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  1. Book ; Online ; E-Book: Nanoarchitectonics for Brain Drug Delivery

    Kumar Singh, Anurag / Chaturvedi, Vivek K. / Singh, Jay

    (Advances in Bionanotechnology Series)

    2024  

    Abstract: This book discusses basics of brain diseases and role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and need for novel drug delivery approaches. It highlights the current ...

    Author's details edited by Anurag Kumar Singh, Vivek K. Chaturvedi, and Jay Singh
    Series title Advances in Bionanotechnology Series
    Abstract "This book discusses basics of brain diseases and role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and need for novel drug delivery approaches. It highlights the current route for the intranasal advanced drug delivery systems for brain diseases. It also discusses the innovative categories of drug delivery systems, including mesoporous silica nanoparticles, polymeric nanocarriers, lipid-based nanocarriers through multi-responsive DDSs and their implications in brain disorders. Includes overview of brain diseases and highlights the need for novel drug delivery approaches. Focusses on theoretical aspects of the advanced drug delivery systems for brain diseases including challenges and progress in nose-to-brain delivery. Provides an overview of the technological approaches and their implications in the neurodegenerative disorders, CNS, and brain drug delivery in brain cancer. Discusses key advances in the development of polymer nanoparticles for drug delivery to the CNS. Review role of herbal medicines and naturally derived polymeric nanoparticle for the treatment of neurodegenerative disorders. This book is aimed at graduate students and researchers in biomedical engineering, biotechnology, drug delivery, and neurology"--
    MeSH term(s) Brain Diseases/drug therapy. ; Neurodegenerative Diseases/drug therapy. ; Nanoparticle Drug Delivery System/chemistry. ; Nanoparticle Drug Delivery System/therapeutic use. ; Nanoparticles/therapeutic use. ; Biotechnology/methods.
    Keywords Nanomedicine ; Drug carriers (Pharmacy)
    Subject code 615.19
    Language English
    Size 1 online resource (0 pages)
    Edition First edition.
    Publisher CRC Press
    Publishing place Boca Raton, FL
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-03-266196-8 ; 1-003-85184-3 ; 9781032661957 ; 978-1-03-266196-4 ; 978-1-003-85184-4 ; 103266195X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Efficient removal of endocrine disrupting compounds 17 α-ethynyl estradiol and 17 β-estradiol by Enterobacter sp. strain BHUBP7 and elucidation of the degradation pathway by HRAMS analysis.

    Prakash, Chandra / Kumar, Vivek / Chaturvedi, Venkatesh

    World journal of microbiology & biotechnology

    2023  Volume 39, Issue 8, Page(s) 218

    Abstract: Owing to the increased population and their overuse, estrogens are being detected in the environment at alarming levels. They act as endocrine disrupting compounds (EDC's) posing adverse effects on animals and humans. In this study, a strain belonging to ...

