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Article ; Online: Sepsis and multi-organ failure due to genital herpes in a healthy person.

Li, Ruolin / Zhou, Junying

2024 Volume 35, Issue 6, Page(s) 490–493

Abstract: Herpes simplex virus type 2 (HSV-2) is highly prevalent in several regions of the world and is the main pathogen causing genital herpes, which is transmitted almost exclusively through sexual contact. Systemically disseminated infections caused by HSV-2 ... ...

Abstract	Herpes simplex virus type 2 (HSV-2) is highly prevalent in several regions of the world and is the main pathogen causing genital herpes, which is transmitted almost exclusively through sexual contact. Systemically disseminated infections caused by HSV-2 are rare and most often seen in newborns, pregnant women, or immunocompromised populations. The virus can invade multiple organs and cause damage. In this paper, we present an extremely rare case of an immunocompetent 36-year-old male who came to our hospital with a high fever with abdominal pain and died of sepsis and multiple organ dysfunction syndrome within a short period. After the exclusion of common pathogens such as bacterial and fungal infections during hospitalization, metagenomic next generation sequencing of the patient's peripheral blood and ascites gave us the answer, and very high nucleic acid sequence counts of HSV-2 were detected in both his peripheral blood and ascites, confirming HSV-2 as the causative virus. In addition, this paper provides a brief review of the relevant literature.
MeSH term(s)	Humans ; Male ; Herpes Genitalis/diagnosis ; Herpes Genitalis/complications ; Herpes Genitalis/virology ; Adult ; Herpesvirus 2, Human/isolation & purification ; Multiple Organ Failure/virology ; Sepsis/virology ; Fatal Outcome
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article ; Case Reports
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/09564624241229465
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ab Jg. 2022: Lesesaal (EG)

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Article: Mechanistic Study of Glycyrrhizic Acid Improving Alcoholic Fatty Liver Disease by Modulating the SHP1/SYK Signaling Pathway in Macrophages.

Liu, Qian / Li, Yuanyuan / Li, Junqing / Zhou, Junying

Alternative therapies in health and medicine

2024

Abstract: Objective: To investigate glycyrrhizin's effects and molecular mechanisms on the progression of alcoholic fatty liver.: Methods: An alcoholic fatty liver model was established, followed by the administration of glycyrrhizin ammonium (20 mg/kg). Liver ...

Abstract	Objective: To investigate glycyrrhizin's effects and molecular mechanisms on the progression of alcoholic fatty liver. Methods: An alcoholic fatty liver model was established, followed by the administration of glycyrrhizin ammonium (20 mg/kg). Liver tissue pathological changes were observed using oil red O staining, and pyroptotic bodies were observed using transmission electron microscopy. Western blot was used to detect the expression of related proteins. To establish a model of alcoholic fatty liver cells to explore the molecular mechanism of glycolic acid in this disease. Results: Glycyrrhizin ammonium reduced the area of oil red staining in liver tissue and the number of pyroptotic bodies decreased the relative protein expression of NOX2, NOX3, p-SYK, STING, p-PDE4B, NLRP3, IL-1β, GSDMD, Caspase-1, and Caspase-4, and increased the relative protein expression of p-SHP1 and Nrf2. Conclusion: Glycyrrhizin ameliorates the progression of alcoholic fatty liver by modulating the SHP1/SYK signaling pathway in macrophages, thereby inhibiting hepatic lipid peroxidation and pyroptosis.
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4504: Show issues

Location:
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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Research on Determinants Affecting Users' Impulsive Purchase Intention in Live Streaming from the Perspective of Perceived Live Streamers' Ability.

Chen, Jun / Luo, Junying / Zhou, Tian

Behavioral sciences (Basel, Switzerland)

2024 Volume 14, Issue 3

Abstract: As an innovative marketing pattern, live-streaming e-commerce supplies advantages over traditional e-commerce in stimulating impulsive purchases. This study developed a theoretical model that examines how perceived live streamers' abilities (perceived ... ...

