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Article ; Online: Validation of the Levenson Self-Report Psychopathy (LSRP) scale in the non-institutionalized Lebanese population.

Ghossoub, Elias / Itani, Hala / Touma Sawaya, Rayah / Ghanime, Pia Maria / Cherro, Michele / Elbejjani, Martine / Barakat, Marc / El Asmar, Khalil

BMC psychiatry

2024 Volume 24, Issue 1, Page(s) 72

Abstract: Background: Psychopathy has been described as "the first personality disorder to be recognized in psychiatry". It has three core features: affective, interpersonal, and behavioral. The Levenson Self-Report Psychopathy (LSRP) scale is used to screen for ... ...

Abstract	Background: Psychopathy has been described as "the first personality disorder to be recognized in psychiatry". It has three core features: affective, interpersonal, and behavioral. The Levenson Self-Report Psychopathy (LSRP) scale is used to screen for and measure psychopathy. Our study aims to validate the LSRP as a tool to measure psychopathy in the non-institutionalized Lebanese population. Methods: We surveyed Lebanese individuals residing in Lebanon and aged 18 through 65. It was a convenience sample collected via an online survey. 534 Lebanese participants completed the survey and were included in our analyses. Nearly 80% were female, 90% were college educated, and 60% were employed. We used exploratory graph analysis and confirmatory factor analyses to measure internal validity of the LSRP. We also used the HEXACO Personality Inventory-Revised (HEXACO-PI-R), the Subtypes of Antisocial Behavior Questionnaire (STAB), and the Short version of the Urgency, Premeditation (lack of), Perseverance (lack of), Sensation Seeking, Positive Urgency, Impulsive Behavior Scale (S-UPPS-P) to measure external validity of LSRP. Results: The exploratory graph analysis showed that the LSRP had a three-factor structure (Egocentric, Callous and Antisocial) in the Lebanese population. This three-factor structure (RMSEA = 0.05, CFI = 0.83, SRMR = 0.06) yielded a better fit than the two-factor, and three-factor Brinkley models. The LSRP was negatively correlated with the Honesty-Humility dimension of the HEXACO-PI-R and positively correlated with the STAB and S-UPPS-P subscales. Conclusions: The LSRP scale is a valid measure of psychopathy in the Lebanese non-institutionalized population, adding to the currently limited literature addressing psychopathy in the Arab World.
MeSH term(s)	Female ; Humans ; Male ; Self Report ; Antisocial Personality Disorder ; Personality Disorders ; Factor Analysis, Statistical ; Impulsive Behavior
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-024-05499-4
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Article ; Online: Endovascular Cell Therapy Introducing an Anatomical Sparing Strategy in a Preclinical Model of Aortic Isthmus Saccular Aneurysm.

Touma, Joseph / Brossier, Julien / Schneider, Fabrice / Rouard, Hélène / Gervais, Marianne / Allaire, Eric

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2021 Volume 62, Issue 2, Page(s) 312–313

MeSH term(s)	Actins/metabolism ; Angiography ; Animals ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/pathology ; Aortic Aneurysm, Thoracic/therapy ; Elastin/ultrastructure ; Hydrogels ; Magnetic Resonance Imaging ; Mesenchymal Stem Cell Transplantation ; Organ Sparing Treatments ; Stents ; Swine ; Vascular Patency
Chemical Substances	Actins ; Hydrogels ; Elastin (9007-58-3)
Language	English
Publishing date	2021-05-27
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2021.03.002
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Article ; Online: Nighttime migrations and behavioral patterns of Pempheris schwenkii

Keita Koeda / Hideyuki Touma / Katsunori Tachihara

PeerJ, Vol 9, p e

2021 Volume 12412

Abstract: ... the target fishes started nighttime migration from the entrance of their cave within 1 h after sunset ... but they migrated long distance (379–786 m/h) during each observation. The behavior observed in the aquarium tank ...

