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Article ; Online: Empirically Derived Principles for Research Funding Success: A Primer for Early Career Academic Investigators.

Wahid, Kareem A / Rooney, Michael K / Gunther, Jillian R / Moreno, Amy C / Pinnix, Chelsea C / Thomas, Charles R / Fuller, Clifton D

International journal of radiation oncology, biology, physics

2024 Volume 118, Issue 3, Page(s) 590–594

MeSH term(s)	Humans ; United States ; Biomedical Research ; Career Choice
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Editorial
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2023.09.030
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Article ; Online: The Use of MR-Guided Radiation Therapy for Head and Neck Cancer and Recommended Reporting Guidance.

McDonald, Brigid A / Dal Bello, Riccardo / Fuller, Clifton D / Balermpas, Panagiotis

Seminars in radiation oncology

2023 Volume 34, Issue 1, Page(s) 69–83

Abstract: Although magnetic resonance imaging (MRI) has become standard diagnostic workup for head and neck malignancies and is currently recommended by most radiological societies for pharyngeal and oral carcinomas, its utilization in radiotherapy has been ... ...

Abstract	Although magnetic resonance imaging (MRI) has become standard diagnostic workup for head and neck malignancies and is currently recommended by most radiological societies for pharyngeal and oral carcinomas, its utilization in radiotherapy has been heterogeneous during the last decades. However, few would argue that implementing MRI for annotation of target volumes and organs at risk provides several advantages, so that implementation of the modality for this purpose is widely accepted. Today, the term MR-guidance has received a much broader meaning, including MRI for adaptive treatments, MR-gating and tracking during radiotherapy application, MR-features as biomarkers and finally MR-only workflows. First studies on treatment of head and neck cancer on commercially available dedicated hybrid-platforms (MR-linacs), with distinct common features but also differences amongst them, have also been recently reported, as well as "biological adaptation" based on evaluation of early treatment response via functional MRI-sequences such as diffusion weighted ones. Yet, all of these approaches towards head and neck treatment remain at their infancy, especially when compared to other radiotherapy indications. Moreover, the lack of standardization for reporting MR-guided radiotherapy is a major obstacle both to further progress in the field and to conduct and compare clinical trials. Goals of this article is to present and explain all different aspects of MR-guidance for radiotherapy of head and neck cancer, summarize evidence, as well as possible advantages and challenges of the method and finally provide a comprehensive reporting guidance for use in clinical routine and trials.
MeSH term(s)	Humans ; Radiotherapy Planning, Computer-Assisted/methods ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/radiotherapy ; Magnetic Resonance Imaging/methods ; Radiotherapy, Image-Guided/methods ; Radiotherapy, Intensity-Modulated/methods
Language	English
Publishing date	2023-12-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1146999-7
ISSN	1532-9461 ; 1053-4296
ISSN (online)	1532-9461
ISSN	1053-4296
DOI	10.1016/j.semradonc.2023.10.003
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Zs.A 3654: Show issues

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Article ; Online: Factors Associated With Altmetric Attention Scores for Randomized Phase III Cancer Clinical Trials.

Rooney, Michael K / Sharifi, Bahareh / Ludmir, Ethan B / Fuller, Clifton D / Warner, Jeremy L

JCO clinical cancer informatics

2023 Volume 7, Page(s) e2300082

Abstract: Purpose: Altmetric Attention Scores (Altmetrics) are real-time measures of scientific impact and attention through various public outlets, including news, blogs, and social media. Herein, we aimed to describe and characterize the relationship between ... ...

Abstract	Purpose: Altmetric Attention Scores (Altmetrics) are real-time measures of scientific impact and attention through various public outlets, including news, blogs, and social media. Herein, we aimed to describe and characterize the relationship between Altmetrics, conventional impact metrics, and features of published cancer clinical trials. Methods: We identified two-arm phase III cancer randomized clinical trials with a superiority end point and publication date between 2015 and 2020 from HemOnc and tabulated the following data: Altmetric, study positivity, US Food and Drug Administration (FDA) registration trial status, cancer site/category, treatment context (curative or palliative), trial design, primary end point type, experimental/control arm modality, and journal tier. We further collected conventional bibliometrics including the number of citations and relative citation ratio (RCR) for all published studies. Multiple linear regression modeling identified clinical trial factors predictive of Altmetrics, with alpha = .05 defining statistical significance. Results: Altmetrics were found for 681 (98%) of 698 publications, with a median score of 38.5 (IQR, 13-132.8). FDA registration studies (β [95% CI], 84.7 [48.8 to 120.6]; Conclusion: FDA registration trials describing curative interventions, studies published in traditionally defined high-impact journals, and genitourinary trial publications tend to have the greatest Altmetrics. We observed a strong relationship between Altmetrics and conventional bibliometrics. The significance and consequences of these relationships warrant further investigation.
MeSH term(s)	United States ; Humans ; Journal Impact Factor ; Bibliometrics ; Social Media ; Neoplasms/diagnosis ; Neoplasms/therapy
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
ISSN	2473-4276
ISSN (online)	2473-4276
DOI	10.1200/CCI.23.00082
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Artificial Intelligence and Radiomics in Head and Neck Cancer Care: Opportunities, Mechanics, and Challenges.

van Dijk, Lisanne V / Fuller, Clifton D

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

2021 Volume 41, Page(s) 1–11

Abstract: The advent of large-scale high-performance computing has allowed the development of machine-learning techniques in oncologic applications. Among these, there has been substantial growth in radiomics (machine-learning texture analysis of images) and ... ...