Abstract	As an innovative marketing pattern, live-streaming e-commerce supplies advantages over traditional e-commerce in stimulating impulsive purchases. This study developed a theoretical model that examines how perceived live streamers' abilities (perceived live interaction ability and perceived linguistic persuasion ability) affect impulsive purchase intention based on interaction theory, affective distance theory, trust theory, and Aristotle's rhetorical appeals. We conducted empirical research through a survey questionnaire to verify the effectiveness of the model. A total of 330 valid samples were gathered from live-streaming users, and partial least squares-structural equation modeling (PLS-SEM) was employed for data analysis. The results indicate that perceived live interaction ability, encompassing responsiveness, entertainment, and personalization, significantly impacts affective distance. Among the four dimensions of perceived linguistic persuasion ability, emotional contagion significantly influences affective distance, whereas expertise, logic, and morality significantly affect cognitive trust. Both affective distance and cognitive trust promote consumers' impulsive purchases through affective trust. Our research findings provide theoretical and practical recommendations for live-streaming platforms and merchants engaged in live marketing.
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs14030190
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Human Aha1's N-terminal extension confers it holdase activity in vitro.

Tang, Junying / Hu, Huifang / Zhou, Chen / Zhang, Naixia

Protein science : a publication of the Protein Society

2023 Volume 32, Issue 9, Page(s) e4735

Abstract: Molecular chaperones are key components of protein quality control system, which plays an essential role in controlling protein homeostasis. Aha1 has been identified as a co-chaperone of Hsp90 known to strongly accelerate Hsp90's ATPase activity. ... ...

Abstract	Molecular chaperones are key components of protein quality control system, which plays an essential role in controlling protein homeostasis. Aha1 has been identified as a co-chaperone of Hsp90 known to strongly accelerate Hsp90's ATPase activity. Meanwhile, it is reported that Aha1 could also act as an autonomous chaperone and protect stressed or disordered proteins from aggregation. Here, in this article, a series of in vitro experiments were conducted to verify whether Aha1 has a non-Hsp90-dependent holdase activity and to elucidate the associated molecular mechanism for substrate recognition. According to the results of the refolding assay, the highly conserved N-terminal extension spanning M1 to R16 in Aha1 from higher eukaryotes is responsible for the holdase activity of the protein. As revealed by the NMR data, Aha1's N-terminal extension mainly adopts a disordered conformation in solution and shows no tight contacts with the core structure of Aha1's N-terminal domain. Based on the intrinsically disordered structure feature and the primary sequence of Aha1's N-terminal extension, the fuzzy-type protein-protein interactions involving this specific region and the unfolded substrate proteins are expected. The following mutation analysis data demonstrated that the Van der Waals contacts potentially involving two tryptophans including W4 and W11 do not play a dominant role in the interaction between Aha1 and unfolded maltose binding protein (MBP). Meanwhile, since the high concentration of NaCl could abolish the holdase activity of Aha1, the electrostatic interactions mediated by those charged residues in Aha1's N-terminal extension are thus indicated to play a crucial role in the substrate recognition.
MeSH term(s)	Humans ; HSP90 Heat-Shock Proteins/chemistry ; Molecular Chaperones/chemistry ; Protein Binding
Chemical Substances	HSP90 Heat-Shock Proteins ; Molecular Chaperones ; AHSA1 protein, human
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1106283-6
ISSN	1469-896X ; 0961-8368
ISSN (online)	1469-896X
ISSN	0961-8368
DOI	10.1002/pro.4735
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3407: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Excessive Daytime Sleepiness Is Associated With Non-motor Symptoms of Multiple System Atrophy: A Cross-Sectional Study in China.

Wang, Hui / Tang, Xiangdong / Zhou, Junying / Xu, Yanming

Frontiers in neurology

2022 Volume 12, Page(s) 798771

Abstract: Objectives: ...

Abstract	Objectives:
Language	English
Publishing date	2022-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.798771
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Integrating Whole-Genome Resequencing and RNA Sequencing Data Reveals Selective Sweeps and Differentially Expressed Genes Related to Nervous System Changes in Luxi Gamecocks.

