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  1. Article: Returning Wholeness to Health.

    Mills, Paul J / Bushell, William C

    Global advances in health and medicine

    2022  Volume 11, Page(s) 2164957X221092358

    Language English
    Publishing date 2022-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2709002-4
    ISSN 2164-9561 ; 2164-957X
    ISSN (online) 2164-9561
    ISSN 2164-957X
    DOI 10.1177/2164957X221092358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Conference proceedings: Longevity, regeneration, and optimal health

    Bushell, William C.

    integrating eastern and western perspectives ; [result of a Conference Entitled Longevity and Optimal Health: Integrating Eastern and Western Perspectives, held on Sept. 18 - 21, 2006 at the Menla Mountain Retreat and Conference Center, Phoenicia, New York]

    (Annals of the New York Academy of Sciences ; 1172)

    2009  

    Event/congress Conference Entitled Longevity and Optimal Health: Integrating Eastern and Western Perspectives (2006)
    Author's details ed. by William C. Bushell
    Series title Annals of the New York Academy of Sciences ; 1172
    Collection
    Language English
    Size VII, 361 S. : Ill., graph. Darst.
    Publisher Blackwell
    Publishing place Boston, Mass
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016068554
    ISBN 978-1-57331-677-4 ; 1-57331-677-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 110 -1172- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Yoga and pain: A mind-body complex system.

    Chopra, Deepak / Stern, Eddie / Bushell, William C / Castle, Ryan D

    Frontiers in pain research (Lausanne, Switzerland)

    2023  Volume 4, Page(s) 1075866

    Abstract: Introduction: The human body's response to pain is indicative of a complex adaptive system. Therapeutic yoga potentially represents a similar complex adaptive system that could interact with the pain response system with unique benefits.: Objectives: ...

    Abstract Introduction: The human body's response to pain is indicative of a complex adaptive system. Therapeutic yoga potentially represents a similar complex adaptive system that could interact with the pain response system with unique benefits.
    Objectives: To determine the viability of yoga as a therapy for pain and whether pain responses and/or yoga practice should be considered complex adaptive systems.
    Methods: Examination through 3 different approaches, including a narrative overview of the evidence on pain responses, yoga, and complex system, followed by a network analysis of associated keywords, followed by a mapping of the functional components of complex systems, pain response, and yoga.
    Results: The narrative overview provided extensive evidence of the unique efficacy of yoga as a pain therapy, as well as articulating the relevance of applying complex systems perspectives to pain and yoga interventions. The network analysis demonstrated patterns connecting pain and yoga, while complex systems topics were the most extensively connected to the studies as a whole.
    Conclusion: All three approaches support considering yoga a complex adaptive system that exhibits unique benefits as a pain management system. These findings have implications for treating chronic, pervasive pain with behavioral medicine as a systemic intervention. Approaching yoga as complex system suggests the need for research of mind-body topics that focuses on long-term systemic changes rather than short-term isolated effects.
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-561X
    ISSN (online) 2673-561X
    DOI 10.3389/fpain.2023.1075866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Returning Wholeness to Health

    Paul J. Mills PhD / William C. Bushell PhD

    Global Advances in Health and Medicine, Vol

    2022  Volume 11

    Keywords Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Global Correlations Between Chronic Inflammation and Violent Incidents: Potential Behavioral Consequences of Inflammatory Illnesses Across Socio-Demographic Levels.

    Castle, Ryan / Bushell, William C / Mills, Paul J / Williams, Michelle A / Chopra, Deepak / Rindfleisch, James A

    International journal of general medicine

    2021  Volume 14, Page(s) 6677–6691

    Abstract: Introduction: This review explores the potential correlation between conditions associated with chronic inflammation and measures of violence across five socioeconomic subgroups. The hypothesis being that since chronic inflammation is associated with ... ...

