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Article ; Online: The 90 plus: longevity and COVID-19 survival.

Zatz, Mayana / Silva, Monize V R / de Castro, Mateus V / Naslavsky, Michel S

2022 Volume 27, Issue 4, Page(s) 1936–1944

Abstract: The world population is getting older and studies aiming to enhance our comprehension of the underlying mechanisms responsible for health span are of utmost interest for longevity and as a measure for health care. In this review, we summarized previous ... ...

Abstract	The world population is getting older and studies aiming to enhance our comprehension of the underlying mechanisms responsible for health span are of utmost interest for longevity and as a measure for health care. In this review, we summarized previous genetic association studies (GWAS) and next-generation sequencing (NGS) of elderly cohorts. We also present the updated hypothesis for the aging process, together with the factors associated with healthy aging. We discuss the relevance of studying older individuals and build databanks to characterize the presence and resistance against late-onset disorders. The identification of about 2 million novel variants in our cohort of more than 1000 elderly Brazilians illustrates the importance of studying highly admixed populations of non-European ancestry. Finally, the ascertainment of nonagenarians and particularly of centenarians who were recovered from COVID-19 or remained asymptomatic opens new avenues of research aiming to enhance our comprehension of biological mechanisms associated with resistance against pathogens.
MeSH term(s)	Aged ; Aged, 80 and over ; Brazil ; COVID-19 ; Cohort Studies ; Genetic Association Studies ; Humans ; Longevity/genetics
Language	English
Publishing date	2022-02-08
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-022-01461-6
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Article ; Online: Immunological evaluation of young unvaccinated patients with Turner syndrome after COVID-19.

de Castro, Mateus V / Silva, Monize V R / Oliveira, Luana de M / Gozzi-Silva, Sarah C / Naslavsky, Michel S / Scliar, Marilia O / Magalhães, Monize L / da Rocha, Katia M / Nunes, Kelly / Castelli, Erick C / Magawa, Jhosiene Y / Santos, Keity S / Cunha-Neto, Edecio / Sato, Maria N / Zatz, Mayana

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2023 Volume 129, Page(s) 207–215

Abstract: Objectives: The X-chromosome contains the largest number of immune-related genes, which play a major role in COVID-19 symptomatology and susceptibility. Here, we had a unique opportunity to investigate, for the first time, COVID-19 outcomes in six ... ...

Abstract	Objectives: The X-chromosome contains the largest number of immune-related genes, which play a major role in COVID-19 symptomatology and susceptibility. Here, we had a unique opportunity to investigate, for the first time, COVID-19 outcomes in six unvaccinated young Brazilian patients with Turner syndrome (TS; 45, X0), including one case of critical illness in a child aged 10 years, to evaluate their immune response according to their genetic profile. Methods: A serological analysis of humoral immune response against SARS-CoV-2, phenotypic characterization of antiviral responses in peripheral blood mononuclear cells after stimuli, and the production of cytotoxic cytokines of T lymphocytes and natural killer cells were performed in blood samples collected from the patients with TS during the convalescence period. Whole exome sequencing was also performed. Results: Our volunteers with TS showed a delayed or insufficient humoral immune response to SARS-CoV-2 (particularly immunoglobulin G) and a decrease in interferon-γ production by cluster of differentiation (CD)4+ and CD8+ T lymphocytes after stimulation with toll-like receptors 7/8 agonists. In contrast, we observed a higher cytotoxic activity in the volunteers with TS than the volunteers without TS after phorbol myristate acetate/ionomycin stimulation, particularly granzyme B and perforin by CD8+ and natural killer cells. Interestingly, two volunteers with TS carry rare genetic variants in genes that regulate type I and III interferon immunity. Conclusion: Following previous reports in the literature for other conditions, our data showed that patients with TS may have an impaired immune response against SARS-CoV-2. Furthermore, other medical conditions associated with TS could make them more vulnerable to COVID-19.
MeSH term(s)	Child ; Humans ; COVID-19 ; SARS-CoV-2 ; Turner Syndrome/complications ; Turner Syndrome/genetics ; Leukocytes, Mononuclear ; CD8-Positive T-Lymphocytes ; Antibodies, Viral
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2023-02-08
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2023.01.042
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Article: Corrigendum: Follow-up of young adult monozygotic twins after simultaneous critical coronavirus disease 2019: a case report.

