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Article ; Online: Gender-based violence during COVID-19 outbreak in Spain.

Rodriguez-Jimenez, Roberto / Fares-Otero, Natalia E / García-Fernández, Lorena

2020 Volume 53, Issue 1, Page(s) 299–300

MeSH term(s)	Humans ; COVID-19 ; Gender-Based Violence ; Spain/epidemiology ; Violence ; Disease Outbreaks
Language	English
Publishing date	2020-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291720005024
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Article ; Online: Cell Membrane-Coated Nanoparticles for Precision Medicine: A Comprehensive Review of Coating Techniques for Tissue-Specific Therapeutics.

Fernández-Borbolla, Andrés / García-Hevia, Lorena / Fanarraga, Mónica L

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: Nanoencapsulation has become a recent advancement in drug delivery, enhancing stability, bioavailability, and enabling controlled, targeted substance delivery to specific cells or tissues. However, traditional nanoparticle delivery faces challenges such ... ...

Abstract	Nanoencapsulation has become a recent advancement in drug delivery, enhancing stability, bioavailability, and enabling controlled, targeted substance delivery to specific cells or tissues. However, traditional nanoparticle delivery faces challenges such as a short circulation time and immune recognition. To tackle these issues, cell membrane-coated nanoparticles have been suggested as a practical alternative. The production process involves three main stages: cell lysis and membrane fragmentation, membrane isolation, and nanoparticle coating. Cell membranes are typically fragmented using hypotonic lysis with homogenization or sonication. Subsequent membrane fragments are isolated through multiple centrifugation steps. Coating nanoparticles can be achieved through extrusion, sonication, or a combination of both methods. Notably, this analysis reveals the absence of a universally applicable method for nanoparticle coating, as the three stages differ significantly in their procedures. This review explores current developments and approaches to cell membrane-coated nanoparticles, highlighting their potential as an effective alternative for targeted drug delivery and various therapeutic applications.
MeSH term(s)	Precision Medicine ; Cell Membrane/metabolism ; Drug Delivery Systems ; Nanoparticles
Language	English
Publishing date	2024-02-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042071
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Article ; Online: Corrigendum to "What about mental health after one year of COVID-19 pandemic? A comparison with the initial peak" [J. Psychiatr. Res. 153 (2022) 104-108].

García-Fernández, Lorena / Romero-Ferreiro, Verónica / Rodríguez, Victoria / Alvarez-Mon, Miguel A / Lahera, Guillermo / Rodriguez-Jimenez, Roberto

Journal of psychiatric research

2022 Volume 154, Page(s) 10

Language	English
Publishing date	2022-07-20
Publishing country	England
Document type	Published Erratum
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2022.07.027
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Article ; Online: Different emotional profile of health care staff and general population during the COVID-19 outbreak.

García-Fernández, Lorena / Romero-Ferreiro, Verónica / Padilla, Sergio / Lahera, Guillermo / Rodriguez-Jimenez, Roberto

Psychological trauma : theory, research, practice and policy

2021 Volume 14, Issue 2, Page(s) 266–272

Abstract: Objective: The aims of this study were to assess COVID-19 outbreak-related emotions, to identify vulnerable groups within health care workers (HCW) and to study the relationship between the emotional state and some environmental features.: Method: We ...

Abstract	Objective: The aims of this study were to assess COVID-19 outbreak-related emotions, to identify vulnerable groups within health care workers (HCW) and to study the relationship between the emotional state and some environmental features. Method: We conducted a cross-sectional study on March 29 to April 5, 2020 based on a national online survey using snowball sampling techniques. A list of emotional states was compared in HCW and non-HCW and within HCW roles. The relationship between COVID-19 related symptoms, information, and protective measures and the emotional state was analyzed. Results: Fear ( Conclusions: The knowledge of the most prevalent different emotional patterns in HCW, as well as in the general population, will allow the detection of subjects at risk for the development of mental disorders and the implementation of therapeutic approaches in future similar situations of pandemic or outbreak of the current one. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
MeSH term(s)	COVID-19 ; Cross-Sectional Studies ; Delivery of Health Care ; Emotions ; Health Personnel ; Humans ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2497028-1
ISSN	1942-969X ; 1942-9681
ISSN (online)	1942-969X
ISSN	1942-9681
DOI	10.1037/tra0001024
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Article ; Online: What about mental health after one year of COVID-19 pandemic? A comparison with the initial peak.

García-Fernández, Lorena / Romero-Ferreiro, Verónica / Rodríguez, Victoria / Alvarez-Mon, Miguel A / Lahera, Guillermo / Rodriguez-Jimenez, Roberto

Journal of psychiatric research

2022 Volume 153, Page(s) 104–108

Abstract: A psychiatric epidemic has accompanied the COVID-19 pandemic and specific vulnerable populations have been identified. We aimed to explore the presence of anxiety, acute stress and depression among these vulnerable groups after a year of pandemic and ... ...

