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  1. Book ; Online: Towards Global, Socio-Economic, and Culturally Aware Recommender Systems

    Yohe, Kelley Ann

    2023  

    Abstract: ... While these systems have primarily focused on applications such as advertisement recommendations (e.g., Google ... personalized suggestions (e.g., Netflix and Spotify), and retail selection (e.g., Amazon), there is potential ... machine learning models and develop a final artificial neural network model (ANN) that addresses this gap ...

    Abstract Recommender systems have gained increasing attention to personalise consumer preferences. While these systems have primarily focused on applications such as advertisement recommendations (e.g., Google), personalized suggestions (e.g., Netflix and Spotify), and retail selection (e.g., Amazon), there is potential for these systems to benefit from a more global, socio-economic, and culturally aware approach, particularly as companies seek to expand into diverse markets. This paper aims to investigate the potential of a recommender system that considers cultural identity and socio-economic factors. We review the most recent developments in recommender systems and explore the impact of cultural identity and socio-economic factors on consumer preferences. We then propose an ontology and approach for incorporating these factors into recommender systems. To illustrate the potential of our approach, we present a scenario in consumer subscription plan selection within the entertainment industry. We argue that existing recommender systems have limited ability to precisely understand user preferences due to a lack of awareness of socio-economic factors and cultural identity. They also fail to update recommendations in response to changing socio-economic conditions. We explore various machine learning models and develop a final artificial neural network model (ANN) that addresses this gap. We evaluate the effectiveness of socio-economic and culturally aware recommender systems across four dimensions: Precision, Accuracy, F1, and Recall. We find that a highly tuned ANN model incorporating domain-specific data, select cultural indices and relevant socio-economic factors predicts user preference in subscriptions with an accuracy of 95%, a precision of 94%, a F1 Score of 92\%, and a Recall of 90\%.
    Keywords Computer Science - Information Retrieval ; Computer Science - Computers and Society
    Subject code 303
    Publishing date 2023-12-10
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Vascular injury is associated with repetitive head impacts and tau pathology in chronic traumatic encephalopathy.

    Kirsch, Daniel / Shah, Arsal / Dixon, Erin / Kelley, Hunter / Cherry, Jonathan D / Xia, Weiming / Daley, Sarah / Aytan, Nurgul / Cormier, Kerry / Kubilus, Carol / Mathias, Rebecca / Alvarez, Victor E / Huber, Bertrand R / McKee, Ann C / Stein, Thor D

    Journal of neuropathology and experimental neurology

    2023  Volume 82, Issue 2, Page(s) 127–139

    Abstract: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive head impacts (RHI) and characterized by perivascular hyperphosphorylated tau (p-tau) deposits. The role of vascular injury, blood-brain barrier leakage, and ... ...

    Abstract Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive head impacts (RHI) and characterized by perivascular hyperphosphorylated tau (p-tau) deposits. The role of vascular injury, blood-brain barrier leakage, and neuroinflammation in CTE pathogenesis is not well understood. We performed quantitative immunoassays for intercellular adhesion molecule 1 (ICAM1), vascular cellular adhesion molecule 1 (VCAM1), and C-reactive protein (CRP) within the postmortem dorsolateral frontal cortex of participants with and without a history of RHI and CTE (n = 156), and tested for associations with RHI, microgliosis, and tau pathology measures. Levels of vascular injury-associated markers ICAM1, VCAM1, and CRP were increased in CTE compared to RHI-exposed and -naïve controls. ICAM1 and CRP increased with RHI exposure duration (p < 0.01) and were associated with increased microglial density (p < 0.001) and tau pathology (AT8, p-tau396, p-tau202; p < 0.05). Histologically, there was significantly increased ICAM1 staining of the microvasculature, extracellular space, and astrocytes at the sulcal depths in high stage CTE compared to both low stage CTE and controls. Multifocal perivascular immunoreactivity for serum albumin was present in all RHI-exposed individuals. These findings demonstrate that vascular injury markers are associated with RHI exposure, duration, and microgliosis, are elevated in CTE, and increase with disease severity.
    MeSH term(s) Humans ; Chronic Traumatic Encephalopathy/pathology ; Neurodegenerative Diseases ; Vascular System Injuries/complications ; Frontal Lobe/metabolism ; Blood-Brain Barrier/pathology ; tau Proteins/metabolism
    Chemical Substances tau Proteins
    Language English
    Publishing date 2023-01-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlac122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Worms clear the smoke surrounding nicotine addiction.