Zhou, Jieke / Chang, Ying / Li, Junying / Bao, Haigang / Wu, Changxin

Genes

2023 Volume 14, Issue 3

Abstract: The Luxi gamecock developed very unique morphological and behavioral features under the special artificial selection of the most famous Chinese gamecocks. There are very few research studies on the genetics and selection of the Luxi gamecock. We used six ...

Abstract	The Luxi gamecock developed very unique morphological and behavioral features under the special artificial selection of the most famous Chinese gamecocks. There are very few research studies on the genetics and selection of the Luxi gamecock. We used six methods (Fst, Tajima's D, hapFLK, iHS, XP-EHH, and Runs of homozygosity) to detect selective sweeps in whole-genome resequencing data of 19 Luxi gamecocks compared to other Chinese indigenous chickens. Eleven genes that were highly related to nervous system development (
MeSH term(s)	Animals ; Humans ; Chickens/genetics ; Base Sequence ; Sequence Analysis, DNA ; Sequence Analysis, RNA ; Nervous System ; Membrane Proteins/genetics ; Chloride-Bicarbonate Antiporters/genetics ; Carboxy-Lyases/genetics
Chemical Substances	LRIG3 protein, human ; Membrane Proteins ; SLC4A2 protein, human ; Chloride-Bicarbonate Antiporters ; GADL1 protein, human (EC 4.1.1.-) ; Carboxy-Lyases (EC 4.1.1.-)
Language	English
Publishing date	2023-02-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14030584
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Polysaccharide-Based Supramolecular Hydrogel Coatings with Corrosion Barrier Zone for Protection of Patina Bronze.

Zhang, Jiamei / Huang, Xia / Chen, Jiachang / Zhou, Sheng / Chen, Junying

Polymers

2023 Volume 15, Issue 16

Abstract: Protective coatings for bronze relics should adhere to the basic principles of cultural relic preservation, such as not altering the color and appearance of the artifacts, and being moderately combined with the artifacts to resist erosion due to external ...

Abstract	Protective coatings for bronze relics should adhere to the basic principles of cultural relic preservation, such as not altering the color and appearance of the artifacts, and being moderately combined with the artifacts to resist erosion due to external environments (such as water and gas). This paper presents the development of a physically crosslinked supramolecular hydrogel produced from guanidinium-based chitosan (GC). The hydrogel exhibits the excellent adsorption protection of bronze, and the addition of clay enhances the water barrier properties of the chitosan film. The supramolecular interaction between sodium polyacrylate/GC/clay confers corrosion buffering capability to the hydrogel coating in corrosive environments, and the gel coating can be self-healing at room temperature for 24 h. The fabricated nanocomposites were comprehensively characterized using various methods (Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, X-ray photoelectron spectroscopy, scanning electron microscopy, etc.). The electrochemical properties of coated specimens were evaluated, and the impedance spectrum revealed a large impedance arc indicating high charge resistance, which has a corrosion resistance effect.
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15163357
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The role of intestinal flora on tumor immunotherapy

Yimin Zhou / Xiangdong Liu / Wei Gao / Xin Luo / Junying Lv / Yunshan Wang / Duanrui Liu

Heliyon, Vol 10, Iss 1, Pp e23919- (2024)

recent progress and treatment implications

1481

Abstract: Immunotherapy, specifically immune checkpoint inhibitors, has emerged as a promising approach for treating malignant tumors. The gut, housing approximately 70 % of the body's immune cells, is abundantly populated with gut bacteria that actively interact ... ...

Abstract	Immunotherapy, specifically immune checkpoint inhibitors, has emerged as a promising approach for treating malignant tumors. The gut, housing approximately 70 % of the body's immune cells, is abundantly populated with gut bacteria that actively interact with the host's immune system. Different bacterial species within the intestinal flora are in a delicate equilibrium and mutually regulate each other. However, when this balance is disrupted, pathogenic microorganisms can dominate, adversely affecting the host's metabolism and immunity, ultimately promoting the development of disease. Emerging researches highlight the potential of interventions such as fecal microflora transplantation (FMT) to improve antitumor immune response and reduce the toxicity of immunotherapy. These remarkable findings suggest the major role of intestinal flora in the development of cancer immunotherapy and led us to the hypothesis that intestinal flora transplantation may be a new breakthrough in modifying immunotherapy side effects.
Keywords	Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spinal subdural hematoma and subdural anesthesia following combined spinal-epidural anesthesia: a case report.