Abstract	The advent of large-scale high-performance computing has allowed the development of machine-learning techniques in oncologic applications. Among these, there has been substantial growth in radiomics (machine-learning texture analysis of images) and artificial intelligence (which uses deep-learning techniques for "learning algorithms"); however, clinical implementation has yet to be realized at scale. To improve implementation, opportunities, mechanics, and challenges, models of imaging-enabled artificial intelligence approaches need to be understood by clinicians who make the treatment decisions. This article aims to convey the basic conceptual premises of radiomics and artificial intelligence using head and neck cancer as a use case. This educational overview focuses on approaches for head and neck oncology imaging, detailing current research efforts and challenges to implementation.
MeSH term(s)	Algorithms ; Artificial Intelligence ; Diagnostic Imaging ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/therapy ; Humans ; Machine Learning
Language	English
Publishing date	2021-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2431126-1
ISSN	1548-8756 ; 1548-8748
ISSN (online)	1548-8756
ISSN	1548-8748
DOI	10.1200/EDBK_320951
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Article ; Online: Systematic Review of Genetic Polymorphisms Associated with Acute Pain Induced by Radiotherapy for Head and Neck Cancers.

Salama, Vivian / Geng, Yimin / Rigert, Jillian / Fuller, Clifton D / Shete, Sanjay / Moreno, Amy C

Clinical and translational radiation oncology

2023 Volume 43, Page(s) 100669

Abstract: Background/objective: Pain is the most common acute symptom following radiation therapy (RT) for head and neck cancer (HNC). The multifactorial origin of RT-induced pain makes it highly challenging to manage. Multiple studies were conducted to identify ... ...

Abstract	Background/objective: Pain is the most common acute symptom following radiation therapy (RT) for head and neck cancer (HNC). The multifactorial origin of RT-induced pain makes it highly challenging to manage. Multiple studies were conducted to identify genetic variants associated with cancer pain, however few of them focused on RT-induced acute pain. In this review, we summarize the potential mechanisms of acute pain after RT in HNC and identify genetic variants associated with RT-induced acute pain and relevant acute toxicities. Methods: A comprehensive search of Ovid Medline, EMBASE and Web of Science databases using terms including "Variants", "Polymorphisms", "Radiotherapy", "Acute pain", "Acute toxicity" published up to February 28, 2022, was performed by two reviewers. Review articles and citations were reviewed manually. The identified SNPs associated with RT-induced acute pain and toxicities were reported, and the molecular functions of the associated genes were described based on genetic annotation using The Human Gene Database; GeneCards. Results: A total of 386 articles were identified electronically and 8 more articles were included after manual search. 21 articles were finally included. 32 variants in 27 genes, of which 25% in inflammatory/immune response, 20% had function in DNA damage response and repair, 20% in cell death or cell cycle, were associated with RT-inflammatory pain and acute oral mucositis or dermatitis. 4 variants in 4 genes were associated with neuropathy and neuropathic pain. 5 variants in 4 genes were associated with RT-induced mixed types of post-RT-throat/neck pain. Conclusion: Different types of pain develop after RT in HNC, including inflammatory pain; neuropathic pain; nociceptive pain; and mixed oral pain. Genetic variants involved in DNA damage response and repair, cell death, inflammation and neuropathic pathways may affect pain presentation post-RT. These variants could be used for personalized pain management in HNC patients receiving RT.
Language	English
Publishing date	2023-08-19
Publishing country	Ireland
Document type	Journal Article ; Review
ISSN	2405-6308
ISSN (online)	2405-6308
DOI	10.1016/j.ctro.2023.100669
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Systematic Review of Genetic Polymorphisms Associated with Acute Pain Induced by Radiotherapy for Head and Neck Cancers

Vivian Salama / Yimin Geng / Jillian Rigert / Clifton D. Fuller / Sanjay Shete / Amy C. Moreno

Clinical and Translational Radiation Oncology, Vol 43, Iss , Pp 100669- (2023)

