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Article ; Online: G

Wilson, Eric A / Sun, Hui / Cui, Zhenzhong / Jahnke, Marshal T / Pandey, Mritunjay / Metzger, Peter / Gavrilova, Oksana / Chen, Min / Weinstein, Lee S

American journal of physiology. Endocrinology and metabolism

2020 Volume 320, Issue 2, Page(s) E270–E280

Abstract: The G-protein subunits G ...

Abstract	The G-protein subunits G
MeSH term(s)	Animals ; Autonomic Nervous System Diseases/genetics ; Autonomic Nervous System Diseases/metabolism ; Autonomic Nervous System Diseases/physiopathology ; Energy Metabolism/genetics ; GTP-Binding Protein alpha Subunits, Gq-G11/deficiency ; GTP-Binding Protein alpha Subunits, Gq-G11/genetics ; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism ; Hypothalamus/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Obesity/genetics ; Obesity/metabolism ; Obesity/physiopathology ; Organ Specificity/genetics ; Sympathetic Nervous System/metabolism ; Sympathetic Nervous System/physiopathology
Chemical Substances	GTP-Binding Protein alpha Subunits, Gq-G11 (EC 3.6.5.1)
Language	English
Publishing date	2020-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	603841-4
ISSN	1522-1555 ; 0193-1849
ISSN (online)	1522-1555
ISSN	0193-1849
DOI	10.1152/ajpendo.00059.2020
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Article: Barriers to g

Foroughi, Olivia / Madraswala, Shaheen / Hayes, Jennifer / Glover, Kara / Lee, Liam / Chaki, Moumita / Redpath, Stella / Yu, Agnes Weixuan / Chiu, David / Amanti, Kristen Garner / Gustavsen, Gary

Journal of personalized medicine

2023 Volume 13, Issue 8

Abstract: Despite the OlympiA trial demonstrating that early-stage, high-risk, HER2- ... ...

Abstract	Despite the OlympiA trial demonstrating that early-stage, high-risk, HER2- germline
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13081228
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Article ; Online: G

Chen, Min / Wilson, Eric A / Cui, Zhenzhong / Sun, Hui / Shrestha, Yogendra B / Podyma, Brandon / Le, Christina H / Naglieri, Benedetta / Pacak, Karel / Gavrilova, Oksana / Weinstein, Lee S

Molecular metabolism

2019 Volume 25, Page(s) 142–153

Abstract: Objective: G: Methods: We created mice (DMHGsKO) with G: Results: DMHGsKO mice developed ... in the DMH suggest that defective DMH MC4R/G: Conclusions: DMH G ...

Abstract	Objective: G Methods: We created mice (DMHGsKO) with G Results: DMHGsKO mice developed severe, early-onset obesity associated with hyperphagia and reduced energy expenditure and locomotor activity, along with impaired brown adipose tissue thermogenesis. Studies in mice with loss of MC4R in the DMH suggest that defective DMH MC4R/G Conclusions: DMH G
MeSH term(s)	Adipose Tissue, Brown/metabolism ; Animals ; Energy Metabolism/physiology ; GTP-Binding Protein alpha Subunits, Gs/genetics ; GTP-Binding Protein alpha Subunits, Gs/metabolism ; Gene Expression Regulation ; Genetic Predisposition to Disease/genetics ; Glucose/metabolism ; Homeostasis/physiology ; Hyperphagia/metabolism ; Hypothalamus/metabolism ; Leptin/metabolism ; Male ; Mice ; Mice, Knockout ; Obesity/genetics ; Obesity/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Receptor, Melanocortin, Type 4/metabolism ; Signal Transduction/physiology ; Sympathetic Nervous System/metabolism ; Thermogenesis/physiology
Chemical Substances	Leptin ; MC4R protein, mouse ; Receptor, Melanocortin, Type 4 ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 (EC 3.1.3.48) ; Ptpn1 protein, mouse (EC 3.1.3.48) ; GTP-Binding Protein alpha Subunits, Gs (EC 3.6.5.1) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2019-04-12
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Intramural
ISSN	2212-8778
ISSN (online)	2212-8778
DOI	10.1016/j.molmet.2019.04.005
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Article ; Online: Reply to G.B. Mann et al and S. Sorscher.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2024 , Page(s) JCO2400224

Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.24.00224
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Noncanonical scaffolding of G

Smith, Jeffrey S / Pack, Thomas F / Inoue, Asuka / Lee, Claudia / Zheng, Kevin / Choi, Issac / Eiger, Dylan S / Warman, Anmol / Xiong, Xinyu / Ma, Zhiyuan / Viswanathan, Gayathri / Levitan, Ian M / Rochelle, Lauren K / Staus, Dean P / Snyder, Joshua C / Kahsai, Alem W / Caron, Marc G / Rajagopal, Sudarshan

Science (New York, N.Y.)

2021 Volume 371, Issue 6534

Abstract: Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) are common ... drug targets and canonically couple to specific G ...

Abstract	Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) are common drug targets and canonically couple to specific G
MeSH term(s)	Bioluminescence Resonance Energy Transfer Techniques ; Cell Movement ; Extracellular Signal-Regulated MAP Kinases/metabolism ; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism ; HEK293 Cells ; Humans ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction ; beta-Arrestins/metabolism
Chemical Substances	Receptors, G-Protein-Coupled ; beta-Arrestins ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; GTP-Binding Protein alpha Subunits, Gi-Go (EC 3.6.5.1)
Language	English
Publishing date	2021-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.aay1833
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Baicalein Induces G

Chuang, Tzu-Chao / Shao, Wei-Syun / Hsu, Shih-Chung / Lee, Shou-Lun / Kao, Ming-Ching / Wang, Vinchi

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 3

Abstract: ... growth inhibition is mediated by the cell cycle arrest in the G ...

Abstract	Ovarian cancer is a lethal gynecological cancer because drug resistance often results in treatment failure. The CHK2, a tumor suppressor, is considered to be an important molecular target in ovarian cancer due to its role in DNA repair. Dysfunctional CHK2 impairs DNA damage-induced checkpoints, reduces apoptosis, and confers resistance to chemotherapeutic drugs and radiation therapy in ovarian cancer cells. This provides a basis for finding new effective agents targeting CHK2 upregulation or activation to treat or prevent the progression of advanced ovarian cancer. Here, the results show that baicalein (5,6,7-trihydroxyflavone) treatment inhibits the growth of highly invasive ovarian cancer cells, and that baicalein-induced growth inhibition is mediated by the cell cycle arrest in the G
MeSH term(s)	Humans ; Female ; Reactive Oxygen Species/metabolism ; M Cells ; Checkpoint Kinase 2/metabolism ; Cell Line, Tumor ; Cell Cycle Checkpoints ; DNA Damage ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology ; Mitosis ; Apoptosis ; Cell Cycle
Chemical Substances	Reactive Oxygen Species ; baicalein (49QAH60606) ; Checkpoint Kinase 2 (EC 2.7.1.11)
Language	English
Publishing date	2023-01-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28031039
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Zs.MO 81: Show issues

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Article ; Online: The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

Alexander, Stephen P H / Christopoulos, Arthur / Davenport, Anthony P / Kelly, Eamonn / Mathie, Alistair A / Peters, John A / Veale, Emma L / Armstrong, Jane F / Faccenda, Elena / Harding, Simon D / Davies, Jamie A / Abbracchio, Maria Pia / Abraham, George / Agoulnik, Alexander / Alexander, Wayne / Al-Hosaini, Khaled / Bäck, Magnus / Baker, Jillian G / Barnes, Nicholas M /

