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  1. Article ; Online: Lipid nanoparticles for oral delivery of nucleic acids for treating inflammatory bowel disease.

    Yang, Chunhua / Alpini, Gianfranco / Glaser, Shannon / Merlin, Didier

    Nanomedicine (London, England)

    2022  Volume 17, Issue 21, Page(s) 1501–1504

    MeSH term(s) Humans ; Nucleic Acids/therapeutic use ; Inflammatory Bowel Diseases/drug therapy ; Colitis, Ulcerative ; Nanoparticles
    Chemical Substances Lipid Nanoparticles ; Nucleic Acids
    Language English
    Publishing date 2022-11-01
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2022-0222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6617: Show issues Location:
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  2. Article ; Online: Pathophysiological Roles of Ductular Reaction in Liver Inflammation and Hepatic Fibrogenesis.

    Sato, Keisaku / Pham, Linh / Glaser, Shannon / Francis, Heather / Alpini, Gianfranco

    Cellular and molecular gastroenterology and hepatology

    2022  Volume 15, Issue 3, Page(s) 803–805

    MeSH term(s) Humans ; Hepatocytes ; Hepatitis ; Inflammation
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2022.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pleiotropic effects of CD5L in hepatic inflammation and fibrosis.

    Zhou, Tianhao / Glaser, Shannon S

    EBioMedicine

    2019  Volume 44, Page(s) 22–23

    MeSH term(s) Humans ; Inflammation ; Liver Cirrhosis ; Liver Diseases ; Macrophages
    Language English
    Publishing date 2019-05-28
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2019.05.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  4. Article ; Online: Preparation and Characterization of IL-22 mRNA-loaded Lipid Nanoparticles.

    Alghoul, Zahra / Sung, Junsik / Wu, Kenji / Alpini, Gianfranco / Glaser, Shannon / Yang, Chunhua / Merlin, Didier

    Bio-protocol

    2023  Volume 13, Issue 7, Page(s) e4647

    Abstract: Interleukin-22 (IL-22) has been demonstrated as a critical regulator of epithelial homeostasis and repair; it showed an anti-inflammatory effect against ulcerative colitis. Local microinjection of IL-22 cDNA vector has been shown to be effective in ... ...

    Abstract Interleukin-22 (IL-22) has been demonstrated as a critical regulator of epithelial homeostasis and repair; it showed an anti-inflammatory effect against ulcerative colitis. Local microinjection of IL-22 cDNA vector has been shown to be effective in treating ulcerative colitis in mouse models. However, microinjection comes with multiple technical challenges for routine colon-targeted drug delivery. In contrast, oral administration can get around these challenges and provide comparable efficacy. We showed in previous studies that oral administration of new lipid nanoparticles (nLNP)-encapsulated IL-22 mRNA targets the colon region and efficiently ameliorates colitis. This protocol describes the details of preparing and characterizing the nLNP-encapsulated IL-22 mRNA using three major lipids that mimic the natural ginger-derived nanoparticles. It provides an nLNP platform that can be used to orally deliver other types of nucleic acids to the colon.
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis.

    Medford, Abigail / Childs, Jonathan / Little, Ashleigh / Chakraborty, Sanjukta / Baiocchi, Leonardo / Alpini, Gianfranco / Glaser, Shannon

    Journal of clinical and translational hepatology

    2023  Volume 11, Issue 4, Page(s) 949–957

    Abstract: The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated ... ...

    Abstract The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated with loss of tolerance to mitochondrial antigens. At this time there is no definitive cure for PBC; however, ursodeoxycholic acid (UDCA) has been shown to reduce injury when administered as the first line of treatment. Additional therapeutics can be given concurrently or as an alternative to UDCA to manage the symptoms and further curb disease progression. Currently, a liver transplant is the only potentially curative option when the patient has developed end-stage liver disease or intractable pruritus. This review aims to delineate the pathogenesis of primary biliary cholangitis and shed light on current therapeutic strategies in the treatment of PBC.
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2022.00398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Novel β-catenin/farnesoid X receptor interaction regulates hepatic bile acid metabolism during cholestasis.

    Ehrlich, Laurent / Glaser, Shannon S

    Hepatology (Baltimore, Md.)

    2018  Volume 67, Issue 3, Page(s) 829–832

    MeSH term(s) Bile Acids and Salts ; Cholestasis ; Humans ; Liver ; Receptors, Cytoplasmic and Nuclear ; beta Catenin
    Chemical Substances Bile Acids and Salts ; Receptors, Cytoplasmic and Nuclear ; beta Catenin
    Language English
    Publishing date 2018-01-26
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.29584
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Concise Review: Functional Roles and Therapeutic Potentials of Long Non-coding RNAs in Cholangiopathies.