    Abstract Introduction: This review explores the potential correlation between conditions associated with chronic inflammation and measures of violence across five socioeconomic subgroups. The hypothesis being that since chronic inflammation is associated with increased aggression, an extreme version of which is violence, there should be a correlation between incidents of violence and diseases with one or more inflammatory factors, without an equivalent correlation with the contrast group. An extension of this reasoning would predict a higher correlation among lower socio-demographic index (SDI) populations as a result of fewer resources to prevent either inflammatory disease or violent crime.
    Methods: In order to examine this potential correlation, an analysis was made comparing rates of change in incidence between violence, inflammatory conditions, and a contrast group disease of noninflammatory nature, as determined by Pearson's correlation coefficient.
    Results: In the low socio-demographic index, inflammatory conditions demonstrated 80% correlation with interpersonal violence, middle-low socio-demographic index inflammatory conditions demonstrated 60% correlation with interpersonal violence, middle socio-demographic index inflammatory conditions demonstrated 0% correlation with interpersonal violence, middle-high socio-demographic index inflammatory conditions demonstrated 60% correlation with interpersonal violence, and high socio-demographic index inflammatory conditions demonstrated 40% correlation with interpersonal violence.
    Discussion: The majority of socio-demographic groups showed a significant correlation between rates of change in incidence of violence and inflammatory conditions. This correlation was not found with a similar frequency or strength in diseases not causally linked to inflammation. As predicted in the hypothesis, the highest correlations of inflammatory diseases with violence existed in the lower socio-demographic populations, supporting a link between inflammatory levels and incidences of violence.
    Language English
    Publishing date 2021-10-12
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S324367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Longevity: potential life span and health span enhancement through practice of the basic yoga meditation regimen.

    Bushell, William C

    Annals of the New York Academy of Sciences

    2009  Volume 1172, Page(s) 20–27

    Abstract: This chapter briefly reviews recent psychological, physiological, molecular biological, and anthropological research which has important implications, both direct and indirect, for the recognition and understanding of the potential life span and health ... ...

    Abstract This chapter briefly reviews recent psychological, physiological, molecular biological, and anthropological research which has important implications, both direct and indirect, for the recognition and understanding of the potential life span and health span enhancing effects of the basic yoga meditational regimen. This regimen consists of meditation, yogic breath control practices, physical exercises (of both a postural- and movement-based, including aerobic nature), and dietary practices. While each of these component categories exhibit variations in different schools, lineages, traditions, and cultures, the focus of this chapter is primarily on basic forms of relaxation meditation and breath control, as well as postural and aerobic physical exercises (e.g., yogic prostration regimens, see below), and a standard form of yogic or ascetic diet, all of which constitute a basic form of regimen found in many if not most cultures, though with variations.
    MeSH term(s) Caloric Restriction ; Exercise/physiology ; Health Promotion/methods ; Humans ; Immune System/physiology ; Longevity ; Meditation ; Stress, Psychological/physiopathology ; Yoga
    Language English
    Publishing date 2009-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.2009.04538.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: New beginnings: evidence that the meditational regimen can lead to optimization of perception, attention, cognition, and other functions.

    Bushell, William C

    Annals of the New York Academy of Sciences

    2009  Volume 1172, Page(s) 348–361

    Abstract: A "framework" is presented for understanding empirically confirmed and unconfirmed phenomena in the Indo-Tibetan meditation system, from an integrative perspective, and providing evidence that certain meditative practices enable meditators to realize the ...

    Abstract A "framework" is presented for understanding empirically confirmed and unconfirmed phenomena in the Indo-Tibetan meditation system, from an integrative perspective, and providing evidence that certain meditative practices enable meditators to realize the innate human potential to perceive light "at the limits imposed by quantum mechanics," on the level of individual photons. This is part of a larger Buddhist agenda to meditatitively develop perceptual/attentional capacities to achieve penetrating insight into the nature of phenomena. Such capacities may also allow advanced meditators to perceive changes in natural scenes that are "hidden" from persons with "normal" attentional capacities, according to research on "change blindness," and to enhance their visual system functioning akin to high-speed and time-lapse photography, in toto allowing for the perception, as well as sophisticated understanding, of the "moment to moment change or impermanence" universally characteristic of the phenomenal world but normally outside untrained attention and perception according to Buddhist doctrine.
    MeSH term(s) Algorithms ; Attention/physiology ; Buddhism ; Cognition/physiology ; Consciousness/physiology ; Humans ; Meditation ; Perception/physiology ; Visual Perception/physiology
    Language English
    Publishing date 2009-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.2009.04960.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β-dependent regulation of PLK4.

    Whyte, Declan / Skalka, George / Walsh, Peter / Wilczynska, Ania / Paul, Nikki R / Mitchell, Claire / Nixon, Colin / Clarke, William / Bushell, Martin / Morton, Jennifer P / Murphy, Daniel J / Muthalagu, Nathiya

    Molecular oncology

    2023  Volume 17, Issue 7, Page(s) 1212–1227

    Abstract: The AMP-activated protein kinase (AMPK)-related kinase NUAK1 (NUAK family SNF1-like kinase 1) has emerged as a potential vulnerability in MYC-dependent cancer but the biological roles of NUAK1 in different settings are poorly characterised, and the ... ...

