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  1. Book ; Online ; Thesis: Novel approaches to transgenesis in the teleost medaka (Oryzias latipes)

    Grabher, Clemens

    2003  

    Author's details vorgelegt von Clemens Grabher
    Keywords Transposition ; Japankärpfling
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Heidelberg, 2003
    Database Former special subject collection: coastal and deep sea fishing

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  2. Article ; Online: The zebrafish embryo as a model for assessing off-target drug effects.

    Strähle, Uwe / Grabher, Clemens

    Disease models & mechanisms

    2010  Volume 3, Issue 11-12, Page(s) 689–692

    Abstract: Although first used experimentally for the genetic analysis of vertebrate development and neurobiology, the zebrafish has been adapted as a model for many human diseases. In recent years, the zebrafish embryo has increasingly attracted the attention of ... ...

    Abstract Although first used experimentally for the genetic analysis of vertebrate development and neurobiology, the zebrafish has been adapted as a model for many human diseases. In recent years, the zebrafish embryo has increasingly attracted the attention of chemists and pharmacologists for its utility in identifying chemicals with pharmacological activity in a whole-animal context. Its experimental virtues make it an ideal system with which to identify new bioactive molecules, and to assess their toxicity and teratogenicity at medium-to-high throughput. More recently, the zebrafish embryo has been applied to identify off-target effects of drug candidates. Here, we discuss the value of the zebrafish embryo for detecting off-target effects, and propose that this model could be useful for improving the efficiency of the drug-development pipeline.
    MeSH term(s) Animals ; Benzothiazoles/pharmacology ; Cholinesterase Inhibitors/pharmacology ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/metabolism ; Drug-Related Side Effects and Adverse Reactions ; Embryo, Nonmammalian/drug effects ; Humans ; Models, Animal ; Nuclear Proteins/antagonists & inhibitors ; Nuclear Proteins/metabolism ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Toluene/analogs & derivatives ; Toluene/pharmacology ; Tumor Protein p73 ; Tumor Suppressor Protein p53/antagonists & inhibitors ; Tumor Suppressor Protein p53/metabolism ; Tumor Suppressor Proteins/antagonists & inhibitors ; Tumor Suppressor Proteins/metabolism ; Zebrafish/embryology
    Chemical Substances Benzothiazoles ; Cholinesterase Inhibitors ; DNA-Binding Proteins ; Nuclear Proteins ; Pyrazoles ; Pyrimidines ; Tumor Protein p73 ; Tumor Suppressor Protein p53 ; Tumor Suppressor Proteins ; dorsomorphin (10K52CIC1Z) ; Toluene (3FPU23BG52) ; pifithrin (D213B92S1Y)
    Language English
    Publishing date 2010-09-27
    Publishing country England
    Document type Journal Article
    ISSN 1754-8411
    ISSN (online) 1754-8411
    DOI 10.1242/dmm.006312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Differential Nanoparticle Sequestration by Macrophages and Scavenger Endothelial Cells Visualized

    Hayashi, Yuya / Takamiya, Masanari / Jensen, Pia Bomholt / Ojea-Jiménez, Isaac / Claude, Hélicia / Antony, Claude / Kjaer-Sorensen, Kasper / Grabher, Clemens / Boesen, Thomas / Gilliland, Douglas / Oxvig, Claus / Strähle, Uwe / Weiss, Carsten

    ACS nano

    2020  Volume 14, Issue 2, Page(s) 1665–1681

    Abstract: Despite the common knowledge that the reticuloendothelial system is largely responsible for blood clearance of systemically administered nanoparticles, the sequestration mechanism remains a "black box". Using transgenic zebrafish embryos with cell type- ... ...

    Abstract Despite the common knowledge that the reticuloendothelial system is largely responsible for blood clearance of systemically administered nanoparticles, the sequestration mechanism remains a "black box". Using transgenic zebrafish embryos with cell type-specific fluorescent reporters and fluorescently labeled model nanoparticles (70 nm SiO
    MeSH term(s) Animals ; Endothelial Cells/chemistry ; Endothelial Cells/metabolism ; Kinetics ; Macrophages/chemistry ; Macrophages/metabolism ; Nanoparticles/chemistry ; Nanoparticles/metabolism ; Particle Size ; Silicon Dioxide/chemistry ; Silicon Dioxide/metabolism ; Surface Properties ; Time Factors ; Zebrafish/embryology
    Chemical Substances Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2020-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.9b07233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Recent advances in meganuclease-and transposon-mediated transgenesis of medaka and zebrafish.

    Grabher, Clemens / Wittbrodt, Joachim

    Methods in molecular biology (Clifton, N.J.)

    2008  Volume 461, Page(s) 521–539

    MeSH term(s) Animals ; Animals, Genetically Modified ; DNA Transposable Elements/physiology ; Deoxyribonucleases/metabolism ; Deoxyribonucleases/physiology ; Embryo, Nonmammalian ; Gene Transfer Techniques ; Microinjections/methods ; Models, Biological ; Mutagenesis/physiology ; Oryzias/embryology ; Oryzias/genetics ; Zebrafish/embryology ; Zebrafish/genetics
    Chemical Substances DNA Transposable Elements ; Deoxyribonucleases (EC 3.1.-)
    Language English
    Publishing date 2008
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1064-3745
    ISSN 1064-3745
    DOI 10.1007/978-1-60327-483-8_36
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  5. Article ; Online: Sharing chemical libraries within the European zebrafish community.

