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Article ; Online: Melatonin Alleviates Liver Fibrosis by Inhibiting Autophagy.

Jie, Lei / Hong, Ru-Tao / Zhang, Yu-Jie / Sha, Lu-Lin / Chen, Wei / Ren, Xiao-Fei

2022 Volume 42, Issue 3, Page(s) 498–504

Abstract: Objective: Melatonin has been reported to suppress inflammation and alleviate liver fibrosis, but its effect on autophagy in liver fibrosis has not been studied. This study investigated the effect of melatonin on autophagy in an animal model of liver ... ...

Abstract	Objective: Melatonin has been reported to suppress inflammation and alleviate liver fibrosis, but its effect on autophagy in liver fibrosis has not been studied. This study investigated the effect of melatonin on autophagy in an animal model of liver fibrosis and the hepatic stellate cell (HSC)-T6 cell line. Methods: The model was established in rats through carbon tetrachloride treatment, and melatonin was administered at three doses (2.5, 5.0, and 10.0 mg/kg). Haematoxylin and eosin staining and Van Gieson's staining were performed to examine the pathological changes of liver. The expression of alpha-smooth muscle actin (α-SMA) and Beclin1 in liver tissues was detected by immunohistochemical staining. The protein levels of α-SMA, Beclin1 and LC3 in the animal model were detected by Western blot analysis, and gene levels of Beclin1 and LC3 were detected by quantitative real-time PCR (qRT-PCR) in the animal model. HSC-T6 cells were activated by platelet-derived growth factor-BB (PDGF-BB). The expression of α-SMA, Beclin1 and collagen I was detected by Western blot analysis, and the gene expression of Beclin1 and LC3 was detected by qRT-PCR. Results: Melatonin reduced the expression of α-SMA, Beclin1 and LC3 in liver tissues. In addition, melatonin inhibited the activation of HSC-T6 cells and the expression of α-SMA, Beclin1 and LC3 in these cells. These results revealed that melatonin could inhibit autophagy and HSC activation. Conclusion: Melatonin might ameliorate liver fibrosis by regulating autophagy, suggesting that melatonin is a potential therapeutic agent for liver fibrosis.
MeSH term(s)	Animals ; Autophagy ; Beclin-1/genetics ; Beclin-1/metabolism ; Beclin-1/pharmacology ; Disease Models, Animal ; Hepatic Stellate Cells ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; Melatonin/metabolism ; Rats
Chemical Substances	Beclin-1 ; Melatonin (JL5DK93RCL)
Language	English
Publishing date	2022-05-17
Publishing country	China
Document type	Journal Article
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-022-2530-7
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Article ; Online: Evaluation and Improvement of Internet Printing Protocol Based on HCPN Model Detection Method

Tao Feng / Hong-Ru Bei

Applied Sciences, Vol 13, Iss 3467, p

2023 Volume 3467

Abstract: The Internet Printing Protocol (IPP) is a bridge between hosts and printers, and is supported by more than 98 percent of printers today. In addition to supporting local use, the IPP protocol also supports online use. Although this can expand the scope of ...

Abstract	The Internet Printing Protocol (IPP) is a bridge between hosts and printers, and is supported by more than 98 percent of printers today. In addition to supporting local use, the IPP protocol also supports online use. Although this can expand the scope of its application, it has also introduced potential risks to user data. IPP has security components that should be able to guarantee confidentiality, integrity, and non-repudiation. In order to verify whether its security components can achieve this goal, this study modeled the 0-RTT authentication process of the IPP protocol based on Petri net theory and CPN Tools, introducing the improved Dolev–Yao adversary model to perform security evaluation on the protocol model. The result showed that the server could not resist the adversary’s replay attacks on early data. Accordingly, we proposed an improved authentication scheme that introduced a random number signature to enhance the server’s anti-replay capability. Using the same attack model to verify, the result proved that the new scheme was feasible and effective. The method used in this article could easily observe the movement of the security protocol message flow and the specific actions of each participant (including the adversary), which ensured researchers could easily locate the protocol defects and make improvements.
Keywords	IPP ; colored Petri nets ; formal analysis ; TLS 1.3 ; 0-RTT ; early data ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Melatonin Ameliorates Liver Fibrosis Induced by Carbon Tetrachloride in Rats via Inhibiting TGF-β1/Smad Signaling Pathway.