de Castro, Mateus V / Silva, Monize V R / Soares, Flávia B / Cória, Vivian R / Naslavsky, Michel S / Scliar, Marilia O / Castelli, Erick C / de Oliveira, Jamile R / de Medeiros, Giuliana X / Sasahara, Greyce L / Santos, Keity S / Cunha-Neto, Edecio / Kalil, Jorge / Zatz, Mayana

Frontiers in medicine

2023 Volume 10, Page(s) 1185833

Abstract: This corrects the article DOI: 10.3389/fmed.2022.1008585.]. ...

Abstract	[This corrects the article DOI: 10.3389/fmed.2022.1008585.].
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1185833
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Article ; Online: Men are the main COVID-19 transmitters: behavior or biology?

Silva, Monize V R / de Castro, Mateus V / Passos-Bueno, Maria Rita / Otto, Paulo A / Naslavsky, Michel S / Zatz, Mayana

Discover mental health

2022 Volume 2, Issue 1, Page(s) 1

Abstract: Background: COVID-19 has affected millions of people worldwide. Clinical manifestations range from severe cases with lethal outcome to mild or asymptomatic cases. Although the proportion of infected individuals does not differ between sexes, men are ... ...

Abstract	Background: COVID-19 has affected millions of people worldwide. Clinical manifestations range from severe cases with lethal outcome to mild or asymptomatic cases. Although the proportion of infected individuals does not differ between sexes, men are more susceptible to severe COVID-19, with a higher risk of death than women. Also, men are pointed out as more lax regarding protective measures, mask wearing and vaccination. Thus, we questioned whether sex-bias may be explained by biological pathways and/or behavioral aspects or both. Methods: Between July 2020 and July 2021, we performed an epidemiological survey including 1744 unvaccinated adult Brazilian couples, with there was at least one infected symptomatic member, who were living together during the COVID-19 infection without protective measures. Presence or absence of infection was confirmed by RT-PCR and/or serology results. Couples were divided into two groups: (1) both partners were infected (concordant couples) and (2) one partner was infected and the spouse remained asymptomatic despite the close contact with the COVID-19 symptomatic partner (discordant couples). Statistical analysis of the collected data was performed aiming to verify a differential transmission potential between genders in couples keeping contact without protective measures. Results: The combination of our collected data showed that the man is the first (or the only) affected member in most cases when compared to women and that this difference may be explained by biological and behavioral factors. Conclusions: The present study confirmed the existence of gender differences not only for susceptibility to infection and resistance to COVID-19 but also in its transmission rate.
Language	English
Publishing date	2022-01-24
Publishing country	Switzerland
Document type	Journal Article
ISSN	2731-4383
ISSN (online)	2731-4383
DOI	10.1007/s44192-022-00004-3
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Article: Follow-up of young adult monozygotic twins after simultaneous critical coronavirus disease 2019: A case report.

de Castro, Mateus V / Silva, Monize V R / Soares, Flávia B / Cória, Vivian R / Naslavsky, Michel S / Scliar, Marilia O / Castelli, Erick C / de Oliveira, Jamile R / Sasahara, Greyce L / Santos, Keity S / Cunha-Neto, Edecio / Kalil, Jorge / Zatz, Mayana

Frontiers in medicine

2022 Volume 9, Page(s) 1008585

Abstract: Background: The influence of the host genome on coronavirus disease 2019 (COVID-19) susceptibility and severity is supported by reports on monozygotic (MZ) twins where both were infected simultaneously with similar disease outcomes, including several ... ...

