LIVIVO - Search results -

Search results

Result 1 - 10 of total 1292

Search options

Article ; Online: The Inhibitory Roles of Vitamin K in Progression of Vascular Calcification.

Shioi, Atsushi / Morioka, Tomoaki / Shoji, Tetsuo / Emoto, Masanori

2020 Volume 12, Issue 2

Abstract: Vitamin K is a fat-soluble vitamin that is indispensable for the activation of vitamin K-dependent ... signaling pathway. Vitamin K has been demonstrated to exert anti-inflammatory effects through antagonizing NF-κB ... signaling in both in vitro and in vivo studies, suggesting that vitamin K may prevent vascular calcification ...

Abstract	Vitamin K is a fat-soluble vitamin that is indispensable for the activation of vitamin K-dependent proteins (VKDPs) and may be implicated in cardiovascular disease (CVD). Vascular calcification is intimately associated with CV events and mortality and is a chronic inflammatory process in which activated macrophages promote osteoblastic differentiation of vascular smooth muscle cells (VSMCs) through the production of proinflammatory cytokines such as IL-1β, IL-6, TNF-α, and oncostatin M (OSM) in both intimal and medial layers of arterial walls. This process may be mainly mediated through NF-κB signaling pathway. Vitamin K has been demonstrated to exert anti-inflammatory effects through antagonizing NF-κB signaling in both in vitro and in vivo studies, suggesting that vitamin K may prevent vascular calcification via anti-inflammatory mechanisms. Matrix Gla protein (MGP) is a major inhibitor of soft tissue calcification and contributes to preventing both intimal and medial vascular calcification. Vitamin K may also inhibit progression of vascular calcification by enhancing the activity of MGP through facilitating its γ-carboxylation. In support of this hypothesis, the procalcific effects of warfarin, an antagonist of vitamin K, on arterial calcification have been demonstrated in several clinical studies. Among the inactive MGP forms, dephospho-uncarboxylated MGP (dp-ucMGP) may be regarded as the most useful biomarker of not only vitamin K deficiency, but also vascular calcification and CVD. There have been several studies showing the association of circulating levels of dp-ucMGP with vitamin K intake, vascular calcification, mortality, and CVD. However, additional larger prospective studies including randomized controlled trials are necessary to confirm the beneficial effects of vitamin K supplementation on CV health.
MeSH term(s)	Animals ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/pathology ; Disease Progression ; Humans ; Inflammation/blood ; Inflammation/drug therapy ; Inflammation/pathology ; Vascular Calcification/blood ; Vascular Calcification/drug therapy ; Vitamin K/therapeutic use
Chemical Substances	Biomarkers ; Vitamin K (12001-79-5)
Language	English
Publishing date	2020-02-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12020583
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: The Inhibitory Roles of Vitamin K in Progression of Vascular Calcification

Shioi, Atsushi / Morioka, Tomoaki / Shoji, Tetsuo / Emoto, Masanori

Nutrients. 2020 Feb. 23, v. 12, no. 2

2020

Abstract	Vitamin K is a fat-soluble vitamin that is indispensable for the activation of vitamin K-dependent proteins (VKDPs) and may be implicated in cardiovascular disease (CVD). Vascular calcification is intimately associated with CV events and mortality and is a chronic inflammatory process in which activated macrophages promote osteoblastic differentiation of vascular smooth muscle cells (VSMCs) through the production of proinflammatory cytokines such as IL-1β, IL-6, TNF-α, and oncostatin M (OSM) in both intimal and medial layers of arterial walls. This process may be mainly mediated through NF-κB signaling pathway. Vitamin K has been demonstrated to exert anti-inflammatory effects through antagonizing NF-κB signaling in both in vitro and in vivo studies, suggesting that vitamin K may prevent vascular calcification via anti-inflammatory mechanisms. Matrix Gla protein (MGP) is a major inhibitor of soft tissue calcification and contributes to preventing both intimal and medial vascular calcification. Vitamin K may also inhibit progression of vascular calcification by enhancing the activity of MGP through facilitating its γ-carboxylation. In support of this hypothesis, the procalcific effects of warfarin, an antagonist of vitamin K, on arterial calcification have been demonstrated in several clinical studies. Among the inactive MGP forms, dephospho-uncarboxylated MGP (dp-ucMGP) may be regarded as the most useful biomarker of not only vitamin K deficiency, but also vascular calcification and CVD. There have been several studies showing the association of circulating levels of dp-ucMGP with vitamin K intake, vascular calcification, mortality, and CVD. However, additional larger prospective studies including randomized controlled trials are necessary to confirm the beneficial effects of vitamin K supplementation on CV health.
Keywords	antagonists ; anti-inflammatory activity ; biomarkers ; calcification ; cardiovascular diseases ; in vivo studies ; interleukin-6 ; macrophages ; mortality ; myocytes ; nutrients ; prospective studies ; proteins ; randomized clinical trials ; signal transduction ; smooth muscle ; vitamin K ; walls ; warfarin
Language	English
Dates of publication	2020-0223
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12020583
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Monitoring of endometrial K-ras mutation in tamoxifen-treated patients with breast cancer.

Tsujioka, Hiroshi / Hachisuga, Toru / Fukuoka, Miyoko / Ueda, Taeko / Miyahara, Daisuke / Horiuchi, Shinji / Shirota, Kyoko / Yoshizato, Toshiyuki / Emoto, Makoto / Miyamoto, Shingo / Kawarabayashi, Tatsuhiko

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2008 Volume 19, Issue 6, Page(s) 1052–1056

Abstract: Introduction: A high incidence of endometrial K-ras mutations has been reported in tamoxifen (TAM ... treated patients with breast cancer. We examined the changes in the frequency of the endometrial K-ras ... Metal Industry, Inc, Tokyo, Japan). K-ras codon 12 mutations were monitored in these 28 patients.: Results ...

Abstract	Introduction: A high incidence of endometrial K-ras mutations has been reported in tamoxifen (TAM)-treated patients with breast cancer. We examined the changes in the frequency of the endometrial K-ras mutations after the cessation of TAM treatment. Methods: DNA was extracted from fresh cytological or polypectomy samples of the endometrium in 28 patients who had undergone TAM treatment of breast cancer. Mutations were detected by an enriched polymerase chain reaction-enzyme-linked minisequence assay (Sumitomo Metal Industry, Inc, Tokyo, Japan). K-ras codon 12 mutations were monitored in these 28 patients. Results: An initial examination detected endometrial K-ras mutations in 13 of the 28 patients. However, repeated examinations performed after cessation of TAM treatment did not detect endometrial K-ras mutations in any of these 13 patients. No endometrial K-ras mutation has been detected in the repeated examinations performed for these patients for more than 2 years since the cessation of TAM treatment. In addition, the 15 patients who did not have endometrial K-ras mutations in the initial examination did not demonstrate them in repeat examinations. Conclusions: The cessation of TAM treatment may reduce the risk of developing endometrial cancers through K-ras mutations.
MeSH term(s)	Adult ; Aged ; Antineoplastic Agents, Hormonal/adverse effects ; Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Carcinoma/drug therapy ; Carcinoma/genetics ; Carcinoma/pathology ; DNA Mutational Analysis ; Endometrial Neoplasms/chemically induced ; Endometrial Neoplasms/epidemiology ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/pathology ; Endometrium/metabolism ; Endometrium/pathology ; Female ; Gene Frequency ; Genes, ras ; Humans ; Middle Aged ; Monitoring, Physiologic/methods ; Mutation/physiology ; Neoplasms, Second Primary/epidemiology ; Neoplasms, Second Primary/genetics ; Neoplasms, Second Primary/pathology ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins p21(ras) ; Retrospective Studies ; Tamoxifen/adverse effects ; Tamoxifen/therapeutic use ; Withholding Treatment ; ras Proteins/genetics ; ras Proteins/metabolism
Chemical Substances	Antineoplastic Agents, Hormonal ; KRAS protein, human ; Proto-Oncogene Proteins ; Tamoxifen (094ZI81Y45) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; ras Proteins (EC 3.6.5.2)
Language	English
Publishing date	2008-04-04
Publishing country	England
Document type	Evaluation Studies ; Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1111/IGC.0b013e3181a8b0aa
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3198: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: K-ras mutation in tamoxifen-related endometrial polyps.

Hachisuga, Toru / Miyakawa, Takashi / Tsujioka, Hiroshi / Horiuchi, Shinji / Emoto, Makoto / Kawarabayashi, Tatsuhiko

Cancer

2003 Volume 98, Issue 9, Page(s) 1890–1897

Abstract: Background: K-ras mutation is thought to occur at an early stage of neoplastic progression ... in the endometrium. The authors investigated mutations in codon 12 of K-ras in tamoxifen (TAM)-related endometrial ... and Ki-67.: Results: Mutations in codon 12 of K-ras were observed in 7 of 11 TAM-related ...

Abstract	Background: K-ras mutation is thought to occur at an early stage of neoplastic progression in the endometrium. The authors investigated mutations in codon 12 of K-ras in tamoxifen (TAM)-related endometrial polyps. Methods: DNA was extracted from 11 frozen endometrial polyps from TAM-treated patients with breast carcinoma. Mutations were detected using the mutant allele-specific amplification method. The results subsequently were analyzed for correlations with immunohistochemical data that were obtained using antibodies against estrogen receptors (ERs; alpha and beta forms), progesterone receptors (PRs; A and B forms), and Ki-67. Results: Mutations in codon 12 of K-ras were observed in 7 of 11 TAM-related endometrial polyps. Expression levels of ER-alpha and PR-B were high in the glandular epithelium and low in the stroma. PR-A expression was high in both the glandular epithelium and the stroma. In the glandular epithelium, expression of ER-beta appeared to be lower than expression of ER-alpha. The Ki-67 index in the glandular epithelium ranged from 2 to 38, whereas the index ranged from 0 to 4 in the stroma (P < 0.01). Conclusions: The incidence of mutations in codon 12 of K-ras in TAM-related endometrial polyps (64%) was greater than the incidence of these same mutations in sporadic endometrial hyperplasias (4.5-23%). High expression levels of ER-alpha, PR-A, and PR-B in the glandular epithelium were observed in all polyps, regardless of K-ras codon 12 mutation status and Ki-67 index. The authors' findings may support the hypothesis that the polyp-carcinoma sequence partly indicates the development of endometrial carcinoma in postmenopausal women who have been treated with TAM.
MeSH term(s)	Aged ; Antineoplastic Agents, Hormonal/adverse effects ; Breast Neoplasms/diet therapy ; Codon ; Endometrial Neoplasms/chemically induced ; Endometrial Neoplasms/genetics ; Female ; Genes, ras ; Humans ; Immunohistochemistry ; Middle Aged ; Mutation ; Polyps/chemically induced ; Polyps/genetics ; Precancerous Conditions/genetics ; Receptors, Estrogen/analysis ; Receptors, Progesterone/analysis ; Tamoxifen/adverse effects
Chemical Substances	Antineoplastic Agents, Hormonal ; Codon ; Receptors, Estrogen ; Receptors, Progesterone ; Tamoxifen (094ZI81Y45)
Language	English
Publishing date	2003-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.11728
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.146: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Successful Multimodal Treatment of Pancreatic Cancer With Extensive Superior Mesenteric Vein Thrombosis Utilizing Chemotherapy Combined With Direct Oral Anticoagulant.

Harada, Kei / Fujikawa, Takahisa / Matsuoka, Taisuke / Uemoto, Yusuke / Emoto, Norio

Cureus

2024 Volume 16, Issue 2, Page(s) e53657

Abstract: It is well known that portal vein thrombosis (PVT) sometimes occurs in pancreatic cancer (PC). However, no effective treatment plan for PVT in PC patients has yet been proposed. We experienced a successfully treated case of borderline resectable ... ...

Abstract	It is well known that portal vein thrombosis (PVT) sometimes occurs in pancreatic cancer (PC). However, no effective treatment plan for PVT in PC patients has yet been proposed. We experienced a successfully treated case of borderline resectable pancreatic cancer (PC-BR) with extensive superior mesenteric vein thrombosis utilizing intensive chemotherapy combined with direct oral anticoagulant. The thrombus disappeared and the tumor shrank, enabling curative surgery, and long-term survival for more than five years has been achieved. We report this successful case that we experienced as an option for the treatment of PC-BR with PVT in the future era when multimodal treatment is important.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.53657
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The circadian clock in the piriform cortex intrinsically tunes daily changes of odor-evoked neural activity.

Takeuchi, Shunsuke / Shimizu, Kimiko / Fukada, Yoshitaka / Emoto, Kazuo

Communications biology

2023 Volume 6, Issue 1, Page(s) 332

Abstract: The daily activity in the brain is typically fine-tuned by the circadian clock in the local neurons as well as by the master circadian clock in the suprachiasmatic nucleus (SCN) of the hypothalamus. In the olfactory response, odor-evoked activity in the ... ...

Abstract	The daily activity in the brain is typically fine-tuned by the circadian clock in the local neurons as well as by the master circadian clock in the suprachiasmatic nucleus (SCN) of the hypothalamus. In the olfactory response, odor-evoked activity in the piriform cortex (PC) and olfactory behavior retain circadian rhythmicity in the absence of the SCN, yet how the circadian rhythm in the PC is achieved independently of the SCN remains elusive. Here, to define neurons regulating the circadian rhythm of the odor-evoked activity in the PC, we knocked out the clock gene Bmal1 in a host of specific neurons along the olfactory circuit. We discovered that Bmal1 knockout in the PC largely abolishes the circadian rhythm of the odor-evoked activity. We further showed that isolated PC exhibits sustained circadian rhythms of the clock gene Per2 expression. Quantitative PCR analysis revealed that expression patterns of multiple genes involved in neural activity and synaptic transmission exhibit circadian rhythm in the PC in a BMAL1-dependent manner. Our findings indicate that BMAL1 acts intrinsically in the PC to control the circadian rhythm of the odor-evoked activity in the PC, possibly through regulating expression patterns of multiple genes involved in neural activity and transmission.
MeSH term(s)	Circadian Clocks/genetics ; Odorants ; ARNTL Transcription Factors/genetics ; Piriform Cortex ; Circadian Rhythm/genetics
Chemical Substances	ARNTL Transcription Factors
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-04691-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Threat gates visual aversion via theta activity in Tachykinergic neurons.

Tsuji, Masato / Nishizuka, Yuto / Emoto, Kazuo

Nature communications

2023 Volume 14, Issue 1, Page(s) 3987

Abstract: Animals must adapt sensory responses to an ever-changing environment for survival. Such sensory modulation is especially critical in a threatening situation, in which animals often promote aversive responses to, among others, visual stimuli. Recently, ... ...

Abstract	Animals must adapt sensory responses to an ever-changing environment for survival. Such sensory modulation is especially critical in a threatening situation, in which animals often promote aversive responses to, among others, visual stimuli. Recently, threatened Drosophila has been shown to exhibit a defensive internal state. Whether and how threatened Drosophila promotes visual aversion, however, remains elusive. Here we report that mechanical threats to Drosophila transiently gate aversion from an otherwise neutral visual object. We further identified the neuropeptide tachykinin, and a single cluster of neurons expressing it ("Tk-GAL4
MeSH term(s)	Animals ; Drosophila melanogaster/physiology ; Drosophila Proteins ; Drosophila ; Neuropeptides/genetics ; Neurons/physiology
Chemical Substances	Drosophila Proteins ; Neuropeptides
Language	English
Publishing date	2023-07-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39667-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: K-ras mutation in the endometrium of tamoxifen-treated breast cancer patients, with a comparison of tamoxifen and toremifene.

Hachisuga, T / Tsujioka, H / Horiuchi, S / Udou, T / Emoto, M / Kawarabayashi, T

British journal of cancer

2003 Volume 92, Issue 6, Page(s) 1098–1103

Abstract: The putative presence of a mutation in codon 12 of the K-ras gene was investigated ... Mutations were detected by enriched PCR and an enzyme-linked mini-sequence assay (ELMA). K-ras mutation was ... premenopausal patients, K-ras mutation was found in seven (43.8%) of 16 patients with less than 47 months of TAM ...

