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  1. Book: Der Immun Guide

    DiNicolantonio, James / Land Siim

    Warum das Immunsystem Ursache vieler Krankheiten ist. Wie man es heilt. Entzündungen, Autoimmun- und chronische Krankheiten bekämpfen, Krebs vorbeugen

    2021  

    Title translation The Immunity Fix
    Author's details James DiNicolantonio, Siim Land
    Keywords Abnehmen ; Ernährungs-Docs ; Hormesis ; millemari ; Immunsystem ; Immun-Code ; Übergewicht ; Auto-Immunkrankheiten ; Metabolisches Syndrom ; Intervallfasten ; Himbeeren ; Krebs ; Nahrungsergänzung ; Immunität ; Stress ; Gesundheit ; Diät ; Corona ; Schlaf ; Krebszellen ; Pandemie ; Insulinresistenz ; Herzinfarkt ; Medizin ; Krankheit ; Ätiologie
    Subject Körpereigene Abwehr ; Körpereigene Abwehrkräfte ; Körpereigenes Abwehrsystem ; Abwehrkräfte ; Krankheitsursache ; Krankheit ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos
    Language German
    Size 280 Seiten, 23.8 cm x 15.5 cm
    Edition 1. Auflage
    Publisher millemari
    Publishing place Iffeldorf
    Publishing country Germany
    Document type Book
    HBZ-ID HT020947798
    ISBN 978-3-96706-042-3 ; 3-96706-042-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Vbx available for loan (reading room) Lesesaal EG Gesundheitsliteratur

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  2. Article: Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetes.

    DiNicolantonio, James J / H O'Keefe, James

    Open heart

    2022  Volume 9, Issue 1

    MeSH term(s) Diabetes, Gestational/diagnosis ; Diabetes, Gestational/metabolism ; Female ; Humans ; Inositol/metabolism ; Inositol/therapeutic use ; Insulin ; Insulin Resistance ; Polycystic Ovary Syndrome/diagnosis ; Polycystic Ovary Syndrome/metabolism ; Pregnancy
    Chemical Substances Insulin ; Inositol (4L6452S749)
    Language English
    Publishing date 2022-03-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2022-001989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sodium restriction and insulin resistance

    James J. DiNicolantonio / James H. O'Keefe

    Journal of Insulin Resistance, Vol 6, Iss 1, Pp e1-e

    A review of 23 clinical trials

    2023  Volume 9

    Abstract: Background: Many clinicians recommend low-salt diets for lowering blood pressure but there may be unintended consequences such as worsening insulin resistance. Aim: This paper aimed to find human clinical studies looking at low-salt diets on markers of ... ...

    Abstract Background: Many clinicians recommend low-salt diets for lowering blood pressure but there may be unintended consequences such as worsening insulin resistance. Aim: This paper aimed to find human clinical studies looking at low-salt diets on markers of glucose and insulin. Methods: We reviewed PubMed using the search terms ‘sodium’, ‘insulin’ and ‘insulin resistance’ and found 23 human clinical studies testing low-salt diets showing negative harms on insulin or glucose. Results: Twenty-three human clinical trials have shown that low-salt diets lead to systemic or vascular insulin resistance, glucose intolerance, elevated fasting insulin and/or elevations in glucose and/or insulin levels after an oral glucose tolerance test. Conclusion: We discovered 23 human clinical studies showing that low-salt diets worsen markers of insulin and glucose. Caution is advised when recommending salt restriction for blood pressure control as this may lead to worsening insulin resistance. Contribution: This review has revealed that low salt diets can induce insulin resistance.
    Keywords salt ; sodium ; insulin resistance ; insulin ; hyperinsulinaemia ; glucose ; Internal medicine ; RC31-1245 ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher AOSIS
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article: Monounsaturated Fat vs Saturated Fat: Effects on Cardio-Metabolic Health and Obesity.

    DiNicolantonio, James J / O'Keefe, James H

    Missouri medicine

    2022  Volume 119, Issue 1, Page(s) 69–73

    Abstract: For over 40 years saturated fat, the fat found primarily in animal foods, was thought to be the main culprit for increasing cholesterol levels and causing heart disease. During this same time vegetable oils were promoted as being heart healthy because ... ...