    Kelley, Ann E

    Cell

    2006  Volume 127, Issue 3, Page(s) 460–462

    Abstract: In this issue of Cell, Feng et al. report a worm model of nicotine dependence that shows behavioral adaptations surprisingly similar to those in humans. These authors show a critical link between nicotinic receptors and TRP channels, which may represent ... ...

    Abstract In this issue of Cell, Feng et al. report a worm model of nicotine dependence that shows behavioral adaptations surprisingly similar to those in humans. These authors show a critical link between nicotinic receptors and TRP channels, which may represent a new therapeutic target for treating nicotine addiction.
    MeSH term(s) Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Ankyrin Repeat ; Behavior, Animal/physiology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/physiology ; Humans ; Molecular Sequence Data ; Nicotine/pharmacology ; Protein Structure, Tertiary ; Receptors, Nicotinic/drug effects ; Receptors, Nicotinic/genetics ; Receptors, Nicotinic/metabolism ; Receptors, Nicotinic/physiology ; Sequence Homology, Amino Acid ; TRPC Cation Channels/chemistry ; TRPC Cation Channels/genetics ; TRPC Cation Channels/physiology ; Tobacco Use Disorder
    Chemical Substances Receptors, Nicotinic ; TRPC Cation Channels ; TRPC3 cation channel ; Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2006-11-03
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2006.10.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Risk Factors for Incident Polycystic Ovary Syndrome Diagnosis.

    Christ, Jacob P / Yu, Onchee / Barton, Brooke / Schulze-Rath, Renate / Grafton, Jane / Cronkite, David / Covey, Jennifer / Kelley, Ann / Holden, Erika / Hilpert, Jan / Sacher, Frank / Micks, Elizabeth / Reed, Susan D

    Journal of women's health (2002)

    2024  

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2023.0741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: 100% Fruit Juice and Dental Health: A Systematic Review of the Literature.

    Liska, DeAnn / Kelley, Michael / Mah, Eunice

    Frontiers in public health

    2019  Volume 7, Page(s) 190

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2019-07-12
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2019.00190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evaluation of antimicrobial purchasing by companion animal veterinary facilities in Canada, the United Kingdom, and the United States of America (2019-2021).

    Weese, J Scott / Mosher, Margo / Low, Rochelle / West, Ellie / O'Kelley, Ben / Morrison, Jo Ann / Kimmerlein, Anne / St Bernard, Silene / Blackie, Kathrine / Gronlund, Ulrika / Battersby, Ian

    Journal of veterinary internal medicine

    2024  

    Abstract: Background: Measuring antimicrobial use is a core component of antimicrobial stewardship. Purchasing data may be easier to obtain than prescription data in some situations, but differences in clinic size, caseload and collection timeframes must be ... ...

