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Article: Characterizing the Development of Research Landscapes in Substance Use and HIV/AIDS During 1990 to 2021.

Nguyen, Tham Thi / Nguyen, Hien Thu / Do, Huyen Phuc / Ho, Cyrus Sh / Ho, Roger Cm

Substance abuse : research and treatment

2023 Volume 17, Page(s) 11782218231177515

Abstract: Mitigating the impacts of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) and substance use requires comprehensive and systematic thinking in designing interventions and developing policies. This study describes the growth of ... ...

Abstract	Mitigating the impacts of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) and substance use requires comprehensive and systematic thinking in designing interventions and developing policies. This study describes the growth of research publications from 1991 to 2021 in the Web of Science database and points out current research landscapes in the fields of HIV/AIDS and substance use. Latent Dirichlet Allocation was used for classifying 21 359 papers into corresponding topics. The most common topics were HIV transmission, HIV infection, quality of life and mental health of substance users, and the biomedical effect of substance use. Emerging research landscapes include vulnerabilities of people who inject drugs to HIV transmission and related health problems. This study found a lack of research on health services, interdisciplinary and inter-sectoral in combination with clinical evaluation and treatment services. Future investment and implementation of HIV/AIDS and substance use programs should focus on research of health services and clinical evaluation, especially context-specific interventions.
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1458030-5
ISSN	1547-0164 ; 1178-2218 ; 0889-7077
ISSN (online)	1547-0164
ISSN	1178-2218 ; 0889-7077
DOI	10.1177/11782218231177515
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Article: Mental Health Strategies to Combat the Psychological Impact of COVID-19 Beyond Paranoia and Panic.

Ho, Cyrus Sh / Chee, Cornelia Yi / Ho, Roger Cm

Annals of the Academy of Medicine, Singapore

2020 Volume 49, Issue 3, Page(s) 155–160

MeSH term(s)	Adaptation, Psychological ; COVID-19 ; Communication ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Epidemics ; Fear ; Health Personnel/psychology ; Humans ; Mental Health ; Mental Health Services ; Panic ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; Risk Assessment
Keywords	covid19
Language	English
Publishing date	2020-03-19
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	604527-3
ISSN	0304-4602
ISSN	0304-4602
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Article ; Online: Characterizing the Development of Research Landscapes in Substance Use and HIV/AIDS During 1990 to 2021

Tham Thi Nguyen / Hien Thu Nguyen / Huyen Phuc Do / Cyrus SH Ho / Roger CM Ho

Substance Abuse: Research and Treatment, Vol

2023 Volume 17

Abstract	Mitigating the impacts of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) and substance use requires comprehensive and systematic thinking in designing interventions and developing policies. This study describes the growth of research publications from 1991 to 2021 in the Web of Science database and points out current research landscapes in the fields of HIV/AIDS and substance use. Latent Dirichlet Allocation was used for classifying 21 359 papers into corresponding topics. The most common topics were HIV transmission, HIV infection, quality of life and mental health of substance users, and the biomedical effect of substance use. Emerging research landscapes include vulnerabilities of people who inject drugs to HIV transmission and related health problems. This study found a lack of research on health services, interdisciplinary and inter-sectoral in combination with clinical evaluation and treatment services. Future investment and implementation of HIV/AIDS and substance use programs should focus on research of health services and clinical evaluation, especially context-specific interventions.
Keywords	Public aspects of medicine ; RA1-1270
Subject code	306
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Mental Health Strategies to Combat the Psychological Impact of COVID-19 Beyond Paranoia and Panic

Ho, Cyrus Sh / Chee, Cornelia Yi / Ho, Roger Cm

Annals of the Academy of Medicine, Singapore

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #11686
Database	COVID19

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Article ; Online: The disappearance of white matter in an adult-onset disease: a case report.

Ho, Cyrus Sh / Mangelsdorf, Simone / Walterfang, Mark

BMC psychiatry

2020 Volume 20, Issue 1, Page(s) 137

Abstract: Background: Vanishing white matter disease (VWMD) is one of the most prevalent hereditary white matter diseases in childhood, but it is increasingly recognised in adulthood with high phenotypic variation and severity.: Case presentation: We report a ... ...

