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  1. Book ; Online ; E-Book: Diagnostic and therapeutic applications of exosomes in cancer

    Amiji, Mansoor / Ramesh, Rajagopal

    2018  

    Author's details edited by Mansoor Amiji, Rajagopal Ramesh
    Language English
    Size 1 Online-Ressource (xxii, 379 Seiten)
    Publisher Elsevier AP
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019776297
    ISBN 978-0-12-812804-6 ; 9780128127742 ; 0-12-812804-6 ; 0128127740
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Chemical Composition and Biological Activities of the Essential Oil from Citrus reticulata Blanco Peels Collected from Agrowastes.

    Job, Joice Tom / Visakh, Naduvilthara U / Pathrose, Berin / Alfarhan, Ahmed / Rajagopal, Rajakrishnan / Thayyullathil, Jobiraj / Thejass, P / Ramesh, Varsha / Narayanankutty, Arunaksharan

    Chemistry & biodiversity

    2024  Volume 21, Issue 3, Page(s) e202301223

    Abstract: Citrus fruits have a thick outer coat which is often discarded due to its low economic value and usually contributes to the waste. So this work focused on exploring the potential pharmacological properties of the discarded citrus peels. In the present ... ...

    Abstract Citrus fruits have a thick outer coat which is often discarded due to its low economic value and usually contributes to the waste. So this work focused on exploring the potential pharmacological properties of the discarded citrus peels. In the present study, we extracted the essential oil from peel wastes of Citrus reticulata Blanco (CREO) from the local market. The antioxidant, antibacterial, and anticancer properties of essential oil were evaluated. The CREO exhibited a strong antioxidant property with DPPH radical scavenging, ABTS radical scavenging, H
    MeSH term(s) Oils, Volatile/pharmacology ; Oils, Volatile/chemistry ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Escherichia coli ; Staphylococcus aureus ; Citrus/chemistry ; Anti-Bacterial Agents/pharmacology
    Chemical Substances Oils, Volatile ; Antioxidants ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202301223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chemical Composition of

    Narayanankutty, Arunaksharan / Kunnath, Krishnaprasad / Alfarhan, Ahmed / Rajagopal, Rajakrishnan / Ramesh, Varsha

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 20

    Abstract: Cinnamomum ... ...

    Abstract Cinnamomum verum
    MeSH term(s) Acrolein/analogs & derivatives ; Acrolein/chemistry ; Acrolein/pharmacology ; Acyclic Monoterpenes/chemistry ; Acyclic Monoterpenes/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Cinnamomum zeylanicum/chemistry ; Flowers/chemistry ; Insect Repellents/chemistry ; Insect Repellents/pharmacology ; Insecticides/chemistry ; Insecticides/pharmacology ; Oils, Volatile/chemistry ; Oils, Volatile/pharmacology ; Plant Leaves/chemistry ; Plant Oils/chemistry ; Plant Oils/pharmacology
    Chemical Substances Acyclic Monoterpenes ; Anti-Bacterial Agents ; Insect Repellents ; Insecticides ; Oils, Volatile ; Plant Oils ; Acrolein (7864XYD3JJ) ; linalool (D81QY6I88E) ; cinnamaldehyde (SR60A3XG0F)
    Language English
    Publishing date 2021-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26206303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  4. Book: Business Governance and Society

    Rajagopal / Behl, Ramesh

    Analyzing Shifts, Conflicts, and Challenges

    2018  

    Language English
    Size XII, 277 Seiten, Illustrationen, 23.5 cm x 15.5 cm
    Document type Book
    ISBN 3319946129 ; 9783319946122 ; 9783319946139 ; 3319946137
    Database ECONomics Information System

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  5. Article ; Online: RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer.

    Mehta, Meghna / Raguraman, Rajeswari / Ramesh, Rajagopal / Munshi, Anupama

    Advanced drug delivery reviews

    2022  Volume 191, Page(s) 114569

    Abstract: Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-transcriptional events. Alterations in the expression of proteins that act post-transcriptionally can affect cellular signaling and homeostasis. RNA binding ... ...