Wang, Yu-Rong / Hong, Ru-Tao / Xie, Yuan-Yuan / Xu, Jian-Ming

Current medical science

2018 Volume 38, Issue 2, Page(s) 236–244

Abstract: Melatonin has been reported to inhibit hepatic fibrosis and the mechanism may be correlated to its anti-oxidant effect. Nevertheless, the mechanism is not completely identified. This study was conducted to investigate the effects of melatonin on TGF-β1/ ... ...

Abstract	Melatonin has been reported to inhibit hepatic fibrosis and the mechanism may be correlated to its anti-oxidant effect. Nevertheless, the mechanism is not completely identified. This study was conducted to investigate the effects of melatonin on TGF-β1/Smad signaling pathway in liver fibrosis in rats. The liver fibrosis model was made by the subcutaneous injection of CCl
MeSH term(s)	Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Biomarkers/metabolism ; Carbon Tetrachloride ; Hydroxyproline/metabolism ; Liver/drug effects ; Liver/pathology ; Liver/physiopathology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Malondialdehyde/metabolism ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Oxidative Stress/drug effects ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Smad Proteins/metabolism ; Tissue Extracts ; Transforming Growth Factor beta1/metabolism
Chemical Substances	Biomarkers ; Smad Proteins ; Tissue Extracts ; Transforming Growth Factor beta1 ; Malondialdehyde (4Y8F71G49Q) ; Carbon Tetrachloride (CL2T97X0V0) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; Melatonin (JL5DK93RCL) ; Hydroxyproline (RMB44WO89X)
Language	English
Publishing date	2018-04-30
Publishing country	China
Document type	Journal Article
ISSN	2523-899X
ISSN (online)	2523-899X
DOI	10.1007/s11596-018-1871-8
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Article ; Online: Supramolecular fluorescence sensor array used for the analysis of tyrosine kinase inhibitors in biological fluids and cell imaging.

Yi, Hong-Ling / Yang, Ru-Pei / Tang, Qing / Tao, Zhu / Huang, Ying

Analytica chimica acta

2023 Volume 1287, Page(s) 342124

Abstract: Tyrosine kinase inhibitors (TKIs) are commonly used in tumor targeting therapy. However, the rapid analysis of TKIs remains a significant challenge, especially in complex biological fluid environments. In this work, we have constructed a supramolecular ... ...

Abstract	Tyrosine kinase inhibitors (TKIs) are commonly used in tumor targeting therapy. However, the rapid analysis of TKIs remains a significant challenge, especially in complex biological fluid environments. In this work, we have constructed a supramolecular fluorescence sensor array based on a cucurbituril-dye host-guest complex. The binding affinity between the three complexes and each TKI is different, resulting in different cross-response signals of the complexes to the fluorescence of each TKI. Combined with linear discriminant analysis(LDA), five kinds of TKIs can be well identified. The supramolecular fluorescence sensor array could accurately identify and distinguish the five TKIs in water and could classify mixtures containing different concentrations of TKIs in serum. The concentration and Factor 1 exhibited a good linear relationship and the detection limit (LOD) was as low as 10
MeSH term(s)	Reproducibility of Results ; Tyrosine Kinase Inhibitors ; Cell Differentiation ; Discriminant Analysis ; Drug Monitoring
Chemical Substances	Tyrosine Kinase Inhibitors
Language	English
Publishing date	2023-12-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2023.342124
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Article ; Online: Suspected drug-induced liver injury associated with iguratimod: a case report and review of the literature.