Abstract	Background: Vanishing white matter disease (VWMD) is one of the most prevalent hereditary white matter diseases in childhood, but it is increasingly recognised in adulthood with high phenotypic variation and severity. Case presentation: We report a case of an adult female presenting with emotional lability and cognitive impairment, in addition to progressive dystonia, ataxia, postural instability and recurrent falls. Magnetic resonance imaging (MRI) of the brain and genetic testing confirmed the diagnosis of VWMD. Conclusions: VWMD has a broad clinical presentation in adulthood, and the age at onset of symptoms is one of its most important prognostic factors. It is crucial to recognize the pathognomonic MRI patterns and consider VWMD as a differential diagnosis when assessing patients presenting with psychiatric, cognitive and non-specific neurological symptoms.
MeSH term(s)	Adult ; Brain/diagnostic imaging ; Female ; Humans ; Leukoencephalopathies ; Magnetic Resonance Imaging ; Neuroimaging ; White Matter/diagnostic imaging ; White Matter/pathology
Language	English
Publishing date	2020-03-27
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1471-244X
ISSN (online)	1471-244X
DOI	10.1186/s12888-020-02551-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Improving the diagnostic accuracy for major depressive disorder using machine learning algorithms integrating clinical and near-infrared spectroscopy data.

Ho, Cyrus Sh / Chan, Y L / Tan, Trevor Wk / Tay, Gabrielle Wn / Tang, T B

Journal of psychiatric research

2022 Volume 147, Page(s) 194–202

Abstract: Background: Given that major depressive disorder (MDD) is both biologically and clinically heterogeneous, a diagnostic system integrating neurobiological markers and clinical characteristics would allow for better diagnostic accuracy and, consequently, ... ...

Abstract	Background: Given that major depressive disorder (MDD) is both biologically and clinically heterogeneous, a diagnostic system integrating neurobiological markers and clinical characteristics would allow for better diagnostic accuracy and, consequently, treatment efficacy. Objective: Our study aimed to evaluate the discriminative and predictive ability of unimodal, bimodal, and multimodal approaches in a total of seven machine learning (ML) models-clinical, demographic, functional near-infrared spectroscopy (fNIRS), combinations of two unimodal models, as well as a combination of all three-for MDD. Methods: We recruited 65 adults with MDD and 68 matched healthy controls, who provided both sociodemographic and clinical information, and completed the HAM-D questionnaire. They were also subject to fNIRS measurement when participating in the verbal fluency task. Using the nested cross validation procedure, the classification performance of each ML model was evaluated based on the area under the receiver operating characteristic curve (ROC), balanced accuracy, sensitivity, and specificity. Results: The multimodal ML model was able to distinguish between depressed patients and healthy controls with the highest balanced accuracy of 87.98 ± 8.84% (AUC = 0.92; 95% CI (0.84-0.99) when compared with the uni- and bi-modal models. Conclusions: Our multimodal ML model demonstrated the highest diagnostic accuracy for MDD. This reinforces the biological and clinical heterogeneity of MDD and highlights the potential of this model to improve MDD diagnosis rates. Furthermore, this model is cost-effective and clinically applicable enough to be established as a robust diagnostic system for MDD based on patients' biosignatures.
MeSH term(s)	Adult ; Algorithms ; Depressive Disorder, Major/diagnosis ; Humans ; Machine Learning ; ROC Curve ; Spectroscopy, Near-Infrared/methods
Language	English
Publishing date	2022-01-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2022.01.026
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Article ; Online: Psychological impacts of COVID-19 on Vietnamese health workers over the prolonged restricted COVID-19 responses: a cross-sectional study.

Tran, Bach / Nguyen, Minh Trong / Auquier, Pascal / Boyer, Laurent / Fond, Guillaume / Vu, Giang Thu / Hoang, Thao Phuong / Ho, Phuong Thu / Nguyen, Tu Huu / Latkin, Carl A / Ho, Cyrus Sh / Ho, Roger C M / Zhang, Melvyn W B

BMJ open

2023 Volume 13, Issue 8, Page(s) e069239

Abstract: Objective: We assessed the psychological impact posed by COVID-19 and its associated factors on the healthcare workforce nationwide during the peak of Vietnam's fourth outbreak.: Design: A cross-sectional study.: Setting: Our study was conducted ... ...