Abstract	Background Although the biomass of the nocturnal fishes is almost same as that of diurnal fishes, most of the ecological studies that examine feeding or reproductive behaviors are on diurnal fishes. Therefore, there is limited ecological information regarding the nocturnal fishes. This fact may be attributed to the difficulty in observing them during darkness. Members of the genus Pempheris (Pempheridae) are one of the most abundant nocturnal fishes on coral reefs. Methods The nighttime migrations of Pempheris schwenkii were observed by attaching a chemical luminescent tag. Tagged fishes were followed by an observer without torch and SCUBA, and their positions and estimated depths were plotted on an underwater topographic map. Aquarium tank observation was carried out to further describe their habits during the night. Results The new tagging method provided good data for observing the migration behavior. In all five observations, the target fishes started nighttime migration from the entrance of their cave within 1 h after sunset. All of them immediately left the inner reef and spent most of the observation time near the surface (0–5 m depth) or shallow (5–15 m depth) water-columns of the outer reef. Their migration pattern varied between days, but they migrated long distance (379–786 m/h) during each observation. The behavior observed in the aquarium tank was categorized into five patterns: schooling, shaking, migrating, spawning, and feeding. Shaking and spawning were observed during one of three observation days. Discussion The present study firstly clarified the small-scale but dynamic nocturnal migration pattern of P. schwenkii in nature by a new method using chemical luminescent tags. In addition, combined observations from nature and an aquarium could be used to estimate the behavior of this species. Pempheris schwenkii may reduce their predation risk of eggs and adults by spawning at outer reef in nighttime. It was estimated that they can potentially migrate 4–7 km/night. The rapid growth known for this ...
Keywords	Sweepers ; Pempheridae ; Nocturnal ; Coral reef ; Observation ; Feeding behavior ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	590
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
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Article: Metabolomic rearrangement controls the intrinsic microbial response to temperature changes.

Knapp, Benjamin D / Willis, Lisa / Gonzalez, Carlos / Vashistha, Harsh / Touma, Joanna Jammal / Tikhonov, Mikhail / Ram, Jeffrey / Salman, Hanna / Elias, Josh E / Huang, Kerwyn Casey

bioRxiv : the preprint server for biology

2023

Abstract: Temperature is one of the key determinants of microbial behavior and survival, whose impact is typically studied under heat- or cold-shock conditions that elicit specific regulation to combat lethal stress. At intermediate temperatures, cellular growth ... ...

Abstract	Temperature is one of the key determinants of microbial behavior and survival, whose impact is typically studied under heat- or cold-shock conditions that elicit specific regulation to combat lethal stress. At intermediate temperatures, cellular growth rate varies according to the Arrhenius law of thermodynamics without stress responses, a behavior whose origins have not yet been elucidated. Using single-cell microscopy during temperature perturbations, we show that bacteria exhibit a highly conserved, gradual response to temperature upshifts with a time scale of ~1.5 doublings at the higher temperature, regardless of initial/final temperature or nutrient source. We find that this behavior is coupled to a temperature memory, which we rule out as being neither transcriptional, translational, nor membrane dependent. Instead, we demonstrate that an autocatalytic enzyme network incorporating temperature-sensitive Michaelis-Menten kinetics recapitulates all temperature-shift dynamics through metabolome rearrangement, which encodes a temperature memory and successfully predicts alterations in the upshift response observed under simple-sugar, low-nutrient conditions, and in fungi. This model also provides a mechanistic framework for both Arrhenius-dependent growth and the classical Monod Equation through temperature-dependent metabolite flux.
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.22.550177
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Article: Generation of evidence supporting the content validity of SF-36, FACIT-F, and LupusQoL, and novel patient-reported symptom items for use in patients with systemic lupus erythematosus (SLE) and SLE with lupus nephritis (LN).

Williams-Hall, Rebecca / Berry, Pamela / Williamson, Nicola / Barclay, Melissa / Roberts, Anna / Gater, Adam / Tolley, Chloe / Bradley, Helena / Ward, Amy / Hsia, Elizabeth / Zuraw, Qing / DeLong, Patricia / Touma, Zahi / Strand, Vibeke

Lupus science & medicine

2022 Volume 9, Issue 1

Abstract: Objective: SLE and lupus nephritis (LN) have significant impacts on the health-related quality of life of patients living with the condition, which are important to capture from the patient's perspective using patient-reported outcomes (PROs). The ... ...

