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  1. Article ; Online: The 2023 GOLD Report: Updated Guidelines for Inhaled Pharmacological Therapy in Patients with Stable COPD.

    Terry, Paul D / Dhand, Rajiv

    Pulmonary therapy

    2023  Volume 9, Issue 3, Page(s) 345–357

    Abstract: Over the past 22 years, annual GOLD Reports have documented important changes in guidance and recommendations for uniformly treating patients with chronic obstructive pulmonary disease (COPD) with the goal of improving outcomes in patients suffering from ...

    Abstract Over the past 22 years, annual GOLD Reports have documented important changes in guidance and recommendations for uniformly treating patients with chronic obstructive pulmonary disease (COPD) with the goal of improving outcomes in patients suffering from this condition. The most recent GOLD Report, released in 2023, shows continued refinement in several areas, including more precise definitions of COPD and exacerbations of COPD, a new set of parameters to assess exacerbation severity, an updated COPD assessment tool, updated guidelines for initial and follow-up treatment, new information regarding the association between pharmacological triple therapy and reduction in mortality, and new discussions of inhaler device choice and adherence to COPD medications. Whereas we do not address all of the new or updated material in GOLD's 2023 Report, we summarize key changes in GOLD's recommendations regarding inhalation therapy for stable COPD and frame these changes in the context of previous GOLD recommendations.
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2364-1746
    ISSN (online) 2364-1746
    DOI 10.1007/s41030-023-00233-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction to: Inhalation Therapy for Stable COPD: 20 Years of GOLD Reports.

    Terry, Paul D / Dhand, Rajiv

    Advances in therapy

    2021  Volume 38, Issue 9, Page(s) 4986–4988

    Language English
    Publishing date 2021-07-24
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-021-01857-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2101: Show issues Location:
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  3. Article ; Online: The association of preexisting severe asthma with COVID-19 outcomes.

    Terry, Paul D / Heidel, R Eric / Dhand, Rajiv

    Current opinion in pulmonary medicine

    2023  Volume 29, Issue 3, Page(s) 215–222

    Abstract: Purpose of review: Three years after the emergence of coronavirus disease 2019 (COVID-19), many studies have examined the association between asthma and COVID-related morbidity and mortality, with most showing that asthma does not increase risk. However, ...

    Abstract Purpose of review: Three years after the emergence of coronavirus disease 2019 (COVID-19), many studies have examined the association between asthma and COVID-related morbidity and mortality, with most showing that asthma does not increase risk. However, the U.S. Centers for Disease Control (CDC) currently suggests that patients with severe asthma may, nonetheless, be particularly vulnerable to COVID-19-related morbidity.
    Recent findings: With respect to poor COVID-19 outcomes, our search yielded nine studies that quantified associations with severe asthma, seven that considered use of monoclonal antibodies (mAB), and 14 that considered inhaled corticosteroids (ICS) use. mAb and ICS use have been used as measures of severe asthma in several studies. Severe asthma was significantly associated with poor COVID-19 outcomes. The results for mAb and ICS were mixed.
    Summary: An increased risk of poor COVID-19 outcomes in patients with severe asthma is possible. However, these studies remain sparse and suffer from several methodological limitations that hinder their interpretation. Additional evidence is needed to provide clear, cogent guidance for health agencies seeking to inform patients with asthma about potential risks due to COVID-19.
    MeSH term(s) Humans ; Administration, Inhalation ; Anti-Asthmatic Agents/therapeutic use ; Asthma/complications ; Asthma/drug therapy ; Asthma/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Patient Acuity ; Risk Factors ; Outcome Assessment, Health Care
    Chemical Substances Anti-Asthmatic Agents ; Glucocorticoids ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4900: Show issues Location:
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  4. Article: Cancer Screening in Hard-to-Reach Populations.

    Terry, Paul D

    AIMS public health

    2017  Volume 4, Issue 4, Page(s) 399–401

    Language English
    Publishing date 2017-08-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2777115-5
    ISSN 2327-8994 ; 2327-8994 ; 2373-2415
    ISSN (online) 2327-8994
    ISSN 2327-8994 ; 2373-2415
    DOI 10.3934/publichealth.2017.4.399
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  5. Article: Towards Effective Targeted Alpha Therapy for Neuroendocrine Tumours: A Review.

