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  1. Article ; Online: Cranberry for Bacteriuria in Individuals with Spinal Cord Injury: A Systematic Review and Meta-Analysis.

    Raguzzini, Anna / Toti, Elisabetta / Sciarra, Tommaso / Fedullo, Anna Lucia / Peluso, Ilaria

    Oxidative medicine and cellular longevity

    2020  Volume 2020, Page(s) 9869851

    Abstract: Background: Urinary tract infection (UTI) is common in individuals with spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction (NLUTD) and in veterans with SCI who use antibiotics improperly for asymptomatic bacteriuria. Cranberry (CB) ... ...

    Abstract Background: Urinary tract infection (UTI) is common in individuals with spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction (NLUTD) and in veterans with SCI who use antibiotics improperly for asymptomatic bacteriuria. Cranberry (CB) has been suggested for UTI prevention.
    Methods: We performed a systematic search up to May 2020 in the following databases: AccessMedicine, BioMed Central, CINAHL, Cochrane Library, ProQuest, and PubMed. Quality assessment was performed using a specifically designed quality score. Risk ratio was calculated with both random effect model analysis (DerSimonian-Laird method) and quality effect model analysis (Doi Thalib method).
    Results: Six studies on bacteriuria and SCI were reviewed. From the four studies available for meta-analysis, two of which with individuals taking both CB and control, 477 data from 415 participants were analysed (241 CB and 236 control). No significant differences were detected with meta-analysis. However, bias, limitations, and incompleteness were observed in the reviewed studies.
    Conclusion: Although further studies are needed, we suggest an accurate monitoring of diet and fluid intake, the evaluation of risk for potential food or nutraceutical interactions with drugs, and the inclusion of inflammatory markers among the outcomes in addition to UTI.
    MeSH term(s) Bacteriuria/diet therapy ; Humans ; Spinal Cord Injuries/diet therapy ; Vaccinium macrocarpon
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2020/9869851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era: Implications of Il-6 In Diabesity.

    Fedullo, Anna Lucia / Schiattarella, Antonio / Morlando, Maddalena / Raguzzini, Anna / Toti, Elisabetta / De Franciscis, Pasquale / Peluso, Ilaria

    International journal of molecular sciences

    2021  Volume 22, Issue 3

    Abstract: The aim of this review is to highlight the influence of the Mediterranean Diet (MedDiet) on Gestational Diabetes Mellitus (GDM) and Gestational Weight Gain (GWG) during the COVID-19 pandemic era and the specific role of interleukin (IL)-6 in diabesity. ... ...

    Abstract The aim of this review is to highlight the influence of the Mediterranean Diet (MedDiet) on Gestational Diabetes Mellitus (GDM) and Gestational Weight Gain (GWG) during the COVID-19 pandemic era and the specific role of interleukin (IL)-6 in diabesity. It is known that diabetes, high body mass index, high glycated hemoglobin and raised serum IL-6 levels are predictive of poor outcomes in coronavirus disease 2019 (COVID-19). The immunopathological mechanisms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection include rising levels of several cytokines and in particular IL-6. The latter is associated with hyperglycemia and insulin resistance and could be useful for predicting the development of GDM. Rich in omega-3 polyunsaturated fatty acids, vitamins, and minerals, MedDiet improves the immune system and could modulate IL-6, C reactive protein and Nuclear Factor (NF)-κB. Moreover, polyphenols could modulate microbiota composition, inhibit the NF-κB pathway, lower IL-6, and upregulate antioxidant enzymes. Finally, adhering to the MedDiet prior to and during pregnancy could have a protective effect, reducing GWG and the risk of GDM, as well as improving the immune response to viral infections such as COVID-19.
    MeSH term(s) Animals ; COVID-19/blood ; COVID-19/epidemiology ; Diabetes, Gestational/blood ; Diabetes, Gestational/epidemiology ; Diabetes, Gestational/prevention & control ; Diet, Mediterranean ; Female ; Gestational Weight Gain ; Humans ; Interleukin-6/blood ; Life Style ; Obesity/blood ; Obesity/epidemiology ; Obesity/prevention & control ; Pregnancy
    Chemical Substances Interleukin-6
    Language English
    Publishing date 2021-01-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22031213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hormetic Effects of Bioactive Compounds from Foods, Beverages, and Food Dressing: The Potential Role in Spinal Cord Injury.

