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Article ; Online: Specific

Humphries, Duncan C / O'Connor, Richard A / Stewart, Hazel L / Quinn, Tom M / Gaughan, Erin E / Mills, Beth / Williams, Gareth O S / Stone, James M / Finlayson, Keith / Chabaud-Riou, Martine / Boudet, Florence / Dhaliwal, Kevin / Pavot, Vincent

Frontiers in immunology

2023 Volume 14, Page(s) 1100161

Abstract: Introduction: Pulmonary-resident memory T cells (T: Methods: To address this need, we developed a novel : Results: Initially, cells from human lung digests (confirmed to contain T: Discussion: In ... ...

Abstract	Introduction: Pulmonary-resident memory T cells (T Methods: To address this need, we developed a novel Results: Initially, cells from human lung digests (confirmed to contain T Discussion: In situ
MeSH term(s)	Humans ; Immunologic Memory ; Lung/diagnostic imaging ; CD8-Positive T-Lymphocytes ; Lymphocytes
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1100161
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Landmark Paper That Introduced Proteasome Inhibition in Myeloma.

Devasia, Anup Joseph / Lancman, Guido / Stewart, A Keith

Cancer research

2023 Volume 83, Issue 19, Page(s) 3174–3175

Abstract: The ongoing therapeutic revolution in multiple myeloma care can be traced to the turn of the millennium with the unanticipated discovery in 1999 that the cereblon binding small molecule thalidomide had profound clinical effectiveness and, simultaneously, ...

Abstract	The ongoing therapeutic revolution in multiple myeloma care can be traced to the turn of the millennium with the unanticipated discovery in 1999 that the cereblon binding small molecule thalidomide had profound clinical effectiveness and, simultaneously, the emergence of a new class of targeted therapies inhibiting the proteasome, both of which ultimately target ubiquitinated protein degradation. These contemporaneous discoveries forever changed the landscape of multiple myeloma care, substantially extending survival. Foreshadowing this seismic change, Nobel Prize winning work on the proteasome ubiquitin pathway had stimulated the development of highly specific proteasome inhibitor small molecules, particularly PS-341 (later named bortezomib). An abundance of the proteasome in hematologic malignancies had been recognized and thus PS-341 was logically being explored in relevant preclinical models. Concurrent with phase I trials, which were soon to prove the significant clinical relevance of preclinical models, the laboratory of Dr. Kenneth Anderson and colleagues at Dana-Farber, in partnership with Dr. Julian Adams and scientists at ProScript (later Millennium Pharmaceuticals) first demonstrated that the proteasome inhibitor PS-341 inhibited growth, induced apoptosis, and overcame drug resistance in human multiple myeloma cells. This landmark paper in Cancer Research set the stage for a paradigm shift in how multiple myeloma was managed across all stages of the disease, which changed the lives of patients worldwide. See related article by Hideshima and colleagues, Cancer Res 2001;61:3071-6.
MeSH term(s)	Humans ; Multiple Myeloma/drug therapy ; Multiple Myeloma/pathology ; Bortezomib ; Proteasome Inhibitors/pharmacology ; Proteasome Inhibitors/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Proteasome Endopeptidase Complex ; Boronic Acids/pharmacology ; Boronic Acids/therapeutic use ; Pyrazines/pharmacology
Chemical Substances	Bortezomib (69G8BD63PP) ; Proteasome Inhibitors ; Antineoplastic Agents ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Boronic Acids ; Pyrazines
Language	English
Publishing date	2023-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-23-2629
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mass Cytometry reveals unique phenotypic patterns associated with subclonal diversity and outcomes in multiple myeloma.

