LIVIVO - Search results -

Search results

Result 1 - 10 of total 118

Search options

Book ; Online: Influence of the previous North Atlantic Oscillation (NAO) on the spring dust aerosols over North China

Li, Yan / Xu, Falei / Feng, Juan / Du, Mengying / Song, Wenjun / Li, Chao / Zhao, Wenjing

eISSN: 1680-7324

2023

Abstract: The North Atlantic Oscillation (NAO) has been confirmed to be closely related to the weather and ... the spring DAs in North China are significantly correlated with the previous winter's NAO. According ... to the nine spring DEs affected significantly by the negative phase of the preceding winter's NAO in North ...

Abstract	The North Atlantic Oscillation (NAO) has been confirmed to be closely related to the weather and climate in many regions of the Northern Hemisphere; however, its effect and mechanism upon the formation of dust events (DEs) in China have rarely been discussed. By using the station observation dataset and multi-reanalysis datasets, it is found that the spring dust aerosols (DAs) in North China (30–40 ∘ N, 105–120 ∘ E), a non-dust source region, show high values with a strong interannual variability, and the spring DAs in North China are significantly correlated with the previous winter's NAO. According to the nine spring DEs affected significantly by the negative phase of the preceding winter's NAO in North China during 1980–2020, it is shown that before the outbreak of DEs, due to the transient eddy momentum (heat) convergence (divergence) over the DA source regions, the zonal wind speed increases in the upper-level troposphere, strengthening the zonal wind in the middle–lower levels through momentum downward transmission. Simultaneously, there is transient eddy momentum (heat) divergence (convergence) around the Ural Mountains, which is favorable for the establishment and maintenance of the Ural ridge, as well as the development of the air temperature and vorticity advections. The combined effects of temperature and vorticity advections result in the Siberian Highs and Mongolian cyclone to be established, strengthen, and move southward near the surface, guiding the cold air from high latitudes southward, and is favorable for the uplift and transmission of DAs to North China downstream. Simultaneously, the changes in upstream transient eddy flux transport can cause both energy and mass divergence in North China, resulting in diminishing winds during DEs, which would facilitate the maintenance of dust aerosols here and promote the outbreak of DEs. This study reveals the impact of transient eddy flux transport on the dusty weather anomalies modulated by the NAO negative signal in North China, which deepens the ...
Subject code	551
Language	English
Publishing date	2023-06-01
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Influence of the previous North Atlantic Oscillation (NAO) on the spring dust aerosols over North China

Li, Yan / Xu, Falei / Feng, Juan / Du, Mengying / Song, Wenjun / Li, Chao / Zhao, Wenjing

eISSN:

2023

Abstract	The North Atlantic Oscillation (NAO) has been confirmed to be closely related to the weather and climate in many regions of the Northern Hemisphere; however, its effect and mechanism upon the formation of dust events (DEs) in China have rarely been discussed. By using the station observation dataset and multi-reanalysis datasets, it is found that the spring dust aerosols (DAs) in North China (30–40 ∘ N, 105–120 ∘ E), a non-dust source region, show high values with a strong interannual variability, and the spring DAs in North China are significantly correlated with the previous winter's NAO. According to the nine spring DEs affected significantly by the negative phase of the preceding winter's NAO in North China during 1980–2020, it is shown that before the outbreak of DEs, due to the transient eddy momentum (heat) convergence (divergence) over the DA source regions, the zonal wind speed increases in the upper-level troposphere, strengthening the zonal wind in the middle–lower levels through momentum downward transmission. Simultaneously, there is transient eddy momentum (heat) divergence (convergence) around the Ural Mountains, which is favorable for the establishment and maintenance of the Ural ridge, as well as the development of the air temperature and vorticity advections. The combined effects of temperature and vorticity advections result in the Siberian Highs and Mongolian cyclone to be established, strengthen, and move southward near the surface, guiding the cold air from high latitudes southward, and is favorable for the uplift and transmission of DAs to North China downstream. Simultaneously, the changes in upstream transient eddy flux transport can cause both energy and mass divergence in North China, resulting in diminishing winds during DEs, which would facilitate the maintenance of dust aerosols here and promote the outbreak of DEs. This study reveals the impact of transient eddy flux transport on the dusty weather anomalies modulated by the NAO negative signal in North China, which deepens the ...
Subject code	551
Language	English
Publishing date	2023-06-01
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Conference proceedings ; Online: Water storage variations in the U.S. Great Lakes watershed inferred from GPS and GRACE and connections with ENSO and NAO

