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  1. Article ; Online: Evaluation of the Involvement of Heme Oxygenase-1 Expression in Discoid Lupus Erythematosus Lesions

    Fagone, Paolo / Piombino, Eliana / Mangano, Katia / De Pasquale, Rocco / Nicoletti, F. / Caltabiano, Rosario

    Antioxidants. 2023 June 27, v. 12, no. 7

    2023  

    Abstract: Discoid lupus erythematosus (DLE) is a chronic autoimmune disease that primarily affects the skin, causing red, scaly patches that may be disfiguring and can cause permanent scarring. This study aimed to investigate the potential clinical and therapeutic ...

    Abstract Discoid lupus erythematosus (DLE) is a chronic autoimmune disease that primarily affects the skin, causing red, scaly patches that may be disfiguring and can cause permanent scarring. This study aimed to investigate the potential clinical and therapeutic applications of heme oxygenase-1 (HMOX1) in the context of DLE. Immunohistochemical staining and bioinformatics analysis were performed on skin biopsy samples from DLE patients to examine the levels of HMOX1 and to correlate with markers of inflammation. Our study revealed a negative correlation between HMOX1 levels and the inflammatory status of DLE lesions, as well as an inverse correlation between HMOX1 levels and the infiltration of M1 macrophages and activated mastocytes. These findings suggest that HMOX1 plays a crucial role in the regulation of inflammation in DLE and could be a potential therapeutic target and biomarker for DLE.
    Keywords bioinformatics ; biomarkers ; biopsy ; heme oxygenase (biliverdin-producing) ; immunohistochemistry ; inflammation ; lupus erythematosus ; macrophages
    Language English
    Dates of publication 2023-0627
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12071352
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: The Role of KCNMA1 Expression in Digestive Cancers: A Potential Prognostic Biomarker.

    Pesce, Antonio / Fagone, Paolo / Nicoletti, Ferdinando / Feo, Carlo Vittorio

    Recent patents on anti-cancer drug discovery

    2022  Volume 17, Issue 4, Page(s) 324–325

    MeSH term(s) Biomarkers ; Gastrointestinal Neoplasms ; Gene Expression Regulation, Neoplastic ; Humans ; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/genetics ; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/metabolism ; Prognosis ; RNA, Long Noncoding
    Chemical Substances Biomarkers ; KCNMA1 protein, human ; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits ; RNA, Long Noncoding
    Language English
    Publishing date 2022-01-04
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2250820-X
    ISSN 2212-3970 ; 1574-8928
    ISSN (online) 2212-3970
    ISSN 1574-8928
    DOI 10.2174/1574892817666220104094425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Evaluation of the Involvement of Heme Oxygenase-1 Expression in Discoid Lupus Erythematosus Lesions.

    Fagone, Paolo / Piombino, Eliana / Mangano, Katia / De Pasquale, Rocco / Nicoletti, Ferdinando / Caltabiano, Rosario

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: Discoid lupus erythematosus (DLE) is a chronic autoimmune disease that primarily affects the skin, causing red, scaly patches that may be disfiguring and can cause permanent scarring. This study aimed to investigate the potential clinical and therapeutic ...

    Abstract Discoid lupus erythematosus (DLE) is a chronic autoimmune disease that primarily affects the skin, causing red, scaly patches that may be disfiguring and can cause permanent scarring. This study aimed to investigate the potential clinical and therapeutic applications of heme oxygenase-1 (HMOX1) in the context of DLE. Immunohistochemical staining and bioinformatics analysis were performed on skin biopsy samples from DLE patients to examine the levels of HMOX1 and to correlate with markers of inflammation. Our study revealed a negative correlation between HMOX1 levels and the inflammatory status of DLE lesions, as well as an inverse correlation between HMOX1 levels and the infiltration of M1 macrophages and activated mastocytes. These findings suggest that HMOX1 plays a crucial role in the regulation of inflammation in DLE and could be a potential therapeutic target and biomarker for DLE.
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12071352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Past, Present and (Foreseeable) Future of Biological Anti-TNF Alpha Therapy.

    Leone, Gian Marco / Mangano, Katia / Petralia, Maria Cristina / Nicoletti, Ferdinando / Fagone, Paolo

    Journal of clinical medicine

    2023  Volume 12, Issue 4

    Abstract: Due to the key role of tumor necrosis factor-alpha (TNF-α) in the pathogenesis of immunoinflammatory diseases, TNF-α inhibitors have been successfully developed and used in the clinical treatment of autoimmune disorders. Currently, five anti-TNF-α drugs ... ...

    Abstract Due to the key role of tumor necrosis factor-alpha (TNF-α) in the pathogenesis of immunoinflammatory diseases, TNF-α inhibitors have been successfully developed and used in the clinical treatment of autoimmune disorders. Currently, five anti-TNF-α drugs have been approved: infliximab, adalimumab, golimumab, certolizumab pegol and etanercept. Anti-TNF-α biosimilars are also available for clinical use. Here, we will review the historical development as well as the present and potential future applications of anti-TNF-α therapies, which have led to major improvements for patients with several autoimmune diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), Crohn's disease (CD), ulcerative colitis (UC), psoriasis (PS) and chronic endogenous uveitis. Other therapeutic areas are under evaluation, including viral infections, e.g., COVID-19, as well as chronic neuropsychiatric disorders and certain forms of cancer. The search for biomarkers able to predict responsiveness to anti-TNF-α drugs is also discussed.
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12041630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Preventive and Therapeutic Effects of

    Aleksandrova, Simona / Alexova, Ralitza / Dragomanova, Stela / Kalfin, Reni / Nicoletti, Ferdinando / Fagone, Paolo / Petralia, Maria Cristina / Mangano, Katia / Tancheva, Lyubka

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Pomegranate ( ...

    Abstract Pomegranate (
    MeSH term(s) Polyphenols/pharmacology ; Polyphenols/therapeutic use ; Pomegranate ; Anthocyanins ; Lythraceae ; Tannins/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Hydrolyzable Tannins/pharmacology ; Antioxidants/pharmacology ; Antioxidants/therapeutic use
    Chemical Substances Polyphenols ; Anthocyanins ; Tannins ; Plant Extracts ; Hydrolyzable Tannins ; Antioxidants
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24031856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Computational Analysis of Pathogenetic Pathways in Alzheimer's Disease and Prediction of Potential Therapeutic Drugs.

    Petralia, Maria Cristina / Mangano, Katia / Quattropani, Maria Catena / Lenzo, Vittorio / Nicoletti, Ferdinando / Fagone, Paolo

    Brain sciences

    2022  Volume 12, Issue 7

    Abstract: Background: Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease which affects more than 50 million patients and represents 60-80% of all cases of dementia. Mutations in the APP gene, mostly affecting the γ-secretase site of ... ...

    Abstract Background: Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease which affects more than 50 million patients and represents 60-80% of all cases of dementia. Mutations in the APP gene, mostly affecting the γ-secretase site of cleavage and presenilin mutations, have been identified in inherited forms of AD.
    Methods: In the present study, we performed a meta-analysis of the transcriptional signatures that characterize two familial AD mutations (APP
    Results: Overall, the meta-analysis identified 1479 differentially expressed genes (DEGs), 684 downregulated genes, and 795 upregulated genes. Additionally, we found 14 drugs with a significant anti-similarity to the AD signature, with the top five drugs being naftifine, moricizine, ketoconazole, perindopril, and fexofenadine.
    Conclusions: This study aimed to integrate the transcriptional profiles associated with common familial AD mutations in neurons in order to characterize the pathogenetic mechanisms involved in AD and to find more effective drugs for AD.
    Language English
    Publishing date 2022-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci12070827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Gene Co-Expression Network Modular Analysis Reveals Altered Immune Mechanisms in HIV-HAND.

    Petralia, Maria Cristina / Nicoletti, Ferdinando / Tancheva, Lyubka / Kalfin, Reni / Fagone, Paolo / Mangano, Katia

    Brain sciences

    2022  Volume 12, Issue 10

    Abstract: Although the introduction of HAART has completely changed the natural course of HIV infection, the number of chronic forms of HIV-associated neurocognitive disorder (HAND) has risen. It is estimated that up to half of subjects undergoing HAART therapy ... ...

    Abstract Although the introduction of HAART has completely changed the natural course of HIV infection, the number of chronic forms of HIV-associated neurocognitive disorder (HAND) has risen. It is estimated that up to half of subjects undergoing HAART therapy exhibit mild cognitive impairments. In the current study, we apply the gene co-expression network modular analysis, a well-established system biology approach, to the gene expression profiles of cases from the National NeuroAIDS Tissue Consortium (NNTC). We observed a negative enrichment for genes associated with the control of immune responses and putatively regulated by the transcription factors IRF8 and SPI1 and by both type I and II interferons. Our study provides evidence of altered immune responses, which are likely associated with the occurrence of HAND in the absence of HIV encephalitis (HIVE).
    Language English
    Publishing date 2022-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci12101378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Emerging Therapeutic Potential of Polyphenols from

    Abarova, Silviya / Alexova, Ralitza / Dragomanova, Stela / Solak, Ayten / Fagone, Paolo / Mangano, Katia / Petralia, Maria Cristina / Nicoletti, Ferdinando / Kalfin, Reni / Tancheva, Lyubka

    Biomolecules

    2024  Volume 14, Issue 1

    Abstract: The existing literature supports the anti-inflammatory, antioxidant, and antiviral capacities of the polyphenol extracts derived ... ...

    Abstract The existing literature supports the anti-inflammatory, antioxidant, and antiviral capacities of the polyphenol extracts derived from
    MeSH term(s) Humans ; Polyphenols/pharmacology ; Polyphenols/therapeutic use ; Geranium ; SARS-CoV-2 ; Flavonoids/pharmacology ; Phenols/pharmacology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; COVID-19 ; Virus Diseases/drug therapy
    Chemical Substances Polyphenols ; Flavonoids ; Phenols ; Antiviral Agents ; Plant Extracts
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14010130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evaluation of Cell-Specific Alterations in Alzheimer's Disease and Relevance of In Vitro Models.

    Guido, Giorgio / Mangano, Katia / Tancheva, Lyubka / Kalfin, Reni / Leone, Gian Marco / Saraceno, Andrea / Fagone, Paolo / Nicoletti, Ferdinando / Petralia, Maria Cristina

    Genes

    2023  Volume 14, Issue 12

    Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder classically characterized by two neuropathological hallmarks: β-amyloid plaques and tau tangles in the brain. However, the cellular and molecular mechanisms involved in AD are still elusive, which ... ...

    Abstract Alzheimer's disease (AD) is a neurodegenerative disorder classically characterized by two neuropathological hallmarks: β-amyloid plaques and tau tangles in the brain. However, the cellular and molecular mechanisms involved in AD are still elusive, which dampens the possibility of finding new and more effective therapeutic interventions. Current in vitro models are limited in modelling the complexity of AD pathogenesis. In this study, we aimed to characterize the AD expression signature upon a meta-analysis of multiple human datasets, including different cell populations from various brain regions, and compare cell-specific alterations in AD patients and in vitro models to highlight the appropriateness and the limitations of the currently available models in recapitulating AD pathology. The meta-analysis showed consistent enrichment of the Rho GTPases signaling pathway among different cell populations and in the models. The accuracy of in vitro models was higher for neurons and lowest for astrocytes. Our study underscores the particularly low fidelity in modelling down-regulated genes across all cell populations. The top enriched pathways arising from meta-analysis of human data differ from the enriched pathways arising from the overlap. We hope that our data will prove useful in indicating a starting point in the development of future, more complex, 3D in vitro models.
    MeSH term(s) Humans ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Neurons/metabolism ; Brain/metabolism ; Astrocytes/metabolism
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14122187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Transcriptional upregulation of galectin-3 in multiple sclerosis.

    Mangano, Katia / Petralia, Maria Cristina / Bella, Rita / Pennisi, Manuela / Muñoz-Valle, José Francisco / Hernández-Bello, Jorge / Nicoletti, Ferdinando / Fagone, Paolo

    Immunologic research

    2023  Volume 71, Issue 6, Page(s) 950–958

    Abstract: Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of the central nervous system (CNS) affecting approximately 2.5 million people worldwide. The mechanisms underlying the pathogenesis of MS are still only partially elucidated. Galectins are ...

    Abstract Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of the central nervous system (CNS) affecting approximately 2.5 million people worldwide. The mechanisms underlying the pathogenesis of MS are still only partially elucidated. Galectins are a family of β-galactoside-binding lectins that are involved in the regulation of immune and inflammatory responses and have been shown to exert a role in the maintenance of central nervous system (CNS) homeostasis. There has been an increasing interest in the role of galectin-3 in neuroinflammation and neurodegeneration. In the current study, we have evaluated the expression levels of galectin-3 in different cellular populations involved in the etiopathogenesis of MS. We have observed dramatically higher transcriptomic levels of galectin-3 in encephalitogenic CD4+ T cells in a preclinical model of MS, the MOG-induced experimental allergic encephalomyelitis (EAE). Also, significantly higher levels of galectin-3 were found in microglial cells, astrocytes, and oligodendrocytes isolated from the spinal cord of EAE mice, as well as in human MS-related white matter lesions. Modular co-expression analysis revealed that galectin-3 is co-expressed with genes involved in the regulation of microglia, cytokine production, and chemotaxis. This is the first comprehensive analysis of the expression of galectin-3 in MS, further strengthening its potential pathogenetic role in the etiopathogenesis of this CNS autoimmune disorder.
    MeSH term(s) Animals ; Humans ; Mice ; Encephalomyelitis, Autoimmune, Experimental ; Galectin 3/genetics ; Galectin 3/metabolism ; Galectins/genetics ; Galectins/metabolism ; Mice, Inbred C57BL ; Multiple Sclerosis ; Up-Regulation
    Chemical Substances Galectin 3 ; Galectins ; Lgals3 protein, mouse
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-023-09408-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1755: Show issues Location:
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