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Article: Inhibition of Local Inflammation by Implanted Gold: A Narrative Review of the History and Use of Gold.

Rasmussen, Sten / Frederickson, Chris / Danscher, Gorm

2023 Volume 50, Issue 5, Page(s) 704–705

MeSH term(s)	Humans ; Inflammation ; Tomography, X-Ray Computed
Language	English
Publishing date	2023-03-15
Publishing country	Canada
Document type	Review ; Journal Article
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.221150
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Article ; Online: nanoGold and µGold inhibit autoimmune inflammation: a review.

Danscher, Gorm / Rasmussen, Sten

Histochemistry and cell biology

2023 Volume 159, Issue 3, Page(s) 225–232

Abstract: The newest data on metallic gold have placed the noble metal central in the fight for the safe treatment of autoimmune inflammation. There are two different ways to use gold for the treatment of inflammation: gold microparticles > 20 µm and gold ... ...

Abstract	The newest data on metallic gold have placed the noble metal central in the fight for the safe treatment of autoimmune inflammation. There are two different ways to use gold for the treatment of inflammation: gold microparticles > 20 µm and gold nanoparticles. The injection of gold microparticles (µGold) is a purely local therapy. µGold particles stay put where injected, and gold ions released from them are relatively few and taken up by cells within a sphere of only a few millimeters in diameter from their origin particles. The macrophage-induced release of gold ions may continue for years. Injection of gold nanoparticles (nanoGold), on the other hand, is spread throughout the whole body, and the bio-released gold ions, therefore, affect multitudes of cells all over the body, as when using gold-containing drugs such as Myocrisin. Since macrophages and other phagocytotic cells take up and transport nanoGold and remove it after a short period, repeated treatment is necessary. This review describes the details of the cellular mechanisms that lead to the bio-release of gold ions in µGold and nanoGold.
MeSH term(s)	Humans ; Gold ; Metal Nanoparticles ; Inflammation/drug therapy ; Gold Sodium Thiomalate ; Ions
Chemical Substances	Gold (7440-57-5) ; Gold Sodium Thiomalate (12244-57-4) ; Ions
Language	English
Publishing date	2023-03-02
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1222930-1
ISSN	1432-119X ; 0301-5564 ; 0948-6143
ISSN (online)	1432-119X
ISSN	0301-5564 ; 0948-6143
DOI	10.1007/s00418-023-02182-9
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Article: Endoskopisk perkutan transhepatisk kolelitotripsi til behandling af vanskelige sten i de dybe galdeveje.

Stage, J G / Rasmussen, S G / Brøns, J H / Damgaard, B / Matzen, P / Kehlet, H

Ugeskrift for laeger

1991 Volume 153, Issue 46, Page(s) 3233–3235

Abstract: The results of endoscopic percutaneous transhepatic cholelithotripsy in seven patients with stones in the deep biliary passages which could not be treated by endoscopic papillotomy (EST) or extracorporeal shock wave lithotripsy (ESWL) are presented. A ... ...

Title translation	Endoscopic percutaneous transhepatic cholelithotripsy in the treatment of complicated stones in the deep biliary tracts.
Abstract	The results of endoscopic percutaneous transhepatic cholelithotripsy in seven patients with stones in the deep biliary passages which could not be treated by endoscopic papillotomy (EST) or extracorporeal shock wave lithotripsy (ESWL) are presented. A new dilator technique combined with mechanical or laser-lithotripsy was employed. All of the patients were relieved of the stones after uncomplicated course. It is concluded that endoscopic percutaneous cholelithotripsy which can be carried out under local anaesthesia, should be offered to patients with stones in the deep biliary passages which are not accessible to conventional treatment with EST or ESWL.
MeSH term(s)	Aged ; Cholelithiasis/diagnostic imaging ; Cholelithiasis/therapy ; Endoscopy, Digestive System ; Evaluation Studies as Topic ; Female ; Humans ; Lithotripsy/methods ; Male ; Middle Aged ; Radiography
Language	Danish
Publishing date	1991-11-11
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
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Article ; Online: NSAIDs are superior to paracetamol for osteoarthritic pain and function in a network meta-analysis.

