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  1. Article ; Online: The Phytochemical Screening and Biological Properties of

    Ayadi, Jawaher / Debouba, Mohamed / Rahmani, Rami / Bouajila, Jalloul

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 17

    Abstract: Rutabaga, also known as swede and scientifically classified ... ...

    Abstract Rutabaga, also known as swede and scientifically classified as
    MeSH term(s) Humans ; Brassica napus ; Brassica ; Adenocarcinoma ; Caco-2 Cells ; HEK293 Cells ; Methanol ; Colonic Neoplasms ; Antioxidants/pharmacology ; Plant Extracts/pharmacology
    Chemical Substances Methanol (Y4S76JWI15) ; Cyclohexane (48K5MKG32S) ; ethyl acetate (76845O8NMZ) ; Antioxidants ; Plant Extracts
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28176250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article ; Online: Brassica

    Ayadi, Jawaher / Debouba, Mohamed / Rahmani, Rami / Bouajila, Jalloul

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 18

    Abstract: Traditionally, ...

    Abstract Traditionally,
    MeSH term(s) Animals ; Anti-Infective Agents ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Brassica/chemistry ; COVID-19 ; Ethnopharmacology ; Glucosinolates ; Humans ; Hypoglycemic Agents/pharmacology ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Phytotherapy ; Plant Extracts/chemistry ; Seeds
    Chemical Substances Anti-Infective Agents ; Anti-Inflammatory Agents ; Antioxidants ; Glucosinolates ; Hypoglycemic Agents ; Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2022-09-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27186008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article: Targeting BCL-2 in Cancer: Advances, Challenges, and Perspectives.

    Hafezi, Shirin / Rahmani, Mohamed

    Cancers

    2021  Volume 13, Issue 6

    Abstract: The major form of cell death in normal as well as malignant cells is apoptosis, which is a programmed process highly regulated by the BCL-2 family of proteins. This includes the antiapoptotic proteins (BCL-2, BCL-XL, MCL-1, BCLW, and BFL-1) and the ... ...

    Abstract The major form of cell death in normal as well as malignant cells is apoptosis, which is a programmed process highly regulated by the BCL-2 family of proteins. This includes the antiapoptotic proteins (BCL-2, BCL-XL, MCL-1, BCLW, and BFL-1) and the proapoptotic proteins, which can be divided into two groups: the effectors (BAX, BAK, and BOK) and the BH3-only proteins (BIM, BAD, NOXA, PUMA, BID, BIK, HRK). Notably, the BCL-2 antiapoptotic proteins are often overexpressed in malignant cells. While this offers survival advantages to malignant cells and strengthens their drug resistance capacity, it also offers opportunities for novel targeted therapies that selectively kill such cells. This review provides a comprehensive overview of the extensive preclinical and clinical studies targeting BCL-2 proteins with various BCL-2 proteins inhibitors with emphasis on venetoclax as a single agent, as well as in combination with other therapeutic agents. This review also discusses recent advances, challenges focusing on drug resistance, and future perspectives for effective targeting the Bcl-2 family of proteins in cancer.
    Language English
    Publishing date 2021-03-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13061292
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  4. Article ; Online: Interaction between mitochondria and microbiota modulating cellular metabolism in inflammatory bowel disease.

    Hirose, Misa / Sekar, Priyadharshini / Eladham, Mariam Wed Abdelaziz / Albataineh, Mohammad T / Rahmani, Mohamed / Ibrahim, Saleh Mohamed

    Journal of molecular medicine (Berlin, Germany)

    2023  Volume 101, Issue 12, Page(s) 1513–1526

    Abstract: Inflammatory bowel disease (IBD) is a prototypic complex disease in the gastrointestinal tract that has been increasing in incidence and prevalence in recent decades. Although the precise pathophysiology of IBD remains to be elucidated, a large body of ... ...

    Abstract Inflammatory bowel disease (IBD) is a prototypic complex disease in the gastrointestinal tract that has been increasing in incidence and prevalence in recent decades. Although the precise pathophysiology of IBD remains to be elucidated, a large body of evidence suggests the critical roles of mitochondria and intestinal microbiota in the pathogenesis of IBD. In addition to their contributions to the disease, both mitochondria and gut microbes may interact with each other and modulate disease-causing cell activities. Therefore, we hypothesize that dissecting this unique interaction may help to identify novel pathways involved in IBD, which will further contribute to discovering new therapeutic approaches to the disease. As poorly treated IBD significantly affects the quality of life of patients and is associated with risks and complications, successful treatment is crucial. In this review, we stratify previously reported experimental and clinical observations of the role of mitochondria and intestinal microbiota in IBD. Additionally, we review the intercommunication between mitochondria, and the intestinal microbiome in patients with IBD is reviewed along with the potential mediators for these interactions. We specifically focus on their roles in cellular metabolism in intestinal epithelial cells and immune cells. To this end, we propose a potential therapeutic intervention strategy for IBD.
    MeSH term(s) Humans ; Quality of Life ; Inflammatory Bowel Diseases/metabolism ; Microbiota ; Mitochondria/metabolism
    Language English
    Publishing date 2023-10-11
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-023-02381-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: PROTACs: Walking through hematological malignancies.