    Abstract Background: Measuring antimicrobial use is a core component of antimicrobial stewardship. Purchasing data may be easier to obtain than prescription data in some situations, but differences in clinic size, caseload and collection timeframes must be considered.
    Objective: Our objective was to evaluate purchases of systemic antibacterial agents by small animal veterinary facilities in 5 networks across 3 countries, using a mg/veterinarian full time equivalent (FTE)/week as the metric.
    Methods: Data were obtained from purchasing records of 2194 veterinary facilities from networks from the United States (US, n = 3: US-A, 1036 facilities; US-B, 101 facilities; US-C, 886 facilities), Canada (n = 1: 117 facilities) and the United Kingdom (UK, n = 1: 54 facilities) during 2019-2021.
    Results: In total, 20 020 269 767 mg (20.02 t) of antimicrobials were purchased. Overall differences between the UK and North America were driven by significantly higher purchases of amoxicillin-clavulanic acid in the UK (P < .001), with substantially less purchasing of third generation cephalosporins in the UK (P < .0001). A significant association was found between FTE and purchasing, with decreased purchasing (mg/FTE/week) as facility FTE increased. Significant differences also were found among US regions. Facilities in the top 10% of total purchasing accounted for 23%-30% of purchases, compared to only 1.6%-3.8% for the bottom 10%.
    Conclusions and clinical importance: These data provide useful information about general purchasing trends, inter- and intraregional differences and differences among facility types and identify high purchasing outliers for further investigation.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.17068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Memory and addiction: shared neural circuitry and molecular mechanisms.

    Kelley, Ann E

    Neuron

    2004  Volume 44, Issue 1, Page(s) 161–179

    Abstract: An important conceptual advance in the past decade has been the understanding that the process of drug addiction shares striking commonalities with neural plasticity associated with natural reward learning and memory. Basic mechanisms involving dopamine, ...

    Abstract An important conceptual advance in the past decade has been the understanding that the process of drug addiction shares striking commonalities with neural plasticity associated with natural reward learning and memory. Basic mechanisms involving dopamine, glutamate, and their intracellular and genomic targets have been the focus of attention in this research area. These two neurotransmitter systems, widely distributed in many regions of cortex, limbic system, and basal ganglia, appear to play a key integrative role in motivation, learning, and memory, thus modulating adaptive behavior. However, many drugs of abuse exert their primary effects precisely on these pathways and are able to induce enduring cellular alterations in motivational networks, thus leading to maladaptive behaviors. Current theories and research on this topic are reviewed from an integrative systems perspective, with special emphasis on cellular, molecular, and behavioral aspects of dopamine D-1 and glutamate NMDA signaling, instrumental learning, and drug cue conditioning.
    MeSH term(s) Animals ; Behavior, Addictive/genetics ; Behavior, Addictive/metabolism ; Behavior, Addictive/physiopathology ; Humans ; Memory/physiology ; Nerve Net/physiology
    Language English
    Publishing date 2004-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2004.09.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Nicotinic receptors: addiction's smoking gun?

    Kelley, Ann E

    Nature medicine

    2002  Volume 8, Issue 5, Page(s) 447–449

    MeSH term(s) Humans ; Models, Biological ; Receptors, Nicotinic/physiology ; Smoking/adverse effects ; Tobacco Use Disorder/physiopathology
    Chemical Substances Receptors, Nicotinic
    Language English
    Publishing date 2002-05
    Publishing country United States
    Document type News
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm0502-447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning.

    Kelley, Ann E

    Neuroscience and biobehavioral reviews

    2004  Volume 27, Issue 8, Page(s) 765–776

    Abstract: ... the probability that temporally related actions and events (e.g. lever pressing and delivery of reward) become ...

