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  1. Article ; Online: Effects of fatigue on anaesthetist well-being and patient safety: a narrative review.

    Ippolito, Mariachiara / Einav, Sharon / Giarratano, Antonino / Cortegiani, Andrea

    British journal of anaesthesia

    2024  

    Abstract: The elements that render anaesthesia a captivating profession can also foster stress and fatigue. Professionals considering anaesthesia as a career choice should have a comprehensive understanding of the negative consequences of fatigue and its ... ...

    Abstract The elements that render anaesthesia a captivating profession can also foster stress and fatigue. Professionals considering anaesthesia as a career choice should have a comprehensive understanding of the negative consequences of fatigue and its implications for clinical performance and of the available preventive measures. Available evidence suggests that factors unrelated to patient characteristics or condition can affect clinical outcomes where anaesthetists are involved. Workload, nighttime work, and fatigue are persistent issues in anaesthesia and are perceived as presenting greater perioperative risks to patients. Fatigue seems to negatively affect both physical and mental health of anaesthetists. Existing evidence justifies specific interventions by institutions, stakeholders, and scientific societies to address the effects of anaesthetist fatigue. This narrative review summarises current knowledge regarding the effects of fatigue on anaesthetist well-being and patient safety, and discusses potential preventive solutions.
    Language English
    Publishing date 2024-04-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2024.03.017
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  2. Article: Length of remdesivir treatment in patients with severe COVID-19.

    Ippolito, Mariachiara / Cortegiani, Andrea

    Breathe (Sheffield, England)

    2021  Volume 17, Issue 1, Page(s) 200276

    Abstract: In severe COVID-19, a 5-day remdesivir regimen seems as effective as a 10-day course of treatment and it may be safer. To date, the drug has no clearly proven efficacy over time. ...

    Abstract In severe COVID-19, a 5-day remdesivir regimen seems as effective as a 10-day course of treatment and it may be safer. To date, the drug has no clearly proven efficacy over time.
    Language English
    Publishing date 2021-05-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0276-2020
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  3. Article ; Online: Healthcare-associated central nervous system infections.

    Ippolito, Mariachiara / Giarratano, Antonino / Cortegiani, Andrea

    Current opinion in anaesthesiology

    2022  Volume 35, Issue 5, Page(s) 549–554

    Abstract: Purpose of review: The aim of this review is to provide a practical and updated summary on healthcare-associated central nervous system infections and their management.: Recent findings: The term 'healthcare-associated ventriculitis and meningitis' ... ...

    Abstract Purpose of review: The aim of this review is to provide a practical and updated summary on healthcare-associated central nervous system infections and their management.
    Recent findings: The term 'healthcare-associated ventriculitis and meningitis' has recently been coined and clinical practical guidelines have been published on the management of these nosocomial infections. Many aspects have still to be further investigated (e.g. cerebrospinal fluid biomarkers, indications for novel antibiotics, intrathecal antimicrobial regimens).
    Summary: Clinicians should maintain a high index of suspicion for healthcare-associated central nervous system infections in patients with specific risk factors (i.e. recent neurosurgery, cerebrospinal shunts, drains or implantable devices, head/spinal traumatic events), taking into account systemic signs, and alterations in microbiological, imaging, cerebrospinal fluid findings. The diagnosis is often difficult to confirm because of reduced levels of consciousness or coma. Both Gram-positive and Gram-negative (often multidrug-resistant or even pandrug-resistant) microorganisms may be the cause. Selection of antibiotics must consider susceptibility and penetration into the central nervous system. Ineffective treatments are frequent, and mortality can reach 60%. Future research should focus on the diagnostic performance of biomarkers and on the use of novel antimicrobial regimens, especially for the treatment of difficult to treat infections.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Central Nervous System ; Central Nervous System Infections/chemically induced ; Central Nervous System Infections/diagnosis ; Central Nervous System Infections/therapy ; Cross Infection/diagnosis ; Cross Infection/therapy ; Delivery of Health Care ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000001167
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    Zs.A 2564: Show issues Location:
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  4. Article ; Online: Intentional interruptions during compression only CPR: A scoping review.

    Catalisano, Giulia / Milazzo, Marta / Simone, Barbara / Campanella, Salvatore / Romana Catalanotto, Francesca / Ippolito, Mariachiara / Giarratano, Antonino / Baldi, Enrico / Cortegiani, Andrea

    Resuscitation plus

    2024  Volume 18, Page(s) 100623

    Abstract: Introduction: Out of hospital cardiac arrest (OHCA) remains one of the main causes of death among industrialized countries. The initiation of cardiopulmonary resuscitation (CPR) by laypeople before the arrival of emergency medical services improves ... ...