Abstract	A psychiatric epidemic has accompanied the COVID-19 pandemic and specific vulnerable populations have been identified. We aimed to explore the presence of anxiety, acute stress and depression among these vulnerable groups after a year of pandemic and relate them to our previous results obtained with the same methodology during the initial peak of the pandemic in Spain. A total of 2182 participants conducted a national survey, starting on March 2021. Sociodemographic information and clinical symptoms were assessed. The sample was divided into four groups in order to develop four substudies with these results: 1) Healthcare workers presented lower anxiety, acute stress, and depression than non-Healthcare workers (p < 0.001), being nurses the most affected. 2) People with mental disorders experienced higher anxiety, acute stress, and depression than people without (p < 0.001), as well as a higher rate of COVID cases (14% vs. 9.3%, p = 0.041). 3) People ≥60 years old presented lower anxiety and acute stress than people <60, (p < 0.05) and a weaker depressive syndrome (p = 0.003). 4) Males presented lower anxiety, acute stress and depression than females (p < 0.001). According to the results obtained during the initial peak, Healthcare workers have developed efficient coping strategies, while elders have managed to maintain their previously emotional balance. Notwithstanding, women and people with mental disorders continue to be vulnerable to emotional distress after a year of pandemic. Women and people with mental disorders continue to be especially vulnerable to emotional distress after a year of pandemic.
MeSH term(s)	Aged ; Anxiety/psychology ; COVID-19/epidemiology ; Depression/psychology ; Female ; Humans ; Male ; Mental Health ; Middle Aged ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2022-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2022.07.010
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Article ; Online: Hospital admissions due to suicide attempts during the COVID-19 pandemic, a 3-year longitudinal study.

Rodriguez-Jimenez, Roberto / García-Fernández, Lorena / Baón-Pérez, Beatriz / Ansede-Cascudo, Juan Carlos / Arroba, Cristina Martín-Arriscado / Sendra-Gutierrez, Juan Manuel / Romero-Ferreiro, Verónica / Sánchez-Cabezudo, Ángeles / Alvarez-Mon, Miguel A / Navío-Acosta, Mercedes

Psychiatry research

2023 Volume 327, Page(s) 115346

Abstract: The appearance of the SARS CoV-2 virus and the associated COVID-19 pandemic has been associated with the onset of mental disorders in healthy people and the worsening in those with pre-existing mental conditions. One of the areas that has raised the ... ...

Abstract	The appearance of the SARS CoV-2 virus and the associated COVID-19 pandemic has been associated with the onset of mental disorders in healthy people and the worsening in those with pre-existing mental conditions. One of the areas that has raised the greatest concern is that of suicidality. Most of the published studies have been carried out cross-sectional or with small samples, without stratifying by age and gender. Thus, the aim of this longitudinal research is to study, in a large population sample of around 6,700,000 inhabitants belonging to the entire region of Madrid (Spain), the admissions in psychiatric hospitalization units due to suicidal attempts along 2019, 2020 and 2021. No clear increase in the number of admissions due to suicidality in the total population have been found. In addition, a higher prevalence in admissions among women is verified. Moreover, stratifying by age and gender, a striking and significant increase in hospital admissions due to suicidality has been observed in the group up to 17 years old, from September 2020 until the end of the study. These results highlight the special vulnerability of children and adolescents, specifically girls, and the need for preventive measures in the face of future pandemics.
MeSH term(s)	Adolescent ; Child ; Humans ; Female ; Suicide, Attempted/psychology ; COVID-19 ; Pandemics ; Longitudinal Studies ; Cross-Sectional Studies ; Suicidal Ideation ; Hospitalization ; Hospitals
Language	English
Publishing date	2023-07-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2023.115346
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Article ; Online: Dramatic increase of suicidality in children and adolescents after COVID-19 pandemic start: A two-year longitudinal study.

García-Fernández, Lorena / Romero-Ferreiro, Verónica / Izquierdo-Izquierdo, Marta / Rodríguez, Victoria / Alvarez-Mon, Miguel A / Lahera, Guillermo / Santos, José Luis / Rodriguez-Jimenez, Roberto

Journal of psychiatric research

2023 Volume 163, Page(s) 63–67

Abstract: The COVID-19 pandemic has impacted the mental health of the youngest, worsening their emotional well-being. The demand for care in psychiatric emergencies may indirectly reflect the mental health state of children and adolescents and the emotional ... ...