Zhang, Z. / Zheng, S. / Yan, H. / Li, J.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: ... CHM), and examine the relationship between TWS and climate changes, such as ENSO, NAO etc ... however, the magnitudes and phases of groundwater storage vary markedly among the sub-regions in the GLW. ENSO and NAO ...

Abstract	Assessing spatiotemporal water storage variability in the Great Lakes watershed (GLW) is critical for water resources in the US and Canada. Here, we assess terrestrial water storage (TWS) variations in the GLW by using data from global positioning system (GPS), GRACE satellites and a composite hydrological model (CHM), and examine the relationship between TWS and climate changes, such as ENSO, NAO etc. Observations show a surface water storage increase of ~175 km 3 from 2010 to 2020, however, Earth's crust subsidence caused by this water increase alone cannot explain the GPS recorded vertical displacement, suggesting additional contributions need to be explored.The spatial pattern in annual change of GPS-inverted TWS agrees well with that from the CHM, indicating that the annual cycle mainly dominated by soil moisture and snow. GRACE underestimates the spatial patterns of long-term and seasonal TWS fluctuations w.r.t GPS. The peak in GPS-inverted TWS occurs in March, coinciding with those from GPS, however, one to two months ahead of that appear in the CHM. The magnitude of seasonal groundwater oscillation is ~60 km 3 with peaking in September, coinciding with the Great Lakes surface water peak; however, the magnitudes and phases of groundwater storage vary markedly among the sub-regions in the GLW. ENSO and NAO have impacts on GLW TWS variations at interannual scale through effecting the regional precipitation and temperature. The high-density GPS stations in the GLW represent an independent tool to estimate high-resolution TWS changes and provide critical insights for understanding water storage variations.
Subject code	333
Language	English
Publishing date	2023-07-11
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Multimodal Magnetic Resonance Imaging and Therapeutic Intervention With Yi-nao-jie-yu Decoction in a Rat Model of Post-stroke Depression.

Zhao, Zijun / Zhang, Wen / Zhang, Yuan / Zhao, Yun / Zheng, Chunxiang / Tian, Huiling / Lei, Jianfeng / Liu, Yan / Zhao, Ruizhen / Tang, Qisheng

Frontiers in psychiatry

2020 Volume 11, Page(s) 557423

Abstract: ... for investigating neurophysiological changes associated with PSD. Yi-nao-jie-yu decoction (YNJYD) is a Chinese ...

