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Article: Leánygyermekek szexuális bántalmazása.

Enyedy, Andrea / Csorba, Roland

2017 Volume 158, Issue 23, Page(s) 910–917

Abstract: Introduction and aim: The prevalence of child sexual abuse is 12-13% worldwide (18% by girls, 8% by boys). The exact knowledge of sexual abuse and the spread of the adequate medical diagnosis is an essential medical, social and national requirement. In ... ...

Title translation	Female child sexual abuse.
Abstract	Introduction and aim: The prevalence of child sexual abuse is 12-13% worldwide (18% by girls, 8% by boys). The exact knowledge of sexual abuse and the spread of the adequate medical diagnosis is an essential medical, social and national requirement. In our present study we examine the medical diagnosis of female child sexual abuse. Method: Selective literature research in the available international and domestic databases. Results: Majority of children assessed for suspected sexual abuse have normal genital and anal findings. Contrary to popular belief, the majority of child sexual abuse is a chronic multiple event, caused by a family member. The task of the medical staff is difficult and various, due to the diagnostic challenges of child sexual abuse. The difficulties of the medical diagnosis, evaluation and therapy, the complexity of the legal proceedings and prosecution, the isolation of the profession and the victim and the issue treated like a taboo subject often lead to failure. Conclusion: The physicians dealing with children have suboptimal knowledge of child sexual abuse, the characteristics of victims and perpetretors, the medical diagnosis and therapy of sexual abuse and the rehabilitation of victims. Orv Hetil. 2017; 158(23): 910-917.
MeSH term(s)	Child ; Child Abuse, Sexual/diagnosis ; Child Abuse, Sexual/statistics & numerical data ; Child Welfare/statistics & numerical data ; Female ; Genitalia, Female/injuries ; Humans ; Medical History Taking ; Physical Examination/methods ; Referral and Consultation
Language	Hungarian
Publishing date	2017-06
Publishing country	Hungary
Document type	Journal Article ; Review
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2017.30771
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Article ; Online: Medical and Legal Aspects of Child Sexual Abuse: A Population-Based Study in a Hungarian County.

Enyedy, Andrea / Tsikouras, Panagiotis / Csorba, Roland

International journal of environmental research and public health

2018 Volume 15, Issue 4

Abstract: Background: Very few studies focus on childhood sexual abuse in middle European countries.: Aim: The purpose of our study is to describe the medical and legal characteristics of children who experience sexual abuse and explore common features that ... ...

Abstract	Background: Very few studies focus on childhood sexual abuse in middle European countries. Aim: The purpose of our study is to describe the medical and legal characteristics of children who experience sexual abuse and explore common features that may result in strategies for prevention. Methods: Between 2000 and 2015, 400 girls and 26 boys under the age of 18, suspected of being sexually abused, visited one of the four hospitals in a Hungarian county. Results: Mean age at onset was 10.81 years for boys, 13.46 years for girls. In 278 cases (65.3%), the perpetrator was known to the victim, and a stranger was suspected in 148 cases (34.7%). In 79 cases (30.7% of boys and 17.7% of girls), a family member was the accused perpetrator. In more than one-third (boys) and in one-fifth (girls) of cases, sexual abuse had occurred on multiple occasions. In the case of boys, child and adolescent sexual abuse (CSA) included oral genital, genital touching and genital to genital contact in 14 cases (53.8%) and anal intercourse in 12 (46.2%) cases. In case of girls, sexual abuse included coitus in 219 (54.8%), oral genital, genital touching, genital to genital contact in 164 (41.0%), anal abuse in 14 (3.5%) cases, physical injury was incurred in 15 cases. Legal proceedings followed the CSA in 205 (48.1%) cases. Conclusion: The results highlight the urgent need to address the issue of sexual abuse in Hungary and minimize its impact. Prevention requires a systematic and lifelong approach to educating children about personal space safety and privacy to reduce vulnerability and is the responsibility of parents and professionals.
MeSH term(s)	Adolescent ; Child ; Child Abuse, Sexual/legislation & jurisprudence ; Family ; Female ; Humans ; Hungary ; Male ; Physical Examination
Language	English
Publishing date	2018-04-09
Publishing country	Switzerland
Document type	Journal Article
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph15040701
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Article ; Online: Medical and Legal Aspects of Child Sexual Abuse

Andrea Enyedy / Panagiotis Tsikouras / Roland Csorba

International Journal of Environmental Research and Public Health, Vol 15, Iss 4, p

A Population-Based Study in a Hungarian County

2018 Volume 701

Abstract: Background: Very few studies focus on childhood sexual abuse in middle European countries. Aim: The purpose of our study is to describe the medical and legal characteristics of children who experience sexual abuse and explore common features that may ... ...

