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  1. Book ; Online ; Conference proceedings ; E-Book: Critical issues in head and neck oncology

    Vermorken, Jan B.

    key concepts from the Sixth THNO Meeting

    2018  

    Event/congress Trends in Head and Neck Oncology (6., 2017, Nice)
    Author's details Jan B. Vermorken [und 5 weitere] editors
    Language English
    Size 1 Online-Ressource (ix, 363 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; Conference proceedings ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019928967
    ISBN 978-3-319-98854-2 ; 9783319988535 ; 3-319-98854-9 ; 3319988530
    DOI 10.1007/978-3-319-98854-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book: A new look at induction chemotherapy in locally advanced head and neck cancer

    Vermorken, Jan B.

    (The oncologist ; 15, Suppl. 3)

    2010  

    Author's details ed. Jan B. Vermorken
    Series title The oncologist ; 15, Suppl. 3
    Collection
    Language English
    Size 32 S. : graph. Darst.
    Publisher AlphaMed Press
    Publishing place Durham, NC
    Publishing country United States
    Document type Book
    HBZ-ID HT016601150
    Database Catalogue ZB MED Medicine, Health

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    Zs A 4845 -15,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: Annals of Oncology: a statement of editorial intent.

    Vermorken, J B

    Annals of oncology : official journal of the European Society for Medical Oncology

    2019  Volume 23, Issue 8, Page(s) 1931–1932

    Language English
    Publishing date 2019-12-04
    Publishing country England
    Document type Editorial
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mds251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2862: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online ; Conference proceedings ; E-Book: Critical issues in head and neck oncology

    O'Sullivan, Brian / Vermorken, Jan B. / Budach, Volker / Leemans, C. René / Machiels, Jean-Pascal / Nicolai, Pietro

    key concepts from the Fifth THNO Meeting

    2017  

    Event/congress Trends in Head and Neck Oncology (5., 2015, Lissabon)
    Author's details editors Jan B. Vermorken, Volker Budach, C. René Leemans, Jean-Pascal Machiels, Piero Nicolai, Brian O'Sullivan
    Keywords Head and Neck Neoplasms / diagnosis ; Head and Neck Neoplasms / therapy ; Clinical Decision-Making ; Europe / https://id.nlm.nih.gov/mesh/D005060
    Language English
    Size 1 Online-Ressource (xiii, 296 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; Conference proceedings ; E-Book
    Note Tagungsdaten: 05 Nov - 07 Nov 2015, Lisbon, Portugal
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019470438
    ISBN 978-3-319-42909-0 ; 9783319429076 ; 3-319-42909-4 ; 3319429078
    DOI 10.1007/978-3-319-42909-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  5. Book: Redefining "state of the art" in head and neck cancer

    Vermorken, Jan B.

    9 August 2004, Washington DC, USA

    (Annals of oncology ; 16, Suppl. 6)

    2005  

    Author's details guest ed.: J. B. Vermorken
    Series title Annals of oncology ; 16, Suppl. 6
    Collection
    Language English
    Size 30 S. : Ill.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT014491328
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2862 -16,Suppl.6- not available for loan Zeitschriften-Lesesaal

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  6. Article ; Online: Thank you my friends.

    Vermorken, J B

    Annals of oncology : official journal of the European Society for Medical Oncology

    2013  Volume 24, Issue 12, Page(s) 2931

    MeSH term(s) Editorial Policies ; Humans ; Journal Impact Factor ; Medical Oncology ; Serial Publications/standards
    Language English
    Publishing date 2013-11-24
    Publishing country England
    Document type Editorial
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdt520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2862: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The marker of cobalamin deficiency, plasma methylmalonic acid, may help identifying lysosomal iron trapping in patients. Its possible utility for heart failure.

    Vermorken, Alphons J M / Zhu, Jingjing / Holvoet, Paul / Cui, Yali

    Redox biology

    2021  Volume 44, Page(s) 102011

    Abstract: Iron deficiency is known to aggravate the prognosis of patients with heart failure. Iron has functions in the mitochondrial respiratory chain. In patients with reduced mitochondrial respiration, the mitochondrial ratio between the level of nicotinamide ... ...

