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  1. Book ; Online ; E-Book: Prebiotics and probiotics in disease regulation and management

    Kesharwani, Rajesh Kumar / Rao, T. Jagan Mohan / Keservani, Raj K.

    2022  

    Author's details edited by Rajesh Kumar Kesharwani, T. Jagan Mohan Rao, and Raj K. Keservani
    Keywords Probiotics
    Subject code 615.329
    Language English
    Size 1 online resource (342 pages)
    Publisher Wiley
    Publishing place Hoboken, New Jersey
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-394-16722-9 ; 1-394-16721-0 ; 9781394166275 ; 978-1-394-16722-7 ; 978-1-394-16721-0 ; 1394166273
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Recent trends in soft beverages

    Rao, L. Jagan Mohan

    (Woodhead Publishing India in food science, technology and nutrition)

    2011  

    Author's details [ed. by] L. Jagan Mohan Rao
    Series title Woodhead Publishing India in food science, technology and nutrition
    Keywords Getränkeindustrie ; Alkoholfreies Getränk
    Subject Nichtalkoholisches Getränk ; Alkoholfreie Getränke ; Getränk
    Language English
    Size XVI, 259 S. : Ill., graph. Darst.
    Publisher Woodhead Publ. India, WPI
    Publishing place New Delhi u.a.
    Publishing country India
    Document type Book
    HBZ-ID HT016886421
    ISBN 978-0-85709-009-6 ; 978-93-803081-2-8 ; 0-85709-009-7 ; 93-803081-2-4
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    118/1426 available for loan (reading room) Freihandmagazin (U1)

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  3. Article ; Online: Molecular Docking studies of chemical constituents of Rauwolfia serpentina on hypertension

    Mohan Reddy Jagan / Verma Pankaj / Agrawal Isha / Vyas Manish / Kumar Sahu Sanjeev

    BIO Web of Conferences, Vol 86, p

    2024  Volume 01044

    Abstract: Hypertension is still a prevalent cardiovascular disorder which remains a major global health concern. Rauwolfia serpentina, renowned for its therapeutic potential in managing hypertension, harbors a diverse array of bioactive compounds. This study aimed ...

    Abstract Hypertension is still a prevalent cardiovascular disorder which remains a major global health concern. Rauwolfia serpentina, renowned for its therapeutic potential in managing hypertension, harbors a diverse array of bioactive compounds. This study aimed to elucidate the molecular interactions of chemical constituents derived from Rauwolfia serpentina with key hypertensive targets through molecular docking simulations. Utilizing computational tool, a comprehensive library of phytoconstituents obtained from Rauwolfia serpentina was constructed and subjected to molecular docking analyses against human angiotensin receptor (4ZUD) as target protein. The results revealed significant binding affinities between the chemical constituents of Rauwolfia serpentina and the active sites of these molecular targets. This study bridges the knowledge gap regarding the molecular mechanisms underlying the antihypertensive effects of Rauwolfia serpentina's constituents through computational simulations. The identified compounds exhibiting strong binding affinities and favorable interactions serve as promising candidates for further in vitro and in vivo studies, offering avenues for the development of novel therapeutic agents for hypertension management.
    Keywords Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
    Subject code 541
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Membrane remodeling by SARS-CoV-2 - double-enveloped viral replication.

    Mohan, Jagan / Wollert, Thomas

    Faculty reviews

    2021  Volume 10, Page(s) 17

    Abstract: The ongoing pandemic of the new severe acute respiratory syndrome coronavirus (SARS-CoV-2) has caused more than one million deaths, overwhelmed many public health systems, and led to a worldwide economic recession. This has raised an unprecedented need ... ...

    Abstract The ongoing pandemic of the new severe acute respiratory syndrome coronavirus (SARS-CoV-2) has caused more than one million deaths, overwhelmed many public health systems, and led to a worldwide economic recession. This has raised an unprecedented need to develop antiviral drugs and vaccines, which requires profound knowledge of the fundamental pathology of the virus, including its entry, replication, and release from host cells. The genome of coronaviruses comprises around 30 kb of positive single-stranded RNA, representing one of the largest RNA genomes of viruses. The 5' part of the genome encodes a large polyprotein, PP1ab, which gives rise to 16 non-structural proteins (nsp1- nsp16). Two proteases encoded in nsp3 and nsp5 cleave the polyprotein into individual proteins. Most nsps belong to the viral replicase complex that promotes replication of the viral genome and translation of structural proteins by producing subgenomic mRNAs. The replicase complexes are found on double-membrane vesicles (DMVs) that contain viral double-stranded RNA. Expression of a small subset of viral proteins, including nsp3 and nsp4, is sufficient to induce formation of these DMVs in human cells, suggesting that both proteins deform host membranes into such structures. We will discuss the formation of DMVs and provide an overview of other membrane remodeling processes that are induced by coronaviruses.
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-432X
    ISSN (online) 2732-432X
    DOI 10.12703/r/10-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Valorisation of resistant starch from foxtail millet for the development of gluten-free cereal bars and their quality evaluation

