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Article ; Online: The Chinese medicine Xin-tong-tai granule protects atherosclerosis by regulating oxidative stress through NOX/ROS/NF-κB signal pathway.

Wei, Jia-Ming / Yuan, Hui / Liu, Cheng-Xin / Wang, Zi-Yan / Shi, Min / Guo, Zhi-Hua / Li, Ya

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 165, Page(s) 115200

Abstract: Background: Xin-tong-tai Granule (XTTG), a traditional Chinese medicine, has been used to treat ...

Abstract	Background: Xin-tong-tai Granule (XTTG), a traditional Chinese medicine, has been used to treat atherosclerosis (AS), but its mechanism is poorly understood. Intriguingly, oxidative stress has been recognized as vital factors in the treatment of atherosclerosis. Purpose: This study aims to explore the potential mechanism of XTTG for treating AS. Methods: An in-vivo model of AS was established by feeding ApoE Results: XTTG improved blood lipid levels and pathological aortic changes of ApoE Conclusion: XTTG can inhibit NOX/ROS/NF-κB signaling pathway, reduce damages caused by oxidative stress, and exert anti-AS effects.
MeSH term(s)	Animals ; Humans ; Mice ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Atherosclerosis/genetics ; Lipoproteins, LDL/pharmacology ; NF-kappa B/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Superoxide Dismutase/metabolism ; Drugs, Chinese Herbal/pharmacology
Chemical Substances	Apolipoproteins E ; Lipoproteins, LDL ; NF-kappa B ; Reactive Oxygen Species ; Superoxide Dismutase (EC 1.15.1.1) ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-07-26
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115200
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Article: Cardiac Overexpression of XIN Prevents Dilated Cardiomyopathy Caused by

Li, Bin / Guo, Yifan / Zhan, Yongkun / Zhou, Xinyan / Li, Yongbo / Zhao, Chao / Sun, Ning / Xu, Chen / Liang, Qianqian

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 691749

Abstract: ... ...

Abstract	TNNT2
Language	English
Publishing date	2021-06-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.691749
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Article ; Online: Efficacy of Chinese herbal formula Kai-Xin-San on rodent models of depression: A systematic review and meta-analysis.

Wang, Ya-Ting / Wang, Xiao-Le / Lei, Lan / Guo, Zhen-Yu / Hu, Die / Wang, Zhen-Zhen / Zhang, Yi

Journal of ethnopharmacology

2023 Volume 321, Page(s) 117492

Abstract: Ethnopharmacological relevance: Kai-Xin-San (KXS, or Happy Feeling Powder), a typical Chinese ...

Abstract	Ethnopharmacological relevance: Kai-Xin-San (KXS, or Happy Feeling Powder), a typical Chinese herbal prescription, is frequently used for treating depression by the multi-level and multi-target mechanism. Aim of the study: To systematically investigate the efficacy and safety of KXS on depression in preclinic trials. Materials and methods: We independently searched for preclinical animal studies of KXS on depression from inception to June 28, 2022, using electronic databases, e.g., PUBMED. The measurements were performed to assess the outcomes of behavioral tests. Results: This systematic review and meta-analysis included twenty-four studies and 608 animals. A remarkable effect of KXS in depression behavioral tests, including sucrose consumption test (SMD: 2.36, 95% CI: (1.81, 2.90); Z = 8.49, P < 0.00001)., forced swimming test (MD = -60.52, 95% CI: (-89.04, -31.99); Z = 4.16, P < 0.0001), rearing times (MD=4.48, 95% CI: (3.39, 5.57); Z = 8.05, P < 0.00001) and crossing times (MD = -33.7, 95% CI: (25.74, 41.67); Z = 8.29, P < 0.00001) in the open field test, showing KXS's excellent efficiency in improving depressive-like symptoms of animals. Conclusions: Our meta-analysis showed KXS remarkably relieved animals' depressive-like symptoms, providing evidence that KXS can be a promising drug candidate for depression treatment.
MeSH term(s)	Animals ; Depression/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Rodentia ; Disease Models, Animal
Chemical Substances	Drugs, Chinese Herbal ; Kai-Xin-San
Language	English
Publishing date	2023-11-25
Publishing country	Ireland
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117492
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Article: MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1.