Abstract	Objective: SLE and lupus nephritis (LN) have significant impacts on the health-related quality of life of patients living with the condition, which are important to capture from the patient's perspective using patient-reported outcomes (PROs). The objectives of this study were to evaluate the content validity of PROs commonly used in SLE and LN (36-Item Short Form Health Survey (SF-36), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and Lupus Quality of Life (LupusQoL), as well as novel PRO symptom severity items measuring skin rash, joint pain, joint stiffness and swelling of the legs and/or feet, in both populations. Methods: Qualitative, semi-structured, cognitive interviews were conducted with 48 participants (SLE=28, LN=20). Understanding and relevance of symptom and impact PRO concepts from existing PROs were assessed, alongside novel PRO symptom severity items with different recall periods (24 hours vs 7 days) and response scales (Numerical Rating Scale (NRS) vs Verbal Rating Scale). Interviews were conducted in multiple rounds to allow for modifications to the novel PRO items. Analysis of verbatim interview transcripts was performed. Results: Symptom and impact concepts assessed by the SF-36, FACIT-F, and LupusQoL were well understood by both participants with SLE and LN (≥90.0%), with most considered relevant by over half of the participants asked (≥51.9%). All participants asked (100%) understood the novel PRO symptom severity items, and the majority (≥90.0%) considered the symptoms relevant. Minor modifications to the novel PRO items were made between rounds to improve clarity based on participant feedback. The selected 7-day recall period and NRS in the final iteration of the PRO items were understood and relevant. No differences in interview findings between the SLE and LN samples were identified. Conclusions: Findings provide evidence of content validity for concepts assessed by the SF-36, FACIT-F, LupusQoL and the novel PRO symptom severity items, supporting use of these PROs to comprehensively assess disease impact in future SLE and LN clinical trials.
MeSH term(s)	Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Nephritis/complications ; Lupus Nephritis/diagnosis ; Patient Reported Outcome Measures ; Quality of Life/psychology ; Surveys and Questionnaires
Language	English
Publishing date	2022-08-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2779620-6
ISSN	2053-8790
ISSN	2053-8790
DOI	10.1136/lupus-2022-000712
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Article: QUEST at 25: An enduring innovation in Canadian urology.

Touma, Naji J / Leveridge, Michael J / Beiko, Darren / Rowe, Neal / Warren, Jeff / Watterson, James / Blais, Anne-Sophie / Wilson, James W L / Morales, Alvaro / Razvi, Hassan / Chin, Joseph L K / MacNeily, Andrew E

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

2022 Volume 16, Issue 4, Page(s) 79–80

Language	English
Publishing date	2022-03-31
Publishing country	Canada
Document type	Editorial
ZDB-ID	2431403-1
ISSN	1911-6470
ISSN	1911-6470
DOI	10.5489/cuaj.7855
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Article ; Online: A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours.

Lirussi, Lisa / Ayyildiz, Dilara / Liu, Yan / Montaldo, Nicola P / Carracedo, Sergio / Aure, Miriam R / Jobert, Laure / Tekpli, Xavier / Touma, Joel / Sauer, Torill / Dalla, Emiliano / Kristensen, Vessela N / Geisler, Jürgen / Piazza, Silvano / Tell, Gianluca / Nilsen, Hilde

Nucleic acids research

2022 Volume 50, Issue 18, Page(s) 10449–10468

Abstract: Single-strand selective uracil-DNA glycosylase 1 (SMUG1) initiates base excision repair (BER) of uracil and oxidized pyrimidines. SMUG1 status has been associated with cancer risk and therapeutic response in breast carcinomas and other cancer types. ... ...