    Abstract Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-transcriptional events. Alterations in the expression of proteins that act post-transcriptionally can affect cellular signaling and homeostasis. RNA binding proteins (RBPs) are a family of proteins that specifically bind to RNAs and are involved in post-transcriptional regulation of gene expression and important cellular processes such as cell differentiation and metabolism. Deregulation of RNA-RBP interactions and any changes in RBP expression or function can lead to various diseases including cancer. In cancer cells, RBPs play an important role in regulating the expression of tumor suppressors and oncoproteins involved in various cell-signaling pathways. Several RBPs such as HuR, AUF1, RBM38, LIN28, RBM24, tristetrapolin family and Musashi play critical roles in various types of cancers and their aberrant expression in cancer cells makes them an attractive therapeutic target for cancer treatment. In this review we provide an overview of i). RBPs involved in cancer progression and their mechanism of action ii). the role of RBPs, including HuR, in breast cancer progression and DNA damage response and iii). explore RBPs with emphasis on HuR as therapeutic target for breast cancer therapy.
    MeSH term(s) Humans ; Female ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Gene Expression Regulation ; RNA ; Breast Neoplasms ; DNA Damage
    Chemical Substances RNA-Binding Proteins ; RNA (63231-63-0) ; RBM38 protein, human ; RBM24 protein, human
    Language English
    Publishing date 2022-10-14
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2022.114569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2241: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Organically derived exosomes as carriers of anticancer drugs and imaging agents for cancer treatment.

    Srivastava, Akhil / Rathore, Shipra / Munshi, Anupama / Ramesh, Rajagopal

    Seminars in cancer biology

    2022  Volume 86, Issue Pt 1, Page(s) 80–100

    Abstract: Extracellular vesicles (EVs), is the umbrella term used for different types of vesicles produced by the cells, among which exosomes form the largest group. Exosomes perform intercellular communication by carrying several biologics from donor or parental ... ...

    Abstract Extracellular vesicles (EVs), is the umbrella term used for different types of vesicles produced by the cells, among which exosomes form the largest group. Exosomes perform intercellular communication by carrying several biologics from donor or parental cells and delivering them to recipient cells. Their unique cargo-carrying capacity has recently been explored for use as delivery vehicles of anticancer drugs and imaging agents. Being naturally produced, exosomes have many advantages over synthetic lipid-based nanoparticles currently being used clinically to treat cancer and other diseases. The finding of the role of exosomes in human diseases has led to numerous preclinical and clinical studies exploring their use as an amenable drug delivery vehicle and a theranostic in cancer diagnosis and treatment. However, there are certain limitations associated with exosomes, with the most important being the selection of the biological source for producing highly biocompatible exosomes on a large scale. This review article explores the various sources from which therapeutically viable exosomes can be isolated for use as drug carriers for cancer treatment. The methods of exosome isolation and the process of loading them with cancer therapeutics and imaging agents are also discussed in the follow-up sections. Finally, the article concludes with future directions for exosome-based applications in cancer diagnosis and treatment.
    MeSH term(s) Humans ; Exosomes ; Drug Carriers/therapeutic use ; Drug Delivery Systems ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Extracellular Vesicles ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy
    Chemical Substances Drug Carriers ; Antineoplastic Agents
    Language English
    Publishing date 2022-02-19
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2022.02.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Phytochemical profiling of

    Malayil, Dhilna / Jose, Boby / Narayanankutty, Arunaksharan / Ramesh, Varsha / Rajagopal, Rajakrishnan / Alfarhan, Ahmed

    Saudi journal of biological sciences

    2021  Volume 28, Issue 11, Page(s) 6040–6044

    Abstract: Azima tetracantha, ...

    Abstract Azima tetracantha,
    Language English
    Publishing date 2021-08-02
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2021.07.090
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  8. Article ; Online: Local and network behavior of bistable vibrational energy harvesters considering periodic and quasiperiodic excitations.

    Rajagopal, Karthikeyan / Ramesh, Arthanari / Moroz, Irene / Duraisamy, Prakash / Karthikeyan, Anitha

    Chaos (Woodbury, N.Y.)

    2021  Volume 31, Issue 6, Page(s) 63111

    Abstract: Vibrational energy harvesters can exhibit complex nonlinear behavior when exposed to external excitations. Depending on the number of stable equilibriums, the energy harvesters are defined and analyzed. In this work, we focus on the bistable energy ... ...

    Abstract Vibrational energy harvesters can exhibit complex nonlinear behavior when exposed to external excitations. Depending on the number of stable equilibriums, the energy harvesters are defined and analyzed. In this work, we focus on the bistable energy harvester with two energy wells. Though there have been earlier discussions on such harvesters, all these works focus on periodic excitations. Hence, we are focusing our analysis on both periodic and quasiperiodic forced bistable energy harvesters. Various dynamical properties are explored, and the bifurcation plots of the periodically excited harvester show coexisting hidden attractors. To investigate the collective behavior of the harvesters, we mathematically constructed a two-dimensional lattice array of the harvesters. A non-local coupling is considered, and we could show the emergence of chimeras in the network. As discussed in the literature, energy harvesters are efficient if the chaotic regimes can be suppressed and hence we focus our discussion toward synchronizing the nodes in the network when they are not in their chaotic regimes. We could successfully define the conditions to achieve complete synchronization in both periodic and quasiperiodically excited harvesters.
    Language English
    Publishing date 2021-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1472677-4
    ISSN 1089-7682 ; 1054-1500
    ISSN (online) 1089-7682
    ISSN 1054-1500
    DOI 10.1063/5.0054459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Early Addition of Parathyroid Hormone-Related Peptide Regulates the Hypertrophic Differentiation of Mesenchymal Stem Cells.