Chen, Chao / Xu, Yuan-Jie / Zhang, Shang-Rong / Wang, Xiao-Hui / Hu, Yuan / Guo, Dai-Hong / Zhou, Xiao-Jiang / Zhu, Wei-Yu / Wen, Ai-Dong / Tan, Qing-Rong / Dong, Xian-Zhe / Liu, Ping

Heliyon

2023 Volume 9, Issue 3, Page(s) e14265

Abstract: Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression ...

Abstract	Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. Recent studies indicated that miRNAs were involved in the pathophysiology of depression. However, there have been few studies on the mechanism underlying the miRNAs directly mediating antidepressant at clinical level, especially in nature drugs and TCM compound. In this study, we identified circulating miRNAs defferentially expressed among the depression patients (DPs), DPs who underwent 8weeks of KXS treatment and health controls (HCs). A total of 45 miRNAs (17 were up-regulated and 28 were down-regulated) were significantly differentially expressed among three groups. Subsequently, qRT-PCR was used to verify 10 differentially expressed candidate miRNAs in more serum samples, and the results showed that 6 miRNAs (miR-1281, miR-365a-3p, miR-2861, miR-16-5p, miR-1202 and miR-451a) were consistent with the results of microarray. Among them, miR-1281, was the novel dynamically altered and appeared to be specifically related to depression and antidepressant effects of KXS. MicroRNA-gene-pathway-net analysis showed that miR-1281-regulated genes are mostly key nodes in the classical signaling pathway related to depression. Additionally, our data suggest that ADCY1 and DVL1 were the targets of miR-1281. Thus, based on the discovery of miRNA expression profiles in vivo, our findings suggest a new role for miR-1281 related to depression and demonstrated in vitro that KXS may activate cAMP/PKA/ERK/CREB and Wnt/β-catenin signal transduction pathways by down-regulating miR-1281 that targets ADCY1 and DVL1 to achieve its role in neuronal cell protection.
Language	English
Publishing date	2023-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14265
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Article ; Online: Cardioprotective efficacy of Xin-shu-bao tablet in heart failure with reduced ejection fraction by modulating THBD/ARRB1/FGF1/STIM1 signaling.

Zhang, Fengrong / Xu, Xingyue / Hou, Jinli / Xiao, Honghe / Guo, Feifei / Li, Xianyu / Yang, Hongjun

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 165, Page(s) 115119

Abstract: ... therapeutic efficacy of Xin-shu-bao (XSB) at different stages of HF following induction ...

Abstract	Traditional Chinese medicine offer unique advantages in mitigating and preventing early or intermediate stage for treating heart failure (HF). The purpose of this study was to assess the in vivo therapeutic efficacy of Xin-shu-bao (XSB) at different stages of HF following induction of a myocardial infarction (MI) in mice and use mass spectrometry-based proteomics to identify potential therapeutic targets for different stages of HF based on the molecular changes following XSB treatment. XSB had high cardioprotective efficacy in the pre-HF with reduced ejection fraction (HFrEF) stages, but had a weak or no effect in the post-HFrEF stages. This was supported by echocardiographic measurements showing that XSB decreased ejection fraction and fractional shortening in HF. XSB administration improved cardiac function in the pre- and post-HFrEF mouse model, ameliorated deleterious changes to the morphology and subcellular structure of cardiomyocytes, and reduced cardiac fibrosis. Proteomics analysis showed that XSB intervention exclusively targeted thrombomodulin (THBD) and stromal interaction molecule 1 (STIM1) proteins when administered to the mice for both 8 and 6 weeks. Furthermore, XSB intervention for 8, 6, and 4 weeks after MI induction increased the expression of fibroblast growth factor 1 (FGF1) and decreased arrestin β1 (ARRB1), which are classic biomarkers of cardiac fibroblast transformation and collagen synthesis, respectively. Overall, the study suggests that early intervention with XSB could be an effective strategy for preventing HFrEF and highlights potential therapeutic targets for further investigation into HFrEF remediation strategies.
MeSH term(s)	Animals ; Mice ; Heart Failure/drug therapy ; Heart Failure/metabolism ; Stroke Volume ; Fibroblast Growth Factor 1/metabolism ; Arrestin/metabolism ; Stromal Interaction Molecule 1 ; Thrombomodulin ; Myocardial Infarction/drug therapy
Chemical Substances	Fibroblast Growth Factor 1 (104781-85-3) ; Arrestin ; Stromal Interaction Molecule 1 ; Thrombomodulin ; THBD protein, mouse
Language	English
Publishing date	2023-07-07
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115119
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Ud II Zs.198: Show issues