Abstract	Background: Very few studies focus on childhood sexual abuse in middle European countries. Aim: The purpose of our study is to describe the medical and legal characteristics of children who experience sexual abuse and explore common features that may result in strategies for prevention. Methods: Between 2000 and 2015, 400 girls and 26 boys under the age of 18, suspected of being sexually abused, visited one of the four hospitals in a Hungarian county. Results: Mean age at onset was 10.81 years for boys, 13.46 years for girls. In 278 cases (65.3%), the perpetrator was known to the victim, and a stranger was suspected in 148 cases (34.7%). In 79 cases (30.7% of boys and 17.7% of girls), a family member was the accused perpetrator. In more than one-third (boys) and in one-fifth (girls) of cases, sexual abuse had occurred on multiple occasions. In the case of boys, child and adolescent sexual abuse (CSA) included oral genital, genital touching and genital to genital contact in 14 cases (53.8%) and anal intercourse in 12 (46.2%) cases. In case of girls, sexual abuse included coitus in 219 (54.8%), oral genital, genital touching, genital to genital contact in 164 (41.0%), anal abuse in 14 (3.5%) cases, physical injury was incurred in 15 cases. Legal proceedings followed the CSA in 205 (48.1%) cases. Conclusion: The results highlight the urgent need to address the issue of sexual abuse in Hungary and minimize its impact. Prevention requires a systematic and lifelong approach to educating children about personal space safety and privacy to reduce vulnerability and is the responsibility of parents and professionals.
Keywords	child sexual abuse ; adolescents ; girls ; boys ; gender differences ; legal proceedings ; child-friendly justice ; prevention ; Medicine ; R
Subject code	360
Language	English
Publishing date	2018-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Estradiol-Based Salicylaldehyde (Thio)Semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities

Tatsiana V. Petrasheuskaya / Ferenc Kovács / Nóra Igaz / Andrea Rónavári / Bálint Hajdu / Laura Bereczki / Nóra V. May / Gabriella Spengler / Béla Gyurcsik / Mónika Kiricsi / Éva Frank / Éva A. Enyedy

Molecules, Vol 28, Iss 1, p

2022 Volume 54

Abstract: A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1 H and ¹³C nuclear magnetic resonance spectroscopy, UV– ... ...

Abstract	A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1 H and ¹³C nuclear magnetic resonance spectroscopy, UV–visible and electron paramagnetic resonance spectroscopy, electrospray ionization mass spectrometry and elemental analysis. The structure of the Cu(II)-estradiol-semicarbazone complex was revealed by X-ray crystallography. Proton dissociation constants of the ligands and stability constants of the metal complexes were determined in 30% ( v/v ) DMSO/H 2 O. Estradiol-(T)SCs form mono-ligand complexes with Cu(II) ions and exhibit high stability with the exception of estradiol-SC. The Cu(II) complexes of estradiol-TSC and its N,N -dimethyl derivative displayed the highest cytotoxicity among the tested compounds in MCF-7, MCF-7 KCR, DU-145, and A549 cancer cells. The complexes do not damage DNA according to both in vitro cell-free and cellular assays. All the Cu(II)-TSC complexes revealed significant activity against the Gram-positive Staphylococcus aureus bacteria strain. Estradiol-TSCs showed efficient antioxidant activity, which was decreased by complexation with Cu(II) ions. The exchange of estrone moiety to estradiol did not result in significant changes to physico-chemical and biological properties.
Keywords	estradiol hybrids ; (thio)semicarbazones ; cytotoxicity ; solution equilibrium ; EPR spectroscopy ; X-ray crystal structure ; Organic chemistry ; QD241-441
Subject code	540 ; 500
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Interactions of insulin-mimetic zinc(II) complexes with cell constituents: glutathione and ATP.

Enyedy, Eva Anna / Lakatos, Andrea / Horváth, László / Kiss, Tamás

Journal of inorganic biochemistry

2008 Volume 102, Issue 7, Page(s) 1473–1485

Abstract: Ternary complex formation of some potent insulin-mimetic zinc(II) complexes of bidentate ligands: maltol and 3-hydroxy-1,2-dimethyl-pyridinone with (O,O), 2-picolinic acid and 6-methylpicolinic acid with (N,O) and the tridentate 2,6-dipicolinic acid with ...