Bathgate, Ross / Beaulieu, Jean-Martin / Beck-Sickinger, Annette G / Behrens, Maik / Bernstein, Kenneth E / Bettler, Bernhard / Birdsall, Nigel J M / Blaho, Victoria / Boulay, Francois / Bousquet, Corinne / Bräuner-Osborne, Hans / Burnstock, Geoffrey / Caló, Girolamo / Castaño, Justo P / Catt, Kevin J / Ceruti, Stefania / Chazot, Paul / Chiang, Nan / Chini, Bice / Chun, Jerold / Cianciulli, Antonia / Civelli, Olivier / Clapp, Lucie H / Couture, Réjean / Cox, Helen M / Csaba, Zsolt / Dahlgren, Claes / Dent, Gordon / Douglas, Steven D / Dournaud, Pascal / Eguchi, Satoru / Escher, Emanuel / Filardo, Edward J / Fong, Tung / Fumagalli, Marta / Gainetdinov, Raul R / Garelja, Michael L / de Gasparo, Marc / Gerard, Craig / Gershengorn, Marvin / Gobeil, Fernand / Goodfriend, Theodore L / Goudet, Cyril / Grätz, Lukas / Gregory, Karen J / Gundlach, Andrew L / Hamann, Jörg / Hanson, Julien / Hauger, Richard L / Hay, Debbie L / Heinemann, Akos / Herr, Deron / Hollenberg, Morley D / Holliday, Nicholas D / Horiuchi, Mastgugu / Hoyer, Daniel / Hunyady, László / Husain, Ahsan / IJzerman, Adriaan P / Inagami, Tadashi / Jacobson, Kenneth A / Jensen, Robert T / Jockers, Ralf / Jonnalagadda, Deepa / Karnik, Sadashiva / Kaupmann, Klemens / Kemp, Jacqueline / Kennedy, Charles / Kihara, Yasuyuki / Kitazawa, Takio / Kozielewicz, Pawel / Kreienkamp, Hans-Jürgen / Kukkonen, Jyrki P / Langenhan, Tobias / Larhammar, Dan / Leach, Katie / Lecca, Davide / Lee, John D / Leeman, Susan E / Leprince, Jérôme / Li, Xaria X / Lolait, Stephen J / Lupp, Amelie / Macrae, Robyn / Maguire, Janet / Malfacini, Davide / Mazella, Jean / McArdle, Craig A / Melmed, Shlomo / Michel, Martin C / Miller, Laurence J / Mitolo, Vincenzo / Mouillac, Bernard / Müller, Christa E / Murphy, Philip M / Nahon, Jean-Louis / Ngo, Tony / Norel, Xavier / Nyimanu, Duuamene / O'Carroll, Anne-Marie / Offermanns, Stefan / Panaro, Maria Antonietta / Parmentier, Marc / Pertwee, Roger G / Pin, Jean-Philippe / Prossnitz, Eric R / Quinn, Mark / Ramachandran, Rithwik / Ray, Manisha / Reinscheid, Rainer K / Rondard, Philippe / Rovati, G Enrico / Ruzza, Chiara / Sanger, Gareth J / Schöneberg, Torsten / Schulte, Gunnar / Schulz, Stefan / Segaloff, Deborah L / Serhan, Charles N / Singh, Khuraijam Dhanachandra / Smith, Craig M / Stoddart, Leigh A / Sugimoto, Yukihiko / Summers, Roger / Tan, Valerie P / Thal, David / Thomas, Walter Wally / Timmermans, Pieter B M W M / Tirupula, Kalyan / Toll, Lawrence / Tulipano, Giovanni / Unal, Hamiyet / Unger, Thomas / Valant, Celine / Vanderheyden, Patrick / Vaudry, David / Vaudry, Hubert / Vilardaga, Jean-Pierre / Walker, Christopher S / Wang, Ji Ming / Ward, Donald T / Wester, Hans-Jürgen / Willars, Gary B / Williams, Tom Lloyd / Woodruff, Trent M / Yao, Chengcan / Ye, Richard D

British journal of pharmacology

2023 Volume 180 Suppl 2, Page(s) S23–S144

Abstract: ... of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one ...

Abstract	The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
MeSH term(s)	Humans ; Databases, Pharmaceutical ; Receptors, G-Protein-Coupled ; Ligands ; Ion Channels/chemistry ; Receptors, Cytoplasmic and Nuclear
Chemical Substances	Receptors, G-Protein-Coupled ; Ligands ; Ion Channels ; Receptors, Cytoplasmic and Nuclear
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.16177
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Article ; Online: Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT

Jeong, Jeong Hyun / Lee, Haeun / Kim, Doyoung / Park, Eunseo / Woo, Jiwan / Cho, Yakdol / Keum, Gyochang / Lee, Ansoo / Kang, Taek / Kim, Jeongjin / Choo, Hyunah / Lee, Sanghee / Jeon, Byungsun

ACS chemical neuroscience

2024 Volume 15, Issue 5, Page(s) 1026–1041

Abstract: In consideration of the limited number of FDA-approved drugs for autism spectrum disorder (ASD), significant efforts have been devoted to identifying novel drug candidates. Among these, 5- ... ...

Abstract	In consideration of the limited number of FDA-approved drugs for autism spectrum disorder (ASD), significant efforts have been devoted to identifying novel drug candidates. Among these, 5-HT
MeSH term(s)	Animals ; Mice ; Autism Spectrum Disorder ; Serotonin ; beta-Arrestins ; Signal Transduction ; Mice, Transgenic ; GTP-Binding Proteins ; Disease Models, Animal ; Microfilament Proteins ; Nerve Tissue Proteins ; Biphenyl Compounds
Chemical Substances	diphenyl (2L9GJK6MGN) ; Serotonin (333DO1RDJY) ; beta-Arrestins ; GTP-Binding Proteins (EC 3.6.1.-) ; Shank3 protein, mouse ; Microfilament Proteins ; Nerve Tissue Proteins ; Biphenyl Compounds
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.3c00738
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Article ; Online: Patient-Reported Outcomes in OlympiA: A Phase III, Randomized, Placebo-Controlled Trial of Adjuvant Olaparib in g

Ganz, Patricia A / Bandos, Hanna / Španić, Tanja / Friedman, Sue / Müller, Volkmar / Kuemmel, Sherko / Delaloge, Suzette / Brain, Etienne / Toi, Masakazu / Yamauchi, Hideko / de Dueñas, Eduardo-M / Armstrong, Anne / Im, Seock-Ah / Song, Chuan-Gui / Zheng, Hong / Sarosiek, Tomasz / Sharma, Priyanka / Geng, Cuizhi / Fu, Peifen /

Rhiem, Kerstin / Frauchiger-Heuer, Heike / Wimberger, Pauline / t'Kint de Roodenbeke, Daphné / Liao, Ning / Goodwin, Annabel / Chakiba-Brugère, Camille / Friedlander, Michael / Lee, Keun Seok / Giacchetti, Sylvie / Takano, Toshimi / Henao-Carrasco, Fernando / Virani, Shamsuddin / Valdes-Albini, Frances / Domchek, Susan M / Bane, Charles / McCarron, Edward C / Mita, Monica / Rossi, Giovanna / Rastogi, Priya / Fielding, Anitra / Gelber, Richard D / Scheepers, Elsemieke D / Cameron, David / Garber, Judy / Geyer, Charles E / Tutt, Andrew N J

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2024 Volume 42, Issue 11, Page(s) 1288–1300

Abstract: Purpose: The OlympiA randomized phase III trial compared 1 year of olaparib (OL) or placebo (PL) as adjuvant therapy in patients with germline : Methods: Data were collected before random assignment, and at 6, 12, 18, and 24 months. The primary end ... ...

Abstract	Purpose: The OlympiA randomized phase III trial compared 1 year of olaparib (OL) or placebo (PL) as adjuvant therapy in patients with germline Methods: Data were collected before random assignment, and at 6, 12, 18, and 24 months. The primary end point was fatigue, measured with the Functional Assessment of Chronic Illness Therapy-Fatigue scale. Secondary end points, assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Core 30 item, included nausea and vomiting (NV), diarrhea, and multiple functional domains. Scores were compared between treatment groups using mixed model for repeated measures. Two-sided Results: One thousand five hundred and thirty-eight patients (NACT: 746, ACT: 792) contributed to the analysis. Fatigue severity was statistically significantly greater for OL versus PL, but not clinically meaningfully different by prespecified criteria (≥3 points) at 6 months (diff OL Conclusion: Treatment-emergent symptoms from OL were limited, generally resolving after treatment ended. OL- and PL-treated patients had similar functional scores, slowly improving during the 24 months after (N)ACT and there was no clinically meaningful persistence of fatigue severity in OL-treated patients.
MeSH term(s)	Female ; Humans ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Fatigue/chemically induced ; Mutation ; Nausea ; Patient Reported Outcome Measures ; Phthalazines ; Piperazines ; Quality of Life ; Receptor, ErbB-2 ; Vomiting
Chemical Substances	BRCA1 Protein ; BRCA1 protein, human ; BRCA2 Protein ; BRCA2 protein, human ; ERBB2 protein, human (EC 2.7.10.1) ; olaparib (WOH1JD9AR8) ; Phthalazines ; Piperazines ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.23.01214
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Article ; Online: Constructing B─N─P Bonds in Ultrathin Holey g-C

Hussien, Mahmoud Kamal / Sabbah, Amr / Qorbani, Mohammad / Putikam, Raghunath / Kholimatussadiah, Septia / Tzou, Der-Lii M / Elsayed, Mohamed Hammad / Lu, Yu-Jung / Wang, Yen-Yu / Lee, Xing-Hao / Lin, Tsai-Yu / Thang, Nguyen Quoc / Wu, Heng-Liang / Haw, Shu-Chih / Wu, Kevin C-W / Lin, Ming-Chang / Chen, Kuei-Hsien / Chen, Li-Chyong

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2400724

Abstract: The lack of intrinsic active sites for photocatalytic ... ...

Abstract	The lack of intrinsic active sites for photocatalytic CO
Language	English
Publishing date	2024-04-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202400724
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