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  1. Article ; Online: Medical mask or N95 respirator: When and how to use?

    Azap, Alpay / Erdinç, F Şebnem

    Turkish journal of medical sciences

    2020  Volume 50, Issue SI-1, Page(s) 633–637

    Abstract: COVID-19 pandemic is now a global threat to human health reaching up to 2 million infected people all around the world. Since its first recognition in Wuhan, many topics were discussed intensively about COVID-19, both in the public and ... ...

    Abstract COVID-19 pandemic is now a global threat to human health reaching up to 2 million infected people all around the world. Since its first recognition in Wuhan, many topics were discussed intensively about COVID-19, both in the public and scientific community. Personal protective equipment, especially masks, has been among the hottest topics during this pandemic. Regardless of which mask is used, performing hand hygiene frequently with an alcohol-based hand rub or with soap and water if hands are dirty is the most effective preventive measure for COVID-19. The type of mask used when caring for COVID-19 patients will vary according to the setting, type of personnel/person, and activity. Although the main transmission route for COVID-19 is droplets, during aerosol generating procedures airborne transmission may occur. Keeping the distancing and medical masks and eye protection during close contact efficiently protects against respiratory diseases transmitted via droplets. Airborne precautions include goggles and respiratory protection with the use of an N95 or an equivalent mask respirator to prevent airborne transmission.
    MeSH term(s) Aerosols ; Air Filters ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Health Personnel ; Humans ; Infection Control/methods ; Masks ; Occupational Exposure/adverse effects ; Occupational Exposure/prevention & control ; Pandemics/prevention & control ; Personal Protective Equipment ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-04-21
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-2004-199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: COVID-19 pandemisi sırasında obstrüktif uyku apne yönetimi.

    Gülbay, Banu / Azap, Alpay / Kaya, Akın / Acıcan, Turan

    Tuberkuloz ve toraks

    2020  Volume 68, Issue 2, Page(s) 135–140

    Abstract: Coronavirus disease 2019 (COVID-19) is an infectious disease that causes important mortality and morbidity all over the world caused by SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), which started in China at the end of 2019. It spreads ... ...

    Title translation Management of obstructive sleep apnea during COVID-19 pandemic.
    Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease that causes important mortality and morbidity all over the world caused by SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), which started in China at the end of 2019. It spreads rapidly, mainly through droplets, and especially for all healthcare workers involved in aerosol producing procedures are at high risk. During COVID-19 pandemic , the health systems worldwide, along with the practice of chest diseases daily were affected. In our article, we aimed to give some clinical suggestions related to sleep practices according to current data.
    MeSH term(s) Attitude of Health Personnel ; COVID-19 ; Comorbidity ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Global Health ; Health Personnel/statistics & numerical data ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/therapy ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/therapy
    Keywords covid19
    Language Turkish
    Publishing date 2020-08-04
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2468802-2
    ISSN 0494-1373
    ISSN 0494-1373
    DOI 10.5578/tt.69745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dark Side of the COVID-19 Pandemic;

    Sarıcaoğlu, Elif Mukime / Çınar, Güle / Azap, Alpay / Bayar, Mustafa K / Togay-Işıkay, Canan / Kutlay, Şehim / İbiş, Sinan

    Infectious diseases & clinical microbiology

    2023  Volume 5, Issue 3, Page(s) 205–211

    Abstract: Objective: Besides its morbidity and mortality all over the world, SARS-CoV-2 infection maintains its importance with prolonged symptoms after acute disease. The post-infectious period including a heterogeneous group of symptoms is named : Materials ... ...

    Abstract Objective: Besides its morbidity and mortality all over the world, SARS-CoV-2 infection maintains its importance with prolonged symptoms after acute disease. The post-infectious period including a heterogeneous group of symptoms is named
    Materials and methods: This cross-sectional retrospective study included COVID-19 patients diagnosed with SARS-CoV-2 PCR positivity in the first 18 months of the COVID-19 pandemic, between March 2020 and September 2021. We conducted a survey in 2022 to inquire about the participants' symptoms that lasted three months or more after their own COVID-19 period. All patients were employees of one of the biggest national banks in Turkey. Participants answered a total of 31 questions over the phone. The presence of one or more symptoms persisting ≥3 months was defined as
    Results: A total of 1301 patients were included in our study. The median age of patients was 40 (22-57), and 558 (42.9%) were women. 257 (19.8%) patients had
    Conclusion: Female gender and diabetes mellitus are risk factors for
    Language English
    Publishing date 2023-09-30
    Publishing country Turkey
    Document type Journal Article
    ISSN 2667-646X
    ISSN (online) 2667-646X
    DOI 10.36519/idcm.2023.213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Anaphylaxis is rare due to CoronaVac in a population of healthcare workers.