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Article ; Online: RETRACTED: Unraveling the composition and succession of microbial community and its relationship to flavor substances during Xin-flavor baijiu brewing.

Dong, Weiwei / Zeng, Yiting / Cui, Yuxin / Chen, Ping / Cai, Kaiyun / Guo, Tingting / Tan, Guangxun / Peng, Nan / Liang, Yunxiang / Zhao, Shumiao

publication RETRACTED

International journal of food microbiology

2022 Volume 372, Page(s) 109679

MeSH term(s)	Bacteria/genetics ; Ethanol ; Fermentation ; Flavoring Agents/analysis ; Microbiota
Chemical Substances	Flavoring Agents ; Ethanol (3K9958V90M)
Language	English
Publishing date	2022-04-14
Publishing country	Netherlands
Document type	Journal Article ; Retracted Publication
ZDB-ID	87122-9
ISSN	1879-3460 ; 0168-1605
ISSN (online)	1879-3460
ISSN	0168-1605
DOI	10.1016/j.ijfoodmicro.2022.109679
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Zs.A 4668: Show issues

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Article ; Online: Computational systems pharmacology reveals an antiplatelet and neuroprotective mechanism of Deng-Zhan-Xi-Xin injection in the treatment of ischemic stroke.

Zhao, Jing / Lv, Chao / Wu, Qiuling / Zeng, Huawu / Guo, Xin / Yang, Jian / Tian, Saisai / Zhang, Weidong

Pharmacological research

2019 Volume 147, Page(s) 104365

Abstract: ... by drugs on human signaling networks. To establish proof of principle, the herbal product Deng-Zhan-Xi-Xin ...