    Fedullo, Anna Lucia / Ciccotti, Mario / Giannotta, Paolo / Alviti, Federica / Bernardi, Marco / Raguzzini, Anna / Toti, Elisabetta / Sciarra, Tommaso / Peluso, Ilaria

    Oxidative medicine and cellular longevity

    2021  Volume 2021, Page(s) 6615752

    Abstract: Spinal cord injury (SCI) is a damage or trauma to the spinal cord resulting in a total or partial loss of motor and sensory function. SCI is characterized by a disequilibrium between the production of reactive oxygen species and the levels of antioxidant ...

    Abstract Spinal cord injury (SCI) is a damage or trauma to the spinal cord resulting in a total or partial loss of motor and sensory function. SCI is characterized by a disequilibrium between the production of reactive oxygen species and the levels of antioxidant defences, causing oxidative stress and neuroinflammation. This review is aimed at highlighting the hormetic effects of some compounds from foods, beverages, and food dressing that are able to reduce oxidative stress in patients with SCI. Although curcumin, ginseng, and green tea have been proposed for SCI management, low levels of antioxidant vitamins have been reported in individuals with SCI. Mediterranean diet includes food rich in vitamins and antioxidants. Moreover, food dressing, including spices, herbs, and extra virgin olive oil (EVOO), contains multiple components with hormetic effects. The latter involves the activation of the nuclear factor erythroid-derived 2, consequently increasing the antioxidant enzymes and decreasing inflammation. Furthermore, EVOO improves the bioavailability of carotenoids and could be a delivery system for bioactive compounds. In conclusion, Mediterranean dressing in addition to plant foods can have an important effect on redox balance in individuals with SCI.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Beverages ; Food ; Hormesis ; Humans ; Oxidative Stress ; Spinal Cord Injuries/pathology ; Spinal Cord Injuries/therapy
    Chemical Substances Antioxidants
    Language English
    Publishing date 2021-02-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2021/6615752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Post-Exercise Ketosis, Salivary Uric Acid and Interleukin-6 after a Simulated Wheelchair Basketball Match.

    Raguzzini, Anna / Toti, Elisabetta / Bernardi, Marco / Castellucci, Fabio / Cavedon, Valentina / Fedullo, Anna Lucia / Milanese, Chiara / Sciarra, Tommaso / Peluso, Ilaria

    Endocrine, metabolic & immune disorders drug targets

    2021  Volume 21, Issue 11, Page(s) 2055–2062

    Abstract: Background: Interleukin (IL)-6, total antioxidant capacity (TAC) and uric acid (UA) increase after exercise in able-bodied individuals. Wheelchair Basketball Athletes (WBA), having low muscle mass, could be at risk of post-exercise ketosis.: Objective! ...

