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  1. Article: Chromatin structure and 3D architecture define differential functions of

    Qiu, Kevin / Vu, Duc / Wang, Leran / Bookstaver, Anna / Dinh, Thang N / Goldfarb, Adam N / Tenen, Daniel G / Trinh, Bon Q

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The precise spatio-temporal expression of the hematopoietic ETS transcription ... ...

    Abstract The precise spatio-temporal expression of the hematopoietic ETS transcription factor
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.01.573782
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  2. Article ; Online: Liver kinase B1 (LKB1) in murine erythroid progenitors modulates erythropoietin setpoint in association with maturation control.

    White, Zollie / Elagib, Kamaleldin E / Gru, Alejandro A / Goldfarb, Adam N

    Blood cells, molecules & diseases

    2022  Volume 97, Page(s) 102688

    Abstract: Erythropoiesis is a tightly regulated process. It is stimulated by decreased oxygen in circulation, which leads to the secretion of the hormone erythropoietin (Epo) by the kidneys. An additional layer of control involves the coordinated sensing and use ... ...

    Abstract Erythropoiesis is a tightly regulated process. It is stimulated by decreased oxygen in circulation, which leads to the secretion of the hormone erythropoietin (Epo) by the kidneys. An additional layer of control involves the coordinated sensing and use of nutrients. Much cellular machinery contributes to sensing and responding to nutrient status in cells, and one key participant is the kinase LKB1. The current study examines the role of LKB1 in erythropoiesis using a murine in vivo and ex vivo conditional knockout system. In vivo analysis showed erythroid loss of LKB1 to be associated with a robust increase in serum Epo and mild reticulocytosis. Despite these abnormalities, no evidence of anemia or hemolysis was found. Further characterization using an ex vivo progenitor culture assay demonstrated accelerated erythroid maturation in the LKB1-deficient cells. Based on pharmacologic evidence, this phenotype appeared to result from impaired AMP-activated protein kinase (AMPK) signaling downstream of LKB1. These findings reveal a role for LKB1 in fine-tuning Epo-driven erythropoiesis in association with maturational control.
    MeSH term(s) AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Animals ; Erythroid Precursor Cells/metabolism ; Erythropoiesis/genetics ; Erythropoiesis/physiology ; Erythropoietin/genetics ; Erythropoietin/metabolism ; Humans ; Liver/metabolism ; Mice ; Receptors, Erythropoietin/genetics ; Receptors, Erythropoietin/metabolism
    Chemical Substances Receptors, Erythropoietin ; Erythropoietin (11096-26-7) ; Stk11 protein, mouse (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2022-06-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2022.102688
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1138: Show issues Location:
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  3. Article ; Online: Disparities in the impact of the AJCC 8th edition staging system on differentiated thyroid cancer outcomes.

    Santamaria-Barria, Juan A / Graff-Baker, Amanda N / Chang, Shu-Ching / Khader, Adam / Scholer, Anthony J / Garland-Kledzik, Mary / Goldfarb, Melanie

    Head & neck

    2022  Volume 44, Issue 10, Page(s) 2129–2141

    Abstract: Background: The impact of AJCC8 among self-reported racial/ethnic groups on differentiated thyroid cancer (DTC) outcomes is unknown.: Methods: Multivariate-regression evaluated the association between AJCC7 to AJCC8 stage change and race/ethnicity in ...

    Abstract Background: The impact of AJCC8 among self-reported racial/ethnic groups on differentiated thyroid cancer (DTC) outcomes is unknown.
    Methods: Multivariate-regression evaluated the association between AJCC7 to AJCC8 stage change and race/ethnicity in patients with DTC in the NCDB. Cox-proportional-regression evaluated whether AJCC7 to AJCC8 stage change affects overall survival (OS) differently based on reported race/ethnicity.
    Results: After adjusting for confounders, Hispanics and Asian-Pacific-Islanders (APIs) were 27% and 12% less likely to be down-staged compared to white-non-Hispanics (WNHs) (p < 0.001); black-non-Hispanics (BNHs) had no significant down-staging difference. Down-staged patients had an increased risk of death compared to patients with unchanged staging, regardless of race/ethnicity. However, based on two-way interaction, the magnitude of this negative change on survival from down-staging was only different between WNHs (HR = 2.64) and BNHs (HR = 1.77), (p = 0.04).
    Conclusions: Outcome disparities persist among self-reported racial/ethnic groups with AJCC8. Down-staged patients across all racial/ethnic groups had decreased survival compared to those with unchanged stage, with the least impact in BNHs.
    MeSH term(s) Adenocarcinoma ; Humans ; Neoplasm Staging ; Thyroid Neoplasms/surgery
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27122
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1493: Show issues Location:
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  4. Article ; Online: Megakaryocyte ontogeny: Clinical and molecular significance.