Abstract	Post-stroke depression (PSD) is the most common neuropsychiatric complication after a stroke, though its neuropathological characteristics have not been fully elucidated. Comprehensive and non-invasive magnetic resonance (MR) assessment techniques are urgently needed for current research, as diffusion tensor imaging (DTI), arterial spin labeling (ASL), and magnetic resonance spectroscopy (MRS) can allow for a comprehensive assessment of neuropathological changes in the brain. These techniques can provide information about microscopic tissue integrity, cerebral perfusion, and cerebral metabolism, and can serve as powerful tools for investigating neurophysiological changes associated with PSD. Yi-nao-jie-yu decoction (YNJYD) is a Chinese herbal formulation based on the theory of traditional Chinese medicine, with demonstrated clinical efficacy in the treatment of PSD. The aim of this study was to use these MR techniques to evaluate changes in PSD and YNJYD-treated rats. This is the first experimental study in animals to investigate neuropathological changes associated with PSD using a combination of multiple MR techniques, including DTI, ASL, and MRS. In addition, we investigated the effect of YNJYD in a rat model of PSD by assessing changes in brain tissue microstructure, brain metabolism, and cerebral perfusion. First, depressive-like behaviors of PSD rats were assessed by the open field test (OFT), sucrose preference test (SPT), and Morris water maze (MWM) test, and then the integrity of the rats' microstructure was assessed by DTI, the levels of regional cerebral perfusion were assessed by ASL, and changes in the relative concentrations of brain metabolites were determined by MRS. The results showed that OFT and SPT scores were significantly reduced in PSD rats, as was performance in the MWM; these PSD-associated changes were attenuated in rats administered YNJYD, with improved depressive-like behaviors evidenced by increased OFT and SPT scores and improved performance in the MWM task. Furthermore, we found that PSD rats had lower perfusion levels in the prefrontal cortex (PFC) and hippocampus (HP), microstructural damage, and abnormal changes in the concentrations of brain metabolites; YNJYD exerted therapeutic effects on PSD rats by improving microcirculation in the PFC and HP, regulating glutamatergic systems and membrane phospholipid metabolism, and repairing microstructural damage.
Language	English
Publishing date	2020-11-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2020.557423
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Nao-Xue-Shu Oral Liquid Improves Aphasia of Mixed Stroke.

Yan, Yuping / Wang, Mingzhe / Zhang, Liang / Qiu, Zhenwei / Jiang, Wenfei / Xu, Men / Pan, Weidong / Chen, Xiangjun

Evidence-based complementary and alternative medicine : eCAM

2015 Volume 2015, Page(s) 709568

Abstract: Objective. The objective is to observe whether the traditional Chinese medicine (TCM) Nao-Xue-Shu ... Western medicine plus Nao-Xue-Shu oral liquid (n = 58) were assigned to the treatment group ... with the control group at the end of week 2 and week 4. Conclusion. Nao-Xue-Shu oral liquid formulation improved ...

Abstract	Objective. The objective is to observe whether the traditional Chinese medicine (TCM) Nao-Xue-Shu oral liquid improves aphasia of mixed stroke. Methods. A total of 102 patients with aphasia of mixed stroke were divided into two groups by a single blind random method. The patients treated by standard Western medicine plus Nao-Xue-Shu oral liquid (n = 58) were assigned to the treatment group while the remaining patients treated only by standard Western medicine (n = 58) constituted the control group. Changes in the Western Aphasia Battery (WAB), Modified Rankin Scale (mRS), National Institutes of Health Stroke Scale (NIHSS), and hemorheology parameters were assessed to evaluate the effects of the treatments. Results. Excluding the patients who dropped out, 54 patients in the treatment group and 51 patients in the control group were used to evaluate the effects. Significant and persistent improvements in the WAB score, specifically comprehension, repetition, naming, and calculating, were found in the treatment group when the effects were evaluated at the end of week 2 and week 4, respectively, compared with baseline. The naming and writing scores were also improved at the end of week 4 in this group. The comprehension and reading scores were improved at the end of week 4 in the control group compared with the baseline, but the improvements were smaller than those in the treatment group. The percentages of patients at the 0-1 range of mRS were increased at the end of week 2 and week 4 in both groups, but the improvements in the treatment group were much larger than those in the control group. Greater improvements in the NIHSS scores and the hemorheology parameters in the treatment group were also observed compared with the control group at the end of week 2 and week 4. Conclusion. Nao-Xue-Shu oral liquid formulation improved aphasia in mixed stroke patients and thus might be a potentially effective drug for treating stroke aphasia.
Language	English
Publishing date	2015-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2015/709568
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5995: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The effect of stroke and other components in Xing-Nao-Jing on the pharmacokinetics of geniposide.

