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Article ; Online: Advanced glycation end products modulate electrophysiological remodeling of right ventricular outflow tract cardiomyocytes: A novel target for diabetes-related ventricular arrhythmogenesis.

Chen, Yao-Chang / Lu, Yen-Yu / Wu, Wen-Shiann / Lin, Yung-Kuo / Chen, Yi-Ann / Chen, Shih-Ann / Chen, Yi-Jen

2022 Volume 10, Issue 21, Page(s) e15499

Abstract: Diabetes mellitus is associated with cardiovascular disease and cardiac arrhythmia. Accumulation of advanced glycation end products closely correlates with cardiovascular complications through mitochondrial dysfunction or oxidative stress and evoke ... ...

Abstract	Diabetes mellitus is associated with cardiovascular disease and cardiac arrhythmia. Accumulation of advanced glycation end products closely correlates with cardiovascular complications through mitochondrial dysfunction or oxidative stress and evoke proliferative, inflammatory, and fibrotic reactions, which might impair cardiac electrophysiological characteristics and increase the incidence of cardiac arrhythmia. This study examined the mechanisms how advanced glycation end products may contribute to arrhythmogenesis of right ventricular outflow tract-a unique arrhythmogenic substrate. A whole-cell patch clamp, conventional electrophysiological study, fluorescence imaging, Western blot, and confocal microscope were used to study the electrical activity, and Ca
MeSH term(s)	Humans ; Myocytes, Cardiac/metabolism ; Glycation End Products, Advanced/metabolism ; Arrhythmias, Cardiac/metabolism ; Sodium-Calcium Exchanger/metabolism ; Action Potentials/physiology ; Sodium/metabolism ; Diabetes Mellitus/metabolism ; Calcium/metabolism
Chemical Substances	Glycation End Products, Advanced ; Sodium-Calcium Exchanger ; Sodium (9NEZ333N27) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15499
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Higher hypertension prevalence, lower incidence, and aggressive treatment with decreasing mortality, cardiovascular, and cerebrovascular incidence in Taiwan from 2005 to 2010: A 2 population-based cohorts study.

Liao, Chia-Te / Wu, Pei-Chih / Shih, Jung-Chang / Cheng, Tain-Junn / Wu, Wen-Shiann

Medicine

2020 Volume 99, Issue 39, Page(s) e22437

Abstract: Hypertension continues to be an important public health concern because of its associated morbidity, mortality, and economic impact on society. The aims of this study are to compare the secular changes in age-stratified hypertension prevalence, incidence, ...

Abstract	Hypertension continues to be an important public health concern because of its associated morbidity, mortality, and economic impact on society. The aims of this study are to compare the secular changes in age-stratified hypertension prevalence, incidence, co-morbidity, and 3 years of cardiovascular outcome in Taiwan in the years 2005 and 2010.We enrolled hypertensive individuals from the datasets of the Longitudinal Health Insurance Database (LHID) in 2005 and 2010 in Taiwan separately. We analyzed the hypertension prevalence, incidence, medication treatment, and associated morbidities. The risks of cardiovascular and cerebrovascular events and all-causes mortalities among the hypertensive individuals were evaluated in 3 years of follow-up.There was an increased prevalence of hypertension but decreased incidence of hypertension in those over 65 from 2005 to 2010. Dyslipidemia was the highest rate of co-morbidity in 2005 and 2010. The most frequent categories of anti-hypertensive agents prescribed was 1 or 2 for both 2005 and 2010. Calcium channel blockers were the most common anti-hypertensive agents prescribed, followed by Angiotensin converting enzyme inhibitors/Angiotensin receptor blockers. After 3 years of follow-up, the risks of coronary artery disease (CAD), cerebrovascular diseases (CVD) as well as death were less in 2010 than in 2005 in Taiwan.Our study showed that hypertension individuals had an increased prevalence, younger age, decreased incidence, increased medication treatment associated with decreased the CAD, CVD, and mortalities in 2010 compared to 2005 in Taiwan.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antihypertensive Agents/therapeutic use ; Cerebrovascular Disorders/etiology ; Cerebrovascular Disorders/mortality ; Female ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Hypertension/mortality ; Incidence ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Taiwan/epidemiology ; Young Adult
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2020-09-29
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000022437
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Ua VI Zs.171: Show issues

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Article ; Online: Predicting the 14-Day Hospital Readmission of Patients with Pneumonia Using Artificial Neural Networks (ANN).