    Abstract Introduction: Out of hospital cardiac arrest (OHCA) remains one of the main causes of death among industrialized countries. The initiation of cardiopulmonary resuscitation (CPR) by laypeople before the arrival of emergency medical services improves survival. Mouth-to-mouth ventilation may constitute a hindering factor to start bystander CPR, while during continuous chest compressions (CCC) CPR quality decreases rapidly. The aim of this scoping review is to examine the existing literature on strategies that investigate the inclusion of intentional pauses during compression-only resuscitation (CO-CPR) to improve the performance in the context of single lay rescuer OHCA.
    Methods: The protocol of this Scoping review was prospectively registered in Open Science Framework (https://osf.io/rvn8j). A systematic search of PubMed, Scopus, EMBASE, CINAHL was performed.
    Results: Six articles were included. All studies were carried out on simulation manikins and involved a total of 1214 subjects. One study had a multicenter design. Three studies were randomized controlled simulation trials, the rest were prospective randomized crossover studies. The tested protocols were heterogeneous and compared CCC to CO-CPR with intentional interruptions of various length. The most common primary outcome was compressions depth. Compression rate, rescuers' perceived exertion and composite outcomes were also evaluated. Compressions depth and perceived exertion improved in most study groups while compression rate and chest compression fraction remained within guidelines indications.
    Conclusions: In simulation studies, the inclusion of intentional interruptions during CO-CPR within the specific scenario of single rescuer bystander CPR during OHCA may improve the rate of compressions with correct depth and lower rate of perceived exertion. Further high-quality research and feasibility and safety of protocols incorporating intentional interruptions during CO-CPR may be justified.
    Language English
    Publishing date 2024-04-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2666-5204
    ISSN (online) 2666-5204
    DOI 10.1016/j.resplu.2024.100623
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  5. Article ; Online: Vasopressor and inotrope treatment for septic shock: An umbrella review of reviews.

    Einav, Sharon / Helviz, Yigal / Ippolito, Mariachiara / Cortegiani, Andrea

    Journal of critical care

    2021  Volume 65, Page(s) 65–71

    Abstract: Purpose: To review the characteristics, findings and quality of systematic reviews (SRs) on the effect of any vasopressor/inotrope on outcomes in adult patients with sepsis compared with either no treatment, another vasopressor or inotrope or fluids.: ...

    Abstract Purpose: To review the characteristics, findings and quality of systematic reviews (SRs) on the effect of any vasopressor/inotrope on outcomes in adult patients with sepsis compared with either no treatment, another vasopressor or inotrope or fluids.
    Materials and methods: We systematically searched Cochrane Central Register of Controlled Trials, PubMed and Embase (January 1993-March 2021). Descriptive statistics were used.
    Results: Among the 28 SRs identified, mortality was the primary outcome in most (26/28) and mortality was usually (23/28) studied using randomised controlled trials (RCTs). Fifteen SRs focused exclusively on patients with sepsis or septic shock. Sepsis and septic shock were always grouped for the analysis. Publication bias was consistently low when studied. The most consistent findings were a survival advantage with norepinephrine versus dopamine, which disappeared in analyses restricted to 28-day mortality, and more arrhythmias with dopamine. However, these analyses were dominated by a single study. Only 2 SRs were judged to be of moderate-high quality. Lack of blinding and attrition bias may have affected the outcomes.
    Conclusions: The quality of SRs on the effect of vasopressors/inotropes on the outcomes of adult patients with sepsis can be improved, but high-quality, multicenter, RCTs should be preferred to additional SRs on this topic.
    MeSH term(s) Adult ; Humans ; Multicenter Studies as Topic ; Norepinephrine ; Sepsis/drug therapy ; Shock, Septic/drug therapy ; Systematic Reviews as Topic ; Vasoconstrictor Agents/therapeutic use
    Chemical Substances Vasoconstrictor Agents ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2021-05-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2021.05.017
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    Zs.A 2152: Show issues Location:
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  6. Article ; Online: Retracted papers on SARS-CoV-2 and COVID-19.

    Cortegiani, Andrea / Catalisano, Giulia / Ippolito, Mariachiara / Giarratano, Antonino / Absalom, Anthony R / Einav, Sharon

    British journal of anaesthesia

    2021  Volume 126, Issue 4, Page(s) e155–e156

    Language English
    Publishing date 2021-01-19
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2021.01.008
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  7. Article ; Online: Chloroquine for COVID-19: rationale, facts, hopes.

    Cortegiani, Andrea / Ippolito, Mariachiara / Ingoglia, Giulia / Einav, Sharon

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 210

    MeSH term(s) Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Chloroquine/pharmacology ; Chloroquine/therapeutic use ; Clinical Trials as Topic ; Coronavirus Infections/drug therapy ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Treatment Outcome
    Chemical Substances Antimalarials ; Antiviral Agents ; Chloroquine (886U3H6UFF)
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country England
    Document type Editorial
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-02932-4
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  8. Article ; Online: Inclusion of pregnant women in clinical trials of COVID-19 therapies: what have we learned?

    Einav, Sharon / Ippolito, Mariachiara / Cortegiani, Andrea

    British journal of anaesthesia

    2020  Volume 125, Issue 3, Page(s) e326–e328

    MeSH term(s) Betacoronavirus ; COVID-19 ; Clinical Trials as Topic ; Coronavirus Infections/drug therapy ; Female ; Humans ; Pandemics ; Patient Selection ; Pneumonia, Viral/drug therapy ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-31
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.05.020
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  9. Article ; Online: Global warming "heating up" the ICU through Candida auris infections: the climate changes theory.

    Misseri, Giovanni / Ippolito, Mariachiara / Cortegiani, Andrea

    Critical care (London, England)

    2019  Volume 23, Issue 1, Page(s) 416

    Language English
    Publishing date 2019-12-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-019-2702-4
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  10. Article ; Online: Chloroquine for COVID-19

    Andrea Cortegiani / Mariachiara Ippolito / Giulia Ingoglia / Sharon Einav

    Critical Care, Vol 24, Iss 1, Pp 1-

    rationale, facts, hopes

    2020  Volume 3

    Keywords COVID-19 ; Chloroquine ; SARS-CoV-2 ; Pneumonia ; Coronavirus ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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