    Abstract For over 40 years saturated fat, the fat found primarily in animal foods, was thought to be the main culprit for increasing cholesterol levels and causing heart disease. During this same time vegetable oils were promoted as being heart healthy because they could lower cholesterol. However, recently the evidence implicating saturated fat as being harmful to heart health has been challenged and more studies are beginning to show the harms from consuming industrially produced vegetable oils. Furthermore, monounsaturated fats, found in olives, olive oil, certain nuts and avocadoes have been promoted as being part of a healthy Mediterranean diet. This paper will provide a brief review comparing the effects of saturated fat to monounsaturated fat.
    MeSH term(s) Cholesterol ; Dietary Fats ; Fatty Acids ; Humans ; Obesity ; Plant Oils
    Chemical Substances Dietary Fats ; Fatty Acids ; Plant Oils ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 427362-x
    ISSN 0026-6620
    ISSN 0026-6620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 182: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Low-grade metabolic acidosis as a driver of insulin resistance.

    DiNicolantonio, James J / O'Keefe, James H

    Open heart

    2021  Volume 8, Issue 2

    MeSH term(s) Acidosis/complications ; Acidosis/diagnosis ; Acidosis/metabolism ; Female ; Humans ; Insulin Resistance/physiology ; Male ; Metabolic Syndrome/etiology ; Metabolic Syndrome/metabolism ; Middle Aged
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Editorial
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2021-001788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Low-grade metabolic acidosis as a driver of chronic disease: a 21st century public health crisis.

    DiNicolantonio, James J / O'Keefe, James

    Open heart

    2021  Volume 8, Issue 2

    MeSH term(s) Acidosis/complications ; Acidosis/diagnosis ; Acidosis/metabolism ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Chronic Disease ; Humans ; Public Health ; Severity of Illness Index
    Language English
    Publishing date 2021-10-23
    Publishing country England
    Document type Editorial
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2021-001730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Magnesium and Vitamin D Deficiency as a Potential Cause of Immune Dysfunction, Cytokine Storm and Disseminated Intravascular Coagulation in covid-19 patients.

    DiNicolantonio, James J / O'Keefe, James H

    Missouri medicine

    2021  Volume 118, Issue 1, Page(s) 68–73

    Abstract: Magnesium and vitamin D each have the possibility of affecting the immune system and consequently the cytokine storm and coagulation cascade in COVID-19 infections. Vitamin D is important for reducing the risk of upper respiratory tract infections and ... ...

    Abstract Magnesium and vitamin D each have the possibility of affecting the immune system and consequently the cytokine storm and coagulation cascade in COVID-19 infections. Vitamin D is important for reducing the risk of upper respiratory tract infections and plays a role in pulmonary epithelial health. While the importance of vitamin D for a healthy immune system has been known for decades, the benefits of magnesium has only recently been elucidated. Indeed, magnesium is important for activating vitamin D and has a protective role against oxidative stress. Magnesium deficiency increases endothelial cell susceptibility to oxidative stress, promotes endothelial dysfunction, reduces fibrinolysis and increases coagulation. Furthermore, magnesium deficient animals and humans have depressed immune responses, which, when supplemented with magnesium, a partial or near full reversal of the immunodeficiency occurs. Moreover, intracellular free magnesium levels in natural killer cells and CD8 killer T cells regulates their cytotoxicity. Considering that magnesium and vitamin D are important for immune function and cellular resilience, a deficiency in either may contribute to cytokine storm in the novel coronavirus 2019 (COVID-19) infection.
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/drug effects ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/virology ; Cytokine Release Syndrome/etiology ; Disseminated Intravascular Coagulation/etiology ; Humans ; Immune System Diseases/etiology ; Killer Cells, Natural/drug effects ; Magnesium/administration & dosage ; Magnesium/pharmacology ; Magnesium/therapeutic use ; Magnesium Deficiency/complications ; Oxidative Stress/drug effects ; SARS-CoV-2/drug effects ; SARS-CoV-2/genetics ; Vitamin D/administration & dosage ; Vitamin D/pharmacology ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications ; Vitamins/administration & dosage ; Vitamins/pharmacology ; Vitamins/therapeutic use
    Chemical Substances Vitamins ; Vitamin D (1406-16-2) ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2021-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 427362-x
    ISSN 0026-6620
    ISSN 0026-6620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 182: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: The benefits of marine omega-3s for preventing arrhythmias.

