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  1. Article ; Online: Feasibility of daily pain measurement using text messages in hidradenitis suppurativa clinical trials; data from the THESEUS study.

    Hasan, Samar B / Bates, Janine / Cannings-John, Rebecca / Collier, Fiona / Evans, Judith / Gibbons, Angela / Harris, Ceri / Howells, Laura / Hood, Kerenza / Howes, Rachel / Leighton, Paul / Riaz, Muhammad / Rodrigues, Jeremy / Stanton, Helen / Thomas, Kim S / Thomas-Jones, Emma / Ingram, John R

    The British journal of dermatology

    2024  Volume 190, Issue 5, Page(s) 775–777

    MeSH term(s) Humans ; Hidradenitis Suppurativa/drug therapy ; Pain Measurement ; Text Messaging ; Feasibility Studies ; Quality of Life
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljae057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Biophysical studies of lipid nanodomains using different physical characterization techniques.

    Kinnun, Jacob J / Scott, Haden L / Bolmatov, Dima / Collier, C Patrick / Charlton, Timothy R / Katsaras, John

    Biophysical journal

    2023  Volume 122, Issue 6, Page(s) 931–949

    Abstract: For the past 50 years, evidence for the existence of functional lipid domains has been steadily accumulating. Although the notion of functional lipid domains, also known as "lipid rafts," is now widely accepted, this was not always the case. This ... ...

    Abstract For the past 50 years, evidence for the existence of functional lipid domains has been steadily accumulating. Although the notion of functional lipid domains, also known as "lipid rafts," is now widely accepted, this was not always the case. This ambiguity surrounding lipid domains could be partly attributed to the fact that they are highly dynamic, nanoscopic structures. Since most commonly used techniques are sensitive to microscale structural features, it is therefore, not surprising that it took some time to reach a consensus regarding their existence. In this review article, we will discuss studies that have used techniques that are inherently sensitive to nanoscopic structural features (i.e., neutron scatting, nuclear magnetic resonance, and Förster resonance energy transfer). We will also mention techniques that may be of use in the future (i.e., cryoelectron microscopy, droplet interface bilayers, inelastic x-ray scattering, and neutron reflectometry), which can further our understanding of the different and unique physicochemical properties of nanoscopic lipid domains.
    MeSH term(s) Lipid Bilayers/chemistry ; Cryoelectron Microscopy ; Fluorescence Resonance Energy Transfer
    Chemical Substances Lipid Bilayers
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2023.01.024
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  3. Article ; Online: A tribute to Sjur: Sjur Olsnes, 1939-2014.

    Collier, R John

    Pathogens and disease

    2015  Volume 73, Issue 8, Page(s) ftv077

    MeSH term(s) Bacterial Proteins/metabolism ; Bacterial Proteins/toxicity ; History, 20th Century ; History, 21st Century ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Plant Proteins/metabolism ; Plant Proteins/toxicity ; Toxins, Biological/metabolism ; Toxins, Biological/toxicity ; Virus Internalization
    Chemical Substances Bacterial Proteins ; Intercellular Signaling Peptides and Proteins ; Plant Proteins ; Toxins, Biological
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ISSN 2049-632X
    ISSN (online) 2049-632X
    DOI 10.1093/femspd/ftv077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exploring the Utility of Buchwald Ligands for C-H Oxidative Direct Arylation Polymerizations.

    Collier, Graham S / Reynolds, John R

    ACS macro letters

    2019  Volume 8, Issue 8, Page(s) 931–936

    Abstract: Oxidative C-H/C-H cross-coupling polymerizations provide an opportunity to synthesize conjugated polymers with an increased ease of monomer preparation, reduced environmental impact, and increased sustainability. Considering these attributes, it is ... ...

    Abstract Oxidative C-H/C-H cross-coupling polymerizations provide an opportunity to synthesize conjugated polymers with an increased ease of monomer preparation, reduced environmental impact, and increased sustainability. Considering these attributes, it is necessary to expand the diversity of monomers that readily and efficiently participate in this coupling strategy to enable the development of conjugated polymers with a wide range of properties. Herein, the oxidative direct arylation polymerization toolbox is expanded to include 3,4-propylenedioxythiophene being synthesized via C-H/C-H cross-coupling methodologies. In conjunction with these efforts, the utilization of Buchwald ligands in C-H/C-H cross coupling polymerizations also is reported, and variations in the ligand structure provide insight into the role ligand choice has on C-H cross-coupling polymerizations. Specifically, it is determined that the phosphine functionality affects the rate-determining, concerted metalation-deprotonation step of the catalytic cycle, while bulky isopropyl substituents on the ligand's lower aryl ring promote reductive elimination. By balancing these steric effects on the ancillary ligands, polymers are synthesized to exhibit molecular weights above the effective conjugation length, with recovered yields >90%. In addition to expanding the scope of conjugated polymers accessible via oxidative direct arylation polymerization, these results provide the foundational understanding for utilizing Buchwald-type ligands in C-H-activated polymerizations.
    Language English
    Publishing date 2019-07-16
    Publishing country United States
    Document type Journal Article
    ISSN 2161-1653
    ISSN (online) 2161-1653
    DOI 10.1021/acsmacrolett.9b00395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: IoT Data Quality Assessment Framework Using Adaptive Weighted Estimation Fusion.