    Abstract Background: Interleukin (IL)-6, total antioxidant capacity (TAC) and uric acid (UA) increase after exercise in able-bodied individuals. Wheelchair Basketball Athletes (WBA), having low muscle mass, could be at risk of post-exercise ketosis.
    Objective: This study aimed to evaluate the post-exercise ketosis, IL-6, and antioxidant response, in WBA of the Italian National team, after a simulated match.
    Methods: Dietary intakes, Starvation Symptoms Inventory (SSI), percentage of fat mass (FM%) and basal Respiratory Exchange Ratio (RER) and Basal Energy Expenditure (BEE), were evaluated. Salivary TAC, UA and IL-6 were measured: before (PreM), at the end (EM) and 20 minutes after (PostM) the match. Capillary glucose and β-hydroxybutyrate (βHB) were monitored. Percentage of Heart Rate Reserve (%HRR) was measured to evaluate exercise intensity.
    Results: WBA had low carbohydrates (43.5% of daily energy intake (En)) and high fat (36.3% En) intakes. The increase in UA at PostM correlated with En (0.810, p<0.01) and was inversely related to βHB at EM (-0.719, p<0.05). Furthermore, at PostM growing IL-6 levels correlated with BEE (0.778, p<0.05) and inversely related to FM% (-0.762, p<0.5) were found, which in turn was correlated to SSI (0.781, p<0.05). Also βHB PostM correlated with SSI (0.761, p<0.05) but was inversely related to RER (-0.745, p<0.05) and En (-0.826, p<0.01).
    Conclusion: Our study suggests that some WBA should improve their dietary habit in order to prevent post-exercise ketosis and ameliorate the endogenous antioxidant response after exercise.
    MeSH term(s) Basketball/physiology ; Humans ; Interleukin-6 ; Ketosis ; Uric Acid ; Wheelchairs
    Chemical Substances Interleukin-6 ; Uric Acid (268B43MJ25)
    Language English
    Publishing date 2021-01-11
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
    DOI 10.2174/1871530321999210111202724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era

    Anna Lucia Fedullo / Antonio Schiattarella / Maddalena Morlando / Anna Raguzzini / Elisabetta Toti / Pasquale De Franciscis / Ilaria Peluso

    International Journal of Molecular Sciences, Vol 22, Iss 3, p

    Implications of Il-6 In Diabesity

    2021  Volume 1213

    Abstract: The aim of this review is to highlight the influence of the Mediterranean Diet (MedDiet) on Gestational Diabetes Mellitus (GDM) and Gestational Weight Gain (GWG) during the COVID-19 pandemic era and the specific role of interleukin (IL)-6 in diabesity. ... ...

    Abstract The aim of this review is to highlight the influence of the Mediterranean Diet (MedDiet) on Gestational Diabetes Mellitus (GDM) and Gestational Weight Gain (GWG) during the COVID-19 pandemic era and the specific role of interleukin (IL)-6 in diabesity. It is known that diabetes, high body mass index, high glycated hemoglobin and raised serum IL-6 levels are predictive of poor outcomes in coronavirus disease 2019 (COVID-19). The immunopathological mechanisms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection include rising levels of several cytokines and in particular IL-6. The latter is associated with hyperglycemia and insulin resistance and could be useful for predicting the development of GDM. Rich in omega-3 polyunsaturated fatty acids, vitamins, and minerals, MedDiet improves the immune system and could modulate IL-6, C reactive protein and Nuclear Factor (NF)-κB. Moreover, polyphenols could modulate microbiota composition, inhibit the NF-κB pathway, lower IL-6, and upregulate antioxidant enzymes. Finally, adhering to the MedDiet prior to and during pregnancy could have a protective effect, reducing GWG and the risk of GDM, as well as improving the immune response to viral infections such as COVID-19.
    Keywords cardio-diabesity ; inflammation ; oxidative stress ; nutraceuticals ; plant foods ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Dietary Intakes and Food Habits of Wheelchair Basketball Athletes Compared to Gym Attendees and Individuals who do not Practice Sport Activity.

    Toti, Elisabetta / Cavedon, Valentina / Raguzzini, Anna / Fedullo, Anna Lucia / Milanese, Chiara / Bernardi, Elisabetta / Bellito, Sheila / Bernardi, Marco / Sciarra, Tommaso / Peluso, Ilaria

    Endocrine, metabolic & immune disorders drug targets

    2021  Volume 22, Issue 1, Page(s) 38–48

    Abstract: Background: Mediterranean diet (Med-D) has been previously suggested for athletes, but Paralympics usually have a low intake of plant foods. Orthorexia nervosa (ON) can drive dietary intake of both athletes and gym attendees.: Objective: We aimed to ... ...