Xu, Pan / Du, Shou-ying / Lu, Yang / Bai, Jie / Guo, Yi-wang / Du, Qiu / Cao, Yan-feng

Journal of ethnopharmacology

2014 Volume 152, Issue 2, Page(s) 302–307

Abstract: ... which has been used in traditional Chinese preparation, such as "Xing-Nao-Jing" (XNJ) for stroke treatment ...

Abstract	Ethnopharmacological relevance: Geniposide is a bioactive substance derived from gardenia, which has been used in traditional Chinese preparation, such as "Xing-Nao-Jing" (XNJ) for stroke treatment. Stroke and the ingredients of herbal preparation affect the pharmacokinetics of geniposide. A comparative pharmacokinetic study of geniposide in stroke and sham-operated rats after administration of XNJ and geniposide was proceeded to evaluate the effect of stroke on pharmacokinetics of geniposide, while the influence of other components in XNJ was determined by using gardenia extract and geniposide-borneol compounds in rats with stroke to compare. Materials and methods: Stroke was induced by middle cerebral artery occlusion followed by reperfusion 2h later. Plasma concentration of geniposide was determined by HPLC. Various pharmacokinetic parameters were estimated from the plasma concentration versus time data using non-compartmental methods. Results: The maximum plasma concentration (Cmax) and area under the curve (AUC0-t) in stroke after administration of XNJ were 5.97±3.82 μg/mL, and 570.06±274.32 μg·min/mL, respectively, which were 5 times compared with sham-operated rats or the stroke-afflicted rats given geniposide. In stroke, the Cmax and AUC(0-t) of geniposide-borneol group and gardenia extraction group were close to XNJ group and geniposide group, respectively. The geniposide-borneol group had a higher value. Conclusion: Stroke improved the absorption of geniposide in XNJ. Borneol may be the key ingredient in XNJ improving the absorption of geniposide.
MeSH term(s)	Animals ; Area Under Curve ; Bornanes/isolation & purification ; Bornanes/pharmacology ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Gardenia/chemistry ; Iridoids/isolation & purification ; Iridoids/pharmacokinetics ; Male ; Models, Biological ; Rats ; Rats, Sprague-Dawley ; Stroke/physiopathology
Chemical Substances	Bornanes ; Drugs, Chinese Herbal ; Iridoids ; geniposide (145295QLXY) ; isoborneol (L88RA8N5EG)
Language	English
Publishing date	2014-03-14
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2013.12.046
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1494: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Multimodal Magnetic Resonance Imaging and Therapeutic Intervention With Yi-nao-jie-yu Decoction in a Rat Model of Post-stroke Depression

Zijun Zhao / Wen Zhang / Yuan Zhang / Yun Zhao / Chunxiang Zheng / Huiling Tian / Jianfeng Lei / Yan Liu / Ruizhen Zhao / Qisheng Tang

Frontiers in Psychiatry, Vol

2020 Volume 11

Abstract: ... for investigating neurophysiological changes associated with PSD. Yi-nao-jie-yu decoction (YNJYD) is a Chinese ...