    Öztürk, Betül Özdel / Akdemir, İrem / Azap, Alpay / Çelik, Gülfem / Bavbek, Sevim / Mungan, Dilşad

    Asia Pacific allergy

    2022  Volume 12, Issue 4, Page(s) e35

    Abstract: Background: CoronaVac, the first coronavirus disease 2019 vaccine administered in our country, was found safe in clinical trials.: Objective: We aimed to reveal the rate and features of CoronaVac vaccine-associated allergic reactions among vaccinated ...

    Abstract Background: CoronaVac, the first coronavirus disease 2019 vaccine administered in our country, was found safe in clinical trials.
    Objective: We aimed to reveal the rate and features of CoronaVac vaccine-associated allergic reactions among vaccinated healthcare workers (HCWs) in real-life.
    Methods: This study was planned as a questionnaire-based study. Participants who reported a postvaccination allergic reaction were interviewed on phone and their medical records were also checked for confirmation.
    Results: A total of 2,488 HCWs took part in the study and 4,054 postvaccination complete questionnaire-responses were obtained. Twenty-one HCWs (female: male, 17:4) with a mean age of 40.95 ± 10.09 stated that they had an allergic reaction after a total of 23 vaccine injections. Accordingly, the reaction rate was 0.56% among all vaccine doses. The most common reactions were systemic skin reactions (2.7%) consisting of generalized pruritus, diffuse pruritic erythema, urticaria, and maculopapular rash. That was followed by local injection site reaction (0.12%). Anaphylaxis was reported in 4 cases (0.09%) with a mean onset time of 12 ± 6 minutes. One of them had a history of anaphylaxis with 2 drugs, another had venom and food allergy. Three of the subjects had level 2 diagnostic certainty according to the Brighton Collaboration criteria and one had level 3. All anaphylaxis cases were discharged within 24 hours and none of them required intensive care.
    Conclusion: Our study demonstrated that allergic reactions to CoronaVac were rare and mostly mild. Although anaphylaxis was also rare, the importance of early intervention with close follow-up was once again emphasized.
    Language English
    Publishing date 2022-10-17
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2614800-6
    ISSN 2233-8268 ; 2233-8276
    ISSN (online) 2233-8268
    ISSN 2233-8276
    DOI 10.5415/apallergy.2022.12.e35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The challenges in the monitoring of infectious diseases after the earthquake in Türkiye in 2023.

    Ergönül, Önder / Keske, Şiran / Ksinzik, Apolina / Güldan, Mustafa / Özbek, Laşin / Azap, Alpay / Şimşek-Yavuz, Serap / Can, Füsun / Sakarya, Sibel

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 11, Page(s) e482–e488

    Abstract: After the devastating earthquake in Türkiye and Syria in February, 2023, the long-term failure to meet the need for shelter, unfavourable living conditions in tent settlements, poor access to clean drinking water, water suitable for personal hygiene, and ...

    Abstract After the devastating earthquake in Türkiye and Syria in February, 2023, the long-term failure to meet the need for shelter, unfavourable living conditions in tent settlements, poor access to clean drinking water, water suitable for personal hygiene, and sanitary facilities, as well as interruptions in provision of primary health-care services, have emerged as the most important risk factors contributing to the spread of infectious diseases. 3 months after the earthquake, most of these problems persist in Türkiye. Data on the control of infectious diseases are scarce according to the reports prepared by medical specialist associations based on observations of health-care providers working in the region and statements made by the local health authorities. According to these unsystematised data, and considering the conditions in the region, faecal-oral transmissible gastrointestinal infections, as well as respiratory and vector-borne infections, are the main challenges. Vaccine-preventable diseases, such as measles, varicella, meningitis, and polio can be spread in temporary shelters due to interrupted vaccine services and crowded living conditions. In addition to controlling risk factors for infectious diseases, sharing data on the status and control of infectious diseases in the region with the community, health-care providers, and relevant expert groups should be a priority to improve the understanding of the effects of interventions and prepare for possible infectious disease outbreaks.
    MeSH term(s) Humans ; Earthquakes ; Communicable Diseases/epidemiology ; Disease Outbreaks ; Health Services ; Syria
    Language English
    Publishing date 2023-07-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00362-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Medical mask or N95 respirator: When and how to use?