Abstract	Background: The influence of the host genome on coronavirus disease 2019 (COVID-19) susceptibility and severity is supported by reports on monozygotic (MZ) twins where both were infected simultaneously with similar disease outcomes, including several who died due to the SARS-CoV-2 infection within days apart. However, successive exposures to pathogens throughout life along with other environmental factors make the immune response unique for each individual, even among MZ twins. Case presentation and methods: Here we report a case of a young adult monozygotic twin pair, who caught attention since both presented simultaneously severe COVID-19 with the need for oxygen support despite age and good health conditions. One of the twins, who spent more time hospitalized, reported symptoms of long-COVID even 7 months after infection. Immune cell profile and specific responses to SARS-CoV-2 were evaluated as well as whole exome sequencing. Conclusion: Although the MZ twin brothers shared the same genetic mutations which may be associated with their increased risk of developing severe COVID-19, their clinical progression was different, reinforcing the role of both immune response and genetics in the COVID-19 presentation and course. Besides, post-COVID syndrome was observed in one of them, corroborating an association between the duration of hospitalization and the occurrence of long-COVID symptoms.
Language	English
Publishing date	2022-09-29
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.1008585
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Article ; Online: Men are the main COVID-19 transmitters: lessons from couples

Silva, Monize V. R. / de Castro, Mateus V. / Passos-Bueno, Maria Rita / Otto, Paulo A. / Naslavsky, Michel S. / Zatz, Mayana

medRxiv

Abstract: Background: COVID-19 has affected millions of people worldwide. Clinical manifestations range from severe cases with a lethal outcome to mild or asymptomatic cases. Although there is the same proportion of infected genders, men are more susceptible to ... ...

Abstract	Background: COVID-19 has affected millions of people worldwide. Clinical manifestations range from severe cases with a lethal outcome to mild or asymptomatic cases. Although there is the same proportion of infected genders, men are more susceptible to severe COVID-19, with a higher risk of death than women. This sex-bias may be explained by biological pathways. Methods: We performed an epidemiological survey from July 2020 to July 2021 including 1744 unvaccinated adult Brazilian couples with at least one infected spouse despite living together during the COVID-19 infection without protective measures. The presence or absence of infection was confirmed by RT-PCR and/or serology results. The couples were divided between groups where both partners were infected (concordant couples) or only one spouse remained asymptomatic despite the close contact with the infected one (discordant couples). Statistical analysis of the collected data was performed aiming to verify a differential transmitter potential between genders in household contact. Results: The combination of our data collected from concordant and discordant couples showed that the man is the first (or the only) affected in the major occurrences when compared to women. Our findings support other published surveys and are in concordance with previous studies of our group. Conclusions: These observations support the hypothesis according to which male individuals are more efficient virus transmitters than females, independently of the use of protective masks. In short, the present study confirmed the existence of gender differences not only for susceptibility to infection and resistance to COVID-19 but also in the transmission rate.
Keywords	covid19
Language	English
Publishing date	2021-08-24
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.08.18.21262187
Database	COVID19

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Article: Correction: The oldest unvaccinated Covid-19 survivors in South America.

de Castro, Mateus V / Silva, Monize V R / Naslavsky, Michel S / Scliar, Marilia O / Nunes, Kelly / Passos-Bueno, Maria Rita / Castelli, Erick C / Magawa, Jhosiene Y / Adami, Flávia L / Moretti, Ana I S / de Oliveira, Vivian L / Boscardin, Silvia B / Cunha-Neto, Edecio / Kalil, Jorge / Jouanguy, Emmanuelle / Bastard, Paul / Casanova, Jean-Laurent / Quiñones-Vega, Mauricio / Sosa-Acosta, Patricia /

Guedes, Jéssica de S / de Almeida, Natália P / Nogueira, Fábio C S / Domont, Gilberto B / Santos, Keity S / Zatz, Mayana

Immunity & ageing : I & A

2022 Volume 19, Issue 1, Page(s) 61

Language	English
Publishing date	2022-12-07
Publishing country	England
Document type	Published Erratum
ZDB-ID	2168941-6
ISSN	1742-4933
ISSN	1742-4933
DOI	10.1186/s12979-022-00319-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 in twins: What can we learn from them

Castro, Mateus V. / Silva, Monize V. R. / Naslavsky, Michel S. / Santos, Keity S. / Magawa, Jhosiene Y. / Cunha-Neto, Edecio / Passos Bueno, Maria Rita / Zatz, Mayana

medRxiv

Abstract: Investigations on the concordance in monozygotic (MZ) as compared to dizygotic (DZ) twins may reveal if there is a genetic component increasing the susceptibility or resistance against an infectious disease. Here, we compared the concordance rates of ... ...