2023

Abstract	Background/objective: Pain is the most common acute symptom following radiation therapy (RT) for head and neck cancer (HNC). The multifactorial origin of RT-induced pain makes it highly challenging to manage. Multiple studies were conducted to identify genetic variants associated with cancer pain, however few of them focused on RT-induced acute pain. In this review, we summarize the potential mechanisms of acute pain after RT in HNC and identify genetic variants associated with RT-induced acute pain and relevant acute toxicities. Methods: A comprehensive search of Ovid Medline, EMBASE and Web of Science databases using terms including “Variants”, “Polymorphisms”, “Radiotherapy”, “Acute pain”, “Acute toxicity” published up to February 28, 2022, was performed by two reviewers. Review articles and citations were reviewed manually. The identified SNPs associated with RT-induced acute pain and toxicities were reported, and the molecular functions of the associated genes were described based on genetic annotation using The Human Gene Database; GeneCards. Results: A total of 386 articles were identified electronically and 8 more articles were included after manual search. 21 articles were finally included. 32 variants in 27 genes, of which 25% in inflammatory/immune response, 20% had function in DNA damage response and repair, 20% in cell death or cell cycle, were associated with RT-inflammatory pain and acute oral mucositis or dermatitis. 4 variants in 4 genes were associated with neuropathy and neuropathic pain. 5 variants in 4 genes were associated with RT-induced mixed types of post-RT-throat/neck pain. Conclusion: Different types of pain develop after RT in HNC, including inflammatory pain; neuropathic pain; nociceptive pain; and mixed oral pain. Genetic variants involved in DNA damage response and repair, cell death, inflammation and neuropathic pathways may affect pain presentation post-RT. These variants could be used for personalized pain management in HNC patients receiving RT.
Keywords	Genetic variants ; Polymorphisms ; Radiation pain ; Radiation mucositis ; Radiation dermatitis ; Head and neck cancers ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	616
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Radical Radiotherapy Should Remain the Standard of Care for Carcinoma Oropharynx-Reply.

Hutcheon, Katherine / Gross, Neil D / Fuller, Clifton

JAMA otolaryngology-- head & neck surgery

2020 Volume 146, Issue 5, Page(s) 505–506

MeSH term(s)	Carcinoma ; Humans ; Oropharyngeal Neoplasms ; Oropharynx ; Pharyngeal Neoplasms ; Standard of Care
Language	English
Publishing date	2020-03-09
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2701825-8
ISSN	2168-619X ; 2168-6181
ISSN (online)	2168-619X
ISSN	2168-6181
DOI	10.1001/jamaoto.2020.0092
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Article ; Online: National Institutes of Health Diversity Supplement Awards: Experience of Radiation Oncology Principal Investigators and Trainees.

Yorke, Afua A / Rooney, Michael K / Rigert, Jillian / Moreno, Amy C / Fuller, Clifton D / Ford, Eric C

International journal of radiation oncology, biology, physics

2023 Volume 116, Issue 2, Page(s) 375–378

MeSH term(s)	United States ; Humans ; Radiation Oncology ; National Institutes of Health (U.S.) ; Financing, Government ; Awards and Prizes ; Biomedical Research
Language	English
Publishing date	2023-04-22
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2023.03.034
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Article: Editorial: Online Adaptive MR-Guided Radiotherapy.

Kerkmeijer, Linda G W / Valentini, Vincenzo / Fuller, Clifton D Dave / Slotman, Ben J

Frontiers in oncology

2021 Volume 11, Page(s) 748685

Language	English
Publishing date	2021-08-30
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.748685
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Article ; Online: Longitudinal changes in the carotid arteries of head and neck cancer patients following radiation therapy: Results from a prospective serial imaging biomarker characterization study.

Koutroumpakis, Efstratios / Mohamed, Abdallah Sherif Radwan / Chaftari, Peter / Rosenthal, David I / Gujral, Dorothy / Nutting, Christopher / Kamel, Serageldin / Naser, Mohamed A / Kim, Peter / Bassett, Roland / Fuller, Clifton D / Mouhayar, Elie

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2024 Volume 195, Page(s) 110220

Abstract: Introduction: We prospectively evaluated morphologic and functional changes in the carotid arteries of patients treated with unilateral neck radiation therapy (RT) for head and neck cancer.: Methods: Bilateral carotid artery duplex studies were ... ...

Abstract	Introduction: We prospectively evaluated morphologic and functional changes in the carotid arteries of patients treated with unilateral neck radiation therapy (RT) for head and neck cancer. Methods: Bilateral carotid artery duplex studies were performed at 0, 3, 6, 12, 18 months and 2, 3, 4, and 5 years following RT. Intima media thickness (IMT); global and regional circumferential, as well as radial strain, arterial elasticity, stiffness, and distensibility were calculated. Results: Thirty-eight patients were included. A significant difference in the IMT from baseline between irradiated and unirradiated carotid arteries was detected at 18 months (median, 0.073 mm vs -0.003 mm; P = 0.014), which increased at 3 and 4 years (0.128 mm vs 0.013 mm, P = 0.016, and 0.177 mm vs 0.023 mm, P = 0.0002, respectively). A significant transient change was noted in global circumferential strain between the irradiated and unirradiated arteries at 6 months (median difference, -0.89, P = 0.023), which did not persist. No significant differences were detected in the other measures of elasticity, stiffness, and distensibility. Conclusions: Functional and morphologic changes of the carotid arteries detected by carotid ultrasound, such as changes in global circumferential strain at 6 months and carotid IMT at 18 months, may be useful for the early detection of radiation-induced carotid artery injury, can guide future research aiming to mitigate carotid artery stenosis, and should be considered for clinical surveillance survivorship recommendations after head and neck RT.
Language	English
Publishing date	2024-03-11
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2024.110220
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