Baughn, Linda B / Jessen, Erik / Sharma, Neeraj / Tang, Hongwei / Smadbeck, James B / Long, Mark D / Pearce, Kathryn / Smith, Matthew / Dasari, Surendra / Sachs, Zohar / Linden, Michael A / Cook, Joselle / Keith Stewart, A / Chesi, Marta / Mitra, Amit / Leif Bergsagel, P / Van Ness, Brian / Kumar, Shaji K

Blood cancer journal

2023 Volume 13, Issue 1, Page(s) 84

Abstract: Multiple myeloma (MM) remains an incurable plasma cell (PC) malignancy. Although it is known that MM tumor cells display extensive intratumoral genetic heterogeneity, an integrated map of the tumor proteomic landscape has not been comprehensively ... ...

Abstract	Multiple myeloma (MM) remains an incurable plasma cell (PC) malignancy. Although it is known that MM tumor cells display extensive intratumoral genetic heterogeneity, an integrated map of the tumor proteomic landscape has not been comprehensively evaluated. We evaluated 49 primary tumor samples from newly diagnosed or relapsed/refractory MM patients by mass cytometry (CyTOF) using 34 antibody targets to characterize the integrated landscape of single-cell cell surface and intracellular signaling proteins. We identified 13 phenotypic meta-clusters across all samples. The abundance of each phenotypic meta-cluster was compared to patient age, sex, treatment response, tumor genetic abnormalities and overall survival. Relative abundance of several of these phenotypic meta-clusters were associated with disease subtypes and clinical behavior. Increased abundance of phenotypic meta-cluster 1, characterized by elevated CD45 and reduced BCL-2 expression, was significantly associated with a favorable treatment response and improved overall survival independent of tumor genetic abnormalities or patient demographic variables. We validated this association using an unrelated gene expression dataset. This study represents the first, large-scale, single-cell protein atlas of primary MM tumors and demonstrates that subclonal protein profiling may be an important determinant of clinical behavior and outcome.
MeSH term(s)	Humans ; Multiple Myeloma/genetics ; Multiple Myeloma/metabolism ; Proteomics ; Plasma Cells/metabolism
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2600560-8
ISSN	2044-5385 ; 2044-5385
ISSN (online)	2044-5385
ISSN	2044-5385
DOI	10.1038/s41408-023-00851-5
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Article ; Online: The RAVI registry: prospective, multicenter study of radial access in embolization procedures - 30 days follow up.

Guimaraes, Marcelo / Fischman, Aaron / Yu, Hyeon / Tasse, Jordan / Stewart, Jessica / Pereira, Keith

CVIR endovascular

2024 Volume 7, Issue 1, Page(s) 15

Abstract: Background: There is a lack of registry studies about transradial access (TRA) outcomes. This prospective registry evaluated the TRA and procedure outcomes of visceral embolizations performed via TRA with 30-day follow-up.: Material & methods: ... ...

Abstract	Background: There is a lack of registry studies about transradial access (TRA) outcomes. This prospective registry evaluated the TRA and procedure outcomes of visceral embolizations performed via TRA with 30-day follow-up. Material & methods: Prospective, multicenter registry included uterine fibroids (UFE), prostate artery (PAE), liver tumors (LT), and other hypervascular tumors (OHT) embolization performed in six US hospitals. Between February 2020 and January 2022, 99 patients underwent one radial artery visceral intervention (RAVI); 70 had UFE (70.7%), 16 PAE (16.2%), 7 LT (7.1%), and 6 OHT (6.1%). The mean age was 50.1 (±11.1) years, and 74/99 (74.7%) were females. The primary safety endpoints included hand ischemia, stroke, and death. Procedural success was defined as completing the intended procedure via radial artery (RA) access. Technical success was defined as the successful delivery of HydroPearl™ microspheres and complete embolization of the target vessel. Results: Procedural and technical successes were 100% and 97%, respectively. There was no stroke, hand ischemia, radial-to-femoral conversion, access-related serious adverse events, or clinically evident radial artery occlusion at 30 days. There were two deaths: one respiratory failure and one progression of liver disease. Minor RA-related adverse event included arterial spasm, hematoma, and post-procedure discomfort. Conclusion: This prospective, multicenter, open-label registry confirmed the high safety profile and effectiveness of radial access in UFE, PAE, LT, and OHT embolization procedures without stroke, hand ischemia, or access-related serious adverse events at 30-day follow-up.
Language	English
Publishing date	2024-01-30
Publishing country	Switzerland
Document type	Journal Article
ISSN	2520-8934
ISSN (online)	2520-8934
DOI	10.1186/s42155-023-00415-5
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Article: The mode of delivery and content of communication strategies used in mandatory and non-mandatory biosimilar transitions