    Byabazaire, John / O'Hare, Gregory M P / Collier, Rem / Delaney, Declan

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 13

    Abstract: Timely data quality assessment has been shown to be crucial for the development of IoT-based applications. Different IoT applications' varying data quality requirements pose a challenge, as each application requires a unique data quality process. This ... ...

    Abstract Timely data quality assessment has been shown to be crucial for the development of IoT-based applications. Different IoT applications' varying data quality requirements pose a challenge, as each application requires a unique data quality process. This creates scalability issues as the number of applications increases, and it also has financial implications, as it would require a separate data pipeline for each application. To address this challenge, this paper proposes a novel approach integrating fusion methods into end-to-end data quality assessment to cater to different applications within a single data pipeline. By using real-time and historical analytics, the study investigates the effects of each fusion method on the resulting data quality score and how this can be used to support different applications. The study results, based on two real-world datasets, indicate that Kalman fusion had a higher overall mean quality score than Adaptive weighted fusion and Naïve fusion. However, Kalman fusion also had a higher computational burden on the system. The proposed solution offers a flexible and efficient approach to addressing IoT applications' diverse data quality needs within a single data pipeline.
    Language English
    Publishing date 2023-06-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23135993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Research priorities in the management of hidradenitis suppurativa.

    Leighton, Paul / Howells, Laura / Bates, Janine / Gibbons, Angela / Cannings-John, Rebecca / Collier, Fiona / Evans, Judith / Harris, Ceri / Hood, Kerry / Howes, Rachel / Riaz, Muhammad / Rodrigues, Jeremy / Stanton, Helen / Thomas-Jones, Emma / Thomas, Kim / Ingram, John R

    The British journal of dermatology

    2023  Volume 189, Issue 3, Page(s) 343–345

    MeSH term(s) Humans ; Hidradenitis Suppurativa/diagnosis ; Hidradenitis Suppurativa/therapy ; Research
    Language English
    Publishing date 2023-05-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad152
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  7. Article ; Online: The Holobiont/Hologenome Concept Series.

    Collier, R John / Casadevall, Arturo

    mBio

    2016  Volume 7, Issue 2, Page(s) e00605–16

    MeSH term(s) Editorial Policies ; Genome ; Humans ; Symbiosis
    Language English
    Publishing date 2016-04-14
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00605-16
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  8. Article ; Online: Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs.

    Collier, Fiona / Howes, Rachel / Rodrigues, Jeremy / Thomas, Kim S / Leighton, Paul / Ingram, John R

    BJGP open

    2021  Volume 5, Issue 5

    Abstract: Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that causes painful discharging nodules and skin tunnels. HS has associations with several systemic diseases, including cardiovascular disease (CVD), anxiety, and ... ...

    Abstract Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that causes painful discharging nodules and skin tunnels. HS has associations with several systemic diseases, including cardiovascular disease (CVD), anxiety, and depression. High levels of chronic morbidity suggest an important role for primary care. However, little evidence exists regarding current management of HS and its comorbidities in UK general practice.
    Aim: To describe current practice among UK GPs in treating and referring people with HS.
    Design & setting: A web-based survey was circulated to UK Primary Care Dermatology Society (PCDS) members and GPs in Forth Valley, Scotland.
    Method: Survey responses were analysed with descriptive statistics.
    Results: A total of 134 UK GPs completed the survey. Seventy per cent (
    Conclusion: GPs regularly diagnose and manage uncomplicated HS, but screening for important comorbidities associated with HS is not common practice.
    Language English
    Publishing date 2021-10-26
    Publishing country England
    Document type Journal Article
    ISSN 2398-3795
    ISSN (online) 2398-3795
    DOI 10.3399/BJGPO.2021.0051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The surgical management of hidradenitis suppurativa in the United Kingdom: a national survey of care pathways informing the THESEUS study.