    Azap, Alpay / Erdinç, F Sebnem

    Turk J Med Sci

    Abstract: COVID-19 pandemic is now a global threat to human health reaching up to 2 million infected people all around the world. Since its first recognition in Wuhan, many topics were discussed intensively about COVID-19, both in the public and scientific ... ...

    Abstract COVID-19 pandemic is now a global threat to human health reaching up to 2 million infected people all around the world. Since its first recognition in Wuhan, many topics were discussed intensively about COVID-19, both in the public and scientific community. Personal protective equipment, especially masks, has been among the hottest topics during this pandemic. Regardless of which mask is used, performing hand hygiene frequently with an alcohol-based hand rub or with soap and water if hands are dirty is the most effective preventive measure for COVID-19. The type of mask used when caring for COVID-19 patients will vary according to the setting, type of personnel/person, and activity. Although the main transmission route for COVID-19 is droplets, during aerosol generating procedures airborne transmission may occur. Keeping the distancing and medical masks and eye protection during close contact efficiently protects against respiratory diseases transmitted via droplets. Airborne precautions include goggles and respiratory protection with the use of an N95 or an equivalent mask respirator to prevent airborne transmission.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #124993
    Database COVID19

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  7. Article: Herpes Zoster Burden of Disease and Clinical Management in Turkey: A Comprehensive Literature Review.

    Badur, Selim / Senol, Esin / Azap, Alpay / Yesiloglu, Cihan / Ozakay, Alev / Ozturk, Serdar / Guzman-Holst, Adriana

    Infectious diseases and therapy

    2023  Volume 12, Issue 8, Page(s) 1937–1954

    Abstract: Introduction: Herpes zoster (HZ), or shingles, is caused by the reactivation of varicella zoster virus (VZV) and typically presents as an acute, painful dermatomal rash, but can lead to long-term, distressing complications such as postherpetic neuralgia ...

    Abstract Introduction: Herpes zoster (HZ), or shingles, is caused by the reactivation of varicella zoster virus (VZV) and typically presents as an acute, painful dermatomal rash, but can lead to long-term, distressing complications such as postherpetic neuralgia (PHN). Increasing trends in HZ cases are evident globally among the aging population; however, reviews investigating the epidemiology and clinical management of HZ in Turkey are lacking. Therefore, a literature review of local studies in Turkey was conducted to identify the data available and identify gaps in the literature.
    Methods: Literature searches were carried out in PubMed and local journals to retrieve published articles that reported surveillance data, seroepidemiology, patient outcomes, or clinical management related to HZ or VZV in Turkey until April 30, 2022. Studies included primary data reports, case studies, secondary data reviews, and epidemiological studies in healthy or at-risk populations; HZ was the primary focus of the review.
    Results: No studies reported VZV or HZ epidemiological data at a national level. One large retrospective study in Istanbul reported that HZ incidence rates significantly increased in adults 18-44 years of age between 2011 and 2019. Four single-center studies reported the proportion of dermatological patients with HZ at 0.43-1.56%. PHN was the most common reported complication, occurring in 8-58.9% of patients with HZ. However, out of 39 identified case reports, HZ ophthalmicus was the most frequently reported complication. Two studies highlighted poor disease awareness and risk perception of HZ among Turkish citizens.
    Conclusion: Overall, there were limited comprehensive epidemiological data on HZ in Turkey. However, the abundance of case studies on HZ complications indicates a strong disease presence and diverse clinical management in Turkey. Further research will be important to understand the impact of HZ, increase disease awareness, and support the introduction of new preventative strategies.
    Language English
    Publishing date 2023-08-02
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-023-00849-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Present and Future Aspects of Life-Long Pertussis Prevention: Narrative Review with Regional Perspectives for Türkiye.

    Pehlivan, Tamer / Dinleyici, Ener Cagri / Kara, Ateş / Kurugöl, Zafer / Tezer, Hasan / Aksakal, Nur Baran / Biri, Aydan / Azap, Alpay

    Infectious diseases and therapy

    2023  Volume 12, Issue 11, Page(s) 2495–2512

    Abstract: Pertussis, caused by Bordetella pertussis, remains one of the most widespread, contagious, and vaccine-preventable diseases. It results in notable morbidity and mortality as well as severe medical, social, and economic burden. Despite high global vaccine ...