    Abstract Owing to the increased population and their overuse, estrogens are being detected in the environment at alarming levels. They act as endocrine disrupting compounds (EDC's) posing adverse effects on animals and humans. In this study, a strain belonging to Enterobacter sp. strain BHUBP7 was recovered from a Sewage Treatment Plant (STP) situated in Varanasi city, U.P., India, and was capable of metabolizing both 17 α-Ethynylestradiol (EE2) and 17 β-Estradiol (E2) separately as a sole carbon source. The strain BHUBP7 exhibited high rates of E2 degradation as compared to EE2 degradation. The degradation of E2 (10 mg/L) was 94.3% after four days of incubation, whereas the degradation of EE2 (10 mg/L) under similar conditions was 98% after seven days of incubation. The kinetics of EE2 and E2 degradation fitted well with the first-order reaction rate. FTIR analysis revealed the involvement of functional groups like C = O, C-C, C-OH during the degradation process. The metabolites generated during degradation of EE2 and E2 were identified using HRAMS and a plausible pathway was elucidated. It was observed that metabolism of both E2 and EE2 proceeded with the formation of estrone, which was then hydroxylated to 4-hydroxy estrone, followed by ring opening at the C4-C5 position, and was further metabolized by the 4,5 seco pathway leading to the formation of 3-(7a-methyl-1,5-dioxooctahydro-1H-inden-4-yl) propanoic acid (HIP). It is the first report on the complete pathway of EE2 and E2 degradation in Enterobacter sp. strain BHUBP7. Moreover, the formation of Reactive Oxygen Species (ROS) during the degradation of EE2 and E2 was observed. It was concluded that both hormones elicited the generation of oxidative stress in the bacterium during the degradation process.
    MeSH term(s) Humans ; Estradiol/analysis ; Estradiol/metabolism ; Estrone/analysis ; Estrone/metabolism ; Ethinyl Estradiol/analysis ; Ethinyl Estradiol/metabolism ; Bacteria/metabolism ; India ; Water Pollutants, Chemical/metabolism
    Chemical Substances Estradiol (4TI98Z838E) ; Estrone (2DI9HA706A) ; Ethinyl Estradiol (423D2T571U) ; Water Pollutants, Chemical
    Language English
    Publishing date 2023-06-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1499109-3
    ISSN 1573-0972 ; 0959-3993
    ISSN (online) 1573-0972
    ISSN 0959-3993
    DOI 10.1007/s11274-023-03662-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Folate-Mediated Targeting and Controlled Release: PLGA-Encapsulated Mesoporous Silica Nanoparticles Delivering Capecitabine to Pancreatic Tumor.

    Tripathi, Abhay Dev / Labh, Yamini / Katiyar, Soumya / Singh, Anurag Kumar / Chaturvedi, Vivek K / Mishra, Abha

    ACS applied bio materials

    2024  

    Abstract: The discovery of specifically tailored therapeutic delivery systems has sparked the interest of pharmaceutical researchers considering improved therapeutic effectiveness and fewer adverse effects. The current study concentrates on the design and ... ...

    Abstract The discovery of specifically tailored therapeutic delivery systems has sparked the interest of pharmaceutical researchers considering improved therapeutic effectiveness and fewer adverse effects. The current study concentrates on the design and characterization of PLGA (polylactic-co-glycolic acid) capped mesoporous silica nanoparticles (MSN)-based systems for drug delivery for pH-sensitive controlled drug release in order to achieve a targeted drug release inside the acidic tumor microenvironment. The physicochemical properties of the nanoformulations were analyzed using TEM, zeta potential, AFM, TGA, FTIR, and BET analyses in addition to DLS size. The final formed PLGA-FoA-MSN-CAP and pure MSN had sizes within the therapeutic ranges of 164.5 ± 1.8 and 110.7 ± 2.2, respectively. Morphological characterization (TEM and AFM) and elemental analysis (FTIR and XPS) confirmed the proper capping and tagging of PLGA and folic acid (FoA). The PLGA-coated FoA-MSN exhibited a pH-dependent controlled release of the CAP (capecitabine) drug, showing efficient release at pH 6.8. Furthermore, the
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.4c00019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: Anticancer potential of oroxylin A: from mechanistic insight to synergistic perspectives.

    Tuli, Hardeep Singh / Garg, Vivek Kumar / Kumar, Ajay / Aggarwal, Diwakar / Anand, Uttpal / Parashar, Nidarshana Chaturvedi / Saini, Adesh K / Mohapatra, Ranjan K / Dhama, Kuldeep / Kumar, Manoj / Singh, Tejveer / Kaur, Jagjit / Sak, Katrin

    Naunyn-Schmiedeberg's archives of pharmacology

    2024  

    Language English
    Publishing date 2024-04-15
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-024-03083-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.5: Show issues Location:
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  5. Article ; Online: Decreased expression of CD200 on peripheral blood leukocytes in alcohol dependence.

    Chaturvedi, Abhishek / Rao, Guruprasad / Praharaj, Samir Kumar / Guruprasad, Kanive Parashiva / Pais, Vivek / Sadacharan, Chakravarthy Marx

    Alcohol (Fayetteville, N.Y.)

