ezhilarasu, Hariharan / Vishalli, Dinesh / Dheen, S Thameem / Bay, Boon-Huat / Srinivasan, Dinesh Kumar

    Nanomaterials (Basel, Switzerland)

    2020  Volume 10, Issue 6

    Abstract: Diabetes mellitus (DM) is a common endocrine disease characterized by a state of hyperglycemia (higher level of glucose in the blood than usual). DM and its complications can lead to diabetic foot ulcer (DFU). DFU is associated with impaired wound ... ...

    Abstract Diabetes mellitus (DM) is a common endocrine disease characterized by a state of hyperglycemia (higher level of glucose in the blood than usual). DM and its complications can lead to diabetic foot ulcer (DFU). DFU is associated with impaired wound healing, due to inappropriate cellular and cytokines response, infection, poor vascularization, and neuropathy. Effective therapeutic strategies for the management of impaired wound could be attained through a better insight of molecular mechanism and pathophysiology of diabetic wound healing. Nanotherapeutics-based agents engineered within 1-100 nm levels, which include nanoparticles and nanoscaffolds, are recent promising treatment strategies for accelerating diabetic wound healing. Nanoparticles are smaller in size and have high surface area to volume ratio that increases the likelihood of biological interaction and penetration at wound site. They are ideal for topical delivery of drugs in a sustained manner, eliciting cell-to-cell interactions, cell proliferation, vascularization, cell signaling, and elaboration of biomolecules necessary for effective wound healing. Furthermore, nanoparticles have the ability to deliver one or more therapeutic drug molecules, such as growth factors, nucleic acids, antibiotics, and antioxidants, which can be released in a sustained manner within the target tissue. This review focuses on recent approaches in the development of nanoparticle-based therapeutics for enhancing diabetic wound healing.
    Language English
    Publishing date 2020-06-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano10061234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Nanoparticle-Based Technology Approaches to the Management of Neurological Disorders

    Tao Ming Sim / Dinesh Tarini / S. Thameem Dheen / Boon Huat Bay / Dinesh Kumar Srinivasan

    International Journal of Molecular Sciences, Vol 21, Iss 6070, p

    2020  Volume 6070

    Abstract: Neurological disorders are the most devastating and challenging diseases associated with the central nervous system (CNS). The blood-brain barrier (BBB) maintains homeostasis of the brain and contributes towards the maintenance of a very delicate ... ...

    Abstract Neurological disorders are the most devastating and challenging diseases associated with the central nervous system (CNS). The blood-brain barrier (BBB) maintains homeostasis of the brain and contributes towards the maintenance of a very delicate microenvironment, impairing the transport of many therapeutics into the CNS and making the management of common neurological disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), cerebrovascular diseases (CVDs) and traumatic brain injury (TBI), exceptionally complicated. Nanoparticle (NP) technology offers a platform for the design of tissue-specific drug carrying systems owing to its versatile and modifiable nature. The prospect of being able to design NPs capable of successfully crossing the BBB, and maintaining a high drug bioavailability in neural parenchyma, has spurred much interest in the field of nanomedicine. NPs, which also come in an array of forms including polymeric NPs, solid lipid nanoparticles (SLNs), quantum dots and liposomes, have the flexibility of being conjugated with various macromolecules, such as surfactants to confer the physical or chemical property desired. These nanodelivery strategies represent potential novel and minimally invasive approaches to the treatment and diagnosis of these neurological disorders. Most of the strategies revolve around the ability of the NPs to cross the BBB via various influx mechanisms, such as adsorptive-mediated transcytosis (AMT) and receptor-mediated transcytosis (RMT), targeting specific biomarkers or lesions unique to that pathological condition, thereby ensuring high tissue-specific targeting and minimizing off-target side effects. In this article, insights into common neurological disorders and challenges of delivering CNS drugs due to the presence of BBB is provided, before an in-depth review of nanoparticle-based theranostic strategies.
    Keywords neurological disorders ; blood-brain barrier ; Alzheimer’s disease ; Parkinson’s disease ; cerebrovascular diseases ; traumatic brain injury ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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