Abstract	Post-stroke depression (PSD) is the most common neuropsychiatric complication after a stroke, though its neuropathological characteristics have not been fully elucidated. Comprehensive and non-invasive magnetic resonance (MR) assessment techniques are urgently needed for current research, as diffusion tensor imaging (DTI), arterial spin labeling (ASL), and magnetic resonance spectroscopy (MRS) can allow for a comprehensive assessment of neuropathological changes in the brain. These techniques can provide information about microscopic tissue integrity, cerebral perfusion, and cerebral metabolism, and can serve as powerful tools for investigating neurophysiological changes associated with PSD. Yi-nao-jie-yu decoction (YNJYD) is a Chinese herbal formulation based on the theory of traditional Chinese medicine, with demonstrated clinical efficacy in the treatment of PSD. The aim of this study was to use these MR techniques to evaluate changes in PSD and YNJYD-treated rats. This is the first experimental study in animals to investigate neuropathological changes associated with PSD using a combination of multiple MR techniques, including DTI, ASL, and MRS. In addition, we investigated the effect of YNJYD in a rat model of PSD by assessing changes in brain tissue microstructure, brain metabolism, and cerebral perfusion. First, depressive-like behaviors of PSD rats were assessed by the open field test (OFT), sucrose preference test (SPT), and Morris water maze (MWM) test, and then the integrity of the rats' microstructure was assessed by DTI, the levels of regional cerebral perfusion were assessed by ASL, and changes in the relative concentrations of brain metabolites were determined by MRS. The results showed that OFT and SPT scores were significantly reduced in PSD rats, as was performance in the MWM; these PSD-associated changes were attenuated in rats administered YNJYD, with improved depressive-like behaviors evidenced by increased OFT and SPT scores and improved performance in the MWM task. Furthermore, we found ...
Keywords	post-stroke depression ; diffusion tensor imaging ; arterial spin labeling ; magnetic resonance spectroscopy ; yi-nao-jie-yu decoction ; traditional Chinese medicine ; Psychiatry ; RC435-571
Subject code	610
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Tong Luo Jiu Nao, a Chinese Medicine Formula, Reduces Inflammatory Stress in a Mouse Model of Alzheimer's Disease.

Gao, Ai-She / Du, Huan / Gao, Qing / Wang, Yi-Jing / Wang, Xie-Yan / Liu, Jian-Wei / Lu, Bin

American journal of Alzheimer's disease and other dementias

2016 Volume 31, Issue 5, Page(s) 413–421

Abstract: Aim: The aim of this study is to extend the molecular mechanism of Tong Luo Jiu Nao (TLJN ...

Abstract	Aim: The aim of this study is to extend the molecular mechanism of Tong Luo Jiu Nao (TLJN) for Alzheimer's disease (AD), which is a modern Chinese formula that has been used to treat AD. Methods: The senescence-accelerated mouse prone 8 strain (SAMP8) is one of the most appropriate models to study the mechanism that underlies AD. The levels of plasma amyloid β (Aβ) and the Aβ deposits were measured using enzyme-linked immunosorbent assay and immunohistochemistry. Immunoblotting was used to observe the effect of TLJN on inflammatory mediator expression in an senescence-accelerated mouse model of AD. Results: Our data showed that the TLJN-treated groups exhibited a reduction in plasma Aβ levels and reduced Aβ expression. Moreover, TLJN effectively attenuated Aβ-induced activation of extracellular signal-regulated kinase and c-Jun N-terminal kinases and blocked changes in inflammatory mediator expression. Conclusion: These data suggest that TLJN might have protective effects and could potentially act to attenuate inflammatory stress in the pathogenesis of AD.
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/blood ; Amyloid beta-Peptides/metabolism ; Animals ; Brain/drug effects ; Disease Models, Animal ; Drugs, Chinese Herbal/administration & dosage ; Enzyme-Linked Immunosorbent Assay/methods ; Inflammation ; Mice
Chemical Substances	Amyloid beta-Peptides ; Drugs, Chinese Herbal ; tongluo jiunao
Language	English
Publishing date	2016-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283069-0
ISSN	1938-2731 ; 0895-5336 ; 1082-5207 ; 1533-3175
ISSN (online)	1938-2731
ISSN	0895-5336 ; 1082-5207 ; 1533-3175
DOI	10.1177/1533317515628051
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3299: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Nao-Xue-Shu Oral Liquid Improves Aphasia of Mixed Stroke

Yuping Yan / Mingzhe Wang / Liang Zhang / Zhenwei Qiu / Wenfei Jiang / Men Xu / Weidong Pan / Xiangjun Chen

Evidence-Based Complementary and Alternative Medicine, Vol

2015 Volume 2015

Abstract: Objective. The objective is to observe whether the traditional Chinese medicine (TCM) Nao-Xue-Shu ... Western medicine plus Nao-Xue-Shu oral liquid (n=58) were assigned to the treatment group ... with the control group at the end of week 2 and week 4. Conclusion. Nao-Xue-Shu oral liquid formulation improved ...