Gasteiger, Chiara / den Broeder, Alfons A. / Stewart, Sarah / Gasteiger, Norina / Scholz, Urte / Dalbeth, Nicola / Petrie, Keith J.

Health Psychology Review

A systematic review with meta-analysis

2023 Volume 17, Issue 1, Page(s) 148–168

Abstract: Effective patient-provider communication is crucial to promote shared decision-making. However, it is unclear how to explain treatment changes to ensure patient acceptance, such as when transitioning from a bio-originator to a biosimilar. This review ... ...

Title translation	Art und Inhalt der Kommunikationsstrategien bei der Umstellung auf Biosimilars - obligatorisch und nicht obligatorisch: Eine systematische Überprüfung und Meta-Analyse
Abstract	Effective patient-provider communication is crucial to promote shared decision-making. However, it is unclear how to explain treatment changes to ensure patient acceptance, such as when transitioning from a bio-originator to a biosimilar. This review investigates communication strategies used to educate patients on transitioning to biosimilars and explores whether the willingness to transition and treatment persistence differs for the delivery (verbal or written) and the amount of information provided. MEDLINE, Embase, Scopus, and relevant conference databases were systematically searched. Communication strategies from 33 studies (88% observational cohort studies) published from 2012 to 2020 were synthesized and willingness to transition, persistence, and subjective adverse events explored. Patients only received information verbally in 11 studies. The remaining 22 studies also provided written information. Cost-saving was the main reason provided for the transition. Patients were most willing to transition when receiving written and verbal information (chi(2) = 5.83, p = .02) or written information that only addressed a few (3-5) concerns (chi(2) = 16.08, p < .001). There was no significant difference for persistence or subjective adverse events (p's > .05). Few randomized controlled trials have been conducted. Available data shows more willingness to transition when patients received written and verbal information. Initial documents should contain basic information and consultations or telephone calls used to address concerns.
Keywords	Aufklärung von Klientinnen und Klienten ; Client Education ; Cognitive Processes ; Communication ; Decision Making ; Entscheidungsfindung ; Information ; Interpersonal Interaction ; Interpersonale Interaktion ; Kognitive Prozesse ; Kommunikation ; Meta Analysis ; Metaanalyse ; Patientinnen und Patienten ; Patients ; Systematic Review ; Systematischer Literaturüberblick
Language	English
Document type	Article
ZDB-ID	2364161-7
ISSN	1743-7202 ; 1743-7199
ISSN (online)	1743-7202
ISSN	1743-7199
DOI	10.1080/17437199.2021.1970610
Database	PSYNDEX

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Article ; Online: The mode of delivery and content of communication strategies used in mandatory and non-mandatory biosimilar transitions: a systematic review with meta-analysis.

Gasteiger, Chiara / den Broeder, Alfons A / Stewart, Sarah / Gasteiger, Norina / Scholz, Urte / Dalbeth, Nicola / Petrie, Keith J

