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  1. Article ; Online: Perturbações do comportamento alimentar em adolescentes - o que procurar?

    Bacalhau, Sílvia / Moleiro, Pascoal

    Acta medica portuguesa

    2010  Volume 23, Issue 5, Page(s) 777–784

    Abstract: Background: Increase in the incidence and prevalence of Eating Disorders have made it increasingly important that Health Care Professionals be familiar with the early detection and appropriate management of this group of disorders.: Objectives: To ... ...

    Title translation Eating disorders in adolescents - what to look for?.
    Abstract Background: Increase in the incidence and prevalence of Eating Disorders have made it increasingly important that Health Care Professionals be familiar with the early detection and appropriate management of this group of disorders.
    Objectives: To characterize an adolescent population followed in Adolescent Medicine office visit of Pediatric Department in Leiria's Hospital with Eating Disorders for type of disorder, presence of alert signs and symptoms and risk factors for an early detection of disease.
    Methods: Retrospective analytic study conducted by consulting clinical processes and first office visit questionnaires of adolescent population followed for Eating Disorders, between August 2005 and April 2008. Criteria of Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition were considered to define Eating Disorder type.
    Results: Twenty two adolescents were included, with 20 girls. Five adolescents met all Anorexia Nervosa criteria and two met all Bulimia Nervosa criteria. The other 15 were included in Eating Disorder Not Otherwise Specified. All samples showed intense fear of gaining weight and 20 adolescents a disturbed body image. All adolescents confessed having restrictive eating attitudes, half had compensatory behaviors and four assume having recurrent episodes of binge eating. Almost all revealed some type of somatic complaint and 19 showed psychological symptoms. One third of this population had personal history of obesity/overweight. Most adolescents presented weight lost when observed in the first office visit. Six adolescents showed body weight under 85% of that expected. One third of postmenarche adolescents suffered from secondary amenorrhea. Half of adolescents reported dysfunctional family and one quarter had separate parents; eight adolescents had family history of mental illness.
    Conclusion: Most adolescents were included in the diagnosis of Eating Disorder Not Otherwise Specified, according with other studies in this age. This fact implies that in practice the suspicion of an Eating Disorder in an adolescent should not be restricted to the meeting of other categories criteria. For an early detection, relevance should be given to aspects like a weight loss even without an abnormal body mass index, an inappropriate eating attitude, a dissatisfaction with body image, associated with a multiplicity of psychosomatic complaints, in a dysfunctional family environment.
    MeSH term(s) Adolescent ; Child ; Feeding and Eating Disorders/diagnosis ; Female ; Humans ; Male ; Retrospective Studies ; Surveys and Questionnaires
    Language Portuguese
    Publishing date 2010-09
    Publishing country Portugal
    Document type English Abstract ; Journal Article
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Doença de Arranhadura do Gato em Adolescente

    Miguel Pereira / Sofia Carneiro / Mónica Braz / Sílvia Bacalhau / Cristina Borges / Ana Serrão Neto

    Gazeta Médica, Vol 5, Iss

    2018  Volume 4

    Abstract: A doença da arranhadura do gato manifesta-se, na maioria dos casos, por linfadenopatia regional e autolimitada, com resolução gradual sem antibioterapia. Apresentamos o caso de uma adolescente com tumefação da região ântero-medial do cotovelo direito com ...

    Abstract A doença da arranhadura do gato manifesta-se, na maioria dos casos, por linfadenopatia regional e autolimitada, com resolução gradual sem antibioterapia. Apresentamos o caso de uma adolescente com tumefação da região ântero-medial do cotovelo direito com sinais inflamatórios com 4 semanas de evolução, associada a febre e cansaço. Medicada inicialmente em ambulatório com amoxicilina/ácido clavulânico, azitromicina e clindamicina sem melhoria, pelo que ficou internada sob ceftriaxone e clindamicina. A ecografia revelou coleções abcedadas que foram puncionadas, com saída de conteúdo purulento. Serologias compatíveis com infeção recente a Bartonella henselae. Teve alta clinicamente melhorada sob ciprofloxacina oral. Relatamos uma apresentação persistente da infeção a Bartonella henselae com lesões abcedadas, com necessidade de internamento para antibioterapia endovenosa e punção da lesão.
    Keywords Adolescente ; Doença da Arranhadura do Gato ; Bartonella henselae ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher José de Mello Saúde
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Meningite bacteriana. Uma etiologia pouco frequente.