Abstract	Objective. The objective is to observe whether the traditional Chinese medicine (TCM) Nao-Xue-Shu oral liquid improves aphasia of mixed stroke. Methods. A total of 102 patients with aphasia of mixed stroke were divided into two groups by a single blind random method. The patients treated by standard Western medicine plus Nao-Xue-Shu oral liquid (n=58) were assigned to the treatment group while the remaining patients treated only by standard Western medicine (n=58) constituted the control group. Changes in the Western Aphasia Battery (WAB), Modified Rankin Scale (mRS), National Institutes of Health Stroke Scale (NIHSS), and hemorheology parameters were assessed to evaluate the effects of the treatments. Results. Excluding the patients who dropped out, 54 patients in the treatment group and 51 patients in the control group were used to evaluate the effects. Significant and persistent improvements in the WAB score, specifically comprehension, repetition, naming, and calculating, were found in the treatment group when the effects were evaluated at the end of week 2 and week 4, respectively, compared with baseline. The naming and writing scores were also improved at the end of week 4 in this group. The comprehension and reading scores were improved at the end of week 4 in the control group compared with the baseline, but the improvements were smaller than those in the treatment group. The percentages of patients at the 0-1 range of mRS were increased at the end of week 2 and week 4 in both groups, but the improvements in the treatment group were much larger than those in the control group. Greater improvements in the NIHSS scores and the hemorheology parameters in the treatment group were also observed compared with the control group at the end of week 2 and week 4. Conclusion. Nao-Xue-Shu oral liquid formulation improved aphasia in mixed stroke patients and thus might be a potentially effective drug for treating stroke aphasia.
Keywords	Other systems of medicine ; RZ201-999
Subject code	150
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: The effect of stroke and other components in Xing-Nao-Jing on the pharmacokinetics of geniposide

Xu, Pan / Jie Bai / Qiu Du / Shou-ying Du / Yan-feng Cao / Yang Lu / Yi-wang Guo

Journal of ethnopharmacology. 2014 Mar. 14, v. 152, no. 2

2014

Abstract: ... Chinese preparation, such as “Xing-Nao-Jing” (XNJ) for stroke treatment. Stroke and the ingredients ...

Abstract	Geniposide is a bioactive substance derived from gardenia, which has been used in traditional Chinese preparation, such as “Xing-Nao-Jing” (XNJ) for stroke treatment. Stroke and the ingredients of herbal preparation affect the pharmacokinetics of geniposide. A comparative pharmacokinetic study of geniposide in stroke and sham-operated rats after administration of XNJ and geniposide was proceeded to evaluate the effect of stroke on pharmacokinetics of geniposide, while the influence of other components in XNJ was determined by using gardenia extract and geniposide–borneol compounds in rats with stroke to compare.Stroke was induced by middle cerebral artery occlusion followed by reperfusion 2h later. Plasma concentration of geniposide was determined by HPLC. Various pharmacokinetic parameters were estimated from the plasma concentration versus time data using non-compartmental methods.The maximum plasma concentration (Cmax) and area under the curve (AUC0−t) in stroke after administration of XNJ were 5.97±3.82μg/mL, and 570.06±274.32μg·min/mL, respectively, which were 5 times compared with sham-operated rats or the stroke-afflicted rats given geniposide. In stroke, the Cmax and AUC0−t of geniposide–borneol group and gardenia extraction group were close to XNJ group and geniposide group, respectively. The geniposide–borneol group had a higher value.Stroke improved the absorption of geniposide in XNJ. Borneol may be the key ingredient in XNJ improving the absorption of geniposide.
Keywords	absorption ; bioactive compounds ; borneol ; Gardenia ; high performance liquid chromatography ; ingredients ; pharmacokinetics ; rats ; stroke ; traditional medicine
Language	English
Dates of publication	2014-0314
Size	p. 302-307.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2013.12.046
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 90/710: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED