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  1. Article: Dissociation of superoxide production by mitochondrial complex I from NAD(P)H redox state.

    Lambert, Adrian J / Buckingham, Julie A / Brand, Martin D

    FEBS letters

    2008  Volume 582, Issue 12, Page(s) 1711–1714

    Abstract: The relationship between the rate of superoxide production by complex I and NAD(P)H redox state was ... succinate oxidation; the rate during pyruvate oxidation was over fourfold lower. However, the NAD(P)H pool ... of the NAD(P)H pool. Our data suggest that less than 10% of the superoxide originates from the flavin site ...

    Abstract The relationship between the rate of superoxide production by complex I and NAD(P)H redox state was investigated in rat skeletal muscle mitochondria. A high rate of superoxide production was observed during succinate oxidation; the rate during pyruvate oxidation was over fourfold lower. However, the NAD(P)H pool was significantly less reduced during succinate oxidation than during pyruvate oxidation. We conclude that there is no unique relationship between superoxide production by complex I and the reduction state of the NAD(P)H pool. Our data suggest that less than 10% of the superoxide originates from the flavin site during reverse electron transport from succinate.
    MeSH term(s) Animals ; Electron Transport Complex I/metabolism ; Female ; Flavins/metabolism ; Mitochondria, Muscle/enzymology ; NADP/metabolism ; Oxidation-Reduction ; Rats ; Rats, Wistar ; Superoxides/metabolism
    Chemical Substances Flavins ; Superoxides (11062-77-4) ; NADP (53-59-8) ; Electron Transport Complex I (EC 7.1.1.2)
    Language English
    Publishing date 2008-04-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1016/j.febslet.2008.04.030
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  2. Article ; Online: Novel C3 mutation p.Lys65Gln in aHUS affects complement factor H binding.

    Volokhina, Elena / Westra, Dineke / Xue, Xiaoguang / Gros, Piet / van de Kar, Nicole / van den Heuvel, Lambert

    Pediatric nephrology (Berlin, Germany)

    2012  Volume 27, Issue 9, Page(s) 1519–1524

    Abstract: ... complement proteins and regulators and with autoantibodies against complement factor H (CFH). Approximately half ... novel missense change p.Lys65Gln in C3 was found in 3 aHUS patients. The alteration leads to decreased ... thus might lead to impaired C3b inactivation in vivo. The p.Lys65Gln is likely to be associated with aHUS after ...

    Abstract Background: Atypical hemolytic uremic syndrome (aHUS) is associated with mutations affecting complement proteins and regulators and with autoantibodies against complement factor H (CFH). Approximately half of the aHUS patients progress to end-stage renal disease. DNA analysis of the risk factor genes is important for prognosis of aHUS recurrence after renal transplantation.
    Methods: Mutational screening of C3 encoding the central complement component was performed by Sanger sequencing in 70 aHUS patients. Mutated and wild type recombinant C3b proteins were produced and their affinity to CFH was analyzed by ELISA.
    Results: A single novel missense change p.Lys65Gln in C3 was found in 3 aHUS patients. The alteration leads to decreased binding of C3b to CFH in vitro. All three patients acquired the illness as adults and had a first aHUS episode after renal transplantation or suffered recurrence of the disease after transplantation.
    Conclusions: The novel C3 change was found in 3 aHUS patients. It results in decreased C3b binding to CFH and thus might lead to impaired C3b inactivation in vivo. The p.Lys65Gln is likely to be associated with aHUS after kidney transplantation and, therefore, might be an important prognostic factor.
    MeSH term(s) Adolescent ; Adult ; Amino Acid Sequence ; Atypical Hemolytic Uremic Syndrome ; Base Sequence ; Child ; Child, Preschool ; Complement C3/chemistry ; Complement C3/genetics ; Complement C3b/metabolism ; Complement Factor H/metabolism ; DNA Mutational Analysis ; Female ; Hemolytic-Uremic Syndrome/blood ; Hemolytic-Uremic Syndrome/genetics ; Humans ; Infant ; Male ; Middle Aged ; Molecular Sequence Data ; Mutation, Missense ; Protein Binding ; Young Adult
    Chemical Substances Complement C3 ; Complement C3b (80295-43-8) ; Complement Factor H (80295-65-4)
    Language English
    Publishing date 2012-06-06
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-012-2183-z
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  3. Book ; Online: Comparison of asexual blood-stage antigens of Plasmodium falciparum recognized by antibody reagents from nine laboratories / R. Dayal, C. Decrind & P. H. Lambert

    Dayal, Rekha / Decrind, C / Lambert, P. H

    1986  

    Keywords Plasmodium falciparum ; Parasitic Diseases and their Control ; immunology
    Document type Book ; Online
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  4. Book ; Online: Comparison of asexual blood-stage antigens of Plasmodium falciparum recognized by antibody reagents from nine laboratories / R. Dayal, C. Decrind & P. H. Lambert

    Dayal, Rekha / Decrind, C / Lambert, P. H

    1986  

    Keywords Plasmodium falciparum ; Parasitic Diseases and their Control ; immunology
    Document type Book ; Online
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  5. Article: [Besprechung von:] Lévy-Lambert, H. et J.-P.Dupuy: Les choix économiques dans lʹentreprise et dans lʹadministration. Paris 1973

    Gautrin, Jean-François / Dupuy, J.-P / Lévy-Lambert, H

    The Canadian journal of economics Vol. 8, No. 3 , p. 472-474

    Collection Finance Appliquée. Vol. 43-44

    1975  Volume 8, Issue 3, Page(s) 472–474

    Author's details Jean-François Gautrin
    Publisher Blackwell
    Publishing place Boston, Mass. [u.a.]
    Document type Article
    ZDB-ID 218117-4
    Database ECONomics Information System

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  6. Article ; Online: Étude comparative oral/écrit des procédures de reformulation effectuées par des étudiants de 18 à 20 ans (FLM, FLS, FLE)

    Lambert Valérie

    SHS Web of Conferences, Vol 138, p

    2022  Volume 06007

    Abstract: Cette étude compare pour la première fois les procédures de reformulation effectuées à l’oral à celles produites à l’écrit une semaine après lors d’une tâche de restitution d’une histoire appelée « texte source » (TS) (Martinot, 2018), chez quinze ... ...

    Abstract Cette étude compare pour la première fois les procédures de reformulation effectuées à l’oral à celles produites à l’écrit une semaine après lors d’une tâche de restitution d’une histoire appelée « texte source » (TS) (Martinot, 2018), chez quinze étudiants. Elle a pour objectif d’analyser l’organisation prédicative résultant de chaque mode de restitution (Berrendonner, 2004) : le contenu informatif restitué est-il le même à l’oral et à l’écrit ? En analysant les processus de transformation mis en oeuvre par les étudiants selon le cadre théorique harrissien (Harris, 2007), nous observerons si les procédures de reformulation utilisées à l’oral tendent vers une simplification des prédications sources tandis qu’à l’écrit, les étudiants tentent de maintenir leur degré de complexité. Les résultats nous permettront d’observer le degré de maîtrise de la langue parlée et écrite chez ces étudiants. Enfin, les stratégies mises en place par ces derniers pour produire leur écrit lors de la seconde passation seront étudiées, en tentant de repérer si les scripteurs s’appuient ou non sur leur propre restitution orale antérieure (Vénérin, 2017). Ce résultat fournira des informations sur la manière d’améliorer l’expression écrite grâce à l’oral.
    Keywords Social Sciences ; H
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
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  7. Article ; Online: Continuous Wound Irrigation and Intraoperative Methadone Decreases Opioid Use and Shortens Length of Stay After CRS/HIPEC.

    Boesl, Markus A / Brown, Noah / Bleicher, Josh / Call, Tyler / Lambert, Donald H / Lambert, Laura A

    Annals of surgical oncology

    2024  

    Abstract: ... methadone. Length of stay was significantly shorter with CWIS + methadone versus epidural (7 vs. 8 days, p ... confidence interval [CI] 0.52-0.98, p = 0.04; Daily: 32.8 ± 2.0 MME vs. 51.9 ± 5.7 MME, OR 0.72, 95% CI 0.52-0.99, p ... epidural (135 MME vs. 7.5 MME, p < 0.001) and longer length of stay versus CWIS + methadone (9 vs. 7 days ...

    Abstract Background: Epidural analgesia is resource and labor intense and may limit postoperative management options and delay discharge. This study compared postoperative outcomes after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) with epidural analgesia versus continuous wound infusion system (CWIS) with/without intraoperative methadone.
    Methods: A single-institution, retrospective chart review was performed including all patients undergoing open CRS/HIPEC from 2018 to 2021. Patient demographics, surgical characteristics, length of stay, and in-hospital analgesic use were reviewed. In-hospital opioid exposure in morphine milligram equivalents (MME) was calculated. Multivariate analysis (MVA) for mean total and daily opioid exposure was conducted.
    Results: A total of 157 patients were included. Fifty-three (34%) had epidural analgesia, 96 (61%) had CWIS, and 79 (50%) received methadone. Length of stay was significantly shorter with CWIS + methadone versus epidural (7 vs. 8 days, p < 0.01). MVA showed significantly lower mean total and daily opioid exposure with CWIS+methadone versus epidural (total: 252.8 ± 17.7 MME vs. 486.8 ± 86.6 MME; odds ratio [OR] 0.72, 95% confidence interval [CI] 0.52-0.98, p = 0.04; Daily: 32.8 ± 2.0 MME vs. 51.9 ± 5.7 MME, OR 0.72, 95% CI 0.52-0.99, p ≤ 0.05). The CWIS-only group (n = 17) had a significantly lower median oral opioid exposure versus epidural (135 MME vs. 7.5 MME, p < 0.001) and longer length of stay versus CWIS + methadone (9 vs. 7 days, p = 0.04), There were no CWIS or methadone-associated complications and one epidural abscess.
    Conclusions: CWIS + methadone safely offers better pain control with less in-hospital opioid use, shorter length of stay, and decreased resource utilization compared with epidural analgesia in patients undergoing CRS-HIPEC.
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-14900-1
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  8. Article: Discussion de la lecture intitulée: "Notre expérience de la ponction-biopsie rénale. A propos de 250 observations personnelles", par H. Van Cauwenberge, Correspondent; P. Lefebvre, E. H. Betz et G. Booz.

    Lambert, P P

    Bulletin de l'Academie royale de medecine de Belgique

    1966  Volume 6, Issue 3, Page(s) 201–209

    Title translation Discussion of the lecture entitled: "Our experience with renal puncture biopsy. Apropos of 250 personal cases", by WH. Van Cauwenberge, correspondant; P. Lefebvre, E. H. Betz and G. Booz.
    MeSH term(s) Biopsy ; Humans ; In Vitro Techniques ; Kidney Diseases/diagnosis
    Language French
    Publishing date 1966
    Publishing country Belgium
    Document type Journal Article
    ZDB-ID 419139-0
    ISSN 0001-4168
    ISSN 0001-4168
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  9. Article: Chimiothérapie préopératoire des tumeurs des voies excrétrices supérieures : impact sur la fonction rénale.

    Gabriel, P-E / Lambert, T / Dumont, C / Gauthier, H / Masson-Lecomte, A / Culine, S

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

    2023  Volume 33, Issue 8-9, Page(s) 446–455

    Title translation Preoperative chemotherapy for patients with upper tract urothelial carcinoma: Impact on renal function.
    MeSH term(s) Humans ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/surgery ; Carcinoma, Transitional Cell/pathology ; Urinary Bladder Neoplasms/drug therapy ; Retrospective Studies ; Prospective Studies ; Chemotherapy, Adjuvant ; Kidney/physiology ; Kidney/pathology ; Ureteral Neoplasms/drug therapy ; Ureteral Neoplasms/surgery ; Ureteral Neoplasms/pathology
    Language French
    Publishing date 2023-07-04
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 1186190-3
    ISSN 1166-7087
    ISSN 1166-7087
    DOI 10.1016/j.purol.2023.06.003
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  10. Article ; Online: Ceramic Bonding Interface under Shear-Compression Stress: Ultra-High-Speed Imaging Contribution.

    Lambert, H / Corn, S / Léger, R / Ienny, P / Slangen, P / Fages, M

    Journal of dental research

    2022  Volume 102, Issue 3, Page(s) 295–301

    Abstract: The aim of this study is to visualize and characterize by ultra-high-speed imaging (UHSI) the failure phenomena at the resin-ceramic bonding interface of lithium disilicate (LiSi2) samples bonded with gold-standard protocol (Monobond Plus [MB]) and the ... ...

    Abstract The aim of this study is to visualize and characterize by ultra-high-speed imaging (UHSI) the failure phenomena at the resin-ceramic bonding interface of lithium disilicate (LiSi2) samples bonded with gold-standard protocol (Monobond Plus [MB]) and the nontoxic one (Monobond Etch & Prime [MEP]) subjected to mechanical loading. Unprecedented frame rate, image resolution, and recording time were reached by using the most advanced UHSI camera. The finite element analysis (FEA) of the proposed mechanical test confirmed that the specific design of our samples enables a combined shear and compression stress state, prone to test the bonding interface while being close to physiological stresses. Ten LiSi2 samples were pretreated by gold standard (MB,
    MeSH term(s) Dental Bonding ; Resin Cements ; Surface Properties ; Materials Testing ; Silanes ; Hydrofluoric Acid ; Ceramics ; Dental Porcelain ; Dental Stress Analysis
    Chemical Substances Resin Cements ; Silanes ; Hydrofluoric Acid (RGL5YE86CZ) ; Dental Porcelain (12001-21-7)
    Language English
    Publishing date 2022-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345221138500
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