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Article ; Online: Introduction to Mediation Analysis and Examples of Its Application to Real-world Data.

Jung, Sun Jae

Journal of preventive medicine and public health = Yebang Uihakhoe chi

2021 Volume 54, Issue 3, Page(s) 166–172

Abstract: Traditional epidemiological assessments, which mainly focused on evaluating the statistical association between two major components-the exposure and outcome-have recently evolved to ascertain the in-between process, which can explain the underlying ... ...

Abstract	Traditional epidemiological assessments, which mainly focused on evaluating the statistical association between two major components-the exposure and outcome-have recently evolved to ascertain the in-between process, which can explain the underlying causal pathway. Mediation analysis has emerged as a compelling method to disentangle the complex nature of these pathways. The statistical method of mediation analysis has evolved from simple regression analysis to causal mediation analysis, and each amendment refined the underlying mathematical theory and required assumptions. This short guide will introduce the basic statistical framework and assumptions of both traditional and modern mediation analyses, providing examples conducted with real-world data.
MeSH term(s)	Data Analysis ; Humans ; Mediation Analysis ; Multivariate Analysis
Language	English
Publishing date	2021-05-07
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2620879-9
ISSN	2233-4521 ; 2233-4521
ISSN (online)	2233-4521
ISSN	2233-4521
DOI	10.3961/jpmph.21.069
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Numerical Simulation of Deformation in Hot Runner Manifold.

Jung, Jae Sung / Kim, Sun Kyoung

Micromachines

2023 Volume 14, Issue 7

Abstract: This study simulated the deformation of a hot runner manifold and nozzle assembly during operation, aiming to address potential leaks and premature failure. Both thermal and mechanical models were used simultaneously to accurately capture system behavior. ...

Abstract	This study simulated the deformation of a hot runner manifold and nozzle assembly during operation, aiming to address potential leaks and premature failure. Both thermal and mechanical models were used simultaneously to accurately capture system behavior. A simplified set of boundary conditions was proposed for efficient problem-solving. Analysis of the simulation results revealed that thermal deformation posed a risk of catastrophic failures and leaks. Deformation from melt pressure was relatively small compared to thermal loading, not exceeding 12%. The study provided design recommendations based on the simulation findings, guiding the development of hot runner systems for improved reliability.
Language	English
Publishing date	2023-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14071337
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Association between COVID-19 and incidence of cardiovascular disease and all-cause mortality among patients with diabetes.

Jung, Hee Sun / Choi, Jae Woo

Frontiers in endocrinology

2023 Volume 14, Page(s) 1230176

Abstract: Introduction: Although the risk of coronavirus disease 2019 (COVID-19) infection is higher in patients who are diagnosed with diabetes than in those who are not, research on the risk of cardiovascular disease (CVD) in COVID-19 infected patients ... ...

Abstract	Introduction: Although the risk of coronavirus disease 2019 (COVID-19) infection is higher in patients who are diagnosed with diabetes than in those who are not, research on the risk of cardiovascular disease (CVD) in COVID-19 infected patients diagnosed with diabetes compared to those who are not infected by COVID-19 is lacking. This study aimed to examine the association between COVID-19, incidence of CVD, and all-cause mortality in patients with diabetes. Methods: This study used data from the Health Insurance Review and Assessment, and included 16,779 patients with COVID-19 and 16,779 matched controls between January 2017 and June 2021. The outcomes included cardiovascular disease (CVD), coronary heart disease, stroke, and all-cause mortality. Cox proportional hazards regression models were used to evaluate these associations. Results: Patients with diabetes hospitalized because of COVID-19 had a significantly increased risk of CVD (adjusted hazard ratio [AHR], 2.12; 95% confidence interval [CI]: 1.97, 2.27) than those without COVID-19. The risks of coronary heart disease (AHR, 2.00; 95% CI: 1.85, 2.17) and stroke (AHR, 2.21; 95% CI: 1.90, 2.57) were higher in the intervention group than in the control group. In the case of all-cause mortality for middle-aged adults, we observed a higher risk in diabetes patients hospitalized due to COVID-19 than in patients without COVID-19 (AHR, 1.37; 95% CI: 1.18, 1.59). Conclusions: This study showed that patients with diabetes hospitalized due to COVID-19 had an increased risk of CVD, coronary heart disease, stroke incidence, and mortality than those who were not COVID-19 infected, suggesting more careful prevention and management among patients with COVID-19.
MeSH term(s)	Adult ; Middle Aged ; Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Incidence ; COVID-19/complications ; COVID-19/epidemiology ; Diabetes Mellitus/epidemiology ; Stroke/complications ; Coronary Disease
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1230176
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Role of individual deprivation and community-level deprivation on suicidal behaviors: Insights from the UK Biobank study.