    Abstract Background: Mediterranean diet (Med-D) has been previously suggested for athletes, but Paralympics usually have a low intake of plant foods. Orthorexia nervosa (ON) can drive dietary intake of both athletes and gym attendees.
    Objective: We aimed to compare dietary intakes and food habits of elite wheelchair basketball athletes (WBA) and able-bodied individuals who practice or not sport activity and with different fat mass percentage (FM%).
    Methods: We recruited 15 WBA from the Italian National team and 3 control groups (15 each group): healthy individuals who do not practice any sports activity (NSA) and gym attendees with low (GAL, FM%<17) and high (GAH, FM%>18) FM%. Food consumption was monitored by a 3- d diary, while Med-D scores and ON score were evaluated through standardized questionnaires. In WBA we also assessed Neurogenic Bowel Dysfunction (NBD), GastroEsophageal Reflux Disease (GERD), allergy questionnaire for athletes (AQUA) and Starvation Symptoms Inventory (SSI).
    Results: In WBA, ON correlated with GERD and SSI. WBA and GAH with eating behavior of ON had higher adherence to Med-D, whereas NSA had less adherence to Med-D. Sub-score, including fruits, vegetables and legumes, was higher in the GAL and GAH groups compared to the WBA and NSA groups. Med-D was inversely related to animal protein intake (PRO-AN) in NSA and GAL. FM% was inversely related to PRO-AN in WBA and GAH, and to ON only in GAH. In WBA, PRO-AN and vegetable protein intake correlated with both carbohydrate and energy intakes.
    Conclusion: In WBA, commitment to wellness (ON and Med-D adherence) could be a response to gastrointestinal and starvation symptoms. WBA should be involved in setting their own individualized dietary strategies.
    MeSH term(s) Adult ; Basketball/statistics & numerical data ; Body Composition/physiology ; Diet, Mediterranean/statistics & numerical data ; Eating/physiology ; Exercise/physiology ; Exercise/statistics & numerical data ; Feeding Behavior/physiology ; Humans ; Italy/epidemiology ; Male ; Para-Athletes/statistics & numerical data ; Sedentary Behavior ; Spinal Cord Injuries/epidemiology ; Spinal Dysraphism/epidemiology ; Surveys and Questionnaires ; Wheelchairs ; Young Adult
    Language English
    Publishing date 2021-02-10
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
    DOI 10.2174/1871530321666210208213046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Longitudinal Effects of Dietary Advice on Wheelchair Basketball Athletes

    Elisabetta Toti / Anna Raguzzini / Anna Lucia Fedullo / Valentina Cavedon / Chiara Milanese / Marco Bernardi / Bianca Maria Mariani / Luca Massaro / Francesco Mellara / Tommaso Sciarra / Ilaria Peluso

    Sustainability, Vol 13, Iss 5244, p

    Nutritional and Environmental Aspects

    2021  Volume 5244

    Abstract: Background: Diet impacts both human and environmental health and must be designed to optimize the training and performance of athletes. The aim of this study was to quantify the effect of dietary advice (DA) on the food intake of wheelchair basketball ... ...

    Abstract Background: Diet impacts both human and environmental health and must be designed to optimize the training and performance of athletes. The aim of this study was to quantify the effect of dietary advice (DA) on the food intake of wheelchair basketball athletes (WBA) and the environmental impact longitudinally. Methods: DA were provided to WBA of the Italian national team (DAM-T1). Nutritional assessment and evaluation of the environmental impact of diet were performed two months (DAM-T2) and one year later (DAM-T3), when a post-COVID-19 survey was performed also in WBA who did not receive counselling (men: NDAM-T3, women: NDAW-T3). Results: After DA, WBA showed a reduced percentage of energy derived from sugars and fats. Athletes adjusted their protein intake according to the personalized recommendations. The intake of some micronutrients improved after DA and was higher compared to NDAM-T3 and NDAW-T3. Despite the lower impact of diet in NDAW-T3, they presented more nutritional deficiency than men. The mean intake of vegetables was in the range of the EAT-Lancet Commission suggestion only two months after DA. After DA, fiber intake increased and adapted to the tolerated level. Conclusions: WBA improved their diet after DA but did not comply with the EAT-Lancet suggestion for red meat and legumes.
    Keywords Paralympics ; pain ; body mass ; nutritional adequacy ; ecological footprints ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 796
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Diet in neurogenic bowel management: A viewpoint on spinal cord injury.