Health psychology review

2021 Volume 17, Issue 1, Page(s) 148–168

Abstract	Effective patient-provider communication is crucial to promote shared decision-making. However, it is unclear how to explain treatment changes to ensure patient acceptance, such as when transitioning from a bio-originator to a biosimilar. This review investigates communication strategies used to educate patients on transitioning to biosimilars and explores whether the willingness to transition and treatment persistence differs for the delivery (verbal or written) and the amount of information provided. MEDLINE, Embase, Scopus, and relevant conference databases were systematically searched. Communication strategies from 33 studies (88% observational cohort studies) published from 2012 to 2020 were synthesized and willingness to transition, persistence, and subjective adverse events explored. Patients only received information verbally in 11 studies. The remaining 22 studies also provided written information. Cost-saving was the main reason provided for the transition. Patients were most willing to transition when receiving written and verbal information (
MeSH term(s)	Humans ; Biosimilar Pharmaceuticals ; Communication ; Telecommunications ; Databases, Factual ; Decision Making, Shared
Chemical Substances	Biosimilar Pharmaceuticals
Language	English
Publishing date	2021-08-30
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2364161-7
ISSN	1743-7202 ; 1743-7199
ISSN (online)	1743-7202
ISSN	1743-7199
DOI	10.1080/17437199.2021.1970610
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Galen's theory of black bile

Stewart, Keith Andrew

Hippocratic tradition, manipulation, innovation

(Studies in ancient medicine ; volume 51)

2018

Author's details	by Keith Andrew Stewart
Series title	Studies in ancient medicine ; volume 51
Collection
Keywords	Galenus ; Körperflüssigkeit
Subject	Körperwasser ; Biologische Flüssigkeit ; Körpersäfte
Language	English
Size	VIII, 178 Seiten
Publisher	Brill
Publishing place	Leiden
Publishing country	Netherlands
Document type	Book
HBZ-ID	HT019883558
ISBN	978-90-04-38278-7 ; 9789004382794 ; 90-04-38278-X ; 9004382798
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2018 A 1804	available for loan (reading room)	Lesesaal EG

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Article ; Online: Transcriptional profiles define drug refractory disease in myeloma.

Zhu, Yuan Xiao / Bruins, Laura A / Chen, Xianfeng / Shi, Chang-Xin / Bonolo De Campos, Cecilia / Meurice, Nathalie / Wang, Xuewei / Ahmann, Greg J / Ramsower, Colleen A / Braggio, Esteban / Rimsza, Lisa M / Stewart, A Keith

EJHaem

2022 Volume 3, Issue 3, Page(s) 804–814

Abstract: Identifying biomarkers associated with disease progression and drug resistance are important for personalized care. We investigated the expression of 121 curated genes, related to immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs) ... ...

Abstract	Identifying biomarkers associated with disease progression and drug resistance are important for personalized care. We investigated the expression of 121 curated genes, related to immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs) responsiveness. We analyzed 28 human multiple myeloma (MM) cell lines with known drug sensitivities and 130 primary MM patient samples collected at different disease stages, including newly diagnosed (ND), on therapy (OT), and relapsed and refractory (RR, collected within 12 months before the patients' death) timepoints. Our findings led to the identification of a subset of genes linked to clinical drug resistance, poor survival, and disease progression following combination treatment containing IMIDs and/or PIs. Finally, we built a seven-gene model (MM-IMiD and PI sensitivity-7 genes [IP-7]) using digital gene expression profiling data that significantly separates ND patients from IMiD- and PI-refractory RR patients. Using this model, we retrospectively analyzed RNA sequcencing (RNAseq) data from the Mulltiple Myeloma Research Foundation (MMRF) CoMMpass (
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Journal Article
ISSN	2688-6146
ISSN (online)	2688-6146
DOI	10.1002/jha2.455
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Article ; Online: Carfilzomib for the treatment of patients with relapsed and/or refractory multiple myeloma.

Stewart, A Keith

Future oncology (London, England)

2015 Volume 11, Issue 15, Page(s) 2121–2136

Abstract: Carfilzomib is a proteasome inhibitor that irreversibly binds to its target, resulting in sustained proteasomal inhibition with minimal off-target effects. As a single agent, carfilzomib has demonstrated durable antimyeloma activity with manageable ... ...