Kim, Kwanghyun / Lee, Doo Woong / Jung, Sun Jae

SSM - population health

2024 Volume 26, Page(s) 101654

Abstract: Introduction: This study aimed to investigate the impact of individual- and community-level deprivation on suicidal behaviors among community members.: Methods: Data from 350,884 UK Biobank participants were employed to construct an individual ... ...

Abstract	Introduction: This study aimed to investigate the impact of individual- and community-level deprivation on suicidal behaviors among community members. Methods: Data from 350,884 UK Biobank participants were employed to construct an individual deprivation index. Absolute poverty was defined as a pre-tax annual household income below ₤18,000. Predictors for absolute poverty incorporated variables such as sex, ethnicity, type of accommodation, tenure status, number of vehicles owned, educational qualifications, current employment status, and subjective health rating. The individual deprivation index was constructed using a logistic regression model to predict absolute poverty. Townsend Deprivation Index (TDI) was employed to represent community-level deprivation. The associations between the individual deprivation index, TDI, and suicidal behaviors were examined through multivariate linear regression. Interaction analyses were conducted to investigate effect modification. Results: The logistic regression model demonstrated high predictive accuracy for absolute poverty (area under the receiver operating curve = 0.840). The associations between individual deprivation index and suicidal behaviors were observed to be more substantial than those between TDI and suicidal behaviors. A positive interaction between the individual deprivation index and TDI was detected, indicating an amplifying effect of community-level deprivation on the impact of individual-level deprivation on suicidal behaviors. Conclusion: Our study successfully constructed a comprehensive individual deprivation index that could be applied widely to measure individual-level deprivation. Our findings revealed that individual-level deprivation and community-level deprivation have a synergistic effect on suicidal behaviors, underscoring the importance of multilevel interventions in suicide prevention.
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ISSN	2352-8273
ISSN	2352-8273
DOI	10.1016/j.ssmph.2024.101654
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Introduction to Mediation Analysis and Examples of Its Application to Real-world Data

Sun Jae Jung

Journal of Preventive Medicine and Public Health, Vol 54, Iss 3, Pp 166-

2021 Volume 172

Abstract	Traditional epidemiological assessments, which mainly focused on evaluating the statistical association between two major components-the exposure and outcome-have recently evolved to ascertain the in-between process, which can explain the underlying causal pathway. Mediation analysis has emerged as a compelling method to disentangle the complex nature of these pathways. The statistical method of mediation analysis has evolved from simple regression analysis to causal mediation analysis, and each amendment refined the underlying mathematical theory and required assumptions. This short guide will introduce the basic statistical framework and assumptions of both traditional and modern mediation analyses, providing examples conducted with real-world data.
Keywords	mediation analysis ; epidemiology ; humans ; logic ; probability ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Korean Society for Preventive Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Depressive symptoms and neuroticism mediate the association between traumatic events and suicidality - A latent class mediation analysis of UK Biobank Database.

Lee, Doo Woong / Kim, Kwanghyun / Hyun, Jinhee / Jung, Sun Jae

Journal of affective disorders

2024 Volume 356, Page(s) 13–21

Abstract: Background: Mental disorders that follow traumatic experience may increase risk of suicidality, but a comprehensive approach to understand how these mental disorders mediate the association between psychological traumatic experience and suicidality ... ...

Abstract	Background: Mental disorders that follow traumatic experience may increase risk of suicidality, but a comprehensive approach to understand how these mental disorders mediate the association between psychological traumatic experience and suicidality should be elucidated. In this study, we attempted to provide comprehensive evidence on how depressive symptoms and neuroticism can mediate the association between psychological traumatic experiences and suicidal behaviours including suicidal ideation, suicidal planning, and suicide attempts. Methods: We analyzed 111,931 participants from UK Biobank who had completed mental health web-based questionnaire from 2016 to 2017. "Self-harm and suicidal behaviour and ideation (SSBI) score" was calculated by the response from suicidal behaviours and self-harm questionnaires. Conducting multivariate linear regression, depressive symptoms, anxiety symptoms, and neuroticism were selected as potential mediators. We constructed a latent class mediation model estimated direct effect of psychological traumatic events on suicidality and indirect effect of psychological traumatic events mediated by depressive symptoms and neuroticism. Results: Psychological traumatic events were positively associated with suicidal behaviours. Depressive symptoms and neuroticism significantly mediated the effect of psychological traumatic events on suicidality. Anxiety symptoms did not mediate the association between psychological traumatic events and suicidality. Conclusion: Psychological traumatic events, irrespective of life stage of occurrence, are associated with suicidality. The association between psychological traumatic events and suicidality can be partially explained by depressive symptoms and neuroticism of those who were exposed to psychological trauma.
Language	English
Publishing date	2024-04-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2024.03.171
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Saving Our Healthcare Workers Again During the COVID-19 Pandemic in the Philippines.