    2023  Volume 113, Page(s) 21–25

    Abstract: Chronic alcohol use induces innate immune genes, which activate the innate immune system. Neuroimmune regulatory proteins [e.g., Cluster of Differentiation 200 (CD200)] are immune response regulators and are involved in balancing the immune response. ... ...

    Abstract Chronic alcohol use induces innate immune genes, which activate the innate immune system. Neuroimmune regulatory proteins [e.g., Cluster of Differentiation 200 (CD200)] are immune response regulators and are involved in balancing the immune response. This study aimed to investigate the expression of CD200 on the surface of peripheral blood leukocytes in patients with alcohol use disorder and compare them with controls. Fifty male patients with alcohol use disorder were included in the study. A baseline assessment was done, and alcohol use history, craving, and withdrawal scores were collected. A 2-mL venous blood sample was collected from cases and controls for immunophenotyping of CD200. The control group consisted of 50 participants with similar socio-economic backgrounds. The cellular expression of CD200 on total leukocytes (median ± IQR) [39.94 (28.85, 50.01)] in cases was significantly lower compared to controls [45.07 (37.70, 51.69)] (U = 896, p = 0.015). Expression of CD200 on lymphocytes in cases was negatively correlated with years of heavy drinking and this was statistically significant (r = -0.321, p = 0.023). The study indicates that cellular expression of CD200 on the surface of peripheral blood leukocytes is reduced in alcohol-dependent patients. This reduction can contribute to exaggerated immune activity, release of pro-inflammatory cytokines, chronic microglial activation, neuroinflammation, and neurodegeneration in alcohol dependence.
    MeSH term(s) Humans ; Male ; Alcoholism ; Antigens, CD/metabolism ; Leukocytes/metabolism ; Cytokines/metabolism
    Chemical Substances Antigens, CD ; Cytokines
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605912-0
    ISSN 1873-6823 ; 0741-8329
    ISSN (online) 1873-6823
    ISSN 0741-8329
    DOI 10.1016/j.alcohol.2023.08.003
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    Zs.A 2011: Show issues Location:
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  6. Article ; Online: Hypercalcemia - An enigmatic cause of acute pancreatitis.

    Tiwari, Anurag Kumar / Kumar, Vinod / Yadav, Dawesh P / Shukla, Sunit Kumar / Das, Dipankar / Singh, Gurvachan / Chaturvedi, Deepika / Dixit, Vinod Kumar / Chaturvedi, Vivek Kumar

    Journal of clinical and translational research

    2022  Volume 8, Issue 3, Page(s) 176–180

    Abstract: Background: Acute pancreatitis (AP) continues to be one of the common abdominal emergencies encountered in tertiary care hospitals. The majority of AP is caused by gall stones and alcohol. Hypercalcemia though uncommon has been reported to cause AP, ... ...

    Abstract Background: Acute pancreatitis (AP) continues to be one of the common abdominal emergencies encountered in tertiary care hospitals. The majority of AP is caused by gall stones and alcohol. Hypercalcemia though uncommon has been reported to cause AP, recurrent AP, and chronic pancreatitis (CP).
    Aim: The aim of this study was to describe hypercalcemia-induced AP in different settings.
    Materials and methods: In total 100 patients with AP, admitted from January 2021 to December 2021 at our center, etiologies were biliary (36%), alcohol (19%), idiopathic (21%), alcohol plus Biliary (5%), post-endoscopic retrograde cholangiopancreaticography (7%), drug-induced (6%), hypercalcemia (3%), and dengue infection (3%). Overall mortality was 11%.
    Results: In three patients with hypercalcemia-induced pancreatitis, causes of hypercalcemia were multiple myeloma, parathyroid adenoma leading to hyperparathyroidism, and hypervitaminosis D in association with hyperthyroidism.
    Conclusion: Hypercalcemia-induced AP is not a rare phenomenon and should be actively investigated to prevent further attacks of AP and progression to CP.
    Relevance for patients: Hypercalcemia is a potentially treatable cause of AP and its identification will not only help to treat and prevent further episodes of pancreatitis but also to manage underlying diseases leading to hypercalcemia.
    Language English
    Publishing date 2022-05-25
    Publishing country Singapore
    Document type Case Reports
    ZDB-ID 3019815-X
    ISSN 2424-810X ; 2382-6533
    ISSN (online) 2424-810X
    ISSN 2382-6533
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  7. Article: Commentary: Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.