Rasmussen, Sten

BMJ evidence-based medicine

2018 Volume 23, Issue 1, Page(s) 40–41

MeSH term(s)	Acetaminophen ; Analgesics, Non-Narcotic ; Anti-Inflammatory Agents, Non-Steroidal ; Humans ; Network Meta-Analysis ; Osteoarthritis ; Osteoarthritis, Hip ; Osteoarthritis, Knee ; Pain ; Treatment Outcome
Chemical Substances	Analgesics, Non-Narcotic ; Anti-Inflammatory Agents, Non-Steroidal ; Acetaminophen (362O9ITL9D)
Language	English
Publishing date	2018-02-01
Publishing country	England
Document type	Journal Article ; Review ; Comment
ISSN	2515-4478
ISSN (online)	2515-4478
DOI	10.1136/ebmed-2017-110878
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Article ; Online: Impact of low pneumoperitoneum on renal function and acute kidney injury biomarkers during robot-assisted radical prostatectomy (RARP): a randomised clinical trial.

Alhusseinawi, Hayder / Sander, Lotte / Handberg, Aase / Rasmussen, Rikke W / Kingo, Pernille S / Jensen, Jørgen B / Rasmussen, Sten

Journal of robotic surgery

2024 Volume 18, Issue 1, Page(s) 31

Abstract: The objective of this study was to evaluate the effect of low pneumoperitoneum pressure (Pnp) on renal function and renal injury biomarkers during robot-assisted radical prostatectomy (RARP). A single-centre, triple-blinded, randomised clinical trial was ...

Abstract	The objective of this study was to evaluate the effect of low pneumoperitoneum pressure (Pnp) on renal function and renal injury biomarkers during robot-assisted radical prostatectomy (RARP). A single-centre, triple-blinded, randomised clinical trial was conducted with 98 patients undergoing RARP, who were assigned to either standard Pnp of 12 mmHg or low Pnp of 7 mmHg. The primary outcome was urinary neutrophil gelatinase-associated lipocalin (u-NGAL), and several other kidney injury biomarkers were assessed as secondary outcomes. Acute kidney injury (AKI) was evaluated using the Kidney Disease Improving Global Outcomes (KDIGO) criteria, the gold standard method for defining AKI. The trial was registered on ClinicalTrials.gov (NCT04755452). Patients in the low Pnp group had significantly lower levels of u-NGAL (mean difference - 39.9, 95% CI - 73.7 to - 6.1, p = 0.02) compared to the standard Pnp group. No significant differences were observed for other urinary biomarkers. Interestingly, there was a significant difference in intraoperative urine production between the groups (low Pnp median: 200 mL, IQR: 100-325 vs. standard Pnp median: 100 mL, IQR: 50-200, p = 0.01). Similarly, total postoperative urine production also varied significantly (low Pnp median: 1325 mL, IQR: 1025-1800 vs. standard Pnp median: 1000 mL, IQR: 850-1287, p = 0.001). The occurrence of AKI, as defined by the KDIGO criteria, did not differ significantly between the groups. Low Pnp during RARP resulted in lower u-NGAL levels, suggesting a potential benefit in terms of reduced renal injury. However, the lack of a notable difference in AKI as defined by the KDIGO criteria indicates that the clinical significance of this finding may be limited. Further research is needed to validate and expand on these results, ultimately defining the optimal Pnp strategy for RARP and improving patient outcomes.
MeSH term(s)	Male ; Humans ; Lipocalin-2 ; Pneumoperitoneum/etiology ; Robotics ; Robotic Surgical Procedures/methods ; Prostatectomy/adverse effects ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Kidney/surgery ; Biomarkers
Chemical Substances	Lipocalin-2 ; Biomarkers
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2268283-1
ISSN	1863-2491 ; 1863-2483
ISSN (online)	1863-2491
ISSN	1863-2483
DOI	10.1007/s11701-023-01744-2
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Article ; Online: Methodology considerations for 'Safety and effectiveness of cannabinoids to Danish patients with treatment-refractory chronic pain' by Horsted et al.

Arendt-Nielsen, Lars / Pedersen, Kristian Kjaer-Staal / Dreyer, Lene / Kristensen, Salome / Rasmussen, Sten / Biering-Sørensen, Bo / Kasch, Helge / Rice, Andrew

European journal of pain (London, England)

2023 Volume 27, Issue 6, Page(s) 661–663

MeSH term(s)	Humans ; Chronic Pain/drug therapy ; Cannabinoids/adverse effects ; Pain, Intractable ; Denmark
Chemical Substances	Cannabinoids
Language	English
Publishing date	2023-03-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1390424-3
ISSN	1532-2149 ; 1090-3801
ISSN (online)	1532-2149
ISSN	1090-3801
DOI	10.1002/ejp.2107
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Article ; Online: Simulation-based assessment of upper abdominal ultrasound skills.

