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  1. Article ; Online: Cystic Fibrosis.

    Mulrennan, Siobhain / Jones, Andrew M

    Seminars in respiratory and critical care medicine

    2023  Volume 44, Issue 2, Page(s) 185

    MeSH term(s) Humans ; Cystic Fibrosis/therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1760754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Recommencement of atezolizumab with associated pulmonary sarcoid-like reaction.

    Tam, Khai / Wallace, Michael / Mulrennan, Siobhain

    Respirology case reports

    2024  Volume 12, Issue 5, Page(s) e01363

    Abstract: An 81 year old male with Child-Pugh A cirrhosis and metastatic hepatocellular carcinoma (HCC) treated with 3-weekly atezolizumab and bevacizumab developed a pulmonary sarcoid-like reaction (SLR) after 5 months. Atezolizumab, an immune checkpoint ... ...

    Abstract An 81 year old male with Child-Pugh A cirrhosis and metastatic hepatocellular carcinoma (HCC) treated with 3-weekly atezolizumab and bevacizumab developed a pulmonary sarcoid-like reaction (SLR) after 5 months. Atezolizumab, an immune checkpoint inhibitor, was identified as the likely culprit. He was treated with prednisolone, resulting in improvement, and was successfully rechallenged with both atezolizumab and bevacizumab.
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2750180-2
    ISSN 2051-3380
    ISSN 2051-3380
    DOI 10.1002/rcr2.1363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Me, myself, and I: A systematic review of cystic fibrosis and self-concept.

    Harrigan, Maggie / Jessup, Melanie / Bennett, Kellie / Mulrennan, Siobhain

    Pediatric pulmonology

    2024  Volume 59, Issue 5, Page(s) 1175–1195

    Abstract: Given extensive pertinent disease factors and evolving medical treatments, this systematic review explores qualitative and quantitative cystic fibrosis (CF) research surrounding self-concept, an overarching perception of self. Research methodologies, ... ...

    Abstract Given extensive pertinent disease factors and evolving medical treatments, this systematic review explores qualitative and quantitative cystic fibrosis (CF) research surrounding self-concept, an overarching perception of self. Research methodologies, self-concept dimensions, prominent self-concept findings and clinical recommendations are identified. Preferred Reporting Items for Systematic Review and Meta-analyses guidelines were applied. PubMed, Scopus, Medline, Psycinfo, CINAHL (ebsco), and CENTRAL Cochrane electronic databases were searched from 2012 to 2022. Methodological quality was assessed using the critical appraisal skills program. Data-based convergent synthesis was applied to analyze and report on qualitative and quantitative studies in parallel. Thirty-seven publications met the inclusion criteria, most of which employed a cross-sectional, single-center design within an adolescent and adult population. Self-efficacy, self-esteem, and self-identity studies were dimensions of self-concept identified, with studies relating to self-efficacy surrounding physical health management most prevalent. All three dimensions were positively associated with improved treatment adherence and psychosocial health. Efficacy tested intervention programs to enhance self-concept are limited; however, an extensive range of clinical recommendations are offered, highlighting the importance of clinician self-concept awareness, quality clinician-patient conversations and online CF peer-support. Self-concept is an important mechanism to optimize patient outcomes. Further CF self-concept research is required, particularly multicenter, longitudinal, and interventional studies. Early childhood, post lung transplant and the older adult CF population in particular, lack research attention. Given the potential impact of rapidly evolving CF transmembrane conductance regulator modulator drugs on many aspects of self, future self-concept research beyond the dimension of self-efficacy may be beneficial.
    MeSH term(s) Humans ; Cystic Fibrosis/psychology ; Cystic Fibrosis/therapy ; Self Concept ; Self Efficacy ; Adolescent ; Adult ; Child
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2143: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Cystic Fibrosis

    Mulrennan, Siobhain / Jones, Andrew M.

    Seminars in Respiratory and Critical Care Medicine

    (Cystic Fibrosis)

    2023  Volume 44, Issue 02, Page(s) 185–185

    Series title Cystic Fibrosis
    Language English
    Publishing date 2023-01-24
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1760754
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Medical information and social media in the time of COVID-19.

    Mulrennan, Siobhain / Colt, Henri

    Respirology (Carlton, Vic.)

    2020  Volume 25, Issue 6, Page(s) 578–579

    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13832
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4957: Show issues Location:
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  6. Article ; Online: Living with cystic fibrosis during the COVID-19 pandemic

    Maggie Harrigan / Kellie Bennett / Siobhain Mulrennan / Melanie Jessup

    International Journal of Qualitative Studies on Health & Well-Being, Vol 17, Iss

    a social connectedness perspective

    2022  Volume 1

    Abstract: Purpose This study explores the concept of social connectedness for adults with Cystic Fibrosis (CF), generally and during the onset of the COVID-19 pandemic, to help inform contemporary CF healthcare. Social connectedness is an essential component of ... ...

    Abstract Purpose This study explores the concept of social connectedness for adults with Cystic Fibrosis (CF), generally and during the onset of the COVID-19 pandemic, to help inform contemporary CF healthcare. Social connectedness is an essential component of belonging and refers to an individual’s sense of closeness with the social world. Unique disease factors make exploration of social connectedness pertinent, added to by COVID-19, with the CF population potentially facing increased risk for severe illness. Methods Seventeen adults with CF in Western Australia undertook interviews, with findings categorized as overarching themes. Results In a general sense, participants described social connectedness challenges caused by CF, despite which they reported meaningful connections that benefits their mental and physical health. Within a COVID-19 specific context, participants demonstrated resilience in the face of adversity, highlighted the importance of empathy in relation to the pandemic, and described how social support is both an outcome and enhancer of social connectedness. Conclusions This study contributes to limited social connectedness literature within CF and chronic illness in general, highlighting the importance of social connectedness awareness raising, assessments and interventions in CF healthcare inside and outside the COVID-19 pandemic.
    Keywords cystic fibrosis (cf) ; qualitative ; social connectedness ; covid-19 ; belonging ; resilience ; social support ; mental health ; chronic illness ; western australia ; Medicine (General) ; R5-920
    Subject code 300 ; 360
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Tobramycin safety and efficacy review article.