    Rai, Sachchida Nand / Chaturvedi, Vivek K / Singh, Brijesh Kumar / Singh, Mohan P

    Frontiers in aging neuroscience

    2020  Volume 12, Page(s) 219

    Language English
    Publishing date 2020-08-18
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2020.00219
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  8. Article: Mucuna pruriens

    Rai, Sachchida Nand / Chaturvedi, Vivek K / Singh, Payal / Singh, Brijesh Kumar / Singh, M P

    3 Biotech

    2020  Volume 10, Issue 12, Page(s) 522

    Abstract: ... Mucuna ... ...

    Abstract Mucuna pruriens
    Language English
    Publishing date 2020-11-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-020-02532-7
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  9. Article: Catheter Fracture of Subclavian Venous Chemoport Device at Costoclavicular Junction: Pinch-off Syndrome.

    Goel, Vineet / Kumar, Naveen / Saxena, Vivek / Chaturvedi, Harit

    Indian journal of surgical oncology

    2018  Volume 9, Issue 4, Page(s) 595–597

    Abstract: Chemoport is most commonly used venous access devices for instillation of chemotherapeutic drugs in cancer care. Mechanical complications like catheter fracture can lead to serious morbidity, albeit occurring rarely. We present a case of a 35-year-old ... ...

    Abstract Chemoport is most commonly used venous access devices for instillation of chemotherapeutic drugs in cancer care. Mechanical complications like catheter fracture can lead to serious morbidity, albeit occurring rarely. We present a case of a 35-year-old lady, a case of carcinoma breast, who had spontaneous fracture of chemoport access device in subclavian vein at the level of clavicle after four successful cycles of chemotherapy. The fracture was suspected on chest x-ray and was subsequently confirmed on contrast linogram. The patient was successfully managed with endovascular interventional technique without suffering any ill effects. It is a rare presentation of pinch-off syndrome.
    Language English
    Publishing date 2018-07-30
    Publishing country India
    Document type Case Reports
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-018-0802-2
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  10. Article ; Online: Perioperative Management of a Patient with Chin-On-Chest Deformity Presenting for Reconstructive Spine Surgery.

    Khandelwal, Ankur / Sokhal, Suman / Dube, Surya Kumar / Goyal, Keshav / Singh, Akanksha / Tandon, Vivek / Phalak, Manoj / Chaturvedi, Arvind / Kale, Shashank Sharad

    Neurology India

    2022  Volume 69, Issue 6, Page(s) 1756–1758

    Abstract: Chin-on- chest deformity is not uncommon sequelae of ankylosing spondylitis. Apart from difficult airway, several other considerations might include co-existing cardio-respiratory embarrassment, osteoporotic bones, and neurological perturbations. We ... ...

    Abstract Chin-on- chest deformity is not uncommon sequelae of ankylosing spondylitis. Apart from difficult airway, several other considerations might include co-existing cardio-respiratory embarrassment, osteoporotic bones, and neurological perturbations. We describe the successful anesthetic management of a case of chin-on-chest deformity with no access to midline neck structures and extremely difficult airway posted for corrective spine surgery.
    MeSH term(s) Cervical Vertebrae ; Chin ; Humans ; Kyphosis ; Spondylitis, Ankylosing/complications ; Spondylitis, Ankylosing/surgery ; Treatment Outcome
    Language English
    Publishing date 2022-01-03
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.333489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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