    Sato, Keisaku / Glaser, Shannon / Francis, Heather / Alpini, Gianfranco

    Frontiers in medicine

    2020  Volume 7, Page(s) 48

    Abstract: Long non-coding RNAs (lncRNAs) are RNAs with lengths exceeding 200 nucleotides that are not translated into proteins. It is well-known that small non-coding RNAs, such as microRNAs (miRNAs), regulate gene expression and play an important role in ... ...

    Abstract Long non-coding RNAs (lncRNAs) are RNAs with lengths exceeding 200 nucleotides that are not translated into proteins. It is well-known that small non-coding RNAs, such as microRNAs (miRNAs), regulate gene expression and play an important role in cholangiopathies. Recent studies have demonstrated that lncRNAs may also play a key role in the pathophysiology of cholangiopathies. Patients with cholangiopathies often develop cholangiocarcinoma (CCA), which is cholangiocyte-derived cancer, in the later stage. Cholangiocytes are a primary target of therapies for cholangiopathies and CCA development. Previous studies have demonstrated that expression levels of lncRNAs are altered in the liver of cholangiopathies or CCA tissues. Some lncRNAs regulate gene expression by inhibiting functions of miRNAs leading to diseased liver conditions or CCA progression, suggesting that lncRNAs could be a novel therapeutic target for those disorders. This review summarizes current understandings of functional roles of lncRNAs in cholangiopathies and seek their potentials for novel therapies.
    Language English
    Publishing date 2020-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Conjugated Bile Acids Promote Lymphangiogenesis by Modulation of the Reactive Oxygen Species-p90RSK-Vascular Endothelial Growth Factor Receptor 3 Pathway.

    Banerjee, Priyanka / Kumaravel, Subhashree / Roy, Sukanya / Gaddam, Niyanshi / Odeh, Johnny / Bayless, Kayla J / Glaser, Shannon / Chakraborty, Sanjukta

    Cells

    2023  Volume 12, Issue 4

    Abstract: Conjugated bile acids (BA) are significantly elevated in several liver pathologies and in the metastatic lymph node (LN). However, the effects of BAs on pathological lymphangiogenesis remains unknown. The current study explores the effects of BAs on ... ...

    Abstract Conjugated bile acids (BA) are significantly elevated in several liver pathologies and in the metastatic lymph node (LN). However, the effects of BAs on pathological lymphangiogenesis remains unknown. The current study explores the effects of BAs on lymphangiogenesis. BA levels were elevated in the LN and serum of Mdr2
    MeSH term(s) Mice ; Animals ; Humans ; Lymphangiogenesis ; Reactive Oxygen Species/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Endothelial Cells/metabolism ; Vascular Endothelial Growth Factor Receptor-3/metabolism ; Steroids/metabolism ; Bile Acids and Salts/metabolism
    Chemical Substances Reactive Oxygen Species ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-3 (EC 2.7.10.1) ; Steroids ; Bile Acids and Salts
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12040526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Author Correction: Complex bile duct network formation within liver decellularized extracellular matrix hydrogels.

    Lewis, Phillip L / Su, Jimmy / Yan, Ming / Meng, Fanyin / Glaser, Shannon S / Alpini, Gianfranco D / Green, Richard M / Sosa-Pineda, Beatriz / Shah, Ramille N

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 923

    Language English
    Publishing date 2023-01-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-26508-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Inflammation and Progression of Cholangiocarcinoma: Role of Angiogenic and Lymphangiogenic Mechanisms.

    Roy, Sukanya / Glaser, Shannon / Chakraborty, Sanjukta

    Frontiers in medicine

    2019  Volume 6, Page(s) 293

    Abstract: Cholangiocarcinoma (CCA), or cancer of the biliary epithelium is a relatively rare but aggressive form of biliary duct cancer which has a 5-year survival rate post metastasis of 2%. Although a number of risk factors are established for CCA growth and ... ...

    Abstract Cholangiocarcinoma (CCA), or cancer of the biliary epithelium is a relatively rare but aggressive form of biliary duct cancer which has a 5-year survival rate post metastasis of 2%. Although a number of risk factors are established for CCA growth and progression, a careful evaluation of the existing literature on CCA reveals that an inflammatory environment near the biliary tree is the most common causal link between the risk factors and the development of CCA. The fact that inflammation predisposes affected individuals to CCA is further bolstered by multiple observations where the presence and maintenance of an inflammatory microenvironment at the site of the primary tumor plays a significant role in the development and metastasis of CCA. In addition, mechanisms activating the tumor vasculature and enhancing angiogenesis and lymphangiogenesis significantly contribute to CCA aggressiveness and metastasis. This review aims to address the role of an inflammatory microenvironment-CCA crosstalk and will present the basic concepts, observations, and current perspectives from recent research studies in the field of tumor stroma of CCA.
    Language English
    Publishing date 2019-12-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2019.00293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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