Abstract	Single-strand selective uracil-DNA glycosylase 1 (SMUG1) initiates base excision repair (BER) of uracil and oxidized pyrimidines. SMUG1 status has been associated with cancer risk and therapeutic response in breast carcinomas and other cancer types. However, SMUG1 is a multifunctional protein involved, not only, in BER but also in RNA quality control, and its function in cancer cells is unclear. Here we identify several novel SMUG1 interaction partners that functions in many biological processes relevant for cancer development and treatment response. Based on this, we hypothesized that the dominating function of SMUG1 in cancer might be ascribed to functions other than BER. We define a bad prognosis signature for SMUG1 by mapping out the SMUG1 interaction network and found that high expression of genes in the bad prognosis network correlated with lower survival probability in ER+ breast cancer. Interestingly, we identified hsa-let-7b-5p microRNA as an upstream regulator of the SMUG1 interactome. Expression of SMUG1 and hsa-let-7b-5p were negatively correlated in breast cancer and we found an inhibitory auto-regulatory loop between SMUG1 and hsa-let-7b-5p in the MCF7 breast cancer cells. We conclude that SMUG1 functions in a gene regulatory network that influence the survival and treatment response in several cancers.
MeSH term(s)	Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Humans ; MicroRNAs/genetics ; Prognosis ; Uracil/metabolism ; Uracil-DNA Glycosidase/genetics
Chemical Substances	MicroRNAs ; Uracil (56HH86ZVCT) ; SMUG1 protein, human (EC 3.2.2.-) ; Uracil-DNA Glycosidase (EC 3.2.2.-)
Language	English
Publishing date	2022-09-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkac807
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Article ; Online: Validity and Reliability of a (Brief) Diabetes "Survival Skills" Knowledge Test: KNOW Diabetes.

Youssef, Gretchen / Ip, Edward H / Magee, Michelle / Chen, Shyh-Huei / Wallia, Amisha / Pollack, Teresa / Touma, Emilie / Bourges, Clayton / Brecker, Lynne

The Diabetes educator

2019 Volume 45, Issue 2, Page(s) 184–193

MeSH term(s)	Diabetes Mellitus, Type 2/psychology ; Feasibility Studies ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Psychometrics ; Reproducibility of Results ; Self-Management/psychology ; Surveys and Questionnaires/standards
Language	English
Publishing date	2019-02-25
Publishing country	United States
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
ZDB-ID	603168-7
ISSN	1554-6063 ; 0145-7217
ISSN (online)	1554-6063
ISSN	0145-7217
DOI	10.1177/0145721719828064
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Article ; Online: SARS-CoV-2-mediated liver injury: pathophysiology and mechanisms of disease.

Choaib, Ali / Issa, Elio / El Choueiry, Francesca / Eldin, Jade Nasser / Shbaklo, Khodor / Alhajj, Maryline / Sawaya, Ramy Touma / Assi, Ghaith / Nader, Moni / Chatila, Rajaa / Faour, Wissam H

Inflammation research : official journal of the European Histamine Research Society ... [et al.

2022 Volume 72, Issue 2, Page(s) 301–312

Abstract: ... of tissues damage, e.g., hepatocellular necrosis, mitosis, cellular infiltration, and fatty degeneration ...

Abstract	Background: SARS-CoV-2-induced severe inflammatory response can be associated with severe medical consequences leading to multi-organ failure, including the liver. The main mechanism behind this assault is the aggressive cytokine storm that induces cytotoxicity in various organs. Of interest, hepatic stellate cells (HSC) respond acutely to liver injury through several molecular mechanisms, hence furthering the perpetuation of the cytokine storm and its resultant tissue damage. In addition, hepatocytes undergo apoptosis or necrosis resulting in the release of pro-inflammatory and pro-fibrogenic mediators that lead to chronic liver inflammation. Aims: The aim of this review is to summarize available data on SARS-CoV-2-induced liver inflammation in addition to evaluate the potential effect of anti-inflammatory drugs in attenuating SARS-CoV-2-induced liver inflammation. Methods: Thorough PubMed search was done to gather and summarize published data on SARS-CoV-2-induced liver inflammation. Additionally, various anti-inflammatory potential treatments were also documented. Results: Published data documented SARS-CoV-2 infection of liver tissues and is prominent in most liver cells. Also, histological analysis showed various features of tissues damage, e.g., hepatocellular necrosis, mitosis, cellular infiltration, and fatty degeneration in addition to microvesicular steatosis and inflammation. Finally, the efficacy of the different drugs used to treat SARS-CoV-2-induced liver injury, in particular the anti-inflammatory remedies, are likely to have some beneficial effect to treat liver injury in COVID-19. Conclusion: SARS-CoV-2-induced liver inflammation is a serious condition, and drugs with potent anti-inflammatory effect can play a major role in preventing irreversible liver damage in COVID-19.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; Cytokine Release Syndrome ; Inflammation ; Liver Diseases ; Anti-Inflammatory Agents/therapeutic use ; Necrosis
Chemical Substances	Anti-Inflammatory Agents
Language	English
Publishing date	2022-12-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1221794-3
ISSN	1420-908X ; 1023-3830
ISSN (online)	1420-908X
ISSN	1023-3830
DOI	10.1007/s00011-022-01683-y
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Zs.A 675: Show issues

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Article ; Online: OMERACT 2023 Systemic Lupus Erythematosus Special Interest Group: Winnowing and Binning Preliminary Candidate Domains for the Core Outcome Set.

Nielsen, Wils / Strand, Vibeke / Simon, Lee S / Parodis, Ioannis / Kim, Alfred H J / Desai, Maya / Enman, Yvonne / Wallace, Daniel / Chaichian, Yashaar / Navarra, Sandra / Aranow, Cynthia / MacKay, Meggan / Trotter, Kimberly / Tayer-Shifman, Oshrat E / Duarte-Garcia, Ali / Shan Tam, Lai / Ugarte-Gil, Manuel F / PonsEstel, Guillermo J / Reynolds, John A /

Nikpour, Mandana / Hoi, Alberta / Romero-Diaz, Juanita / Papachristos, Danaë / Aggarwal, Amita / Mok, Chi Chiu / Fujio, Keishi / Ramsey-Goldman, Rosalind / Howe, Aaron / Kia, Behdin Nowrouzi / Bonilla, Dennisse / Thumboo, Julian / Mosca, Marta / Aringer, Martin / Johnson, Sindhu R / Drucker, Aaron M / Morand, Eric / Bruce, Ian / Touma, Zahi

Seminars in arthritis and rheumatism

2024 Volume 65, Page(s) 152380

Abstract: Background: The Outcome Measures in Rheumatology (OMERACT) Systemic Lupus Erythematosus (SLE) Working Group held a Special Interest Group (SIG) at the OMERACT 2023 conference in Colorado Springs where SLE collaborators reviewed domain sub-themes ... ...

Abstract	Background: The Outcome Measures in Rheumatology (OMERACT) Systemic Lupus Erythematosus (SLE) Working Group held a Special Interest Group (SIG) at the OMERACT 2023 conference in Colorado Springs where SLE collaborators reviewed domain sub-themes generated through qualitative research and literature review. Objective: The objective of the SIG and the subsequent meetings of the SLE Working Group was to begin the winnowing and binning of candidate domain sub-themes into a preliminary list of candidate domains that will proceed to the consensus Delphi exercise for the SLE COS. Methods: Four breakout groups at the SLE SIG in Colorado Springs winnowed and binned 132 domain sub-themes into candidate domains, which was continued with a series of virtual meetings by an advisory group of SLE patient research partners (PRPs), members of the OMERACT SLE Working Group Steering Committee, and other collaborators. Results: The 132 domain sub-themes were reduced to a preliminary list of 20 candidate domains based on their clinical and research relevance for clinical trials and research studies. Conclusion: A meaningful and substantial winnowing and binning of candidate domains for the SLE COS was achieved resulting in a preliminary list of 20 candidate domains.
MeSH term(s)	Humans ; Public Opinion ; Outcome Assessment, Health Care ; Lupus Erythematosus, Systemic/therapy ; Rheumatology ; Consensus
Language	English
Publishing date	2024-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	120247-9
ISSN	1532-866X ; 0049-0172
ISSN (online)	1532-866X
ISSN	0049-0172
DOI	10.1016/j.semarthrit.2024.152380
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