    Bernardi, Marco / Fedullo, Anna Lucia / Bernardi, Elisabetta / Munzi, Diego / Peluso, Ilaria / Myers, Jonathan / Lista, Florigio Romano / Sciarra, Tommaso

    World journal of gastroenterology

    2019  Volume 26, Issue 20, Page(s) 2479–2497

    Abstract: The aim of this review is to offer dietary advice for individuals with spinal cord injury (SCI) and neurogenic bowel dysfunction. With this in mind, we consider health conditions that are dependent on the level of lesion including skeletal muscle atrophy, ...

    Abstract The aim of this review is to offer dietary advice for individuals with spinal cord injury (SCI) and neurogenic bowel dysfunction. With this in mind, we consider health conditions that are dependent on the level of lesion including skeletal muscle atrophy, autonomic dysreflexia and neurogenic bladder. In addition, SCI is often associated with a sedentary lifestyle, which increases risk for osteoporosis and diseases associated with chronic low-grade inflammation, including cardiovascular and chronic kidney diseases. The Mediterranean diet, along with exercise and dietary supplements, has been suggested as an anti-inflammatory intervention in individuals with SCI. However, individuals with chronic SCI have a daily intake of whole fruit, vegetables and whole grains lower than the recommended dietary allowance for the general population. Some studies have reported an increase in neurogenic bowel dysfunction symptoms after high fiber intake; therefore, this finding could explain the low consumption of plant foods. Low consumption of fibre induces dysbiosis, which is associated with both endotoxemia and inflammation. Dysbiosis can be reduced by exercise and diet in individuals with SCI. Therefore, to summarize our viewpoint, we developed a Mediterranean diet-based diet and exercise pyramid to integrate nutritional recommendations and exercise guidelines. Nutritional guidelines come from previously suggested recommendations for military veterans with disabilities and individuals with SCI, chronic kidney diseases, chronic pain and irritable bowel syndrome. We also considered the recent exercise guidelines and position stands for adults with SCI to improve muscle strength, flexibility and cardiorespiratory fitness and to obtain cardiometabolic benefits. Finally, dietary advice for Paralympic athletes is suggested.
    MeSH term(s) Adult ; Cardiorespiratory Fitness/physiology ; Combined Modality Therapy/methods ; Diet, Mediterranean ; Dietary Fiber ; Exercise Therapy/methods ; Fruit ; Humans ; Neurogenic Bowel/diet therapy ; Neurogenic Bowel/etiology ; Neurogenic Bowel/physiopathology ; Para-Athletes ; Recommended Dietary Allowances ; Sedentary Behavior ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/physiopathology ; Vegetables ; Whole Grains
    Chemical Substances Dietary Fiber
    Language English
    Publishing date 2019-06-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v26.i20.2479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: IL7R overexpression in adult acute lymphoblastic leukemia is associated to JAK/STAT pathway mutations and identifies patients who could benefit from targeted therapies.