    Bou Malhab, Lara J / Alsafar, Habiba / Ibrahim, Saleh / Rahmani, Mohamed

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1086946

    Abstract: Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that uses the proteasome ubiquitin system to target proteins of interest and promote their degradation with remarkable selectivity. Importantly, unlike conventional small ... ...

    Abstract Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that uses the proteasome ubiquitin system to target proteins of interest and promote their degradation with remarkable selectivity. Importantly, unlike conventional small molecule inhibitors, PROTACs have proven highly effective in targeting undruggable proteins and those bearing mutations. Because of these considerations, PROTACs have increasingly become an emerging technology for the development of novel targeted anticancer therapeutics. Interestingly, many PROTACs have demonstrated a great potency and specificity in degrading several oncogenic drivers. Many of these, following extensive preclinical evaluation, have reached advanced stages of clinical testing in various cancers including hematologic malignancies. In this review, we provide a comprehensive summary of the recent advances in the development of PROTACs as therapeutic strategies in diverse hematological malignancies. A particular attention has been given to clinically relevant PROTACs and those targeting oncogenic mutants that drive resistance to therapies. We also discus limitations, and various considerations to optimize the design for effective PROTACs.
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1086946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Petroselinum crispum

    Nouioura, Ghizlane / El Fadili, Mohamed / El Hachlafi, Naoufal / Abuelizz, Hatem A / Elidrissi, Ahmed Elfallaki / Ferioun, Mohamed / Soulo, Najoua / Er-Rahmani, Sara / Lyoussi, Badiaa / Derwich, Elhoussine

    Heliyon

    2024  Volume 10, Issue 8, Page(s) e29520

    Abstract: This exploratory study aims to identify the volatile compounds in PC-Eo ( ...

    Abstract This exploratory study aims to identify the volatile compounds in PC-Eo (
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29520
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  7. Article ; Online: The financial cost of coccidiosis in Algerian chicken production: a major challenge for the poultry sector.

    Rahmani, Abderrahmen / Ahmed Laloui, Hamza / Kara, Radhouane / Dems, Mohamed Abdesselem / Cherb, Nora / Klikha, Abdenour / Blake, Damer P

    Avian pathology : journal of the W.V.P.A

    2024  , Page(s) 1–12

    Abstract: Coccidiosis, caused by parasites of the ... ...

    Abstract Coccidiosis, caused by parasites of the genus
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476380-1
    ISSN 1465-3338 ; 0307-9457
    ISSN (online) 1465-3338
    ISSN 0307-9457
    DOI 10.1080/03079457.2024.2336091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Positive and Negative Photoconductivity in Ir Nanofilm-Coated MoO

    Basyooni-M Kabatas, Mohamed A / En-Nadir, Redouane / Rahmani, Khalid / Eker, Yasin Ramazan

    Micromachines

    2023  Volume 14, Issue 10

    Abstract: In this study, we delved into the influence of Ir nanofilm coating thickness on the optical and optoelectronic behavior of ultrathin ... ...

    Abstract In this study, we delved into the influence of Ir nanofilm coating thickness on the optical and optoelectronic behavior of ultrathin MoO
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14101860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes.

    Rahmani, Rami / Debouba, Mohamed / Aydi, Sameh Sassi / Aydi, Samir / Bouajila, Jalloul

    Chemistry & biodiversity

    2023  Volume 20, Issue 12, Page(s) e202301177

    Abstract: Limonium. Mill is a genus of flowering plants belonging to the Plumbaginaceae family. The present study aimed to compare two Limonium species (L. pruinosum Kuntze and L. tunetanum (Barratte & Bonnet) Maire) in terms of their chemical composition and ... ...

    Abstract Limonium. Mill is a genus of flowering plants belonging to the Plumbaginaceae family. The present study aimed to compare two Limonium species (L. pruinosum Kuntze and L. tunetanum (Barratte & Bonnet) Maire) in terms of their chemical composition and bioactivity. Chemical profiling showed that the methanolic (MeOH) extracts of both species were the most enriched with total phenolic (TP) and total flavonoid (TF) contents. The TFC were higher in L. tunetanum compared to L. pruinosum. HPLC-DAD analysis showed that distinctly the gallic acid and L-tyrosine 7-amido-4-methylcoumarin were the main compounds for L. pruinosum and L. tunetanum, respectively. For both Limonium. Mil species, the MeOH extracts displayed the highest antioxidant with IC
    MeSH term(s) Antineoplastic Agents ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Plumbaginaceae/chemistry ; Wetlands ; Flavonoids/chemistry ; Flavonoids/pharmacology
    Chemical Substances Antineoplastic Agents ; Antioxidants ; Plant Extracts ; Flavonoids
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202301177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Phytochemical Composition, Antioxidant, Antiacetylcholinesterase, and Cytotoxic Activities of

    Saoudi, Mohamed Marouane / Bouajila, Jalloul / Rahmani, Rami / Alouani, Khaled

    International journal of analytical chemistry

    2021  Volume 2021, Page(s) 6675436

    Abstract: ... Rumex ... ...

    Abstract Rumex crispus
    Language English
    Publishing date 2021-07-02
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2494714-3
    ISSN 1687-8779 ; 1687-8760
    ISSN (online) 1687-8779
    ISSN 1687-8760
    DOI 10.1155/2021/6675436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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