Abstract	Objective: We assessed the psychological impact posed by COVID-19 and its associated factors on the healthcare workforce nationwide during the peak of Vietnam's fourth outbreak. Design: A cross-sectional study. Setting: Our study was conducted in 61 provinces of Vietnam. Methods: A total of 2814 healthcare professionals in 61/63 provinces of Vietnam. An online questionnaire using Patient Health Questionnaire-9 (PHQ-9), Perceived Stress Scale-4 (PSS-4) and Generalised Anxiety Disorder-7 (GAD-7) scales was distributed randomly to a subgroup of 503 respondents. Primary and secondary outcome measures: To determine the impact of COVID-19 on the psychological of health workers, we conducted analyses to test a primary hypothesis related to participants based on three main scales including PHQ-9, PSS-4 and GAD-7 scales. Results: Nearly half (49.7%) of healthcare workers experienced mild depression symptoms, 34.0% underwent moderate anxiety symptoms and 49.3% reported high-stress levels. Respondents who had a monthly income below 5 million VND (~US$212) and had more than 3 days of duty per week had a higher score on the anxiety scales. Compared with medical doctors, nurses/midwives had lower PHQ-9 (Coef=-2.53; 95% CI=-3.71 to -1.36) and GAD-7 scores (Coef=-2.36; 95% CI=-3.56 L to -1.16). Increased workload and work time was the harmful factor that increase the PHQ-9, GAD-7 or PSS-4 scores. More than half (53.9%) of respondents stated no demand for mental healthcare services. Conclusions: Health workers who gained less financial rewards are reported to have higher levels of mental distress than others, implying the need for a raise in basic salary as well as compensation and encouragement schemes. To tackle hesitancy in seeking mental help, integrating online mental health therapy with e-health consultations via social media can be strategically implemented to augment service delivery, and simultaneously enhance the standard of mental health services.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Cross-Sectional Studies ; Southeast Asian People ; Vietnam/epidemiology ; Depression/epidemiology ; Depression/psychology ; Health Personnel/psychology ; Anxiety/epidemiology ; Anxiety/psychology
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-069239
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Avoidance of healthcare service use and correlates among HIV-positive patients in Vietnam: a cross-sectional study.

Nguyen, Huong Lan Thi / Bui, Thu Minh / Dam, Vu Anh Trong / Nguyen, Tham Thi / Nguyen, Hien Thu / Zeng, Ga Mei / Bradley, Don / Nguyen, Quang N / Ngo, Toan Van / Latkin, Carl A / Ho, Roger Cm / Ho, Cyrus Sh

BMJ open

2023 Volume 13, Issue 12, Page(s) e074005

Abstract: Objective: The prevention of HIV/AIDS is not making sufficient progress. The slow reduction of HIV/AIDS infections needs to prioritise hesitancy towards service utilisation, including treatment duration, social support and social stigma. This study ... ...

Abstract	Objective: The prevention of HIV/AIDS is not making sufficient progress. The slow reduction of HIV/AIDS infections needs to prioritise hesitancy towards service utilisation, including treatment duration, social support and social stigma. This study investigates HIV-positive patients' avoidance of healthcare services and its correlates. Design: A cross-sectional study. Setting: The secondary data analysis used cross-sectional data from a randomised controlled intervention, examining the effectiveness of HIV-assisted smartphone applications in the treatment of HIV/AIDS patients in the Bach Mai and Ha Dong clinics in Hanoi. Methods: Simple random sampling was used to identify 495 eligible patients. Two-tailed χ Primary and secondary outcome measures: The main study outcome was the patients' healthcare avoidance and frequency of healthcare avoidance. The association of individual characteristics, social and behavioural determinants of HIV patients' usage of health services was also determined based on the collected data using structured questionnaires. Results: Nearly half of the participants avoid health service use (47.3%), while 30.7% rarely avoid health service use. Duration of antiretroviral therapy and initial CD4 cell count were negatively associated with avoidance of health services and frequency of health service avoidance. Similarly, those with the middle and highest income were more likely to avoid health services compared with those with the lowest income. People having health problems avoided health service use more frequently (OR 1.47, 95% CI 1.35 to 1.61). Conclusions: Our study's findings identify characteristics of significance in relation to health service avoidance and utilisation among HIV-positive patients. The results highlighted the need to improve satisfaction, adherence and utilisation of treatment. Moreover, identifying ways to address or incorporate those social determinants in new policy may also help the treatment of HIV/AIDS and strategically allocate funding in the changing financial and political climate of Vietnam. Trial registration number: Thai Clinical Trials Registry TCTR20220928003.
MeSH term(s)	Humans ; HIV Infections/prevention & control ; Acquired Immunodeficiency Syndrome/drug therapy ; Cross-Sectional Studies ; Vietnam ; Surveys and Questionnaires ; Health Services ; Treatment Refusal
Language	English
Publishing date	2023-12-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-074005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prefrontal Cortical Activation While Doing Mindfulness Task: a Pilot Functional Near-Infrared Spectroscopy Study.