    Elagib, Kamaleldin E / Brock, Ashton T / Goldfarb, Adam N

    Experimental hematology

    2018  Volume 61, Page(s) 1–9

    Abstract: Fetal megakaryocytes (Mks) differ from adult Mks in key parameters that affect their capacity for platelet production. However, despite being smaller, more proliferative, and less polyploid, fetal Mks generally mature in the same manner as adult Mks. The ...

    Abstract Fetal megakaryocytes (Mks) differ from adult Mks in key parameters that affect their capacity for platelet production. However, despite being smaller, more proliferative, and less polyploid, fetal Mks generally mature in the same manner as adult Mks. The phenotypic features unique to fetal Mks predispose patients to several disease conditions, including infantile thrombocytopenia, infantile megakaryoblastic leukemias, and poor platelet recovery after umbilical cord blood stem cell transplantations. Ontogenic Mk differences also affect new strategies being developed to address global shortages of platelet transfusion units. These donor-independent, ex vivo production platforms are hampered by the limited proliferative capacity of adult-type Mks and the inferior platelet production by fetal-type Mks. Understanding the molecular programs that distinguish fetal versus adult megakaryopoiesis will help in improving approaches to these clinical problems. This review summarizes the phenotypic differences between fetal and adult Mks, the disease states associated with fetal megakaryopoiesis, and recent advances in the understanding of mechanisms that determine ontogenic Mk transitions.
    MeSH term(s) Fetal Blood/cytology ; Humans ; Megakaryocytes/cytology ; Megakaryocytes/pathology ; Models, Biological ; Morphogenesis/physiology ; Phenotype ; Thrombocytopenia/pathology
    Language English
    Publishing date 2018-03-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 185107-x
    ISSN 1873-2399 ; 0531-5573 ; 0301-472X
    ISSN (online) 1873-2399
    ISSN 0531-5573 ; 0301-472X
    DOI 10.1016/j.exphem.2018.02.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 922: Show issues Location:
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  5. Article ; Online: Coordinating red cell differentiation with cell cycle arrest: GATA-1 activation of p21.

    Goldfarb, Adam N

    Cell cycle (Georgetown, Tex.)

    2010  Volume 9, Issue 11, Page(s) 2061

    MeSH term(s) Cell Differentiation ; Cell Line ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Erythroid Cells/cytology ; Erythroid Cells/metabolism ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; Humans ; Proto-Oncogene Proteins c-kit/metabolism ; Proto-Oncogene Proteins c-myc/metabolism
    Chemical Substances Cyclin-Dependent Kinase Inhibitor p21 ; GATA1 Transcription Factor ; GATA1 protein, human ; Proto-Oncogene Proteins c-myc ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
    Language English
    Publishing date 2010-06-01
    Publishing country United States
    Document type Comment ; News
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
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    Zs.A 5881: Show issues Location:
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  6. Article ; Online: Megakaryocytic programming by a transcriptional regulatory loop: A circle connecting RUNX1, GATA-1, and P-TEFb.

    Goldfarb, Adam N

    Journal of cellular biochemistry

    2009  Volume 107, Issue 3, Page(s) 377–382

    Abstract: Transcription factors originally identified as drivers of erythroid differentiation subsequently became linked to megakaryopoiesis, reflecting the shared parentage of red cells and platelets. The divergent development of megakaryocytic and erythroid ... ...

    Abstract Transcription factors originally identified as drivers of erythroid differentiation subsequently became linked to megakaryopoiesis, reflecting the shared parentage of red cells and platelets. The divergent development of megakaryocytic and erythroid progenitors relies on signaling pathways that impose lineage-specific transcriptional programs on non-lineage-restricted protein complexes. One such signaling pathway involves RUNX1, a transcription factor upregulated in megakaryocytes and downregulated in erythroid cells. In this pathway, RUNX1 engages the erythro-megakaryocytic master regulator GATA-1 in a megakaryocytic transcriptional complex whose activity is highly dependent on the P-TEFb kinase complex. The implications of this pathway for normal and pathological megakaryopoiesis are discussed.
    MeSH term(s) Animals ; Core Binding Factor Alpha 2 Subunit/genetics ; Core Binding Factor Alpha 2 Subunit/metabolism ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; Humans ; Megakaryocytes/cytology ; Megakaryocytes/metabolism ; Positive Transcriptional Elongation Factor B/metabolism ; Signal Transduction ; Transcription, Genetic
    Chemical Substances Core Binding Factor Alpha 2 Subunit ; GATA1 Transcription Factor ; Positive Transcriptional Elongation Factor B (EC 2.7.11.-)
    Language English
    Publishing date 2009-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 392402-6
    ISSN 1097-4644 ; 0730-2312
    ISSN (online) 1097-4644
    ISSN 0730-2312
    DOI 10.1002/jcb.22142
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    Zs.A 1114: Show issues Location:
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  7. Article ; Online: Megakaryocytic irreversible P-TEFb activation.