Abstract	Herbs are typically prescribed in traditional Chinese medicine (TCM) to treat complex diseases. The multicomponent nature of herbal drug ingredients makes it difficult to readily understand their mode of action. To decipher their molecular mechanisms, here we proposed a novel computational systems pharmacology based approach, which consisted of transcriptome profiling, data collection, statistical analysis, network algorithm, bioinformatics analysis and pharmacological validation. The network algorithm called signed random walk with restart (SRWR) was used to simulate the propagation of drugs' effects on networks. This algorithm could identify proteins either positively or negatively regulated (activated or inhibited) by drugs on human signaling networks. To establish proof of principle, the herbal product Deng-Zhan-Xi-Xin injection (DZXXI), which exhibits pharmacological effects in ischemic stroke but its mechanism was unclear, was analyzed. Eighty-three targets were predicted with high confidence for DZXXI's active compounds in plasma, and 87 differentially expressed genes (DEGs) were identified in MCF7 cells treated with DZXXI. These target genes were further found to be associated with pathways involved in neuronal apoptosis in ischemic stroke, such as NF-κB signaling, TNF signaling, and PI3K-Akt signaling. Intersection analysis between DZXXI's putative targets with ischemic stroke-associated genes identified two important targets (PTGS1, PTGS2) corresponding to four DZXXI compounds, which were further validated using in silico and in vitro/vivo models. The most inhibited genes identified by the SRWR algorithm were significantly enriched with ischemic stroke-associated disease genes, antiplatelet associated pathways, and their encoded proteins were enriched in brain, vascular endothelium and platelets. The CMAP analysis based on DEGs suggested that DZXXI could function as both an anti-inflammatory and anti-platelet agent. Taken together, the computational analysis suggested that DZXXI exhibited anti-platelet and neuroprotective effects in the treatment of ischemic stroke. These deductions were preliminarily confirmed by subsequent in vitro/vivo studies. This approach provides a systems perspective to study the relevance between herbal drugs and disease processes, and can reveal possible pharmacological effects of multiple ingredients within herbal product.
MeSH term(s)	Animals ; Computational Biology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Gene Expression Profiling ; Humans ; Infarction, Middle Cerebral Artery/drug therapy ; MCF-7 Cells ; Male ; Mice ; Molecular Docking Simulation ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Aggregation Inhibitors/therapeutic use ; RAW 264.7 Cells ; Rabbits ; Rats, Sprague-Dawley ; Transcriptome/drug effects
Chemical Substances	Drugs, Chinese Herbal ; Neuroprotective Agents ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2019-07-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2019.104365
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Zs.A 721: Show issues

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Article: Effects of Xin-Ji-Er-Kang on Anticardiovascular Remodeling in

Wang, Li / Cai, Guo-Wei / Ding, Ling / Hu, Juan / Zhang, Yong-Xue / Huang, Guang-Yao / Cheng, Pan / Gao, Shan

Evidence-based complementary and alternative medicine : eCAM

2018 Volume 2018, Page(s) 8067361

Abstract: Background: Xin-Ji-Er-Kang (XJEK) shows protective effects on the myocardial ischemic diseases ...

Abstract	Background: Xin-Ji-Er-Kang (XJEK) shows protective effects on the myocardial ischemic diseases in our previous reports. We hypothesized that XJEK may exert preventing effects on Methods: After treatment with XJEK for four weeks, cardiac function and cardiovascular pathology changes were evaluated. Then, endothelial-dependent vascular relaxation and serum NO, eNOS, AMDA, SOD, MDA content, and cardiac tissue eNOS expression were detected. Results: The hypertensive mice displayed distinct cardiovascular remodeling including increased HW/BW index (4.7 ± 0.33 versus 5.2 ± 0.34), cross-section area, and collagen deposition. In addition, ED was found manifested by decreased serum NO (20.54 ± 8.05 versus 6.29 ± 2.33), eNOS (28.34 ± 2.36 versus 20.37 ± 2.30), content, and decreased eNOS expression in cardiac tissue and damaged endothelium-dependent diastolic function. Moreover, OS was detected confirmed by decreased SOD activity and increased MDA content in serum. However, treatment with XJEK for 4 wk could reverse cardiovascular remodeling (HW/BW index normalized from 5.2 ± 0.34 to 4.59 ± 0.25), ameliorate and preserve endothelial function (NO: 16.67 ± 7.24 versus 6.29 ± 2.33; eNOS: 16.67 ± 7.24 versus 6.29 ± 2.33), and suppress OS. Conclusion: XJEK has protective effects against cardiovascular remodeling in L-NAME induced hypertensive mice.
Language	English
Publishing date	2018-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2018/8067361
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Zs.A 5995: Show issues

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Article ; Online: MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1

Chen, Chao / Xu, Yuan-jie / Zhang, Shang-rong / Wang, Xiao-hui / Hu, Yuan / Guo, Dai-hong / Zhou, Xiao-jiang / Zhu, Wei-yu / Wen, Ai-Dong / Tan, Qing-Rong / Dong, Xian-Zhe / Liu, Ping

Heliyon. 2023 Mar., v. 9, no. 3 p.e14265-

2023

Abstract: Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression ...