Teslak, Kristina E / Post, Julie H / Tolsgaard, Martin G / Rasmussen, Sten / Purup, Mathias M / Friis, Mikkel L

BMC medical education

2024 Volume 24, Issue 1, Page(s) 15

Abstract: Background: Ultrasound is a safe and effective diagnostic tool used within several specialties. However, the quality of ultrasound scans relies on sufficiently skilled clinician operators. The aim of this study was to explore the validity of automated ... ...

Abstract	Background: Ultrasound is a safe and effective diagnostic tool used within several specialties. However, the quality of ultrasound scans relies on sufficiently skilled clinician operators. The aim of this study was to explore the validity of automated assessments of upper abdominal ultrasound skills using an ultrasound simulator. Methods: Twenty five novices and five experts were recruited, all of whom completed an assessment program for the evaluation of upper abdominal ultrasound skills on a virtual reality simulator. The program included five modules that assessed different organ systems using automated simulator metrics. We used Messick's framework to explore the validity evidence of these simulator metrics to determine the contents of a final simulator test. We used the contrasting groups method to establish a pass/fail level for the final simulator test. Results: Thirty seven out of 60 metrics were able to discriminate between novices and experts (p < 0.05). The median simulator score of the final simulator test including the metrics with validity evidence was 26.68% (range: 8.1-40.5%) for novices and 85.1% (range: 56.8-91.9%) for experts. The internal structure was assessed by Cronbach alpha (0.93) and intraclass correlation coefficient (0.89). The pass/fail level was determined to be 50.9%. This pass/fail criterion found no passing novices or failing experts. Conclusions: This study collected validity evidence for simulation-based assessment of upper abdominal ultrasound examinations, which is the first step toward competency-based training. Future studies may examine how competency-based training in the simulated setting translates into improvements in clinical performances.
MeSH term(s)	Humans ; Clinical Competence ; Computer Simulation ; Ultrasonography ; Virtual Reality ; Internship and Residency ; Reproducibility of Results
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-023-05018-1
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Article ; Online: Intra-articular injection of gold micro-particles with hyaluronic acid for painful knee osteoarthritis.

Rasmussen, Sten / Petersen, Kristian Kjaer / Aboo, Christopher / Andersen, Jacob Skallerup / Skjoldemose, Emilie / Jørgensen, Nia Kristine / Stensballe, Allan / Arendt-Nielsen, Lars

BMC musculoskeletal disorders

2024 Volume 25, Issue 1, Page(s) 211

Abstract: Background: Recently, in an open pilot study, we found up to two years, a potential pain-relieving effect of intra-articular gold micro-particles using the patient's synovial fluid for patients with knee osteoarthritis (KOA). During the study the ... ...

Abstract	Background: Recently, in an open pilot study, we found up to two years, a potential pain-relieving effect of intra-articular gold micro-particles using the patient's synovial fluid for patients with knee osteoarthritis (KOA). During the study the excluded group of patients, due to multisite pain, co-morbidities, and other exclusion criteria., received intra-articular gold micro-particles using hyaluronic acid,. We aimed to identify if pre-treatment characteristics influence the global outcome two years after intra-articular treatment for painful KOA with gold microparticles using hyaluronic acid. Methods: Using hyaluronic acid as the carrier, 136 patients with KOA received intraarticular injections with 20 mg gold microparticles (72.000 particles, 20-40 μm in diameter). In the analysis, we included the Global Rating of Change Scale, Pain Detect Questionnaire (PDQ), Body Mass Index (BMI), and Kellgren & Lawrence score at the inclusion, Western Ontario, and McMaster Universities Osteoarthritis Index (WOMAC) sub-scores for pain, stiffness, and function at inclusion and two years. Results: On the Global Rating Change Scale, 69.1% of patients reported a positive effect, 28.7% no effect, and 2.2% worse. PDQ and the three WOMAC subscores all improved at two years of follow-up. PDQ ≥ 13 (P = 0.028), BMI (P = 0.022) and Kellgren & Lawrence grade 4 (P = 0.028) at inclusion reduced the effect with a minor odds ratio compared to the baseline effect of treatment (P = 0.025). WOMAC subscores at inclusion did not influence the outcome (P > 0.5). Conclusions: Severe osteoarthritis, obesity, and neuropathic pain, reduced the effect of intra-articular gold microparticles for knee OA. Trial registration: The study followed the principles of the Declaration of Helsinki and was approved by the local ethics committee of the North Denmark Region by 27/07/2016 (N-20,160,045). The regional data protection agency approved the project by 06/07/2016 (2008-58-0028, ID 2016 - 116) and registered in ClinicalTrial.Gov by 04/01/2018 (NCT03389906).
MeSH term(s)	Humans ; Hyaluronic Acid ; Injections, Intra-Articular ; Neuralgia ; Osteoarthritis, Knee/therapy ; Pilot Projects ; Treatment Outcome
Chemical Substances	Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Clinical Study ; Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-024-07321-4
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Article ; Online: Cost of simulation-based mastery learning for abdominal ultrasound.