Li, Xiao-Li / Liu, Xiao-Chang / Song, Yu-Lin / Hong, Ru-Tao / Shi, Hai

BMC gastroenterology

2018 Volume 18, Issue 1, Page(s) 130

Abstract: Background: Iguratimod is a novel anti-rheumatic drug with the capability of anti-cytokines as report goes. It has been reported that iguratimod is effective and safe for rheumatoid arthritis and other rheumatisms. As side effects, iguratimod can cause ... ...

Abstract	Background: Iguratimod is a novel anti-rheumatic drug with the capability of anti-cytokines as report goes. It has been reported that iguratimod is effective and safe for rheumatoid arthritis and other rheumatisms. As side effects, iguratimod can cause gastrointestinal reactions, dizziness, headache and itchy. Case presentation: In this case report, a 60-year-old female patient was admitted with suspected drug-induced liver injury (DILI) caused by iguratimod. The causality assessment was done by the updated RUCAM, and the possibility of the case in our paper diagnosed as highly probable for the score was 9 points. Iguratimod was discontinued immediately, and methylprednisolone was used for acute liver injury and Sjogren's syndrome. The data showed the patient has improved gradually, and she was discharged on day 27. The true incidence of iguratimod-related hepatotoxicity and its pathogenic mechanism are largely unknown. It is difficult to recognize and diagnose DILI, and there is no standard for diagnosis of DILI. At the same time, the DILI is still lack of specific treatment. Conclusions: Based on this rare case of severe liver injury, we recommend careful monitoring of liver function throughout iguratimod treatment for diseases.
MeSH term(s)	Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/etiology ; Chromones/adverse effects ; Female ; Glucocorticoids/therapeutic use ; Humans ; Immunosuppressive Agents/adverse effects ; Methylprednisolone/therapeutic use ; Middle Aged ; Sjogren's Syndrome/drug therapy ; Sulfonamides/adverse effects
Chemical Substances	Chromones ; Glucocorticoids ; Immunosuppressive Agents ; Sulfonamides ; iguratimod (4IHY34Y2NV) ; Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2018-08-24
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ISSN	1471-230X
ISSN (online)	1471-230X
DOI	10.1186/s12876-018-0858-z
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Article ; Online: Isolation and identification of 3,4-seco-labdane diterpenoids from Callicarpa nudiflora and investigation of their cytotoxicity against HepG2 cells.

Chen, Qian-Qian / Fan, Ming-Hui / Xu, Hong-Tao / Huang, Le-Yi / Liu, Jin-Ling / Zhang, Shan-Shan / Wang, Ru-Ru / Wei, Xiao-Hui / Chou, Gui-Xin

Phytochemistry

2023 Volume 213, Page(s) 113773

Abstract: Twenty-one previously undescribed compounds, including nineteen 3,4-seco-labdanes (nudiflopenes P-W, Y, ... ...

Abstract	Twenty-one previously undescribed compounds, including nineteen 3,4-seco-labdanes (nudiflopenes P-W, Y, A
MeSH term(s)	Humans ; Abietanes ; Hep G2 Cells ; Callicarpa/chemistry ; Diterpenes/pharmacology ; Diterpenes/chemistry ; Drugs, Chinese Herbal/chemistry ; Molecular Structure
Chemical Substances	Abietanes ; Diterpenes ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2023.113773
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Article ; Online: The discovery of an anti-Candida xanthone with selective inhibition of Candida albicans GAPDH.

Chen, Xing-Ru / Zhou, Tao / Zhou, Zhuo-Da / Fang, Zhan-Hong / Wang, Kai-Bo / Zhang, Chao / Kong, Ling-Yi / Yang, Ming-Hua

International journal of antimicrobial agents

2024 , Page(s) 107172

Abstract: Objectives: This study aimed to discover novel antifungals targeting Candida albicans glyceraldehyde-3-phosphate dehydrogenase (CaGAPDH), have an insight into inhibitory mode, and provide evidence supporting CaGAPDH as a target for new antifungals.: ... ...