    Babu, Ayenampudi Surendra / Mohan, Rangarajan Jagan

    Food Measure. 2023 Apr., v. 17, no. 2 p.1899-1908

    2023  

    Abstract: The present study was aimed to develop and test the quality of gluten-free cereal bars supplemented with different types of resistant starches (type 3, 4, and 5) at varying levels (0%, 5%, and 10%). The addition of resistant starch with various ... ...

    Abstract The present study was aimed to develop and test the quality of gluten-free cereal bars supplemented with different types of resistant starches (type 3, 4, and 5) at varying levels (0%, 5%, and 10%). The addition of resistant starch with various concentrations significantly increased the dietary fiber in bars since resistant starch is considered as a component of dietary fiber. Furthermore, resistant starch content of experimental bars prepared with 5 and 10% of resistant starch is ranged between 5.94–6.30% and 10.70–11.54% respectively. Higher resistant starch incorporation (10 g/100 g) negatively influenced the sensory properties of the gluten-free bars during the storage. A significant increase in moisture and hardness values (control bar—6596.85–7383.18 g, experimental bars—4165.11–7113.81 g) were observed in all resistant starch bars during 60 days of storage. It is feasible to incorporate different types of resistant starch at a 5% level in gluten-free bars which will supply a pronounced amount of dietary fiber, iron, and calcium without compromising product acceptability.
    Keywords Setaria italica ; calcium ; dietary fiber ; hardness ; iron ; resistant starch
    Language English
    Dates of publication 2023-04
    Size p. 1899-1908.
    Publishing place Springer US
    Document type Article ; Online
    ZDB-ID 2754612-3
    ISSN 2193-4134 ; 2193-4126
    ISSN (online) 2193-4134
    ISSN 2193-4126
    DOI 10.1007/s11694-022-01745-z
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: ATP-induced conformational change of axonemal outer dynein arms revealed by cryo-electron tomography.

    Zimmermann, Noemi / Noga, Akira / Obbineni, Jagan Mohan / Ishikawa, Takashi

    The EMBO journal

    2023  Volume 42, Issue 12, Page(s) e112466

    Abstract: Axonemal outer dynein arm (ODA) motors generate force for ciliary beating. We analyzed three states of the ODA during the power stroke cycle using in situ cryo-electron tomography, subtomogram averaging, and classification. These states of force ... ...

    Abstract Axonemal outer dynein arm (ODA) motors generate force for ciliary beating. We analyzed three states of the ODA during the power stroke cycle using in situ cryo-electron tomography, subtomogram averaging, and classification. These states of force generation depict the prepower stroke, postpower stroke, and intermediate state conformations. Comparison of these conformations to published in vitro atomic structures of cytoplasmic dynein, ODA, and the Shulin-ODA complex revealed differences in the orientation and position of the dynein head. Our analysis shows that in the absence of ATP, all dynein linkers interact with the AAA3/AAA4 domains, indicating that interactions with the adjacent microtubule doublet B-tubule direct dynein orientation. For the prepower stroke conformation, there were changes in the tail that is anchored on the A-tubule. We built models starting with available high-resolution structures to generate a best-fitting model structure for the in situ pre- and postpower stroke ODA conformations, thereby showing that ODA in a complex with Shulin adopts a similar conformation as the active prepower stroke ODA in the axoneme.
    MeSH term(s) Dyneins/metabolism ; Electron Microscope Tomography ; Axonemal Dyneins/chemistry ; Axonemal Dyneins/metabolism ; Axoneme/metabolism ; Cilia/metabolism ; Adenosine Triphosphate ; Flagella/metabolism
    Chemical Substances Dyneins (EC 3.6.4.2) ; Axonemal Dyneins (EC 3.6.4.2) ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2022112466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1808: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 100: Show issues

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  7. Article ; Online: Progress in the drug encapsulation of poly(lactic-

    Dodda, Jagan Mohan / Remiš, Tomáš / Rotimi, Sadiku / Yeh, Yi-Cheun

    Journal of materials chemistry. B

    2022  Volume 10, Issue 22, Page(s) 4127–4141

    Abstract: Poly(lactic- ...

    Abstract Poly(lactic-
    MeSH term(s) Drug Carriers/chemistry ; Folic Acid/chemistry ; Humans ; Male ; Nanoparticles/chemistry ; Neoplasms ; Polyethylene Glycols/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer ; United States
    Chemical Substances Drug Carriers ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyethylene Glycols (3WJQ0SDW1A) ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2022-06-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d2tb00469k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: AMMI and GGE Stability Analysis of Drought Tolerant Chickpea (Cicer arietinum L) Genotypes for Target Environments

    Jagan Mohan Rao, P. / Sandhyakishore, N. / Srinivasan, S. / Sandeep, S. / G. Praveen / Neelima, G. / Anil Kumar, G.

    Legume research

    2023  Volume 46, Issue 9, Page(s) 1105

    Document type Article
    ZDB-ID 407856-1
    ISSN 0250-5371
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 3393: Show issues

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  9. Article ; Online: In-Vitro Prebiotic Analysis of Microbiota Accessible Pectic Polysaccharides.

    Tingirikari, Jagan Mohan Rao

    Current microbiology

    2019  Volume 76, Issue 12, Page(s) 1452–1460

    Abstract: Pectin is a diverse polysaccharide comprising of polygalacturonic acid, rhamnogalactouronan, and neutral polysaccharides (arabinan and arabinogalactan) as side chains or branches. They are resistant to salivary amylase and gastric juice. In the present ... ...

    Abstract Pectin is a diverse polysaccharide comprising of polygalacturonic acid, rhamnogalactouronan, and neutral polysaccharides (arabinan and arabinogalactan) as side chains or branches. They are resistant to salivary amylase and gastric juice. In the present study the prebiotic potentials of different pectic derived substrates were performed by using intestinal cultures and measuring the growth, change in pH and short chain fatty acid, (SCFA) production. Arabinan, arabinogalactan, and rhamnogalacturonan were fermented by probiotic bacteria such as Bifidobacterium breve, Bi. longum, Bi. bifidum, and Bacteroides thetaiotaomicron (commensal bacteria). While, polygalacturonic acid was fermented by Ba. fragilis, Ba. thetaiotaomicron, and Ba. uniformis. All the screened bacteria significantly decreased the pH from 7 to 5 (pH difference of ≈ 2), which clearly indicated that the above bacteria produced the enzymes necessary for the digestion of the pectic derived polysaccharides. The SCFA profiles of the above screened bacteria clearly demonstrated the production of lactate, acetate and propionate which are the key metabolites involved in maintaining gut health and prevention of several intestinal diseases. Thus, pectic polysaccharides hold potential application in food industry as prebiotic ingredients or dietary fibers.
    MeSH term(s) Animals ; Bacteria/classification ; Bacteria/growth & development ; Bacteria/metabolism ; Dietary Fiber/metabolism ; Fatty Acids, Volatile/analysis ; Fatty Acids, Volatile/metabolism ; Fermentation ; Gastrointestinal Microbiome ; Humans ; Hydrogen-Ion Concentration ; Pectins/chemistry ; Pectins/metabolism ; Polysaccharides/chemistry ; Polysaccharides/metabolism ; Prebiotics/analysis ; Species Specificity
    Chemical Substances Dietary Fiber ; Fatty Acids, Volatile ; Polysaccharides ; Prebiotics ; Pectins (89NA02M4RX)
    Language English
    Publishing date 2019-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-019-01781-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1446: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Seamless Integration of Conducting Hydrogels in Daily Life: From Preparation to Wearable Application.

    Imani, Kusuma Betha Cahaya / Dodda, Jagan Mohan / Yoon, Jinhwan / Torres, Fernando G / Imran, Abu Bin / Deen, G Roshan / Al-Ansari, Renad

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  Volume 11, Issue 13, Page(s) e2306784

    Abstract: Conductive hydrogels (CHs) have received significant attention for use in wearable devices because they retain their softness and flexibility while maintaining high conductivity. CHs are well suited for applications in skin-contact electronics and ... ...

    Abstract Conductive hydrogels (CHs) have received significant attention for use in wearable devices because they retain their softness and flexibility while maintaining high conductivity. CHs are well suited for applications in skin-contact electronics and biomedical devices owing to their high biocompatibility and conformality. Although highly conductive hydrogels for smart wearable devices are extensively researched, a detailed summary of the outstanding results of CHs is required for a comprehensive understanding. In this review, the recent progress in the preparation and fabrication of CHs is summarized for smart wearable devices. Improvements in the mechanical, electrical, and functional properties of high-performance wearable devices are also discussed. Furthermore, recent examples of innovative and highly functional devices based on CHs that can be seamlessly integrated into daily lives are reviewed.
    MeSH term(s) Hydrogels ; Wearable Electronic Devices ; Electronics ; Electric Conductivity
    Chemical Substances Hydrogels
    Language English
    Publishing date 2024-01-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202306784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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