    Abstract The nucleus accumbens is a brain region that participates in the control of behaviors related to natural reinforcers, such as ingestion, sexual behavior, incentive and instrumental learning, and that also plays a role in addictive processes. This paper comprises a review of work from our laboratory that focuses on two main research areas: (i). the role of the nucleus accumbens in food motivation, and (ii). its putative functions in cellular plasticity underlying appetitive learning. First, work within a number of different behavioral paradigms has shown that accumbens neurochemical systems play specific and dissociable roles in different aspects of food seeking and food intake, and part of this function depends on integration with the lateral hypothalamus and amygdala. We propose that the nucleus accumbens integrates information related to cognitive, sensory, and emotional processing with hypothalamic mechanisms mediating energy balance. This system as a whole enables complex hierarchical control of adaptive ingestive behavior. Regarding the second research area, our studies examining acquisition of lever-pressing for food in rats have shown that activation of glutamate N-methyl-d-aspartate (NMDA) receptors, within broadly distributed but interconnected regions (nucleus accumbens core, posterior striatum, prefrontal cortex, basolateral and central amygdala), is critical for such learning to occur. This receptor stimulation triggers intracellular cascades that involve protein phosphorylation and new protein synthesis. It is hypothesized that activity in this distributed network (including D1 receptor activity) computes coincident events and thus enhances the probability that temporally related actions and events (e.g. lever pressing and delivery of reward) become associated. Such basic mechanisms of plasticity within this reinforcement learning network also appear to be profoundly affected in addiction.
    MeSH term(s) Animals ; Appetitive Behavior/physiology ; Basal Ganglia/physiology ; Conditioning, Operant/physiology ; Eating/physiology ; Feeding Behavior/physiology ; Humans ; Hypothalamic Area, Lateral/physiology ; Motivation ; Nerve Net/physiology ; Neuronal Plasticity/physiology ; Nucleus Accumbens/cytology ; Nucleus Accumbens/physiology ; Receptors, N-Methyl-D-Aspartate/physiology ; Reward
    Chemical Substances Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2004-01
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2003.11.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy.

    Rosen, Grace / Kirsch, Daniel / Horowitz, Sarah / Cherry, Jonathan D / Nicks, Raymond / Kelley, Hunter / Uretsky, Madeline / Dell'Aquila, Kevin / Mathias, Rebecca / Cormier, Kerry A / Kubilus, Caroline A / Mez, Jesse / Tripodis, Yorghos / Stein, Thor D / Alvarez, Victor E / Alosco, Michael L / McKee, Ann C / Huber, Bertrand R

    Acta neuropathologica communications

    2023  Volume 11, Issue 1, Page(s) 123

    Abstract: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts (RHI) and characterized by perivascular accumulations of hyperphosphorylated tau protein (p-tau) at the depths of the cortical sulci. ...

    Abstract Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts (RHI) and characterized by perivascular accumulations of hyperphosphorylated tau protein (p-tau) at the depths of the cortical sulci. Studies of living athletes exposed to RHI, including concussive and nonconcussive impacts, have shown increased blood-brain barrier permeability, reduced cerebral blood flow, and alterations in vasoreactivity. Blood-brain barrier abnormalities have also been reported in individuals neuropathologically diagnosed with CTE. To further investigate the three-dimensional microvascular changes in individuals diagnosed with CTE and controls, we used SHIELD tissue processing and passive delipidation to optically clear and label blocks of postmortem human dorsolateral frontal cortex. We used fluorescent confocal microscopy to quantitate vascular branch density and fraction volume. We compared the findings in 41 male brain donors, age at death 31-89 years, mean age 64 years, including 12 donors with low CTE (McKee stage I-II), 13 with high CTE (McKee stage III-IV) to 16 age- and sex-matched non-CTE controls (7 with RHI exposure and 9 with no RHI exposure). The density of vessel branches in the gray matter sulcus was significantly greater in CTE cases than in controls. The ratios of sulcus versus gyrus vessel branch density and fraction volume were also greater in CTE than in controls and significantly above one for the CTE group. Hyperphosphorylated tau pathology density correlated with gray matter sulcus fraction volume. These findings point towards increased vascular coverage and branching in the dorsolateral frontal cortex (DLF) sulci in CTE, that correlates with p-tau pathology.
    MeSH term(s) Humans ; Male ; Middle Aged ; Adult ; Aged ; Aged, 80 and over ; Chronic Traumatic Encephalopathy/pathology ; Neurodegenerative Diseases/pathology ; Brain/pathology ; tau Proteins/metabolism ; Frontal Lobe/metabolism ; Athletes
    Chemical Substances tau Proteins
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2715589-4
    ISSN 2051-5960 ; 2051-5960
    ISSN (online) 2051-5960
    ISSN 2051-5960
    DOI 10.1186/s40478-023-01612-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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