    DiNicolantonio, James J / OKeefe, James

    Open heart

    2020  Volume 7, Issue 1, Page(s) e000904

    MeSH term(s) Action Potentials ; Animals ; Anti-Arrhythmia Agents/adverse effects ; Anti-Arrhythmia Agents/therapeutic use ; Arrhythmias, Cardiac/metabolism ; Arrhythmias, Cardiac/mortality ; Arrhythmias, Cardiac/physiopathology ; Arrhythmias, Cardiac/prevention & control ; Calcium Channels, L-Type/drug effects ; Calcium Channels, L-Type/metabolism ; Dietary Supplements/adverse effects ; Fatty Acids, Omega-3/adverse effects ; Fatty Acids, Omega-3/therapeutic use ; Heart Rate/drug effects ; Humans ; Membrane Fluidity/drug effects ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/metabolism ; Myocardial Ischemia/mortality ; Myocardial Ischemia/physiopathology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Risk Factors ; Treatment Outcome
    Chemical Substances Anti-Arrhythmia Agents ; Calcium Channels, L-Type ; Fatty Acids, Omega-3
    Language English
    Publishing date 2020-02-04
    Publishing country England
    Document type Editorial
    ZDB-ID 2747269-3
    ISSN 2053-3624 ; 2044-6055
    ISSN 2053-3624 ; 2044-6055
    DOI 10.1136/openhrt-2018-000904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity-Nutraceutical Options.

    McCarty, Mark F / DiNicolantonio, James J

    Healthcare (Basel, Switzerland)

    2021  Volume 10, Issue 1

    Abstract: In people with metabolic syndrome, episodic exposure of pancreatic beta cells to elevated levels of both glucose and free fatty acids (FFAs)-or glucolipotoxicity-can induce a loss of glucose-stimulated insulin secretion (GSIS). This in turn can lead to a ...

    Abstract In people with metabolic syndrome, episodic exposure of pancreatic beta cells to elevated levels of both glucose and free fatty acids (FFAs)-or glucolipotoxicity-can induce a loss of glucose-stimulated insulin secretion (GSIS). This in turn can lead to a chronic state of glucolipotoxicity and a sustained loss of GSIS, ushering in type 2 diabetes. Loss of GSIS reflects a decline in beta cell glucokinase (GK) expression associated with decreased nuclear levels of the pancreatic and duodenal homeobox 1 (PDX1) factor that drives its transcription, along with that of Glut2 and insulin. Glucolipotoxicity-induced production of reactive oxygen species (ROS), stemming from both mitochondria and the NOX2 isoform of NADPH oxidase, drives an increase in c-Jun N-terminal kinase (JNK) activity that promotes nuclear export of PDX1, and impairs autocrine insulin signaling; the latter effect decreases PDX1 expression at the transcriptional level and up-regulates beta cell apoptosis. Conversely, the incretin hormone glucagon-like peptide-1 (GLP-1) promotes nuclear import of PDX1 via cAMP signaling. Nutraceuticals that quell an increase in beta cell ROS production, that amplify or mimic autocrine insulin signaling, or that boost GLP-1 production, should help to maintain GSIS and suppress beta cell apoptosis in the face of glucolipotoxicity, postponing or preventing onset of type 2 diabetes. Nutraceuticals with potential in this regard include the following: phycocyanobilin-an inhibitor of NOX2; agents promoting mitophagy and mitochondrial biogenesis, such as ferulic acid, lipoic acid, melatonin, berberine, and astaxanthin; myo-inositol and high-dose biotin, which promote phosphatidylinositol 3-kinase (PI3K)/Akt activation; and prebiotics/probiotics capable of boosting GLP-1 secretion. Complex supplements or functional foods providing a selection of these agents might be useful for diabetes prevention.
    Language English
    Publishing date 2021-12-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10010003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Importance of Maintaining a Low Omega-6/Omega-3 Ratio for Reducing the Risk of Inflammatory Cytokine Storms.

    DiNicolantonio, James J / O'Keefe, James

    Missouri medicine

    2020  Volume 117, Issue 6, Page(s) 539–542

    Abstract: Inflammatory cytokine storms in the lungs are a potential consequence of RNA viruses. One issue that may increase the risk of developing inflammatory cytokine storms in the lungs during viral infections is an imbalance in the dietary omega-6/3 ratio. ... ...

    Abstract Inflammatory cytokine storms in the lungs are a potential consequence of RNA viruses. One issue that may increase the risk of developing inflammatory cytokine storms in the lungs during viral infections is an imbalance in the dietary omega-6/3 ratio. Indeed, over the past 100 years the omega-6/3 ratio in the Western world has increased from approximately 4:1 to 20:1. This has increased the production of pro-inflammatory metabolites from omega-6 and reduced the anti-inflammatory metabolites from omega-3s. A high dietary omega-6/3 ratio may promote excessive inflammation, which may be contributing to inflammatory cytokine storms in the lungs during viral infections.
    MeSH term(s) Cytokine Release Syndrome ; Diet ; Fatty Acids, Omega-3 ; Humans ; Inflammation
    Chemical Substances Fatty Acids, Omega-3
    Language English
    Publishing date 2020-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 427362-x
    ISSN 0026-6620
    ISSN 0026-6620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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