    Abstract Pertussis, caused by Bordetella pertussis, remains one of the most widespread, contagious, and vaccine-preventable diseases. It results in notable morbidity and mortality as well as severe medical, social, and economic burden. Despite high global vaccine coverage, pertussis continues to be a significant epidemiologic problem, with outbreak episodes every few years just as in the pre-vaccination era. In Türkiye, there is a lack of comprehensive data on the current burden of pertussis in different age and risk groups, leading to underdiagnosis and underreporting of the disease, especially in adults who are often not considered at risk. Available data from Türkiye also reveal inadequate levels of protective antibodies in preterm newborns, emphasizing the need for additional preventive measures. Authors stated that improving physician awareness of pertussis symptoms in patients with prolonged cough, increasing access to routine pertussis tests, and conducting surveillance studies would aid in accurate diagnosis and reporting in Türkiye. As the Turkish Ministry of Health Antenatal Care Management Guide suggests routine second and third pregnancy check-up visits at weeks 18-24 and 28-32 correspondingly, this period can be considered the ideal vaccination time for Türkiye. Introducing a booster dose of Tdap at around 10 years of age or during national military service would reduce transmission and protect susceptible individuals. Identifying individuals at high risk of severe pertussis and prioritizing them for a booster dose is also crucial in Türkiye. Enhancing surveillance systems, increasing healthcare professionals' awareness through training, and organizing catch-up visits for missed vaccinations during the COVID-19 pandemic are mentioned as additional strategies to improve pertussis prevention in Türkiye. This review focuses on the global and regional burden of pertussis and obstacles to effective prevention and evaluates existing strategies to achieve lifelong pertussis prevention. Literature and current strategies were also discussed from a Turkish national standpoint.
    Language English
    Publishing date 2023-10-10
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-023-00876-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ceftazidime - Avibactam susceptibility among carbapenem-resistant Enterobacterales in a pilot study in Turkey.

    Ozger, Hasan Selcuk / Evren, Ebru / Yildiz, Serap Suzuk / Erol, Cigdem / Bayrakdar, Fatma / Azap, Ozlem / Azap, Alpay / Senol, Esin

    Acta microbiologica et immunologica Hungarica

    2021  

    Abstract: This study aimed to detect carbapenemase genes and to determine the in vitro susceptibility of Ceftazidime-Avibactam (CZA) in Enterobacterales isolates. Carbapenemase genes were detected by polymerase chain reaction. CZA sensitivity of isolates was ... ...

    Abstract This study aimed to detect carbapenemase genes and to determine the in vitro susceptibility of Ceftazidime-Avibactam (CZA) in Enterobacterales isolates. Carbapenemase genes were detected by polymerase chain reaction. CZA sensitivity of isolates was evaluated with broth microdilution (BMD) and disk diffusion methods. A total of 318 carbapenem-resistant Enterobacterales isolates were included. Most of the isolates (n = 290, 91.2%) were identified as Klebsiella pneumoniae. The most common carbapenemase type was OXA-48 (n = 82, 27.6%). CZA susceptibility was evaluated in 84 isolates with OXA-48 and KPC carbapenemase activity. Both BMD and disk diffusion methods revealed that 95.2% of the isolates were sensitive to CZA; whereas, 4 (4.76%) isolates were resistant to CZA. Among colistin resistant isolates, 96.5% (n = 80) of them were susceptible to CZA. Our study demonstrated high in vitro efficacy of CZA in Enterobacterales isolates producing OXA-48 carbapenemase. High susceptibility rates against colistin resistant isolates which generally are also pan drug resistant, makes CZA a promising therapeutic choice for difficult-to-treat infections. Due to its high correlation with the BMD, disk diffusion method is a suitable and more practical method in detecting CZA in vitro activity.
    Language English
    Publishing date 2021-07-29
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 918256-1
    ISSN 1588-2640 ; 1217-8950
    ISSN (online) 1588-2640
    ISSN 1217-8950
    DOI 10.1556/030.2021.01525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: COVID-19 pandemisi sirasinda obstrüktif uyku apne yönetimi./ [Management of obstructive sleep apnea during COVID-19 pandemic]

    Gülbay, Banu / Azap, Alpay / Kaya, Akin / Acican, Turan

    Tuberk Toraks

    Abstract: Coronavirus disease 2019 (COVID-19) is an infectious disease that causes important mortality and morbidity all over the world caused by SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), which started in China at the end of 2019. It spreads ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease that causes important mortality and morbidity all over the world caused by SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), which started in China at the end of 2019. It spreads rapidly, mainly through droplets, and especially for all healthcare workers involved in aerosol producing procedures are at high risk. During COVID-19 pandemic , the health systems worldwide, along with the practice of chest diseases daily were affected. In our article, we aimed to give some clinical suggestions related to sleep practices according to current data.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #705434
    Database COVID19

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