    Gape, Paul M D / Schultz, Michael K / Stasiuk, Graeme J / Terry, Samantha Y A

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 3

    Abstract: This review article explores the evolving landscape of Molecular Radiotherapy (MRT), emphasizing Peptide Receptor Radionuclide Therapy (PRRT) for neuroendocrine tumours (NETs). The primary focus is on the transition from β-emitting radiopharmaceuticals ... ...

    Abstract This review article explores the evolving landscape of Molecular Radiotherapy (MRT), emphasizing Peptide Receptor Radionuclide Therapy (PRRT) for neuroendocrine tumours (NETs). The primary focus is on the transition from β-emitting radiopharmaceuticals to α-emitting agents in PRRT, offering a critical analysis of the radiobiological basis, clinical applications, and ongoing developments in Targeted Alpha Therapy (TAT). Through an extensive literature review, the article delves into the mechanisms and effectiveness of PRRT in targeting somatostatin subtype 2 receptors, highlighting both its successes and limitations. The discussion extends to the emerging paradigm of TAT, underlining its higher potency and specificity with α-particle emissions, which promise enhanced therapeutic efficacy and reduced toxicity. The review critically evaluates preclinical and clinical data, emphasizing the need for standardised dosimetry and a deeper understanding of the dose-response relationship in TAT. The review concludes by underscoring the significant potential of TAT in treating SSTR2-overexpressing cancers, especially in patients refractory to β-PRRT, while also acknowledging the current challenges and the necessity for further research to optimize treatment protocols.
    Language English
    Publishing date 2024-03-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17030334
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  6. Article ; Online: Reciprocal Effect of Environmental Stimuli to Regulate the Adipogenesis and Osteogenesis Fate Decision in Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs).

    Xu, Xinyun / Zhao, Ling / Terry, Paul D / Chen, Jiangang

    Cells

    2023  Volume 12, Issue 10

    Abstract: Mesenchymal stem cells derived from bone marrow (BM-MSCs) can differentiate into adipocytes and osteoblasts. Various external stimuli, including environmental contaminants, heavy metals, dietary, and physical factors, are shown to influence the fate ... ...

    Abstract Mesenchymal stem cells derived from bone marrow (BM-MSCs) can differentiate into adipocytes and osteoblasts. Various external stimuli, including environmental contaminants, heavy metals, dietary, and physical factors, are shown to influence the fate decision of BM-MSCs toward adipogenesis or osteogenesis. The balance of osteogenesis and adipogenesis is critical for the maintenance of bone homeostasis, and the interruption of BM-MSCs lineage commitment is associated with human health issues, such as fracture, osteoporosis, osteopenia, and osteonecrosis. This review focuses on how external stimuli shift the fate of BM-MSCs towards adipogenesis or osteogenesis. Future studies are needed to understand the impact of these external stimuli on bone health and elucidate the underlying mechanisms of BM-MSCs differentiation. This knowledge will inform efforts to prevent bone-related diseases and develop therapeutic approaches to treat bone disorders associated with various pathological conditions.
    MeSH term(s) Humans ; Adipogenesis ; Osteogenesis ; Bone Marrow ; Cell Differentiation ; Mesenchymal Stem Cells
    Language English
    Publishing date 2023-05-16
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12101400
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  7. Article ; Online: Maintenance Therapy with Nebulizers in Patients with Stable COPD: Need for Reevaluation.

    Terry, Paul D / Dhand, Rajiv

    Pulmonary therapy

    2020  Volume 6, Issue 2, Page(s) 177–192

    Abstract: Patients with stable COPD rely heavily on inhaled bronchodilators and corticosteroids to control symptoms, maximize quality of life, and avoid exacerbations and costly hospitalizations. These drugs are typically delivered by hand-held inhalers or ... ...