Post, Julie H / Teslak, Kristina E / Tolsgaard, Martin G / Rasmussen, Sten / Friis, Mikkel L

BMC medical education

2023 Volume 23, Issue 1, Page(s) 921

Abstract: Background: Ultrasound is an essential diagnostic examination used in several medical specialties. However, the quality of ultrasound examinations is dependent on mastery of certain skills, which may be difficult and costly to attain in the clinical ... ...

Abstract	Background: Ultrasound is an essential diagnostic examination used in several medical specialties. However, the quality of ultrasound examinations is dependent on mastery of certain skills, which may be difficult and costly to attain in the clinical setting. This study aimed to explore mastery learning for trainees practicing general abdominal ultrasound using a virtual reality simulator and to evaluate the associated cost per student achieving the mastery learning level. Methods: Trainees were instructed to train on a virtual reality ultrasound simulator until the attainment of a mastery learning level was established in a previous study. Automated simulator scores were used to track performances during each round of training, and these scores were recorded to determine learning curves. Finally, the costs of the training were evaluated using a micro-costing procedure. Results: Twenty-one out of the 24 trainees managed to attain the predefined mastery level two times consecutively. The trainees completed their training with a median of 2h38min (range: 1h20min-4h30min) using a median of 7 attempts (range: 3-11 attempts) at the simulator test. The cost of training one trainee to the mastery level was estimated to be USD 638. Conclusion: Complete trainees can obtain mastery learning levels in general abdominal ultrasound examinations within 3 hours of training in the simulated setting and at an average cost of USD 638 per trainee. Future studies are needed to explore how the cost of simulation-based training is best balanced against the costs of clinical training.
MeSH term(s)	Humans ; Clinical Competence ; Ultrasonography ; Computer Simulation ; Virtual Reality ; Simulation Training/methods ; Learning Curve
Language	English
Publishing date	2023-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-023-04919-5
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Article ; Online: Acquisition and usage of robotic surgical data for machine learning analysis.

Hashemi, Nasseh / Svendsen, Morten Bo Søndergaard / Bjerrum, Flemming / Rasmussen, Sten / Tolsgaard, Martin G / Friis, Mikkel Lønborg

Surgical endoscopy

2023 Volume 37, Issue 8, Page(s) 6588–6601

Abstract: Background: The increasing use of robot-assisted surgery (RAS) has led to the need for new methods of assessing whether new surgeons are qualified to perform RAS, without the resource-demanding process of having expert surgeons do the assessment. ... ...

Abstract	Background: The increasing use of robot-assisted surgery (RAS) has led to the need for new methods of assessing whether new surgeons are qualified to perform RAS, without the resource-demanding process of having expert surgeons do the assessment. Computer-based automation and artificial intelligence (AI) are seen as promising alternatives to expert-based surgical assessment. However, no standard protocols or methods for preparing data and implementing AI are available for clinicians. This may be among the reasons for the impediment to the use of AI in the clinical setting. Method: We tested our method on porcine models with both the da Vinci Si and the da Vinci Xi. We sought to capture raw video data from the surgical robots and 3D movement data from the surgeons and prepared the data for the use in AI by a structured guide to acquire and prepare video data using the following steps: 'Capturing image data from the surgical robot', 'Extracting event data', 'Capturing movement data of the surgeon', 'Annotation of image data'. Results: 15 participant (11 novices and 4 experienced) performed 10 different intraabdominal RAS procedures. Using this method we captured 188 videos (94 from the surgical robot, and 94 corresponding movement videos of the surgeons' arms and hands). Event data, movement data, and labels were extracted from the raw material and prepared for use in AI. Conclusion: With our described methods, we could collect, prepare, and annotate images, events, and motion data from surgical robotic systems in preparation for its use in AI.
MeSH term(s)	Humans ; Animals ; Swine ; Robotic Surgical Procedures/methods ; Artificial Intelligence ; Machine Learning ; Surgeons ; Motion
Language	English
Publishing date	2023-06-30
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-023-10214-7
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