    Abstract Iron deficiency is known to aggravate the prognosis of patients with heart failure. Iron has functions in the mitochondrial respiratory chain. In patients with reduced mitochondrial respiration, the mitochondrial ratio between the level of nicotinamide adenine dinucleotide and its reduced form decreases. Due to the mitochondrial-lysosomal interplay, decreased mitochondrial respiration also leads to inhibition of lysosomal hydrolysis. As a result, cobalamin and iron will be trapped in lysosomes. This will, even if iron and cobalamin have been consumed and absorbed in sufficient amounts, lead to their functional deficiencies.
    MeSH term(s) Heart Failure ; Homocysteine ; Humans ; Iron ; Lysosomes ; Methylmalonic Acid ; Vitamin B 12
    Chemical Substances Homocysteine (0LVT1QZ0BA) ; Methylmalonic Acid (8LL8S712J7) ; Iron (E1UOL152H7) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2021-05-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2021.102011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Second-line randomized trials in epithelial ovarian cancer.

    Vermorken, J B

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2008  Volume 18 Suppl 1, Page(s) 59–66

    Abstract: Important issues in the treatment of patients with recurrent ovarian cancer (ROC) are 1) to delay the time to symptomatic disease, 2) to reduce symptoms in case of symptomatic disease, 3) to optimize quality of life, and 4) to prolong overall survival. ... ...

    Abstract Important issues in the treatment of patients with recurrent ovarian cancer (ROC) are 1) to delay the time to symptomatic disease, 2) to reduce symptoms in case of symptomatic disease, 3) to optimize quality of life, and 4) to prolong overall survival. However, response assessment and recording of treatment-induced side effects in general get most attention. The likelihood of response to chemotherapy is directly proportional to the length of time between the end of primary chemotherapy and the date of recurrence. Also, the aggressiveness of the recurrence seems related to the prior biological pace of disease progression. For these reasons different disease categories have been identified, ie, platinum/taxane-refractory disease (progressive during first-line stabilization as best response), persistent disease (partial response to first-line therapy), platinum/taxane-resistant disease (clinical complete response [CCR] or no evidence of disease [NED] to/after first line and relapse <6 months), and platinum/taxane-sensitive disease (CCR or NED to/after first line and relapse >6 months). Randomized trials in these different categories did not show a benefit of maintenance or consolidation therapies after first-line therapy but did show differences in tolerability and efficacy (in platinum/taxane-sensitive disease) of different single agents and indicated that in specific circumstances combination chemotherapy is superior to single-agent chemotherapy. However, in all circumstances other aspects such as toxicity (and earlier experienced toxicity), clinical condition, convenience of administration, costs, and patient preference should be considered in the final selection of treatment.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Female ; Humans ; Neoplasm Recurrence, Local/drug therapy ; Neoplasms, Glandular and Epithelial/drug therapy ; Ovarian Neoplasms/drug therapy ; Randomized Controlled Trials as Topic
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2008-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1111/j.1525-1438.2007.01161.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Optimizing vestibular implant electrode positioning using fluoroscopy and intraoperative CT imaging.

    Loos, Elke / Stultiens, Joost J A / Volpe, Benjamin / Vermorken, Bernd L / Van Boxel, Stan C J / Devocht, Elke M J / van Hoof, Marc / Postma, Alinda A / Guinand, Nils / Pérez-Fornos, Angelica / Van Rompaey, Vincent / Denys, Sam / Desloovere, Christian / Verhaert, Nicolas / van de Berg, Raymond

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  

    Abstract: Purpose:  Vestibular implant electrode positioning close to the afferent nerve fibers is considered to be key for effective and selective electrical stimulation. However, accurate positioning of vestibular implant electrodes inside the semicircular ... ...