    Rajagopal, Karthikeyan / Ramesh, Sowmya / Madhuri, Vrisha

    Cartilage

    2020  Volume 13, Issue 2_suppl, Page(s) 143S–152S

    Abstract: Objective: Chondrogenic differentiation of mesenchymal stem cells (MSCs) into hyaline cartilage is complicated by terminal hypertrophic differentiation. In growth plate, parathyroid hormone-related peptide (1-34) (PTHrP) plays a crucial role in ... ...

    Abstract Objective: Chondrogenic differentiation of mesenchymal stem cells (MSCs) into hyaline cartilage is complicated by terminal hypertrophic differentiation. In growth plate, parathyroid hormone-related peptide (1-34) (PTHrP) plays a crucial role in maintaining chondrocytes in their proliferation state by counteracting the hypertrophic differentiation. This study aims to test the effect of PTHrP supplementation at different time points on chondrogenic differentiation of MSCs and assess the final quality of differentiated chondrocytes.
    Methods: Human periosteum and bone marrow MSCs isolated from 3 patient samples (donor unmatched) were characterized by flow cytometry and multilineage differentiation. The cells were differentiated into chondrocytes in the presence of transforming growth factor-β (TGF-β) and the PTHrP (1-34) was added from 4th or 14th day of culture. The outcome was analyzed by histology, immunohistochemistry, and gene expression.
    Results: Flow cytometry and multilineage differentiation confirmed that the cells isolated from periosteum and bone marrow exhibited the phenotype of MSCs. During chondrogenic differentiation, pellets that received PTHrP from the 4th day of culture showed a significant reduction in hypertrophic markers (COL10A1 and RUNX) than the addition of PTHrP from the 14th day and TGF-β alone treated samples. Furthermore, 4th day supplementation of PTHrP significantly improved the expression of cartilage-specific markers (COL2A1, SOX9, ACAN) in both periosteum and bone marrow-derived MSCs. Histology and immunostaining with collagen type X data corroborated the gene expression outcomes.
    Conclusion: The outcome showed that supplementing PTHrP from the 4th day of chondrogenic differentiation produced better chondrocytes with less hypertrophic markers in both bone marrow and periosteal-derived MSCs.
    MeSH term(s) Cell Differentiation/physiology ; Cells, Cultured ; Chondrogenesis/physiology ; Humans ; Mesenchymal Stem Cells ; Parathyroid Hormone-Related Protein/metabolism ; Parathyroid Hormone-Related Protein/pharmacology
    Chemical Substances Parathyroid Hormone-Related Protein
    Language English
    Publishing date 2020-01-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515870-3
    ISSN 1947-6043 ; 1947-6035
    ISSN (online) 1947-6043
    ISSN 1947-6035
    DOI 10.1177/1947603519894727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Start-up enterprises and contemporary innovation strategies in the global marketplace

    Rajagopal / Behl, Ramesh

    (Advances in business strategy and competitive advantage (ABSCA) book series ; Premier reference source)

    2018  

    Abstract: This book discusses new taxonomy of marketing strategies for growing innovations in emerging markets and provides suggestions as how firms can improve business convergence with consumers and new market segments"-- ...

    Author's details Rajagopal, Ramesh Behl
    Series title Advances in business strategy and competitive advantage (ABSCA) book series
    Premier reference source
    Abstract "This book discusses new taxonomy of marketing strategies for growing innovations in emerging markets and provides suggestions as how firms can improve business convergence with consumers and new market segments"--
    Keywords Marketing ; New business enterprises ; Unternehmensgründung ; Innovationsmanagement ; Marketingmanagement ; Schwellenländer
    Language English
    Size xxii, 341 Seiten, Illustrationen
    Publisher Business Science Reference
    Publishing place Hershey, PA, USA
    Document type Book
    Note Enthält 21 Beiträge
    ISBN 9781522548317 ; 9781522548324 ; 1522548319 ; 1522548327
    Database ECONomics Information System

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