    Howes, Rachel / Ingram, John R / Thomas, Kim S / Collier, Fiona / Rodrigues, Jeremy N

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2021  Volume 75, Issue 1, Page(s) 240–247

    Abstract: Background: The evidence-base underpinning treatment efficacy and effectiveness for hidradenitis suppurativa (HS) is limited, as has been highlighted in the wide-ranging research priorities established by a James Lind Alliance priority-setting ... ...

    Abstract Background: The evidence-base underpinning treatment efficacy and effectiveness for hidradenitis suppurativa (HS) is limited, as has been highlighted in the wide-ranging research priorities established by a James Lind Alliance priority-setting partnership (PSP). Understanding the landscape of surgical practice is a key step towards tackling undesired variation in care and resolving treatment uncertainties. This survey of current surgical practice aimed to describe care pathways involving surgeons for the management of HS and surgical approaches to management.
    Methods: In the development of the prospective cohort Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS), a bespoke electronic surgeon survey was conducted to describe variation in care pathways and surgical preferences in the management of HS. This was disseminated to a pre-defined denominator list of surgeons using local collaborators through the reconstructive surgery trials network (RSTN).
    Results: Key results were small numbers of surgeons working in formal multidisciplinary teams (MDTs) (8/198, 4%), heterogeneity of first-line intervention, low rates of guideline endorsed treatments (laser and deroofing in particular), variation in wound closure methods and follow-up length, and that over half of respondents do not use well-validated outcome instruments to determine treatment success/failure (110/198, 56%).
    Conclusions: This survey demonstrated variation in care, which is likely to be undesirable. Surgeons treating HS patients might consider developing MDTs or referring patients to those with an interest in HS and considering routine outcome measurement. Such steps might reduce variation, increase standardisation of care and improve access to specific treatments.
    MeSH term(s) Critical Pathways ; Hidradenitis Suppurativa/surgery ; Humans ; Prospective Studies ; Research ; United Kingdom
    Language English
    Publishing date 2021-09-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2021.08.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Exploring Isomeric Effects on Optical and Electrochemical Properties of Red/Orange Electrochromic Polymers

    Collier, Graham S / Wilkins, Riley / Tomlinson, Aimée L / Reynolds, John R

    Macromolecules. 2021 Feb. 05, v. 54, no. 4

    2021  

    Abstract: Subtle structural changes in monomeric building blocks can have an immense effect, whether positive or detrimental, on the resulting properties of conjugated polymers. With this in mind, it is paramount to understand structure–property relationships that ...

    Abstract Subtle structural changes in monomeric building blocks can have an immense effect, whether positive or detrimental, on the resulting properties of conjugated polymers. With this in mind, it is paramount to understand structure–property relationships that serve as the guiding principles for manipulating optical and electrochemical characteristics. Herein, a family of dialkylthiophene-co-propylenedioxythiophene copolymers are synthesized via direct arylation polymerizations, with a key design motif being minimal changes in the structural composition of the propylenedioxythiophene comonomer. Variation in the substitution pattern on the propylene bridge provides insights into the role of stereo- and compositional isomers on the resulting polymer properties. Specifically, time-dependent density functional theory calculations reveal changes in the number and placement of comonomers with varying composition and stereocenters, impacting the calculated absorbance spectra, as evident from calculated absorbance maxima spanning 75 nm, which ultimately manifests in differences in the calculated color. Experimentally, UV–vis absorbance spectroscopy and colorimetry reveal a dependence on the stereo- and regiospecificity, while electrochromic properties, such as contrast and switching times, are not drastically affected by the substitution patterns. Independent of position and functionality, each polymer exhibited a transmittance change greater than 65% at the maximum absorbance wavelength while maintaining the ability to rapidly switch between colored and transmissive states in organic electrolytes. This work highlights how subtle structural changes can manipulate and optimize optical features without sacrificing electrochromic properties such as kinetic switching time and optical contrast. In addition to fundamental insights into monomeric design of propylenedioxythiophene building blocks and their optical and redox characteristics, the results provide an additional structural handle for fine-tuning the observed color of electrochromic polymers.
    Keywords absorbance ; arylation ; color ; colorimetry ; composite polymers ; density functional theory ; electrochemistry ; propylene ; regioselectivity ; spectroscopy ; transmittance ; wavelengths
    Language English
    Dates of publication 2021-0205
    Size p. 1677-1692.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1491942-4
    ISSN 1520-5835 ; 0024-9297
    ISSN (online) 1520-5835
    ISSN 0024-9297
    DOI 10.1021/acs.macromol.0c02719
    Database NAL-Catalogue (AGRICOLA)

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