    Abstract Purpose:  Vestibular implant electrode positioning close to the afferent nerve fibers is considered to be key for effective and selective electrical stimulation. However, accurate positioning of vestibular implant electrodes inside the semicircular canal ampullae is challenging due to the inability to visualize the target during the surgical procedure. This study investigates the accuracy of a new surgical protocol with real-time fluoroscopy and intraoperative CT imaging, which facilitates electrode positioning during vestibular implant surgery.
    Methods:  Single-center case-controlled cohort study with a historic control group at a tertiary referral center. Patients were implanted with a vestibulocochlear implant, using a combination of intraoperative fluoroscopy and cone beam CT imaging. The control group consisted of five patients who were previously implanted with the former implant prototype, without the use of intraoperative imaging. Electrode positioning was analyzed postoperatively with a high-resolution CT scan using 3D slicer software. The result was defined as accurate if the electrode position was within 1.5 mm of the center of the ampulla.
    Results: With the new imaging protocol, all electrodes could be positioned within a 1.5 mm range of the center of the ampulla. The accuracy was significantly higher in the study group with intraoperative imaging (21/21 electrodes) compared to the control group without intraoperative imaging (10/15 electrodes), (p = 0.008).
    Conclusion:  The combined use of intraoperative fluoroscopy and CT imaging during vestibular implantation can improve the accuracy of electrode positioning. This might lead to better vestibular implant performance.
    Language English
    Publishing date 2024-01-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-08428-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul II Zs.50: Show issues Location:
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  10. Article ; Online: The VertiGO! Trial protocol: A prospective, single-center, patient-blinded study to evaluate efficacy and safety of prolonged daily stimulation with a multichannel vestibulocochlear implant prototype in bilateral vestibulopathy patients.

    Vermorken, Bernd L / Volpe, Benjamin / van Boxel, Stan C J / Stultiens, Joost J A / van Hoof, Marc / Marcellis, Rik / Loos, Elke / van Soest, Alexander / McCrum, Chris / Meijer, Kenneth / Guinand, Nils / Pérez Fornos, Angélica / van Rompaey, Vincent / Devocht, Elke / van de Berg, Raymond

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0301032

    Abstract: Background: A combined vestibular (VI) and cochlear implant (CI) device, also known as the vestibulocochlear implant (VCI), was previously developed to restore both vestibular and auditory function. A new refined prototype is currently being ... ...

    Abstract Background: A combined vestibular (VI) and cochlear implant (CI) device, also known as the vestibulocochlear implant (VCI), was previously developed to restore both vestibular and auditory function. A new refined prototype is currently being investigated. This prototype allows for concurrent multichannel vestibular and cochlear stimulation. Although recent studies showed that VCI stimulation enables compensatory eye, body and neck movements, the constraints in these acute study designs prevent them from creating more general statements over time. Moreover, the clinical relevance of potential VI and CI interactions is not yet studied. The VertiGO! Trial aims to investigate the safety and efficacy of prolonged daily motion modulated stimulation with a multichannel VCI prototype.
    Methods: A single-center clinical trial will be carried out to evaluate prolonged VCI stimulation, assess general safety and explore interactions between the CI and VI. A single-blind randomized controlled crossover design will be implemented to evaluate the efficacy of three types of stimulation. Furthermore, this study will provide a proof-of-concept for a VI rehabilitation program. A total of minimum eight, with a maximum of 13, participants suffering from bilateral vestibulopathy and severe sensorineural hearing loss in the ear to implant will be included and followed over a five-year period. Efficacy will be evaluated by collecting functional (i.e. image stabilization) and more fundamental (i.e. vestibulo-ocular reflexes, self-motion perception) outcomes. Hearing performance with a VCI and patient-reported outcomes will be included as well.
    Discussion: The proposed schedule of fitting, stimulation and outcome testing allows for a comprehensive evaluation of the feasibility and long-term safety of a multichannel VCI prototype. This design will give insights into vestibular and hearing performance during VCI stimulation. Results will also provide insights into the expected daily benefit of prolonged VCI stimulation, paving the way for cost-effectiveness analyses and a more comprehensive clinical implementation of vestibulocochlear stimulation in the future.
    Trial registration: ClinicalTrials.gov: NCT04918745. Registered 28 April 2021.
    MeSH term(s) Humans ; Bilateral Vestibulopathy ; Cochlear Implants/adverse effects ; Prospective Studies ; Single-Blind Method ; Randomized Controlled Trials as Topic ; Cross-Over Studies
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0301032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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