Tey, Shu-Farn / Liu, Chung-Feng / Chien, Tsair-Wei / Hsu, Chin-Wei / Chan, Kun-Chen / Chen, Chia-Jung / Cheng, Tain-Junn / Wu, Wen-Shiann

International journal of environmental research and public health

2021 Volume 18, Issue 10

Abstract: Unplanned patient readmission (UPRA) is frequent and costly in healthcare settings. No indicators during hospitalization have been suggested to clinicians as useful for identifying patients at high risk of UPRA. This study aimed to create a prediction ... ...

Abstract	Unplanned patient readmission (UPRA) is frequent and costly in healthcare settings. No indicators during hospitalization have been suggested to clinicians as useful for identifying patients at high risk of UPRA. This study aimed to create a prediction model for the early detection of 14-day UPRA of patients with pneumonia. We downloaded the data of patients with pneumonia as the primary disease (e.g., ICD-10:J12-J18) at three hospitals in Taiwan from 2016 to 2018. A total of 21,892 cases (1208 (6%) for UPRA) were collected. Two models, namely, artificial neural network (ANN) and convolutional neural network (CNN), were compared using the training (
MeSH term(s)	Humans ; Neural Networks, Computer ; Patient Readmission ; Pneumonia/diagnosis ; Pneumonia/epidemiology ; ROC Curve ; Taiwan/epidemiology
Language	English
Publishing date	2021-05-12
Publishing country	Switzerland
Document type	Journal Article
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph18105110
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Article ; Online: Toll-like receptor 4 activation modulates pericardium-myocardium interactions in lipopolysaccharide-induced atrial arrhythmogenesis.

Lin, Fong-Jhih / Li, Shao-Jung / Lu, Yen-Yu / Wu, Wen-Shiann / Chen, Yao-Chang / Chen, Shih-Ann / Chen, Yi-Jen

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2021 Volume 23, Issue 11, Page(s) 1837–1846

Abstract: Aims: Inflammation plays a role in the pathogenesis of atrial fibrillation (AF). Pericarditis enhanced atrial arrhythmogenesis, but the role of the pericardium remains unclear in AF. Activation of the toll-like receptor 4 (TLR4) by binding to ... ...

Abstract	Aims: Inflammation plays a role in the pathogenesis of atrial fibrillation (AF). Pericarditis enhanced atrial arrhythmogenesis, but the role of the pericardium remains unclear in AF. Activation of the toll-like receptor 4 (TLR4) by binding to lipopolysaccharide (LPS) promotes cardiac electrical remodelling. In this study, we hypothesized that pericarditis may induce atrial arrhythmogenesis via pericardium-myocardium interactions by TLR4 signalling. Methods and results: Pericarditis was induced in rabbits by injecting LPS (1-2 mg/kg) into the pericardium. Conventional microelectrodes were used to record the action potentials of left atrial (LA) posterior walls (LAPWs) and LA appendages (LAAs) with and without attached pericardium in the control or pericarditis-induced rabbits. Cytokine array was used to measure the expression levels of proinflammatory cytokines in control and LPS-treated pericardium. Compared with the controls, the LPS-treated pericardium had higher expressions of IL-1α, IL-8, and MIP-1β. Rapid atrial pacing-induced burst firing in LPS-treated LAPWs and LAAs, and in control LAPWs (but not in LAAs). The incidence of pacing-induced spontaneous activity and burst firing was increased by LPS-treated pericardium but was attenuated by the control pericardium. Moreover, burst firing induced by LPS-treated pericardium was blocked upon administration of the TLR4 inhibitor, TAK-242 (100 ng/mL), ryanodine receptor inhibitor (ryanodine, 3 μM), or calmodulin kinase II inhibitor (KN-93, 1 μM). Conclusions: Healthy and inflamed pericardium differently modulate LPS-induced atrial arrhythmogenesis. Targeting pericardium via TLR4 signalling may be a novel therapeutic strategy for AF.
MeSH term(s)	Animals ; Atrial Fibrillation/chemically induced ; Atrial Fibrillation/drug therapy ; Humans ; Lipopolysaccharides/adverse effects ; Myocardium/metabolism ; Pericardium ; Rabbits ; Toll-Like Receptor 4/therapeutic use
Chemical Substances	Lipopolysaccharides ; Toll-Like Receptor 4
Language	English
Publishing date	2021-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euab073
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Zs.A 5434: Show issues

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Article ; Online: Pulsation of the nailbed.