Abstract	Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. Recent studies indicated that miRNAs were involved in the pathophysiology of depression. However, there have been few studies on the mechanism underlying the miRNAs directly mediating antidepressant at clinical level, especially in nature drugs and TCM compound. In this study, we identified circulating miRNAs defferentially expressed among the depression patients (DPs), DPs who underwent 8weeks of KXS treatment and health controls (HCs). A total of 45 miRNAs (17 were up-regulated and 28 were down-regulated) were significantly differentially expressed among three groups. Subsequently, qRT-PCR was used to verify 10 differentially expressed candidate miRNAs in more serum samples, and the results showed that 6 miRNAs (miR-1281, miR-365a-3p, miR-2861, miR-16-5p, miR-1202 and miR-451a) were consistent with the results of microarray. Among them, miR-1281, was the novel dynamically altered and appeared to be specifically related to depression and antidepressant effects of KXS. MicroRNA-gene-pathway-net analysis showed that miR-1281-regulated genes are mostly key nodes in the classical signaling pathway related to depression. Additionally, our data suggest that ADCY1 and DVL1 were the targets of miR-1281. Thus, based on the discovery of miRNA expression profiles in vivo, our findings suggest a new role for miR-1281 related to depression and demonstrated in vitro that KXS may activate cAMP/PKA/ERK/CREB and Wnt/β-catenin signal transduction pathways by down-regulating miR-1281 that targets ADCY1 and DVL1 to achieve its role in neuronal cell protection.
Keywords	Oriental traditional medicine ; antidepressants ; blood serum ; gene expression regulation ; heart ; microRNA ; microarray technology ; neurons ; pathophysiology ; signal transduction ; spleen ; Depression ; Kai-Xin-San ; miR-1281 ; ADCY1 ; DVL1
Language	English
Dates of publication	2023-03
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14265
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1

Chao Chen / Yuan-jie Xu / Shang-rong Zhang / Xiao-hui Wang / Yuan Hu / Dai-hong Guo / Xiao-jiang Zhou / Wei-yu Zhu / Ai-Dong Wen / Qing-Rong Tan / Xian-Zhe Dong / Ping Liu

Heliyon, Vol 9, Iss 3, Pp e14265- (2023)

2023

Abstract: Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression ...

Abstract	Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. Recent studies indicated that miRNAs were involved in the pathophysiology of depression. However, there have been few studies on the mechanism underlying the miRNAs directly mediating antidepressant at clinical level, especially in nature drugs and TCM compound. In this study, we identified circulating miRNAs defferentially expressed among the depression patients (DPs), DPs who underwent 8weeks of KXS treatment and health controls (HCs). A total of 45 miRNAs (17 were up-regulated and 28 were down-regulated) were significantly differentially expressed among three groups. Subsequently, qRT-PCR was used to verify 10 differentially expressed candidate miRNAs in more serum samples, and the results showed that 6 miRNAs (miR-1281, miR-365a-3p, miR-2861, miR-16-5p, miR-1202 and miR-451a) were consistent with the results of microarray. Among them, miR-1281, was the novel dynamically altered and appeared to be specifically related to depression and antidepressant effects of KXS. MicroRNA-gene-pathway-net analysis showed that miR-1281-regulated genes are mostly key nodes in the classical signaling pathway related to depression. Additionally, our data suggest that ADCY1 and DVL1 were the targets of miR-1281. Thus, based on the discovery of miRNA expression profiles in vivo, our findings suggest a new role for miR-1281 related to depression and demonstrated in vitro that KXS may activate cAMP/PKA/ERK/CREB and Wnt/β-catenin signal transduction pathways by down-regulating miR-1281 that targets ADCY1 and DVL1 to achieve its role in neuronal cell protection.
Keywords	Depression ; Kai-Xin-San ; miR-1281 ; ADCY1 ; DVL1 ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	500
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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