Abstract	Objectives: This study aimed to discover novel antifungals targeting Candida albicans glyceraldehyde-3-phosphate dehydrogenase (CaGAPDH), have an insight into inhibitory mode, and provide evidence supporting CaGAPDH as a target for new antifungals. Methods: Virtual screening was utilized to discover inhibitors of CaGAPDH. The inhibitory effect on cellular GAPDH was evaluated by determining the levels of ATP, NAD, NADH, etc., as well as examining GAPDH mRNA and protein expression. The role of GAPDH inhibition in C. albicans was supported by drug affinity responsive target stability and overexpression experiments. The mechanism of CaGAPDH inhibition was elucidated by Michaelis-Menten enzyme kinetics and site-specific mutagenesis based on docking. Chemical synthesis was used to produce an improved candidate. Different sources of GAPDH were used to evaluate inhibitory selectivity across species. In vitro and in vivo antifungal tests, along with antibiofilm activity, were carried out to evaluate antifungal potential of GAPDH inhibitors. Results: A natural xanthone was identified as the first competitive inhibitor of CaGAPDH. It demonstrated in vitro anti-C. albicans potential but also caused hemolysis. XP-W, a synthetic side-chain-optimized xanthone, demonstrated a better safety profile, exhibiting a 50-fold selectivity for CaGAPDH over human GAPDH. XP-W also exhibited potent antibiofilm activity and displayed broad-spectrum anti-Candida activities in vitro and in vivo, including multi-azole-resistant C. albicans. Conclusion: These results demonstrate for the first time that CaGAPDH is a valuable target for antifungal drug discovery, and XP-W provides a promising lead.
Language	English
Publishing date	2024-04-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107172
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Article ; Online: The congenital birth defects burden in children younger than 14 years of age, 1990 - 2019: An age-period-cohort analysis of the global burden of disease study.

Li, Xin-Yu / Hou, Meng-Jie / Kong, Xiang-Meng / Lv, Jia-Jie / Yang, Cheng-Hao / Li, Da-Tao / Zhang, Ru-Hong

Journal of global health

2024 Volume 14, Page(s) 4012

Abstract: Background: This study aims to delineate the burden of congenital birth defects (CBDs) in children under 14 years of age from 1990 to 2019, using an age-period-cohort framework to analyse data from the Global Burden of Disease Study (GBD).: Methods: ... ...

Abstract	Background: This study aims to delineate the burden of congenital birth defects (CBDs) in children under 14 years of age from 1990 to 2019, using an age-period-cohort framework to analyse data from the Global Burden of Disease Study (GBD). Methods: Data on prevalence cases, age-standardised prevalence rates (ASPRs), death cases, and age-standardised death rates (ASDRs) of congenital birth defects (CBDs) from 1990 to 2019 were obtained from GBD 2019. Using this data set, we conducted an age-period-cohort (APC) analysis to examine patterns and trends in mortality, prevalence, and disability-adjusted life years (DALYs) associated with CBDs, while exploring correlations with age, time periods, and generational birth cohorts. Furthermore, to quantify the temporal trends, we calculated the estimated annual percentage changes (EAPCs) for these parameters. Results: The global prevalence of CBDs decreased from 1404.22 to 1301.66 per 100 000 with an EAPC of -0.18% from 1990 to 2019. CBD mortality decreased by 42.52% between 1990 and 2019, with the global age-standardised death rate declining from 49.72 to 25.58 per 100 000. The age-standardised DALY rate decreased from 4529.16 to 2393.61 per 100 000. Prevalence declined most notably among older children. The risk of CBDs reached its lowest during adolescence (10-14 years) across all regions. The most recent period (2015-2019) showed a reduced risk of prevalence compared to 2000-2004. Earlier birth cohorts displayed declining tendencies followed by slight increases in risk. Conclusions: This study demonstrates encouraging global reductions in the burden of CBDs among children over the past three decades. Prevalence, mortality, and DALYs attributable to CBDs have exhibited downward trajectories, although regional disparities remain. APC analysis provides valuable insights to inform prevention and management strategies for pediatric CBDs.
MeSH term(s)	Adolescent ; Female ; Humans ; Child ; Global Burden of Disease ; Disability-Adjusted Life Years ; Perinatal Death ; Cohort Studies
Language	English
Publishing date	2024-01-19
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2741629-X
ISSN	2047-2986 ; 2047-2986
ISSN (online)	2047-2986
ISSN	2047-2986
DOI	10.7189/jogh.14.04012
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Article ; Online: A white-light-emitting sensor array based on cucurbit[8]uril for quantitative detection of multicomponent nitroaniline isomers.