Abstract	The putative presence of a mutation in codon 12 of the K-ras gene was investigated in the endometrium of tamoxifen (TAM) and toremifene (TOR)-treated breast cancer patients. DNA was extracted from fresh cytologic samples of the endometrium in 86 TAM and 21 TOR-treated breast cancer patients. Mutations were detected by enriched PCR and an enzyme-linked mini-sequence assay (ELMA). K-ras mutation was found in 35 TAM-treated endometrial samples, and in only one TOR-treated endometrium (P<0.003). In 24 premenopausal patients, K-ras mutation was found in seven (43.8%) of 16 patients with less than 47 months of TAM treatment, while none was found in eight patients with more than 48 months of TAM treatment (P<0.03). In 62 postmenopausal-amenorrheic patients, K-ras mutation was found in three (15.8%) of 19 patients with less than 23 months of TAM treatment, while it was found in 16 (61.5%) of 26 patients with 24-47 months of TAM treatment and nine (52.9%) of 17 patients with more than 48 months of TAM treatment (P=0.002). The presence of K-ras mutation is significantly influenced by the duration of TAM treatment and menstrual status of the patients. TOR may have a lower potential genotoxicity than TAM.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Codon ; Endometrium/diagnostic imaging ; Endometrium/metabolism ; Female ; Genes, ras ; Humans ; Middle Aged ; Mutation ; Tamoxifen/therapeutic use ; Toremifene/therapeutic use ; Ultrasonography
Chemical Substances	Antineoplastic Agents, Hormonal ; Codon ; Tamoxifen (094ZI81Y45) ; Toremifene (7NFE54O27T)
Language	English
Publishing date	2003-12-17
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/sj.bjc.6602456
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.142: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Scrap and Build for Functional Neural Circuits: Spatiotemporal Regulation of Dendrite Degeneration and Regeneration in Neural Development and Disease.

Furusawa, Kotaro / Emoto, Kazuo

Frontiers in cellular neuroscience

2021 Volume 14, Page(s) 613320

Abstract: Dendrites are cellular structures essential for the integration of neuronal information. These elegant but complex structures are highly patterned across the nervous system but vary tremendously in their size and fine architecture, each designed to best ... ...

Abstract	Dendrites are cellular structures essential for the integration of neuronal information. These elegant but complex structures are highly patterned across the nervous system but vary tremendously in their size and fine architecture, each designed to best serve specific computations within their networks. Recent
Language	English
Publishing date	2021-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2020.613320
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Patients with infusion-related reactions on fixed-dose rituximab treatment have higher body surface area than those without infusion-related reactions in adults with frequently relapsing minimal change nephrotic syndrome: a retrospective study.

Nishiura, Hironobu / Takahashi, Masaya / Mori, Katsuhito / Sugimoto, Takashi / Emoto, Masanori / Nakamura, Yasutaka

Journal of pharmaceutical health care and sciences

2024 Volume 10, Issue 1, Page(s) 12

Abstract: Background: Infusion-related reactions (IRRs) are major side effects of rituximab administration. Male sex, high body weight, body surface area (BSA), and body mass index are predictive markers of rituximab-induced IRRs. However, as rituximab was not ... ...

Abstract	Background: Infusion-related reactions (IRRs) are major side effects of rituximab administration. Male sex, high body weight, body surface area (BSA), and body mass index are predictive markers of rituximab-induced IRRs. However, as rituximab was not administered at a fixed dosage in a previous study, whether a higher dosage or factors associated with a larger physique are more strongly associated with rituximab-induced IRRs is unknown. Main body: Thirteen adults with frequently relapsing minimal change nephrotic syndrome (MCNS) who received an initial rituximab dose of 500 mg between September 2015 and November 2022 were retrospectively evaluated. Data on IRRs were collected from medical records. The incidence of rituximab-induced IRRs was 38.5% (5/13). The IRR group had a significantly higher BSA than the non-IRR group (median, 1.86 vs. 1.48 m Conclusions: Our study revealed that adults with frequently relapsing MCNS who experienced IRRs tend to have a higher BSA, even with fixed-dose rituximab treatment. Therefore, when patients with higher BSA receive rituximab treatment, clinicians should be careful about monitoring patient condition whether the dosage is fixed or not.
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2809913-8
ISSN	2055-0294
ISSN	2055-0294
DOI	10.1186/s40780-024-00334-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito