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  1. Article ; Online: Michael Sela: Scientist, statesman, sage (1924-2022).

    Steinman, Lawrence

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 34, Page(s) e2211991119

    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2211991119
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    Zs.A 1148: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: From defining antigens to new therapies in multiple sclerosis: honoring the contributions of Ruth Arnon and Michael Sela.

    Steinman, Lawrence / Shoenfeld, Yehuda

    Journal of autoimmunity

    2014  Volume 54, Page(s) 1–7

    Abstract: Ruth Arnon and Michael Sela profoundly influenced the development of a model system to test new ...

    Abstract Ruth Arnon and Michael Sela profoundly influenced the development of a model system to test new therapies in multiple sclerosis (MS). Their application of the animal model, known as experimental autoimmune encephalomyelitis (EAE), for the discovery of Copaxone, opened a new path for testing of drug candidates in MS. By measuring clinical, pathologic, and immunologic outcomes, the biological implications of new drugs could be elucidated. Using EAE they established the efficacy of Copaxone as a therapy for preventing and reducing paralysis and inflammation in the central nervous system without massive immune suppression. This had a huge impact on the field of drug discovery for MS. Much like the use of parabiosis to discover soluble factors associated with obesity, or the replica plating system to probe antibiotic resistance in bacteria, the pioneering research on Copaxone using the EAE model, paved the way for the discovery of other therapeutics in MS, including Natalizumab and Fingolimod. Future applications of this approach may well elucidate novel therapies for the neurodegenerative phase of multiple sclerosis associated with disease progression.
    MeSH term(s) Animals ; Antibodies, Monoclonal, Humanized/history ; Antibodies, Monoclonal, Humanized/therapeutic use ; Encephalomyelitis, Autoimmune, Experimental/drug therapy ; Encephalomyelitis, Autoimmune, Experimental/history ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Fingolimod Hydrochloride ; Glatiramer Acetate ; History, 20th Century ; History, 21st Century ; Humans ; Immunosuppressive Agents/history ; Immunosuppressive Agents/therapeutic use ; Multiple Sclerosis/diet therapy ; Multiple Sclerosis/history ; Multiple Sclerosis/immunology ; Multiple Sclerosis/pathology ; Natalizumab ; Peptides/history ; Peptides/therapeutic use ; Propylene Glycols/history ; Propylene Glycols/therapeutic use ; Sphingosine/analogs & derivatives ; Sphingosine/history ; Sphingosine/therapeutic use
    Chemical Substances Antibodies, Monoclonal, Humanized ; Immunosuppressive Agents ; Natalizumab ; Peptides ; Propylene Glycols ; Glatiramer Acetate (5M691HL4BO) ; Fingolimod Hydrochloride (G926EC510T) ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2014-11
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2014.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2368: Show issues Location:
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  3. Article ; Online: The future of deprescribing research: Seizing opportunities and learning from the past.

    Steinman, Michael A

    Basic & clinical pharmacology & toxicology

    2023  Volume 133, Issue 6, Page(s) 653–656

    MeSH term(s) Deprescriptions ; Biomedical Research
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/bcpt.13852
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  4. Article ; Online: The U.S. deprescribing research network: Catalyzing research and action to optimize medication use in older adults.

    Boyd, Cynthia M / Steinman, Michael A

    Journal of the American Geriatrics Society

    2024  

    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Letter
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18856
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  5. Article ; Online: Reply to: Comment on: 2023 Updated AGS Beers Criteria® for potentially inappropriate medication use in older adults.

    Semla, Todd P / Steinman, Michael A

    Journal of the American Geriatrics Society

    2023  Volume 71, Issue 12, Page(s) 3953–3954

    MeSH term(s) Humans ; Aged ; Potentially Inappropriate Medication List ; Inappropriate Prescribing/prevention & control ; Geriatrics
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18581
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  6. Article ; Online: Reply to: The importance of assessing the safe and effective use of oral anticoagulants in older adults.

    Semla, Todd P / Steinman, Michael A

    Journal of the American Geriatrics Society

    2023  Volume 71, Issue 12, Page(s) 3956–3957

    MeSH term(s) Humans ; Aged ; Anticoagulants/adverse effects ; Atrial Fibrillation/drug therapy ; Administration, Oral
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18588
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  7. Article ; Online: Reply to: Comment on the 2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults.

    Semla, Todd P / Steinman, Michael A

    Journal of the American Geriatrics Society

    2023  Volume 72, Issue 2, Page(s) 634–635

    MeSH term(s) Humans ; Aged ; Potentially Inappropriate Medication List ; Inappropriate Prescribing/prevention & control ; Geriatrics
    Language English
    Publishing date 2023-12-23
    Publishing country United States
    Document type Letter
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18718
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  8. Article ; Online: Cognitive, physical, and sensory deficits that can affect everyday medication use among older adults: A national view.

    Tang, Belinda / Espejo, Edie / Steinman, Michael A / Growdon, Matthew E

    Journal of the American Geriatrics Society

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18922
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  9. Article ; Online: You're so vein, you probably think this model's about you: opportunities and challenges for computational fluid dynamics in cerebral venous disease.

    Steinman, David A / Gounis, Matthew J / Levitt, Michael R

    Journal of neurointerventional surgery

    2023  Volume 15, Issue 7, Page(s) 621–622

    MeSH term(s) Humans ; Hydrodynamics ; Cerebral Veins/diagnostic imaging
    Language English
    Publishing date 2023-05-26
    Publishing country England
    Document type Editorial
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2023-020652
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    Zs.A 6845: Show issues Location:
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  10. Article ; Online: Adverse Drug Events After Hospitalization-Are We Missing the Mark?

    Bongiovanni, Tasce / Steinman, Michael A

    JAMA internal medicine

    2021  Volume 181, Issue 5, Page(s) 618–619

    MeSH term(s) Drug-Related Side Effects and Adverse Reactions/epidemiology ; Hospitalization ; Humans
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2020.9282
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