Yu, Juanhong / Ang, Kai Keng / Choo, Carol C / Ho, Cyrus Sh / Ho, Roger / So, Rosa Q

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2020 Volume 2020, Page(s) 2905–2908

Abstract: Mindfulness interventions are increasingly used in clinical settings. Neurophysiological mechanisms underlying mindfulness offer objective evidence that can help us evaluate the efficacy of mindfulness. Recent advances in technology have facilitated the ... ...

Abstract	Mindfulness interventions are increasingly used in clinical settings. Neurophysiological mechanisms underlying mindfulness offer objective evidence that can help us evaluate the efficacy of mindfulness. Recent advances in technology have facilitated the use of functional Near-Infrared Spectroscopy (fNIRS) as a light weight, portable, and relatively lower cost neuroimaging device as compared to functional Magnetic Resonance Imaging (fMRI). In contrast to numerous fMRI studies, there are scanty investigations using fNIRS to study mindfulness. Hence, this study was done to investigate the feasibility of using a continuous-wave multichannel fNIRS system to study cerebral cortex activations on a mindfulness task versus a baseline task. NIRS data from 14 healthy Asian subjects were collected. A statistical parametric mapping toolbox specific for statistical analysis of NIRS signal called NIRS_SPM was used to study the activations. The results from group analysis performed on the contrast of the mindfulness versus baseline tasks showed foci of activations on the left and central parts of the prefrontal cortex. The findings are consistent with prevailing fMRI studies and show promise of using fNIRS system for studying real-time neurophysiological cortical activations during mindfulness practice.
MeSH term(s)	Cerebral Cortex/diagnostic imaging ; Humans ; Mindfulness ; Pilot Projects ; Prefrontal Cortex/diagnostic imaging ; Spectroscopy, Near-Infrared
Language	English
Publishing date	2020-09-25
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC44109.2020.9175464
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Article ; Online: Crucial choices in a global health crisis: Revealing the demand and willingness to pay for a hypothetical monkeypox vaccine - the PREVENT study.

Tran, Bach Xuan / Anh Do, Linh / Hoang, Thao Phuong / Boyer, Laurent / Auquier, Pascal / Fond, Guillaume / Le, Huong Thi / Le Vu, Minh Ngoc / Dang, Trang Huyen Thi / Nguyen, Anh Hai Tran / Latkin, Carl A / Ho, Roger Cm / Ho, Cyrus Sh / Zhang, Melvyn Wb

Journal of global health

2023 Volume 13, Page(s) 4033

Abstract: Background: The latent monkeypox outbreak has become the most emergent public health challenge globally. This study was conducted to assess the acceptability, and willingness to take and pay for a hypothetical Monkeypox vaccine among the Vietnamese ... ...

Abstract	Background: The latent monkeypox outbreak has become the most emergent public health challenge globally. This study was conducted to assess the acceptability, and willingness to take and pay for a hypothetical Monkeypox vaccine among the Vietnamese general public as well as investigate preference for individual vaccine attributes. Methods: An online cross-sectional study was conducted using snowball sampling among 842 respondents in Vietnam in 2022. A Discrete choice experiment (DCE) on preference for six major attributes of vaccine: effectiveness, immunity duration, side effects, mortality rate, restriction, and the cost was applied. Results: Fear of the impact of monkeypox on public health and the economy, vaccine service satisfaction and responsibility to the community were the most weighted factors in the decision to take a hypothetical monkeypox vaccine. Two-thirds of participants were willing to take the vaccine, while insufficient information on monkeypox and the vaccine were the main reasons for vaccine hesitancy. For vaccine attributes, the mortality rate after seven days of vaccination was the most weighted while cost was the least influential attribute. Factors associated with willingness to take and to pay for the monkeypox vaccine included knowledge of transmission, geographical location, service satisfaction, and risk of infection, while financial burden and fear of vaccine were major drivers of hesitancy. Conclusion: Our findings underline an urgent need for effective information dissemination through social media and counseling. The implementation of nationwide monkeypox vaccination requires prioritization and support for high-risk groups as well as consideration for the country's financial resources.
MeSH term(s)	Humans ; Smallpox Vaccine ; Cross-Sectional Studies ; Global Health ; Mpox (monkeypox) ; Vaccines
Chemical Substances	Smallpox Vaccine ; Vaccines
Language	English
Publishing date	2023-05-05
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2741629-X
ISSN	2047-2986 ; 2047-2986
ISSN (online)	2047-2986
ISSN	2047-2986
DOI	10.7189/jogh.13.04033
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