Lee, Youngrong / Jung, Sun Jae

Journal of preventive medicine and public health = Yebang Uihakhoe chi

2021 Volume 54, Issue 5, Page(s) 382–383

MeSH term(s)	COVID-19 ; Health Personnel ; Humans ; Pandemics/prevention & control ; Philippines/epidemiology ; SARS-CoV-2
Language	English
Publishing date	2021-09-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2620879-9
ISSN	2233-4521 ; 2233-4521
ISSN (online)	2233-4521
ISSN	2233-4521
DOI	10.3961/jpmph.21.483
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Parent-Offspring Associations of Ideal Cardiovascular Health Metrics: Findings From the 2014 to 2021 Korea National Health and Nutrition Examination Survey.

Hoang, Manh Thang / Jung, Sun Jae / Lee, Hokyou / Kim, Hyeon Chang

Journal of the American Heart Association

2024 Volume 13, Issue 2, Page(s) e030995

Abstract: Background: Studies have reported the strength of cardiovascular health (CVH) metrics in parent-offspring relationships. This study aimed to describe the sex-specific associations between CVH in parents and adult offspring.: Methods and results: This ...

Abstract	Background: Studies have reported the strength of cardiovascular health (CVH) metrics in parent-offspring relationships. This study aimed to describe the sex-specific associations between CVH in parents and adult offspring. Methods and results: This study was conducted on the Korea National Health and Nutrition Examination Survey data set, which analyzed trios of mother-father-child, with the child's age from 20 to 39 years. To use the nature of sampling design, survey weighting was applied to all our analyses. Ideal CVH was defined as a cluster of at least 5 ideal individual CVH metrics. We examined the association between parents and their adult offspring regarding clustering CVH and individual CVH metrics through odds ratios and 95% CIs using multiple logistic regression with standard errors adjusted for within-family clustering. The study included 1267 married couples comprising 748 sons and 819 daughters. After adjusting for household income and offspring's sex, age, education, and alcohol consumption, an offspring with either parent attaining a nonideal CVH was 3.52 times more likely to have nonideal CVH. Fathers' nonideal CVH was significantly positively associated with the daughters' nonideal CVH. Maternal nonideal CVH was significantly positively associated with the son's nonideal CVH. When analyzing individual CVH metrics, ideal status in fathers or mothers reduced the likelihood of their offspring having a nonideal status. Conclusions: This cross-sectional study showed positive and differential associations of CVH and its components between parents' and offsprings' nonideal status. Our hypothesis-generating results suggest the relevance of using CVH as a composite indicator in family-centered approaches and heart-health interventions.
MeSH term(s)	Adult ; Male ; Female ; Humans ; Young Adult ; Nutrition Surveys ; Quality Indicators, Health Care ; Cross-Sectional Studies ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Parents ; Republic of Korea/epidemiology ; Health Status ; Risk Factors
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.030995
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metabolic Obesity Phenotypes and Incident Cardiovascular Outcomes in Middle-Aged and Older Korean Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study.

Park, Jae-Min / Lee, Hye Sun / Yang, Juyeon / Jung, Dong-Hyuk / Lee, Ji-Won

Metabolic syndrome and related disorders

2024 Volume 22, Issue 3, Page(s) 232–239

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; Middle Aged ; Humans ; Aged ; Risk Factors ; Coronary Artery Disease/epidemiology ; Prospective Studies ; Obesity/complications ; Obesity/epidemiology ; Obesity/genetics ; Phenotype ; Stroke/epidemiology ; Republic of Korea/epidemiology ; Body Mass Index ; Metabolic Syndrome
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2151220-6
ISSN	1557-8518 ; 1540-4196
ISSN (online)	1557-8518
ISSN	1540-4196
DOI	10.1089/met.2023.0170
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5950: Show issues

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Article ; Online: Saving Our Healthcare Workers Again During the COVID-19 Pandemic in the Philippines

Youngrong Lee / Sun Jae Jung

Journal of Preventive Medicine and Public Health, Vol 54, Iss 5, Pp 382-

2021 Volume 383

Keywords	Medicine ; R ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Korean Society for Preventive Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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