    Gianfelici, Valentina / Messina, Monica / Paoloni, Francesca / Peragine, Nadia / Lauretti, Alessia / Fedullo, Anna Lucia / Di Giacomo, Filomena / Vignetti, Marco / Vitale, Antonella / Guarini, Anna / Chiaretti, Sabina / Foà, Robin

    Leukemia & lymphoma

    2018  Volume 60, Issue 3, Page(s) 829–832

    MeSH term(s) Gene Expression ; Humans ; Immunophenotyping ; Interleukin-7 Receptor alpha Subunit/genetics ; Janus Kinases/metabolism ; Molecular Targeted Therapy ; Mutation ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Prognosis ; STAT Transcription Factors/metabolism ; Signal Transduction
    Chemical Substances IL7R protein, human ; Interleukin-7 Receptor alpha Subunit ; STAT Transcription Factors ; Janus Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2018-09-06
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2018.1499906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cardiovascular Risk Factors and Haematological Indexes of Inflammation in Paralympic Athletes with Different Motor Impairments.

    Bernardi, Marco / Fedullo, Anna Lucia / Di Giacinto, Barbara / Squeo, Maria Rosaria / Aiello, Paola / Dante, Donatella / Romano, Silvio / Magaudda, Ludovico / Peluso, Ilaria / Palmery, Maura / Spataro, Antonio

    Oxidative medicine and cellular longevity

    2019  Volume 2019, Page(s) 6798140

    Abstract: Haematological indexes of both inflammation and platelet activation have been suggested as predictive markers of cardiovascular disease (CVD), which has high prevalence in Paralympic athletes (PA). Different mechanisms could play a role in increasing CVD ...

    Abstract Haematological indexes of both inflammation and platelet activation have been suggested as predictive markers of cardiovascular disease (CVD), which has high prevalence in Paralympic athletes (PA). Different mechanisms could play a role in increasing CVD risk in PA with spinal cord injury (PA-SCI), lower limb amputation (PA-LLA), or upper limb impairment (PA-ULI). We compared, in 4 groups of PA competing in power, intermittent (mixed metabolism), and endurance sports, Framingham Risk Score (FRS), metabolic syndrome criteria (MetS-C), inflammation (INFLA) Score, 5 haematological indexes of platelet activation (mean platelet volume (MPV), platelet distribution width (PDW), and the ratios between MPV and platelet (MPVPR), between MPV and lymphocyte (MPVLR), and between PDW and lymphocyte (PDWLR)) and the endogenous antioxidants uric acid (UA) and bilirubin (BR). A retrospective chart review of PA from preparticipation examinations' records (London 2012 and Sochi 2014 Paralympics) was performed. We included 25 PA-SCI (13 with high and 12 with low lesion, PA-SCI-H and PA-SCI-L), 15 PA-LLA, and 10 PA-ULI. FRS and INFLA Score did not differ among groups, but PA-SCI-H had lower HDL, compared to PA-SCI-L and PA-ULI. PA-LLA had more MetS diagnostic criteria with significant higher glucose levels than other groups. PA-SCI-H had significantly lower lymphocytes' count compared to PA-LLA and higher MPV, PDW, MPVPR, MPVLR, and PDWLR. SCI-H had lower BR, haemoglobin, haematocrit, proteins, and creatinine. No interaction was found between the 3 kinds of sitting sports and the 2 groups of health conditions (PA-SCI and PA-LLA). In conclusion, PA-LLA had a higher cardiometabolic risk, whereas PA-SCI-H had a higher platelet-derived cardiovascular risk. Further larger studies are needed to investigate the relationship between indexes of inflammation/oxidation and dietary habit, body composition, and physical fitness/performance in PA with motor impairments.
    MeSH term(s) Adult ; Biomarkers/analysis ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Humans ; Inflammation/diagnosis ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation Mediators/metabolism ; Male ; Mean Platelet Volume ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/etiology ; Metabolic Syndrome/metabolism ; Motor Disorders/complications ; Para-Athletes/statistics & numerical data ; Platelet Activation ; Retrospective Studies
    Chemical Substances Biomarkers ; Inflammation Mediators
    Language English
    Publishing date 2019-11-18
    Publishing country United States
    Document type Journal Article
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2019/6798140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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