Hsieh, Ming-Ta / Wu, Wen-Shiann

Lancet (London, England)

2012 Volume 380, Issue 9855, Page(s) 1767

MeSH term(s)	Aged ; Aortic Valve Insufficiency/diagnosis ; Aortic Valve Insufficiency/diagnostic imaging ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/diagnostic imaging ; Electrocardiography ; Humans ; Male ; Nails ; Pulsatile Flow ; Radiography
Language	English
Publishing date	2012-11-17
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(12)61153-2
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Article ; Online: Scale Validation of the Mandarin-Language Supportive Care Needs Survey-Adolescent Form.

Wu, Wei-Wen / Tang, Chia-Chun / Jou, Shiann-Tang / Hung, Giun-Yi

Seminars in oncology nursing

2023 Volume 39, Issue 4, Page(s) 151442

Abstract: Objectives: To (1) modify the Mandarin-language 34-item Supportive Care Needs Survey-Adult Form into the Adolescent Form and (2) examine the psychometric properties of the Adolescent Form.: Data sources: A multiphase, iterative scale validation ... ...

Abstract	Objectives: To (1) modify the Mandarin-language 34-item Supportive Care Needs Survey-Adult Form into the Adolescent Form and (2) examine the psychometric properties of the Adolescent Form. Data sources: A multiphase, iterative scale validation process was used in this methodological study. Participants who were 13 to 18 years old and receiving cancer treatment in inpatient or outpatient settings, or receiving follow-up care in outpatient settings, were recruited using a convenience sampling method. Confirmatory factor analysis demonstrated good fitness of indices, and all factor loadings for the 18-item Adolescent Form were >0.50, which supported the scale's construct validity. The Adolescent Form score was significantly correlated with the symptom distress score (r = 0.56, P < .01) and quality of life score (r = -0.65, P < .01), which indicated the scale's convergent validity. The correlated item-total correlations (0.30-0.78), Cronbach's alpha (.93), and test-retest reliability coefficient (0.79) confirmed the scale's stability. Conclusion: This study successfully modified the 34-item Adult Form into the 18-item Adolescent Form. Given its adequate psychometric properties, this concise scale has great promise as a useful, feasible, and age-appropriate tool for evaluating care needs among adolescents with cancer who speak Mandarin. Implications for nursing practice: This scale can screen for unmet care needs in busy pediatric oncology settings or large-scale clinical trials. It allows for cross-sectional comparison of unmet care needs between adolescent and adult populations and for longitudinal follow-up into how unmet care needs change from adolescence into adulthood.
MeSH term(s)	Adult ; Child ; Humans ; Adolescent ; Quality of Life ; Reproducibility of Results ; Cross-Sectional Studies ; Surveys and Questionnaires ; Language
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632682-1
ISSN	1878-3449 ; 0749-2081
ISSN (online)	1878-3449
ISSN	0749-2081
DOI	10.1016/j.soncn.2023.151442
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Zs.B 2849: Show issues

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Article: Exercise capacity-hemodynamics mismatch in elderly patients with pulmonary hypertension: A nationwide multicenter study from Taiwan Society of Cardiology Pulmonary Hypertension Registry (TAIPANS).

Chen, Chang-Ying / Mei-Tzu, Wang / Sung, Shih-Hsien / Wu, Yih-Jer / Hsu, Chih-Hsin / Ho, Wan-Jing / Lin, Yen-Hung / Liu, Wei-Shin / Liu, Ju-Chi / Kao, Yung-Ta / Wu, Wen-Shiann / Wu, Chun-Hsien / Lei, Meng-Huan / Chen, Yu-Wei / Chen-Yu, Chien / Chiu, Yu-Wei / Dai, Zen-Kong / Lin, Tsung-Hsien / Lin, Lin /

Chung, Cheng-Chih / Chung, Chang-Min / Huang, Sung-Hao / Cheng, Chin-Chang / Wu, Yen-Wen / Chao, Ting-Hsing / Hwang, Juey-Jen / Jia-Yin Hou, Charles / Huang, Wei-Chun

Heliyon

2024 Volume 10, Issue 6, Page(s) e27537

Abstract: Background: Demographics of pulmonary hypertension (PH) has changed a lot over the past forty years. Several recent registries noted an increase in mean age of PH but only a few of them investigated the characteristics of elderly patients. Thus, we ... ...