Abstract	Carfilzomib is a proteasome inhibitor that irreversibly binds to its target, resulting in sustained proteasomal inhibition with minimal off-target effects. As a single agent, carfilzomib has demonstrated durable antimyeloma activity with manageable toxicities, which has resulted in its approval in Argentina, Israel, Mexico and the USA for the treatment of patients with relapsed and refractory multiple myeloma. Data from ongoing Phase III studies that are evaluating carfilzomib in earlier lines of therapy may facilitate an expanded indication for this agent, as well as for regulatory approval in the EU. This article summarizes the chemistry, pharmacokinetics, pharmacodynamics and available clinical data for carfilzomib in the treatment of patients with multiple myeloma.
MeSH term(s)	Clinical Trials, Phase III as Topic ; Dose-Response Relationship, Drug ; Drug-Related Side Effects and Adverse Reactions/pathology ; Humans ; Multiple Myeloma/drug therapy ; Multiple Myeloma/pathology ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Oligopeptides/adverse effects ; Oligopeptides/pharmacokinetics ; Oligopeptides/therapeutic use ; Proteasome Endopeptidase Complex/drug effects ; Proteasome Inhibitors/pharmacokinetics ; Proteasome Inhibitors/therapeutic use
Chemical Substances	Oligopeptides ; Proteasome Inhibitors ; carfilzomib (72X6E3J5AR) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2184533-5
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon.15.123
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The effect of long-term soccer training on left ventricular structure and function in elite male youth soccer players.

Unnithan, Viswanath B / Beaumont, Alexander / Rowland, Thomas / George, Keith / Stewart, Laura / Sculthorpe, Nicholas / Lord, Rachel N / Oxborough, David L

Scandinavian journal of medicine & science in sports

2024 Volume 34, Issue 3, Page(s) e14594

Abstract: Aims: Cardiac adaptations in elite, male adolescent youth soccer players have been demonstrated in relation to training status. The time course of these adaptations and the delineation of the influence of volatile growth phases from the training effect ... ...

Abstract	Aims: Cardiac adaptations in elite, male adolescent youth soccer players have been demonstrated in relation to training status. The time course of these adaptations and the delineation of the influence of volatile growth phases from the training effect on these adaptations remain unclear. Consequently, the aims of the study were to evaluate the impact of 3 years of elite-level soccer training on changes in left ventricular (LV) structure and function in a group of highly trained elite youth male soccer players (SP) as they transitioned through the pre-to-adolescent phase of their growth. Methods: Twenty-two male youth SP from the highest Level of English Premier League Academy U-12 teams were evaluated once a year for three soccer seasons as the players progressed from the U-12 to U-14 teams. Fifteen recreationally active control participants (CON) were also evaluated over the same 3-year period. Two-dimensional transthoracic echocardiography was used to quantify LV structure and function. Results: After adjusting for the influence of growth and maturation, training-induced increases in Years 2 and 3 were noted for: LV end diastolic volume (LVEDV; p = 0.02) and LV end systolic volume (LVESV; p = 0.02) in the SP compared to CON. Training-induced decrements were noted for LV ejection fraction (LVEF; p = 0.006) and TDI-S' (p < 0.001). Conclusions: An increase in training volume (Years 2 and 3) were aligned with LV volumetric adaptations and decrements in systolic function in the SP that were independent from the influence of rapid somatic growth. Decrements in systolic function were suggestive of a functional reserve for exercise.
MeSH term(s)	Humans ; Male ; Adolescent ; Soccer ; Heart Ventricles/diagnostic imaging ; Ventricular Function, Left ; Stroke Volume ; Exercise
Language	English
Publishing date	2024-03-08
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1077418-x
ISSN	1600-0838 ; 0905-7188
ISSN (online)	1600-0838
ISSN	0905-7188
DOI	10.1111/sms.14594
Database	MEDical Literature Analysis and Retrieval System OnLINE

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