    Grabher, Clemens / Patton, E Elizabeth / Strähle, Uwe

    Zebrafish

    2010  Volume 7, Issue 1, Page(s) 83

    MeSH term(s) Animals ; Drug Evaluation, Preclinical/economics ; Drug Evaluation, Preclinical/methods ; Phenotype ; Small Molecule Libraries/analysis ; Small Molecule Libraries/economics ; Zebrafish/embryology
    Chemical Substances Small Molecule Libraries
    Language English
    Publishing date 2010-04-12
    Publishing country United States
    Document type Letter
    ZDB-ID 2156020-1
    ISSN 1557-8542 ; 1545-8547
    ISSN (online) 1557-8542
    ISSN 1545-8547
    DOI 10.1089/zeb.2010.0651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Redox imaging using genetically encoded redox indicators in zebrafish and mice.

    Breckwoldt, Michael O / Wittmann, Christine / Misgeld, Thomas / Kerschensteiner, Martin / Grabher, Clemens

    Biological chemistry

    2015  Volume 396, Issue 5, Page(s) 511–522

    Abstract: Redox signals have emerged as important regulators of cellular physiology and pathology. The advent of redox imaging in vertebrate systems now provides the opportunity to dynamically visualize redox signaling during development and disease. In this ... ...

    Abstract Redox signals have emerged as important regulators of cellular physiology and pathology. The advent of redox imaging in vertebrate systems now provides the opportunity to dynamically visualize redox signaling during development and disease. In this review, we summarize recent advances in the generation of genetically encoded redox indicators (GERIs), introduce new redox imaging strategies, and highlight key publications in the field of vertebrate redox imaging. We also discuss the limitations and future potential of in vivo redox imaging in zebrafish and mice.
    MeSH term(s) Animals ; Biosensing Techniques/methods ; Green Fluorescent Proteins/genetics ; Mice ; Oxidation-Reduction ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Zebrafish
    Chemical Substances Reactive Oxygen Species ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2015-05
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2014-0294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Meganuclease and transposon mediated transgenesis in medaka.

    Grabher, Clemens / Wittbrodt, Joachim

    Genome biology

    2007  Volume 8 Suppl 1, Page(s) S10

    Abstract: From among a plethora of various gene delivery methods, the researcher must choose the right one according to availability for a given species and the precise application the transgenic animal is intended for. Here we review the progress in meganuclease ... ...

    Abstract From among a plethora of various gene delivery methods, the researcher must choose the right one according to availability for a given species and the precise application the transgenic animal is intended for. Here we review the progress in meganuclease and Sleeping Beauty transposon mediated transgenesis over recent years with a focus on medaka and zebrafish. We present a side-by-side comparison of these two approaches based on their biologic properties and provide interesting perspectives for future experiments and applications, which are different for the two techniques because of their distinct modes of action.
    MeSH term(s) Animals ; DNA Transposable Elements/genetics ; Deoxyribonucleases, Type II Site-Specific/metabolism ; Gene Transfer Techniques ; Oryzias/genetics ; Saccharomyces cerevisiae Proteins
    Chemical Substances DNA Transposable Elements ; Saccharomyces cerevisiae Proteins ; SCEI protein, S cerevisiae (EC 3.1.21.-) ; Deoxyribonucleases, Type II Site-Specific (EC 3.1.21.4)
    Language English
    Publishing date 2007-11-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1474-760X
    ISSN (online) 1474-760X
    ISSN 1474-760X
    DOI 10.1186/gb-2007-8-s1-s10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Fishing for cancer models.

    Grabher, Clemens / Look, A Thomas

    Nature biotechnology

    2006  Volume 24, Issue 1, Page(s) 45–46

    MeSH term(s) Amino Acid Sequence ; Animals ; Carcinogens ; Conserved Sequence ; Disease Progression ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Liver Neoplasms, Experimental/chemically induced ; Liver Neoplasms, Experimental/genetics ; Liver Neoplasms, Experimental/metabolism ; Molecular Sequence Data ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Sequence Homology, Amino Acid ; Species Specificity ; Zebrafish/genetics ; Zebrafish/metabolism
    Chemical Substances Carcinogens ; Neoplasm Proteins
    Language English
    Publishing date 2006-01
    Publishing country United States
    Document type Comment ; Comparative Study ; News
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/nbt0106-45
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 137: Show issues
    Zs.MG 43: Show issues

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  9. Article: Meganuclease and transposon mediated transgenesis in medaka

    Grabher, Clemens / Joachim Wittbrodt

    Genome biology. 2007 Oct., v. 8, no. Supplement 1

    2007  

    Abstract: From among a plethora of various gene delivery methods, the researcher must choose the right one according to availability for a given species and the precise application the transgenic animal is intended for. Here we review the progress in meganuclease ... ...

    Abstract From among a plethora of various gene delivery methods, the researcher must choose the right one according to availability for a given species and the precise application the transgenic animal is intended for. Here we review the progress in meganuclease and Sleeping Beauty transposon mediated transgenesis over recent years with a focus on medaka and zebrafish. We present a side-by-side comparison of these two approaches based on their biologic properties and provide interesting perspectives for future experiments and applications, which are different for the two techniques because of their distinct modes of action.
    Keywords Danio rerio ; gene transfer ; mechanism of action ; transgenesis ; transgenic animals ; transposons
    Language English
    Dates of publication 2007-10
    Size p. 1761.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1465-6914 ; 1465-6906
    ISSN (online) 1474-760X ; 1465-6914
    ISSN 1465-6906
    DOI 10.1186/gb-2007-8-s1-s10
    Database NAL-Catalogue (AGRICOLA)

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  10. Book ; Online ; Thesis: Novel approaches to transgenesis in the teleost medaka (Oryzias latipes)

    Grabher, Clemens [Verfasser]

    2003  

    Author's details vorgelegt von Clemens Grabher
    Keywords Pflanzen (Botanik) ; Plants (Botany)
    Subject code sg580
    Language English
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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