    Elagib, Kamaleldin E / Goldfarb, Adam N

    Cell cycle (Georgetown, Tex.)

    2014  Volume 13, Issue 12, Page(s) 1827–1828

    MeSH term(s) Animals ; Calpain/physiology ; Cell Transformation, Neoplastic/pathology ; GATA1 Transcription Factor/genetics ; Humans ; Leukemia/pathology ; Megakaryocytes/pathology ; Mutation/genetics ; Positive Transcriptional Elongation Factor B/metabolism ; Ribonucleoproteins, Small Nuclear/metabolism
    Chemical Substances GATA1 Transcription Factor ; Ribonucleoproteins, Small Nuclear ; Positive Transcriptional Elongation Factor B (EC 2.7.11.-) ; Calpain (EC 3.4.22.-)
    Language English
    Publishing date 2014-05-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.4161/cc.29324
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    Zs.A 5881: Show issues Location:
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  8. Article ; Online: A case series of hydroxychloroquine exacerbating the dermatomyositis rash.

    Rypka, Katelyn / Buonomo, Michele / Buechler, Connor / Benolken, Molly / Swigost, Adam / Konstantinov, Nikifor / Gaddis, Kevin / Goldfarb, Noah

    Dermatology online journal

    2023  Volume 29, Issue 5

    Abstract: Hydroxychloroquine (HCQ) is an antimalarial agent that is commonly used in the management of rheumatic skin disease. Few reports exist documenting exacerbation of dermatomyositis (DM) related to HCQ. Herein, we describe three adult patients with ... ...

    Abstract Hydroxychloroquine (HCQ) is an antimalarial agent that is commonly used in the management of rheumatic skin disease. Few reports exist documenting exacerbation of dermatomyositis (DM) related to HCQ. Herein, we describe three adult patients with worsening DM cutaneous disease after starting HCQ and resolution or improvement with cessation. The time to exacerbation ranged from two weeks to nine months after the initiation of HCQ 400mg/day. Two of the three patients had antibodies to transcription intermediary factor 1γ (TIF1γ) and the other had antibodies to anti-nuclear matrix protein 2 (NXP2). After discontinuation of HCQ, the time to improvement or resolution of cutaneous symptoms ranged from six weeks to six months. Hydroxychloroquine may be associated with worsening cutaneous features in DM. In patients who are not improving despite escalation of immunosuppressive medications, or are worsening, we recommend a trial of discontinuing HCQ.
    MeSH term(s) Adult ; Humans ; Hydroxychloroquine/adverse effects ; Dermatomyositis/chemically induced ; Dermatomyositis/drug therapy ; Dermatomyositis/diagnosis ; Retrospective Studies ; Exanthema
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2023-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2026239-5
    ISSN 1087-2108 ; 1087-2108
    ISSN (online) 1087-2108
    ISSN 1087-2108
    DOI 10.5070/D329562407
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  9. Article: ERK expands its empire.

    Goldfarb, Adam N

    Leukemia research

    2005  Volume 29, Issue 11, Page(s) 1235–1236

    MeSH term(s) Animals ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Cell Line, Tumor ; Extracellular Signal-Regulated MAP Kinases/drug effects ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Granulocyte Colony-Stimulating Factor/antagonists & inhibitors ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocytes/cytology ; Granulocytes/drug effects ; Granulocytes/physiology ; Interleukin-3/pharmacology ; Interleukin-6/pharmacology ; MAP Kinase Signaling System/physiology ; Mice ; Monocytes/cytology ; Monocytes/drug effects ; Monocytes/physiology
    Chemical Substances Interleukin-3 ; Interleukin-6 ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2005-11
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2005.05.021
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    Zs.A 1321: Show issues Location:
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  10. Article ; Online: Multiple Squamous Neoplasms Arising in a Red Tattoo After Laser Tattoo Removal.

    Swigost, Adam / Farah, Ronda S / Canova, Erica / Goldfarb, Noah

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2019  Volume 46, Issue 7, Page(s) 970–973

    MeSH term(s) Carcinoma, Squamous Cell/pathology ; Humans ; Laser Therapy ; Male ; Middle Aged ; Postoperative Complications/pathology ; Skin Neoplasms/pathology ; Tattooing
    Language English
    Publishing date 2019-07-15
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000002031
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    Zs.A 1212: Show issues Location:
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