Abstract	Background: Demographics of pulmonary hypertension (PH) has changed a lot over the past forty years. Several recent registries noted an increase in mean age of PH but only a few of them investigated the characteristics of elderly patients. Thus, we aimed to analyze the characteristics of PH in such a population in this study. Methods: This multicenter study enrolled patients diagnosed with PH in group 1, 3, 4, and 5 consecutively from January 1, 2019 to December 31, 2020. A total of 490 patients was included, and patients were divided into three groups by age (≤45 years, 45-65 years, and >65 years). Results: The mean age of PH patients diagnosed with PH was 55.3 ± 16.3 years of age. There was higher proportion of elderly patients classified as group 3 PH (≤45: 1.3, 45-65: 4.5, >65: 8.1 %; Conclusions: Elderly PH patients possess unique hemodynamic profiles and epidemiologic patterns. They had higher PAWP, lower mPAP, and received combination therapy less frequently. Moreover, ageing is a predictor of high mortality for PH patients. Exercise capacity-hemodynamics mismatch and inadequate treatment are noteworthy in the approach of elderly population with PH.
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27537
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Article ; Online: Body of water involved in older adult drowning deaths in the United States.

Wu, Wen-Shiann / Cheng, Tain-Junn / Lu, Tsung-Hsueh / Kawachi, Ichiro

Journal of the American Geriatrics Society

2015 Volume 63, Issue 4, Page(s) 813–815

MeSH term(s)	Drowning/mortality ; Female ; Humans ; Male ; Seasons ; Sex Factors ; United States/epidemiology
Language	English
Publishing date	2015-04
Publishing country	United States
Document type	Letter
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.13367
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Article ; Online: Predicting the 14-Day Hospital Readmission of Patients with Pneumonia Using Artificial Neural Networks (ANN)

Shu-Farn Tey / Chung-Feng Liu / Tsair-Wei Chien / Chin-Wei Hsu / Kun-Chen Chan / Chia-Jung Chen / Tain-Junn Cheng / Wen-Shiann Wu

International Journal of Environmental Research and Public Health, Vol 18, Iss 5110, p

2021 Volume 5110

Abstract	Unplanned patient readmission (UPRA) is frequent and costly in healthcare settings. No indicators during hospitalization have been suggested to clinicians as useful for identifying patients at high risk of UPRA. This study aimed to create a prediction model for the early detection of 14-day UPRA of patients with pneumonia. We downloaded the data of patients with pneumonia as the primary disease (e.g., ICD-10:J12-J18) at three hospitals in Taiwan from 2016 to 2018. A total of 21,892 cases (1208 (6%) for UPRA) were collected. Two models, namely, artificial neural network (ANN) and convolutional neural network (CNN), were compared using the training ( n = 15,324; ≅70%) and test ( n = 6568; ≅30%) sets to verify the model accuracy. An app was developed for the prediction and classification of UPRA. We observed that (i) the 17 feature variables extracted in this study yielded a high area under the receiver operating characteristic curve of 0.75 using the ANN model and that (ii) the ANN exhibited better AUC (0.73) than the CNN (0.50), and (iii) a ready and available app for predicting UHA was developed. The app could help clinicians predict UPRA of patients with pneumonia at an early stage and enable them to formulate preparedness plans near or after patient discharge from hospitalization.
Keywords	unplanned patient readmission ; artificial neural network ; convolutional neural network ; nurse ; Microsoft Excel ; receiver operating characteristic curve ; Medicine ; R
Subject code	006
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Escherichia coli endocarditis of native aortic valve and mitral valve.

Chen, Chien-An / Lin, Zhe-Zhong / Yu, Wen-Liang / Wu, Wen-Shiann

Journal of the Formosan Medical Association = Taiwan yi zhi

2015 Volume 114, Issue 9, Page(s) 893–894

MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Aortic Valve/microbiology ; Ceftazidime/therapeutic use ; Echocardiography, Transesophageal ; Endocarditis/diagnostic imaging ; Endocarditis/drug therapy ; Escherichia coli/isolation & purification ; Escherichia coli Infections/drug therapy ; Female ; Humans ; Middle Aged ; Mitral Valve/microbiology
Chemical Substances	Anti-Bacterial Agents ; Ceftazidime (9M416Z9QNR)
Language	English
Publishing date	2015-09
Publishing country	Singapore
Document type	Case Reports ; Letter
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2015.05.012
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