Abstract	Investigations on the concordance in monozygotic (MZ) as compared to dizygotic (DZ) twins may reveal if there is a genetic component increasing the susceptibility or resistance against an infectious disease. Here, we compared the concordance rates of SARS-CoV-2 infection in MZ versus DZ young twins who shared the same bedrooms and were equally exposed to the virus. The concordance rate was higher in the MZ group supporting a complex multifactorial inheritance responsible for SARS-Cov-2 infection.
Keywords	covid19
Language	English
Publishing date	2021-10-02
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.09.29.21263145
Database	COVID19

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Article ; Online: Recurrence of COVID-19 associated with reduced T-cell responses in a monozygotic twin pair.

de Castro, Mateus V / Santos, Keity S / Apostolico, Juliana S / Fernandes, Edgar R / Almeida, Rafael R / Levin, Gabriel / Magawa, Jhosiene Y / Nunes, João Paulo S / Bruni, Mirian / Yamamoto, Marcio M / Lima, Ariane C / Silva, Monize V R / Matos, Larissa R B / Coria, Vivian R / Castelli, Erick C / Scliar, Marilia O / Kuramoto, Andreia / Bruno, Fernanda R / Jacintho, Lucas C /

Nunes, Kelly / Wang, Jaqueline Y T / Coelho, Veronica P / Neto, Miguel Mitne / Maciel, Rui M B / Naslavsky, Michel S / Passos-Bueno, Maria Rita / Boscardin, Silvia B / Rosa, Daniela S / Kalil, Jorge / Zatz, Mayana / Cunha-Neto, Edecio

Open biology

2022 Volume 12, Issue 2, Page(s) 210240

Abstract: Recurrence of COVID-19 in recovered patients has been increasingly reported. However, the immune mechanisms behind the recurrence have not been thoroughly investigated. The presence of neutralizing antibodies (nAbs) in recurrence/reinfection cases ... ...

Abstract	Recurrence of COVID-19 in recovered patients has been increasingly reported. However, the immune mechanisms behind the recurrence have not been thoroughly investigated. The presence of neutralizing antibodies (nAbs) in recurrence/reinfection cases suggests that other types of immune response are involved in protection against recurrence. Here, we investigated the innate type I/III interferon (IFN) response, binding and nAb assays and T-cell responses to severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) with IFN gamma (IFN
MeSH term(s)	Adolescent ; Adult ; COVID-19/immunology ; Epitopes, T-Lymphocyte/immunology ; Female ; Humans ; Immunity, Cellular ; Male ; Recurrence ; SARS-CoV-2/immunology ; T-Lymphocytes/immunology ; Twins, Monozygotic
Chemical Substances	Epitopes, T-Lymphocyte
Language	English
Publishing date	2022-02-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Twin Study
ZDB-ID	2630944-0
ISSN	2046-2441 ; 2046-2441
ISSN (online)	2046-2441
ISSN	2046-2441
DOI	10.1098/rsob.210240
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The oldest unvaccinated Covid-19 survivors in South America.

Guedes, Jéssica de S / de Almeida, Natália P / Nogueira, Fábio C S / Domont, Gilberto B / Santos, Keity S / Zatz, Mayana

Immunity & ageing : I & A

2022 Volume 19, Issue 1, Page(s) 57

Abstract: Background: Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, ... ...

Abstract	Background: Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Results: Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN. Conclusion: These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.
Language	English
Publishing date	2022-11-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2168941-6
ISSN	1742-4933
ISSN	1742-4933
DOI	10.1186/s12979-022-00310-y
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