Abstract	The COVID-19 pandemic has impacted the mental health of the youngest, worsening their emotional well-being. The demand for care in psychiatric emergencies may indirectly reflect the mental health state of children and adolescents and the emotional consequences of the pandemic. Moreover, suicidality can be considered a marker of severity in this population group. Therefore, we have aimed to longitudinally describe the number of children and adolescents attended in the psychiatry emergency department due to suicidal ideation or attempts and, to explore differences in suicidality according to gender and age. A retrospective study was carried out in the University Hospital of San Juan, Alicante, Spain, from January 01, 2018 to December 31, 2021. A total of 138 participants under 18 years requesting psychiatric care due to suicidal ideation or attempts were included. The sample was composed by 35% of males and the mean age was 14.8 years old (SD = 2.2). The number of cases per year range from 10 in 2018 to 88 in 2021. Attendances were significantly higher between 2021 and the three previous years. Besides, the number of attentions registered in the last 9 months of 2021 equals those that occurred in the entire previous period. Most of the cases were girls and middle adolescents. Suicide ideation or attempts have skyrocketed in children and adolescents. This alarming increase presents a one-year lag peak from the COVID-19 outbreak and continues until the end of 2021. Girls and those over 12 years have been identified as risk groups to present suicidal ideation or attempts.
MeSH term(s)	Male ; Female ; Humans ; Child ; Adolescent ; Suicidal Ideation ; Suicide, Attempted/psychology ; Pandemics ; Longitudinal Studies ; Retrospective Studies ; COVID-19/epidemiology ; Suicide
Language	English
Publishing date	2023-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2023.04.014
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Article: Complete Genome Sequences of Four Mycobacteriophages Involved in Directed Evolution against Undisputed

Cao Yao, Juan Carlos / Garcia Cehic, Damir / Quer, Josep / Méndez, Jesús Navas / Gorrín, Alexis Dorta / Hevia, Lorena García / Fernández, María Teresa Tórtola

Microorganisms

2024 Volume 12, Issue 2

Abstract: Phage therapy is still in its infancy, but it is increasingly promising as a future alternative for treating antibiotic-resistant bacteria. To investigate the effect of phages ... ...

Abstract	Phage therapy is still in its infancy, but it is increasingly promising as a future alternative for treating antibiotic-resistant bacteria. To investigate the effect of phages on
Language	English
Publishing date	2024-02-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12020374
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Article ; Online: Bing-Neel síndrome in a patient with Waldenström macroglobulinemia.

Parra Salinas, Ingrid / Murillo Florez, Ilda / García Fernández, Lorena

Medicina clinica

2022 Volume 159, Issue 11, Page(s) e75–e76

Title translation	Síndrome de Bing-Neel en un paciente con macroglobulinemia de Waldenström.
MeSH term(s)	Humans ; Waldenstrom Macroglobulinemia/complications ; Waldenstrom Macroglobulinemia/diagnosis ; Syndrome ; Magnetic Resonance Imaging
Language	Spanish
Publishing date	2022-09-16
Publishing country	Spain
Document type	Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2022.07.016
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Article ; Online: The impact on mental health patients of COVID-19 outbreak in Spain.

García-Fernández, Lorena / Romero-Ferreiro, Veronica / Padilla, Sergio / López-Roldán, Pedro David / Monzó-García, María / Rodriguez-Jimenez, Roberto

Journal of psychiatric research

2021 Volume 136, Page(s) 127–131

Abstract: Public health studies warn of the vulnerability of people with mental disorders during the COVID-19 outbreak. Thus, the aims of this study were to (1) explore the presence of symptoms of anxiety, depression and acute stress among people with a mental ... ...

Abstract	Public health studies warn of the vulnerability of people with mental disorders during the COVID-19 outbreak. Thus, the aims of this study were to (1) explore the presence of symptoms of anxiety, depression and acute stress among people with a mental disorder (MD); (2) evaluate the rate of COVID-19 infection between MD and non-MD, and (3) study the relationship between the emotional state of people with a mental disorder and some environmental variables. A cross-sectional study starting on March 29 to April 5, 2020 based on a national online survey using snowball sampling techniques was conducted. Symptoms of anxiety (Hamilton Anxiety Scale), depression (Beck Depression Inventory) and acute stress (Acute Stress Disorder Inventory) were compared in MD and non-MD. The rate of COVID-19 confirmed cases among MD and non-MD was compared as well as the relationship between some environmental variables and the emotional state within MD. Up to 1839 [201 (10.9%) MD] participants completed the survey. MD showed significant higher mean (SD) in anxiety [24.7 (11.8) vs. 17 (10.3); p = 0.001], depression [7.9 (6.0) vs. 4.2 (4.2); p = 0.001] and acute stress [6.3 (3.2) vs. 4.4 (3.1); p = 0.001] scores than non-MD. The COVID-19 confirmed cases rate was higher in MD participants than in non-MD (3.5% vs. 0.4%; p < 0.001). Among the MD group, being a COVID-19 confirmed case, the lack in basic needs coverage, the rpesence of violence, drug use and the absence of physical excercise were associated with more severe depressive symptoms. Findings suggest that the COVID-19 has an impact on the emotional state of people with mental disorders.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anxiety/epidemiology ; COVID-19/epidemiology ; Cross-Sectional Studies ; Depression/epidemiology ; Disease Outbreaks ; Female ; Health Surveys ; Humans ; Male ; Mental Disorders/epidemiology ; Mental Health/statistics & numerical data ; Middle Aged ; Spain/epidemiology ; Stress, Psychological/epidemiology ; Young Adult
Language	English
Publishing date	2021-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2021.01.028
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