    Bacalhau, Sílvia / Zarcos, Maria Manuel / Rezende, Teresa

    Acta medica portuguesa

    2011  Volume 24 Suppl 3, Page(s) 627–630

    Abstract: Background: Meningitis is an uncommon clinical manifestation of invasive infection by Streptococcus pyogenes.: Case report: A four years-old female child, previously healthy, started a history of high fever, associated to right otorrhea, prostration ... ...

    Title translation Bacterial meningitis. A rare cause.
    Abstract Background: Meningitis is an uncommon clinical manifestation of invasive infection by Streptococcus pyogenes.
    Case report: A four years-old female child, previously healthy, started a history of high fever, associated to right otorrhea, prostration and vomiting. On admission she was haemodynamically stable but prostrated, with stiff neck and right otorrhea. Laboratory evaluation showed leukocytosis with neutrophilia, thrombocytosis and high C-reactive protein. The cerebrospinal fluid (CSF) examination suggested bacterial meningitis and treatment with ceftriaxone was started. After Streptococcus pyogenes grew in the CSF, clindamycin was added. She completed 15 days of antibiotics and was discharged clinically recovered. No neurological or hearing sequelae were observed.
    Conclusions: Although the incidence of group A streptococcal meningitis seems to be low, invasive infection by this agent is raising. Despite the excellent evolution of this case, a fatal outcome or neurological sequelae can arise, even in healthy children.
    MeSH term(s) Child, Preschool ; Female ; Humans ; Meningitis, Bacterial/microbiology ; Rare Diseases/microbiology ; Streptococcal Infections ; Streptococcus pyogenes
    Language Portuguese
    Publishing date 2011-12
    Publishing country Portugal
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Doença inflamatória intestinal pediátrica: uma patologia em crescendo?

    Fernandes, Ana / Bacalhau, Sílvia / Cabral, José

    Acta medica portuguesa

    2011  Volume 24 Suppl 2, Page(s) 333–338

    Abstract: Introduction: Crohn's disease (CD), Ulcerative Colitis (UC) and Indeterminate Colitis (IC), commonly known as Inflammatory Bowel Disease (IBD) represent a heterogeneous group of chronic diseases of unknown origin and varying course, diagnosed in ... ...

    Title translation Pediatric inflammatory bowel disease: is it still increasing?.
    Abstract Introduction: Crohn's disease (CD), Ulcerative Colitis (UC) and Indeterminate Colitis (IC), commonly known as Inflammatory Bowel Disease (IBD) represent a heterogeneous group of chronic diseases of unknown origin and varying course, diagnosed in pediatric age at 25 to 30% of cases. Epidemiological international studies studies show IBD incidence has increased exponentially in industrialized nations over the last 50 years.
    Objectives: Characterization of the pediatric population diagnosed with IBD, followed at medical consultation in Gastroenterology at Hospital de Dona Estefânia (HDE).
    Material and methods: Descriptive and retrospective study by consulting the medical files of patients diagnosed with IBD followed between 1987 and 2009 (23 years). Clinical, radiological and histological criteria were used to define IBD. The following variables were studied: sex, family history, race, characterization of IBD, age at diagnosis, time from onset of symptoms to diagnosis and clinical presentation. Four different periods of time were compared: 1987-1992, 1993-1998, 1999-2004 and 2005-2009.
    Results: 100 children were included (51 female), of which 59% are CD, 38% UC and 3% IC. Family history of IBD was present in 7 cases, with no sex difference between UC and CD. During the period of time between 2005-2009, it was registered the highest number of new cases (55 total, mean: 11 cases / year) and between 1987-1992 the lowest (9, 1.5 cases / year). Time from onset of symptoms to diagnosis was highly variable, ranging from 9 months (1987-1992) to 4 months (2005-2009). Children's age at the time of diagnosis varied from 14 months to 17 years, with a mean of 10.5 years. The most common symptoms at time of presentation were abdominal pain, diarrhea, and hematochezia.
    Conclusion: IBD are a heterogeneous group of diseases, not always easy to diagnose and difficult to classify as diagnostic criteria are not always uniform. The results show the number of IBD new cases has been rising during the last two decades, mainly CD, with no difference between gender. Time from onset of symptoms to diagnosis has been decreasing although age at time of diagnosis and clinical presentation has showed no difference in the last 20 years.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Inflammatory Bowel Diseases/epidemiology ; Male ; Retrospective Studies ; Time Factors
    Language Portuguese
    Publishing date 2011-12
    Publishing country Portugal
    Document type English Abstract ; Journal Article
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Transmissão perinatal do vírus da hepatite C - Hospital Santo André, Leiria 2002-2006.