Abstract	Ternary complex formation of some potent insulin-mimetic zinc(II) complexes of bidentate ligands: maltol and 3-hydroxy-1,2-dimethyl-pyridinone with (O,O), 2-picolinic acid and 6-methylpicolinic acid with (N,O) and the tridentate 2,6-dipicolinic acid with (O,N,O) coordination modes was studied in aqueous solutions by pH-potentiometry and spectroscopic (UV, CD, ESI-MS) methods in the presence of critical cell constituents such as L-glutathione reduced (GSH) and adenosine 5'-triphosphate (ATP). Results showed that formation of the ternary complexes was hindered in the case of 2,6-dipicolinic acid, especially with ATP, while it was favoured with the bidentate ligands in the physiological pH range. Driving force of the formation of mixed-ligand species was found to be a more enhanced coordination of GSH and ATP as second ligands in the ternary complexes than in their binary ones due to steric and electrostatic reasons. The mitochondrial dehydrogenase activity of the zinc(II) complexes, as an indirect indicator for the glucose intake, was measured on Mono Mac and 3T3-L1 adipocyte cell lines. The activity of the complexes up to approximately 10-100 microM concentration was in the range of the effect of 0.75-1.5 microM insulin, while at higher concentration it was broken down due to the sensitivity of the cells to toxicity of the complexes.
MeSH term(s)	3T3-L1 Cells ; Adenosine Triphosphate/chemistry ; Animals ; Biomimetic Materials/chemistry ; Glutathione/chemistry ; Insulin/chemistry ; Ligands ; Mice ; Organometallic Compounds/chemistry ; Oxidoreductases/metabolism ; Potentiometry ; Spectrum Analysis ; Zinc/chemistry
Chemical Substances	Insulin ; Ligands ; Organometallic Compounds ; Adenosine Triphosphate (8L70Q75FXE) ; Oxidoreductases (EC 1.-) ; Glutathione (GAN16C9B8O) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2008-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2008.01.007
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Article ; Online: 3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on Ru(II)(arene) anticancer complexes with biologically active ligands.

Kurzwernhart, Andrea / Kandioller, Wolfgang / Enyedy, Éva A / Novak, Maria / Jakupec, Michael A / Keppler, Bernhard K / Hartinger, Christian G

Dalton transactions (Cambridge, England : 2003)

2013 Volume 42, Issue 17, Page(s) 6193–6202

Abstract: Ru(II)(η(6)-arene) complexes, especially with bioactive ligands, are considered to be very promising compounds for anticancer drug design. We have shown recently that Ru(II)(η(6)-p-cymene) complexes with 3-hydroxyflavone ligands exhibit very high in ... ...

Abstract	Ru(II)(η(6)-arene) complexes, especially with bioactive ligands, are considered to be very promising compounds for anticancer drug design. We have shown recently that Ru(II)(η(6)-p-cymene) complexes with 3-hydroxyflavone ligands exhibit very high in vitro cytotoxic activities correlating with a strong inhibition of topoisomerase IIα. In order to expand our knowledge about the structure-activity relationships and to determine the impact of lipophilicity of the arene ligand and of the hydrolysis rate on anticancer activity, a series of novel 3-hydroxyflavone derived Ru(II)(η(6)-arene) complexes were synthesised. Furthermore, the impact of the heteroatom in the bioactive ligand backbone was studied by comparing the cytotoxic activity of Ru(II)(η(6)-p-cymene) complexes of 3-hydroxyquinolinone ligands with that of their 3-hydroxyflavone analogues. To better understand the behaviour of these Ru(II) complexes in aqueous solution, the stability constants and pK(a) values for complexes and the corresponding ligands were determined. Furthermore, the interaction with the DNA model 5'-GMP and with a series of amino acids was studied in order to identify potential biological target structures.
MeSH term(s)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/toxicity ; Cell Line, Tumor ; Cell Survival/drug effects ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Coordination Complexes/toxicity ; Drug Stability ; Flavonoids/chemistry ; Humans ; Ligands ; Monoterpenes/chemistry ; Quinolones/chemistry ; Ruthenium/chemistry ; Structure-Activity Relationship
Chemical Substances	Antineoplastic Agents ; Coordination Complexes ; Flavonoids ; Ligands ; Monoterpenes ; Quinolones ; 4-cymene (1G1C8T1N7Q) ; Ruthenium (7UI0TKC3U5) ; 3-hydroxyflavone (ZTG9LSS5QH)
Language	English
Publishing date	2013-05-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c2dt32206d
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Article ; Online: Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity.

Bioorganic & medicinal chemistry letters

2018 Volume 28, Issue 10, Page(s) 1964–1971

Abstract: Germinal center kinase-like kinase (GLK, also known as MAP4K3) has been hypothesized to have an effect on key cellular activities, including inflammatory responses. GLK is required for activation of protein kinase C-θ (PKCθ) in T cells. Controlling the ... ...