    Abstract The AMP-activated protein kinase (AMPK)-related kinase NUAK1 (NUAK family SNF1-like kinase 1) has emerged as a potential vulnerability in MYC-dependent cancer but the biological roles of NUAK1 in different settings are poorly characterised, and the spectrum of cancer types that exhibit a requirement for NUAK1 is unknown. Unlike canonical oncogenes, NUAK1 is rarely mutated in cancer and appears to function as an obligate facilitator rather than a cancer driver per se. Although numerous groups have developed small-molecule NUAK inhibitors, the circumstances that would trigger their use and the unwanted toxicities that may arise as a consequence of on-target activity are thus undetermined. Reasoning that MYC is a key effector of RAS pathway signalling and the GTPase KRAS is almost uniformly mutated in pancreatic ductal adenocarcinoma (PDAC), we investigated whether this cancer type exhibits a functional requirement for NUAK1. Here, we show that high NUAK1 expression is associated with reduced overall survival in PDAC and that inhibition or depletion of NUAK1 suppresses growth of PDAC cells in culture. We identify a previously unknown role for NUAK1 in regulating accurate centrosome duplication and show that loss of NUAK1 triggers genomic instability. The latter activity is conserved in primary fibroblasts, raising the possibility of undesirable genotoxic effects of NUAK1 inhibition.
    MeSH term(s) Humans ; Protein Serine-Threonine Kinases/metabolism ; Protein Kinases/metabolism ; Glycogen Synthase Kinase 3 beta ; AMP-Activated Protein Kinase Kinases ; Pancreatic Neoplasms/genetics ; Centrosome/metabolism ; Repressor Proteins/metabolism
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Protein Kinases (EC 2.7.-) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; AMP-Activated Protein Kinase Kinases (EC 2.7.11.3) ; NUAK1 protein, human (EC 2.7.1.-) ; Repressor Proteins ; PLK4 protein, human (EC 2.7.1.-)
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2415106-3
    ISSN 1878-0261 ; 1574-7891
    ISSN (online) 1878-0261
    ISSN 1574-7891
    DOI 10.1002/1878-0261.13425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6637: Show issues Location:
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  9. Article: Implications for Systemic Approaches to COVID-19: Effect Sizes of Remdesivir, Tocilizumab, Melatonin, Vitamin D3, and Meditation.

    Castle, Ryan D / Williams, Michelle A / Bushell, William C / Rindfleisch, J Adam / Peterson, Christine Tara / Marzolf, James / Brouwer, Kimberly / Mills, Paul J

    Journal of inflammation research

    2021  Volume 14, Page(s) 4859–4876

    Abstract: Introduction: COVID-19 poses a chronic threat to inflammatory systems, reinforcing the need for efficient anti-inflammatory strategies. The purpose of this review and analysis was to determine the efficacy of various interventions upon the inflammatory ... ...

    Abstract Introduction: COVID-19 poses a chronic threat to inflammatory systems, reinforcing the need for efficient anti-inflammatory strategies. The purpose of this review and analysis was to determine the efficacy of various interventions upon the inflammatory markers most affected by COVID-19. The focus was on the markers associated with COVID-19, not the etiology of the virus itself.
    Methods: Based on 27 reviewed papers, information was extracted on the effects of COVID-19 upon inflammatory markers, then the effects of standard treatments (Remdesivir, Tocilizumab) and adjunctive interventions (vitamin D
    Results: The data that were available indicated that adjunctive interventions affected 68.4% of the inflammatory markers impacted by COVID-19, while standard pharmaceutical medication affected 26.3%.
    Discussion: Nonstandard adjunctive care appeared to have comparable or superior effects in comparison to Remdesivir and Tocilizumab on the inflammatory markers most impacted by COVID-19. Alongside standards of care, melatonin, vitamin D
    Language English
    Publishing date 2021-09-22
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S323356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: RNA helicase EIF4A1-mediated translation is essential for the GC response.

    Screen, Michael / Matheson, Louise S / Howden, Andrew Jm / Strathdee, Douglas / Willis, Anne E / Bushell, Martin / Sansom, Owen / Turner, Martin

    Life science alliance

    2023  Volume 7, Issue 2

    Abstract: EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5' untranslated regions. However, very little is known of their roles ... ...

    Abstract EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5' untranslated regions. However, very little is known of their roles in nonmalignant cells. Using mouse models to delete
    MeSH term(s) Animals ; Mice ; Eukaryotic Initiation Factor-4A/genetics ; Eukaryotic Initiation Factor-4A/metabolism ; RNA Helicases/metabolism ; B-Lymphocytes
    Chemical Substances Eukaryotic Initiation Factor-4A (EC 2.7.7.-) ; RNA Helicases (EC 3.6.4.13)
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202302301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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