    Bacalhau, Sílvia / Timóteo, Catarina / Agro, João

    Acta medica portuguesa

    2010  Volume 23, Issue 3, Page(s) 391–398

    Abstract: Background: Vertical transmission of hepatitis C virus (HCV) is the main route of infection in children, occurring in few cases (five percent). Current recommendations for HCV screening include first anti-HCV testing at age > 18 months, reducing false ... ...

    Title translation Perinatal transmission of hepatitis C virus - Santo André Hospital, Leiria 2002-2006.
    Abstract Background: Vertical transmission of hepatitis C virus (HCV) is the main route of infection in children, occurring in few cases (five percent). Current recommendations for HCV screening include first anti-HCV testing at age > 18 months, reducing false positives and false negatives. Positive results must be confirmed by the presence of HCV RNA on two different occasions.
    Aims: To characterize the population of children born to HCV-positive mothers, to identify risk factors for perinatal HCV transmission and to improve the approach to HCV screening.
    Methods: The study was conducted in two phases. An analytic retrospective study enrolling children born to HCV-positive mothers between January 2002 and December 2006 was done, followed by a transversal analysis in order to repeat anti-HCV testing, in cases that didn't meet current recommendations for HCV screening and in those without any HCV screening.
    Results: Fifty-nine children born to HCV-positive mothers in a total of 12 985 births were included, corresponding to a prevalence of 0,45%. A high rate of inadequate pregnancy surveillance, prematurity and low birth weight, mainly in children born to addicted mothers was found. A child with HCV infection without any risk factor for perinatal transmission was found. Among children with negative anti-HCV at age 18 months, half had done anti-HCV prior to nine months of age, all were positive. Children discharged because of negative anti-HCV at nine months of age were called in a second phase of the study, for new anti-HCV at age > 18 months. All were negative.
    Conclusions: Perinatal HCV transmission rate was 2,9%. There was no identified risk factor for perinatal transmission in the single case of HCV infection. A high rate of prematurity, low birth weight and inadequate surveillance of pregnancy was found, with statistical significance to relation with mother addiction. Regarding anti-HCV at age < 18 months, a high rate of false positives but no false negative results were found. This study has enabled the detection and correction of mistakes in the approach to HCV screening.
    MeSH term(s) Cross-Sectional Studies ; Female ; Hepatitis C/epidemiology ; Hepatitis C/transmission ; Hospitals ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/statistics & numerical data ; Male ; Portugal ; Retrospective Studies ; Time Factors
    Language Portuguese
    Publishing date 2010-05
    Publishing country Portugal
    Document type English Abstract ; Journal Article
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Padrões alimentares de mulheres em idade reprodutiva

    Maria Laura Siqueira de Souza Andrade / Raquel Canuto / Juliana Souza Oliveira / Silvia Patrícia Oliveira Silva Bacalhau / Fernanda Cristina Lima Pinto Tavares / Pedro Israel Cabral de Lira / Vanessa Sá Leal

    Demetra, Vol 15, Iss 0, Pp e43552-e

    realidade na Zona da Mata nordestina

    2020  Volume 43552

    Abstract: Objective: To analyze eating patterns and associated factors in women of reproductive age. Methods: This is a cross-sectional study conducted with 322 women aged 12 to 49 years old, residing in Vitória de Santo Antão, Pernambuco's Zona da Mata, Brazil, ... ...

    Abstract Objective: To analyze eating patterns and associated factors in women of reproductive age. Methods: This is a cross-sectional study conducted with 322 women aged 12 to 49 years old, residing in Vitória de Santo Antão, Pernambuco's Zona da Mata, Brazil, through active household survey. Census sectors were drawn in a simple and random manner, covering the health units belonging to the Family Health Strategy. The Eating Frequency Questionnaire allowed identifying eating patterns, categorized into low consumption, 1st and 2nd terciles, and high consumption, higher tercile. The independent variables analyzed were sociodemographic, lifestyle and health. Results: Within the studied group, 59.3% of the women were aged between 20 and 39 years old, and 60.9% had excessive weight. Three eating patterns were observed: Healthy, Brazilian-Typical Common, and Fast-Food. Women aged ≥ 40 years old consumed approximately three times more food of the Healthy pattern compared to those aged ≤ 19 years old. On the other hand, those aged ≥ 40 were less likely to consume foods of the Fast-Food pattern than the younger ones were (≤ 19 years old). Moreover, women with more than eight years of education were more likely to consume foods of the Fast-Food pattern compared to those with ≤ 4 years of education. Conclusions: Younger and better educated women presented a high consumption of foods characterizing the Fast-Food eating pattern compared to older and less educated ones, respectively.
    Keywords consumo de alimentos. estado nutricional. saúde da mulher. mulheres ; Agriculture (General) ; S1-972 ; Public aspects of medicine ; RA1-1270
    Subject code 796
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Universidade do Estado do Rio de Janeiro
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: New cholinesterase inhibitors for Alzheimer's disease: Structure Activity Studies (SARs) and molecular docking of isoquinolone and azepanone derivatives.

    Bacalhau, Patrícia / San Juan, Amor A / Marques, Carolina S / Peixoto, Daniela / Goth, Albertino / Guarda, Cátia / Silva, Mara / Arantes, Sílvia / Caldeira, A Teresa / Martins, Rosário / Burke, Anthony J

    Bioorganic chemistry

    2016  Volume 67, Page(s) 1–8

    Abstract: A library of isoquinolinone and azepanone derivatives were screened for both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity. The strategy adopted included (a) in vitro biological assays, against eel AChE (EeAChE) and equine serum ... ...

    Abstract A library of isoquinolinone and azepanone derivatives were screened for both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity. The strategy adopted included (a) in vitro biological assays, against eel AChE (EeAChE) and equine serum BuChE (EqBuChE) in order to determine the compounds IC50 and their dose-response activity, consolidated by (b) molecular docking studies to evaluate the docking poses and interatomic interactions in the case of the hit compounds, validated by STD-NMR studies. Compound (1f) was identified as one of these hits with an IC50 of 89.5μM for EeAChE and 153.8μM for EqBuChE, (2a) was identified as a second hit with an IC50 of 108.4μM (EeAChE) and 277.8μM (EqBuChE). In order to gain insights into the binding mode and principle active site interactions of these molecules, (R)-(1f) along with 3 other analogues (also as the R-enantiomer) were docked into both RhAChE and hBuChE models. Galantamine was used as the benchmark. The docking study was validated by performing an STD-NMR study of (1f) with EeAChE using galantamine as the benchmark.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/enzymology ; Azepines/chemical synthesis ; Azepines/chemistry ; Azepines/pharmacology ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Cholinesterases/metabolism ; Dose-Response Relationship, Drug ; Humans ; Isoquinolines/chemical synthesis ; Isoquinolines/chemistry ; Isoquinolines/pharmacology ; Magnetic Resonance Spectroscopy ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship
    Chemical Substances Azepines ; Cholinesterase Inhibitors ; Isoquinolines ; Cholinesterases (EC 3.1.1.8)
    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2016.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency.

    Bacalhau, Sílvia / Freitas, Cristina / Valente, Rosalina / Barata, Deolinda / Neves, Conceição / Schäfer, Katrin / Lubatschofski, Annelie / Schulz, Ansgar / Neves, João Farela

    Case reports in medicine

    2011  Volume 2011, Page(s) 527569

    Abstract: In high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary ... ...

    Abstract In high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary immunodeficiency, vaccination strategy against tuberculosis should be redefined in non-high-burden countries. We report the case of a patient with X-linked severe combined immunodeficiency (SCID) who developed disseminated BCG disease, highlighting the specific strategies adopted.
    Language English
    Publishing date 2011-10-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2502642-2
    ISSN 1687-9635 ; 1687-9627
    ISSN (online) 1687-9635
    ISSN 1687-9627
    DOI 10.1155/2011/527569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency

    Sílvia Bacalhau / Cristina Freitas / Rosalina Valente / Deolinda Barata / Conceição Neves / Katrin Schäfer / Annelie Lubatschofski / Ansgar Schulz / João Farela Neves

    Case Reports in Medicine, Vol

    2011  Volume 2011

    Abstract: In high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary ... ...

    Abstract In high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary immunodeficiency, vaccination strategy against tuberculosis should be redefined in non-high-burden countries. We report the case of a patient with X-linked severe combined immunodeficiency (SCID) who developed disseminated BCG disease, highlighting the specific strategies adopted.
    Keywords Medicine ; R
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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