Abstract	Germinal center kinase-like kinase (GLK, also known as MAP4K3) has been hypothesized to have an effect on key cellular activities, including inflammatory responses. GLK is required for activation of protein kinase C-θ (PKCθ) in T cells. Controlling the activity of T helper cell responses could be valuable for the treatment of autoimmune diseases. This approach circumvents previous unsuccessful approaches to target PKCθ directly. The use of structure based drug design, aided by the first crystal structure of GLK, led to the discovery of several inhibitors that demonstrate potent inhibition of GLK biochemically and in relevant cell lines.
MeSH term(s)	Animals ; Binding Sites ; Cell Line ; Humans ; Inhibitory Concentration 50 ; Interleukin-2/metabolism ; Mice ; Mice, Knockout ; Molecular Docking Simulation ; Phosphorylation/drug effects ; Protein Kinase C-theta/metabolism ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Structure, Tertiary ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/metabolism ; Pyridines/chemistry ; Pyridines/metabolism ; Pyridines/pharmacology ; Structure-Activity Relationship ; T-Lymphocytes/cytology ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology
Chemical Substances	Interleukin-2 ; Protein Kinase Inhibitors ; Pyridines ; MAP4K3 protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Protein Kinase C-theta (EC 2.7.11.13)
Language	English
Publishing date	2018-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2018.03.032
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Article ; Online: Ruthenium-nitrosyl complexes with glycine, L-alanine, L-valine, L-proline, D-proline, L-serine, L-threonine, and L-tyrosine: synthesis, X-ray diffraction structures, spectroscopic and electrochemical properties, and antiproliferative activity.

Rathgeb, Anna / Böhm, Andreas / Novak, Maria S / Gavriluta, Anatolie / Dömötör, Orsolya / Tommasino, Jean Bernard / Enyedy, Eva A / Shova, Sergiu / Meier, Samuel / Jakupec, Michael A / Luneau, Dominique / Arion, Vladimir B

Inorganic chemistry

2014 Volume 53, Issue 5, Page(s) 2718–2729

Abstract: The reactions of [Ru(NO)Cl5](2-) with glycine (Gly), L-alanine (L-Ala), L-valine (L-Val), L-proline (L-Pro), D-proline (D-Pro), L-serine (L-Ser), L-threonine (L-Thr), and L-tyrosine (L-Tyr) in n-butanol or n-propanol afforded eight new complexes (1-8) of ...

Abstract	The reactions of [Ru(NO)Cl5](2-) with glycine (Gly), L-alanine (L-Ala), L-valine (L-Val), L-proline (L-Pro), D-proline (D-Pro), L-serine (L-Ser), L-threonine (L-Thr), and L-tyrosine (L-Tyr) in n-butanol or n-propanol afforded eight new complexes (1-8) of the general formula [RuCl3(AA-H)(NO)](-), where AA = Gly, L-Ala, L-Val, L-Pro, D-Pro, L-Ser, L-Thr, and L-Tyr, respectively. The compounds were characterized by elemental analysis, electrospray ionization mass spectrometry (ESI-MS), (1)H NMR, UV-visible and ATR IR spectroscopy, cyclic voltammetry, and X-ray crystallography. X-ray crystallography studies have revealed that in all cases the same isomer type (from three theoretically possible) was isolated, namely mer(Cl),trans(NO,O)-[RuCl3(AA-H)(NO)], as was also recently reported for osmium analogues with Gly, L-Pro, and D-Pro (see Z. Anorg. Allg. Chem. 2013, 639, 1590-1597). Compounds 1, 4, 5, and 8 were investigated by ESI-MS with regard to their stability in aqueous solution and reactivity toward sodium ascorbate. In addition, cell culture experiments in three human cancer cell lines, namely, A549 (nonsmall cell lung carcinoma), CH1 (ovarian carcinoma), and SW480 (colon carcinoma), were performed, and the results are discussed in conjunction with the lipophilicity of compounds.
MeSH term(s)	Amino Acids/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Circular Dichroism ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; Crystallography, X-Ray ; Drug Stability ; Electrochemistry ; Humans ; Mass Spectrometry ; Nitrogen Oxides/chemistry ; X-Ray Diffraction
Chemical Substances	Amino Acids ; Antineoplastic Agents ; Coordination Complexes ; Nitrogen Oxides ; nitrosyl chloride (NHE5I1E5H6)
Language	English
Publishing date	2014-02-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/ic4031359
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