    Abstract Patients with stable COPD rely heavily on inhaled bronchodilators and corticosteroids to control symptoms, maximize quality of life, and avoid exacerbations and costly hospitalizations. These drugs are typically delivered by hand-held inhalers or nebulizers. The majority of patients are prescribed inhalers due to their perceived convenience, portability, and lower cost, relative to nebulizers. Unfortunately, poor inhaler technique compromises symptom relief in most of these patients. In contrast to one or two puffs through an inhaler, nebulizers deliver a drug over many breaths, through tidal breathing, and hence are more forgiving to poor inhalation technique. To what extent susceptibility to errors in their use may influence the relative effectiveness of these two types of inhalation device has received little attention in COPD research. In 2005, a systematic review of the literature concluded that nebulizers and inhalers are equally effective in patients who are adequately trained to use their inhalation device. This conclusion was based on two small clinical trials that only examined objective measures of lung function. Since then, additional studies have found that maintenance therapy administered by nebulizers could improve patients' reported feelings of symptom relief, quality of life, and satisfaction with treatment, compared to therapy administered by inhalers. Because it has been 15 years since the publication of the systematic review, in this article we summarize the results of studies that compared the effectiveness of inhalers with that of nebulizers in patients with stable COPD and discuss their implications for clinical practice and need for future research.
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2364-1746
    ISSN (online) 2364-1746
    DOI 10.1007/s41030-020-00120-x
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  8. Article ; Online: Inhalation Therapy for Stable COPD: 20 Years of GOLD Reports.

    Terry, Paul D / Dhand, Rajiv

    Advances in therapy

    2020  Volume 37, Issue 5, Page(s) 1812–1828

    Abstract: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) was formed in the late 1990s to spread awareness of chronic obstructive pulmonary disease (COPD) as a major public health problem and facilitate its prevention and treatment. GOLD has ... ...

    Abstract The Global Initiative for Chronic Obstructive Lung Disease (GOLD) was formed in the late 1990s to spread awareness of chronic obstructive pulmonary disease (COPD) as a major public health problem and facilitate its prevention and treatment. GOLD has since become internationally recognized for the development of evidence-based strategy documents, most notably the annual GOLD Reports, for COPD diagnosis, management, and prevention. The GOLD Reports incorporate the latest evidence and expert consensus to guide the management and prevention of COPD on a global level. Since the first GOLD Report in 2001, profound innovations have taken place regarding inhaler device options, available pharmaceuticals, knowledge regarding effective dosages and potential side effects, and the various combinations of drugs used to relieve symptoms. Concomitantly, an evolution of expert opinion on how best to apply these innovations to the care of patients with COPD has also taken place, an evolution that is nowhere more detailed or definitive than in the 20 years of annual GOLD Reports. We summarize key features and trends in inhalation therapy for stable COPD in these Reports.
    MeSH term(s) Administration, Inhalation ; Adult ; Aged ; Aged, 80 and over ; Bronchodilator Agents/history ; Bronchodilator Agents/therapeutic use ; Female ; History, 20th Century ; History, 21st Century ; Humans ; Male ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/history ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Respiratory Therapy/history ; Respiratory Therapy/methods
    Chemical Substances Bronchodilator Agents
    Language English
    Publishing date 2020-04-03
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-020-01289-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2101: Show issues Location:
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  9. Article ; Online: Asthma in Adult Patients with COVID-19. Prevalence and Risk of Severe Disease.

    Terry, Paul D / Heidel, R Eric / Dhand, Rajiv

    American journal of respiratory and critical care medicine

    2021  Volume 203, Issue 7, Page(s) 893–905

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Asthma/epidemiology ; COVID-19/epidemiology ; Comorbidity ; Female ; Global Health/statistics & numerical data ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Severity of Illness Index
    Language English
    Publishing date 2021-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202008-3266OC
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  10. Article ; Online: Recovery After Sport-Related Concussion in Collegiate Athletes With Self-Reported Pre-Injury Migraines.

    Terry, Douglas P / Jo, Jacob / Williams, Kristen L / Maxwell, Bruce A / Berkner, Paul D / Iverson, Grant L / Zuckerman, Scott L

    Journal of neurotrauma

    2024  

    Abstract: Pre-injury migraines might be a risk factor for prolonged recovery after sport-related concussion (SRC). We sought to examine whether a pre-injury history of migraines is associated with worse recovery following SRC in collegiate athletes. Data were ... ...

    Abstract Pre-injury migraines might be a risk factor for prolonged recovery after sport-related concussion (SRC). We sought to examine whether a pre-injury history of migraines is associated with worse recovery following SRC in collegiate athletes. Data were collected through a prospective concussion surveillance system in 11 National Collegiate Athletic Association (NCAA) Division III college athletic programs between September 2014 and March 2020. Our primary independent variable, pre-injury migraines, were self-reported by the athletes. Between those with and without migraines, the outcomes of days to return-to-learn (RTL) without academic accommodations and return-to-play (RTP) were compared using Mann-Whitney
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2023.0475
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