    Schwarz, Carsten / Taccetti, Giovanni / Burgel, Pierre-Regis / Mulrennan, Siobhain

    Respiratory medicine

    2022  Volume 195, Page(s) 106778

    Abstract: Pseudomonas aeruginosa is a common respiratory pathogen found in patients with cystic fibrosis (CF), contributing to increased hospitalization, more rapid progression of CF lung disease, and increased risk of death. Guidelines recommend early therapy ... ...

    Abstract Pseudomonas aeruginosa is a common respiratory pathogen found in patients with cystic fibrosis (CF), contributing to increased hospitalization, more rapid progression of CF lung disease, and increased risk of death. Guidelines recommend early therapy using tobramycin inhaled solution (TIS) or inhaled powder (TIP). Both TIS and TIP treatment regimens have demonstrated positive clinical outcomes in efficacy and safety, including improvements in FEV
    MeSH term(s) Administration, Inhalation ; Anti-Bacterial Agents/adverse effects ; Cystic Fibrosis/complications ; Cystic Fibrosis/drug therapy ; Humans ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa ; Tobramycin/adverse effects
    Chemical Substances Anti-Bacterial Agents ; Tobramycin (VZ8RRZ51VK)
    Language English
    Publishing date 2022-02-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2022.106778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.19: Show issues Location:
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  9. Article ; Online: Beyond the Lungs-Emerging Challenges in Adult Cystic Fibrosis Care.

    Mulrennan, Siobhain / Sapru, Karuna / Tewkesbury, Daniel / Jones, Andrew M

    Seminars in respiratory and critical care medicine

    2022  Volume 44, Issue 2, Page(s) 307–314

    Abstract: Cystic fibrosis (CF) is a multisystem disease. This article provides an up-to-date review of many of the nonrespiratory complications of CF, including mental health issues, nutritional and gastrointestinal problems, fertility issues, diabetes mellitus, ... ...

    Abstract Cystic fibrosis (CF) is a multisystem disease. This article provides an up-to-date review of many of the nonrespiratory complications of CF, including mental health issues, nutritional and gastrointestinal problems, fertility issues, diabetes mellitus, bone health and musculoskeletal problems, liver disease, renal problems, and risk of malignancy. It highlights the recent impact of new therapies, including CF transmembrane conductance regulator modulators, on the nonrespiratory complications of CF and provides insights into the potential challenges faced by an aging population of adults with CF and their caregivers, including the potential future risk for cardiovascular disease.
    MeSH term(s) Adult ; Humans ; Aged ; Cystic Fibrosis/complications ; Cystic Fibrosis/therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Gastrointestinal Diseases ; Lung ; Liver Diseases/complications ; Infertility ; Mutation
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2022-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1758734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Telehealth use in Australian cystic fibrosis centers: Clinician experiences.

    Shanthikumar, Shivanthan / Ruseckaite, Rasa / Corda, Jen / Mulrennan, Siobhain / Ranganathan, Sarath / Douglas, Tonia

    Pediatric pulmonology

    2023  Volume 58, Issue 10, Page(s) 2906–2915

    Abstract: Background: Telehealth has been rapidly adopted by cystic fibrosis (CF) centers and ongoing use in routine CF care is endorsed by CF consumers. However, data describing CF clinician perceptions regarding telehealth are scarce. We aimed to describe ... ...

    Abstract Background: Telehealth has been rapidly adopted by cystic fibrosis (CF) centers and ongoing use in routine CF care is endorsed by CF consumers. However, data describing CF clinician perceptions regarding telehealth are scarce. We aimed to describe clinician experiences and attitudes towards telehealth in CF care among health professionals across Australia.
    Methods: CF multidisciplinary health professionals from all CF clinics in Australia were sent an anonymous electronic survey.
    Results: Eighty-five responses were received representing 15 of 23 (65%) centers. Most clinicians reported using telehealth for routine clinic visits, and a range of other clinical encounters (69.9%). Telehealth was widely perceived as acceptable (91.8%), and clinicians were comfortable/very comfortable (81.2%) integrating telehealth into future CF care. Despite this, 64.1% of respondents considered telehealth clinics to be much worse than face-to-face clinics and 57.5% reported quality of care was somewhat/much worse using telehealth. Home spirometry was available in 73.7% of centers, however, only 26.7% of clinics could provide spirometers for >75% eligible patients. Growth and microbiology assessments were often missed in telehealth clinics and 75.7% reported a technical issue had prevented a telehealth consultation from occurring.
    Conclusions: Telehealth for CF in Australia is considered feasible and acceptable by CF clinicians, although use of telehealth varies widely between centers. Concerns exist around the impact of telehealth on health outcomes, especially given core assessments are frequently omitted. Guidelines may help ensure the benefits of telehealth are realized for people with CF without compromising the standard of care.
    MeSH term(s) Humans ; Cystic Fibrosis/therapy ; Australia ; Telemedicine ; Health Personnel ; Ambulatory Care
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26612
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