Huang, Shu-Zhen / Wei, Kai-Ni / Yang, Ru-Pei / Yi, Hong-Ling / Tang, Qing / Tao, Zhu / Huang, Ying

Mikrochimica acta

2023 Volume 190, Issue 12, Page(s) 460

Abstract: A white-light-emitting supramolecular complex through supramolecular interactions has been assembled; the white luminescent supramolecular complex exhibits two emission spectra. Based on this, a dual-channel white-light array sensor was constructed. The ... ...

Abstract	A white-light-emitting supramolecular complex through supramolecular interactions has been assembled; the white luminescent supramolecular complex exhibits two emission spectra. Based on this, a dual-channel white-light array sensor was constructed. The results show that it can quickly identify and detect nitroaniline isomer pollutants (p-nitroaniline, m-nitroaniline, o-nitroaniline). When these three nitroaniline isomers were added to the supramolecular white-light array sensor, the fluorescence intensity of the white-light complex decreased to varying degrees. Linear discriminant analysis (LDA) showed that the supramolecular white-light array sensor could recognize and distinguish three nitroaniline isomers and could classify mixtures containing different concentrations. Factor 1 of the array had a good linear relationship with the concentration of pollutants, and the detection limit (LOD) was as low as 0.7 μM. The method has good reproducibility and stability. In addition, it can also qualitatively detect the nitroaniline isomers in river water and contaminated rice seedling extract. It provides an ideal platform for constructing multiresponse sensors.
Language	English
Publishing date	2023-11-04
Publishing country	Austria
Document type	Journal Article
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-023-06040-2
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Article ; Online: Hydrogen-bonding and π-π interaction promoted solution-processable covalent organic frameworks.

Zhang, Lei / Zhu, Qiu-Hong / Zhou, Yue-Ru / Wang, Shuang-Long / Fu, Jie / Liu, Jia-Ying / Zhang, Guo-Hao / Ma, Lijian / Tao, Guohua / Tao, Guo-Hong / He, Ling

Nature communications

2023 Volume 14, Issue 1, Page(s) 8181

Abstract: Covalent organic frameworks show great potential in gas adsorption/separation, biomedicine, device, sensing, and printing arenas. However, covalent organic frameworks are generally not dispersible in common solvents resulting in the poor processability, ... ...

Abstract	Covalent organic frameworks show great potential in gas adsorption/separation, biomedicine, device, sensing, and printing arenas. However, covalent organic frameworks are generally not dispersible in common solvents resulting in the poor processability, which severely obstruct their application in practice. In this study, we develop a convenient top-down process for fabricating solution-processable covalent organic frameworks by introducing intermolecular hydrogen bonding and π-π interactions from ionic liquids. The bulk powders of imine-linked, azine-linked, and β-ketoenamine linked covalent organic frameworks can be dispersed homogeneously in optimal ionic liquid 1-methyl-3-octylimidazolium bromide after heat treatment. The resulting high-concentration colloids are utilized to create the covalent organic framework inks that can be directly printed onto the surface. Molecular dynamics simulations and the quantum mechanical calculations suggest that C‒H···π and π-π interaction between ionic liquid cations and covalent organic frameworks may promote the formation of colloidal solution. These findings offer a roadmap for preparing solution-processable covalent organic frameworks, enabling their practical applications.
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43905-9
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