Bi, Yanmei / Zhou, Junying

BMC anesthesiology

2021 Volume 21, Issue 1, Page(s) 130

Abstract: Background: Subdural anesthesia and spinal subdural hematoma are rare complications of combined spinal-epidural anesthesia. We present a patient who developed both after multiple attempts to achieve combined spinal-epidural anesthesia.: Case ... ...

Abstract	Background: Subdural anesthesia and spinal subdural hematoma are rare complications of combined spinal-epidural anesthesia. We present a patient who developed both after multiple attempts to achieve combined spinal-epidural anesthesia. Case presentation: A 21-year-old parturient, gravida 1, para 1, with twin pregnancy at gestational age 34 Conclusions: All anesthesiologists should be aware of the possibility of SSDH and subdural block when performing neuraxial anesthesia, especially in patients in whom puncture is difficult. Less traumatic methods of achieving anesthesia, such as epidural anesthesia, single-shot spinal anesthesia, or general anesthesia should be considered in these patients. Furthermore, vital signs and neurologic function should be closely monitored during and after surgery.
MeSH term(s)	Anesthesia, Epidural/adverse effects ; Anesthesia, Obstetrical/adverse effects ; Anesthesia, Spinal/adverse effects ; Cesarean Section ; Female ; Hematoma, Subdural, Spinal/diagnostic imaging ; Hematoma, Subdural, Spinal/etiology ; Humans ; Magnetic Resonance Imaging ; Pregnancy ; Pregnancy, Twin ; Young Adult
Language	English
Publishing date	2021-04-26
Publishing country	England
Document type	Journal Article
ISSN	1471-2253
ISSN (online)	1471-2253
DOI	10.1186/s12871-021-01352-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: As a Modulator, Multitasking Roles of SIRT1 in Respiratory Diseases.

Zhou, Yunxin / Zhang, Fan / Ding, Junying

Immune network

2022 Volume 22, Issue 3, Page(s) e21

Abstract: As far the current severe coronavirus disease 2019 (COVID-19), respiratory disease is still the biggest threat to human health. In addition, infectious respiratory diseases are particularly prominent. In addition to killing and clearing the infection ... ...

Abstract	As far the current severe coronavirus disease 2019 (COVID-19), respiratory disease is still the biggest threat to human health. In addition, infectious respiratory diseases are particularly prominent. In addition to killing and clearing the infection pathogen directly, regulating the immune responses against the pathogens is also an important therapeutic modality. Sirtuins belong to NAD+-dependent class III histone deacetylases. Among 7 types of sirtuins, silent information regulator type-1 (SIRT1) played a multitasking role in modulating a wide range of physiological processes, including oxidative stress, inflammation, cell apoptosis, autophagy, antibacterial and antiviral functions. It showed a critical effect in regulating immune responses by deacetylation modification, especially through high-mobility group box 1 (HMGB1), a core molecule regulating the immune system. SIRT1 was associated with many respiratory diseases, including COVID-19 infection, bacterial pneumonia, tuberculosis, and so on. Here, we reviewed the latest research progress regarding the effects of SIRT1 on immune system in respiratory diseases. First, the structure and catalytic characteristics of SIRT1 were introduced. Next, the roles of SIRT1, and the mechanisms underlying the immune regulatory effect through HMGB1, as well as the specific activators/inhibitors of SIRT1, were elaborated. Finally, the multitasking roles of SIRT1 in several respiratory diseases were discussed separately. Taken together, this review implied that SIRT1 could serve as a promising specific therapeutic target for the treatment of respiratory diseases.
Language	English
Publishing date	2022-06-20
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2536191-0
ISSN	2092-6685 ; 1598-2629
ISSN (online)	2092-6685
ISSN	1598-2629
DOI	10.4110/in.2022.22.e21
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