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Article ; Online: Review of Maria G. Rewakowicz, translator and with an introduction. Mountain and Flower

Lada Kolomiyets

East/West: Journal of Ukrainian Studies, Vol 8, Iss

Selected Poems. By Mykola Vorobiov.

2021 Volume 2

Keywords	Mykola Vorobiov ; History of scholarship and learning. The humanities ; AZ20-999 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	University of Alberta, Canadian Institute of Ukrainian Studies
Document type	Article ; Online
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Article ; Online: N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease.

Pavić, Tamara / Dilber, Dario / Kifer, Domagoj / Selak, Najda / Keser, Toma / Ljubičić, Đivo / Vukić Dugac, Andrea / Lauc, Gordan / Rumora, Lada / Gornik, Olga

Journal of translational medicine

2018 Volume 16, Issue 1, Page(s) 323

Abstract: ... biomarkers and to examine the individual variation of plasma protein and immunoglobulin G (IgG) glycosylation ...

Abstract	Background: Chronic obstructive pulmonary disease (COPD) is a complex condition, whose diagnosis requires spirometric assessment. However, considering its heterogeneity, subjects with similar spirometric parameters do not necessarily have the same functional status. To overcome this limitation novel biomarkers for COPD have been investigated. Therefore, we aimed to explore the potential value of N-glycans as COPD biomarkers and to examine the individual variation of plasma protein and immunoglobulin G (IgG) glycosylation profiles in subjects with COPD and healthy controls. Methods: Both the total plasma protein and IgG N-glycome have been profiled in the total of 137 patients with COPD and 95 matching controls from Croatia. Replication cohort consisted of 61 subjects with COPD and 148 controls recruited at another Croatian medical centre. Results: Plasma protein N-glycome in COPD subjects exhibited significant decrease in low branched and conversely, an increase in more complex glycan structures (tetragalactosylated, trisialylated, tetrasialylated and antennary fucosylated glycoforms). We also observed a significant decline in plasma monogalactosylated species, and the same change replicated in IgG glycome. N-glycans also showed value in distinguishing subjects in different COPD GOLD stages, where the relative abundance of more complex glycan structures increased as the disease progressed. Glycans also showed statistically significant associations with the frequency of exacerbations and demonstrated to be affected by smoking, which is the major risk factor for COPD development. Conclusions: This study showed that complexity of glycans associates with COPD, mirroring also the disease severity. Moreover, changes in N-glycome associate with exacerbation frequency and are affected by smoking. In general, this study provided new insights into plasma protein and IgG N-glycome changes occurring in COPD and pointed out potential novel markers of the disease progression and severity.
MeSH term(s)	Aged ; Blood Proteins/metabolism ; Female ; Glycosylation ; Humans ; Immunoglobulin G/metabolism ; Male ; Middle Aged ; Polysaccharides/metabolism ; Pulmonary Disease, Chronic Obstructive/blood ; Risk Factors ; Smoking
Chemical Substances	Blood Proteins ; Immunoglobulin G ; Polysaccharides ; glycosylated IgG
Language	English
Publishing date	2018-11-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1479-5876
ISSN (online)	1479-5876
DOI	10.1186/s12967-018-1695-0
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Article ; Online: N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease

Tamara Pavić / Dario Dilber / Domagoj Kifer / Najda Selak / Toma Keser / Đivo Ljubičić / Andrea Vukić Dugac / Gordan Lauc / Lada Rumora / Olga Gornik

Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-

2018 Volume 15

Abstract: ... as COPD biomarkers and to examine the individual variation of plasma protein and immunoglobulin G (IgG ...

Abstract	Abstract Background Chronic obstructive pulmonary disease (COPD) is a complex condition, whose diagnosis requires spirometric assessment. However, considering its heterogeneity, subjects with similar spirometric parameters do not necessarily have the same functional status. To overcome this limitation novel biomarkers for COPD have been investigated. Therefore, we aimed to explore the potential value of N-glycans as COPD biomarkers and to examine the individual variation of plasma protein and immunoglobulin G (IgG) glycosylation profiles in subjects with COPD and healthy controls. Methods Both the total plasma protein and IgG N-glycome have been profiled in the total of 137 patients with COPD and 95 matching controls from Croatia. Replication cohort consisted of 61 subjects with COPD and 148 controls recruited at another Croatian medical centre. Results Plasma protein N-glycome in COPD subjects exhibited significant decrease in low branched and conversely, an increase in more complex glycan structures (tetragalactosylated, trisialylated, tetrasialylated and antennary fucosylated glycoforms). We also observed a significant decline in plasma monogalactosylated species, and the same change replicated in IgG glycome. N-glycans also showed value in distinguishing subjects in different COPD GOLD stages, where the relative abundance of more complex glycan structures increased as the disease progressed. Glycans also showed statistically significant associations with the frequency of exacerbations and demonstrated to be affected by smoking, which is the major risk factor for COPD development. Conclusions This study showed that complexity of glycans associates with COPD, mirroring also the disease severity. Moreover, changes in N-glycome associate with exacerbation frequency and are affected by smoking. In general, this study provided new insights into plasma protein and IgG N-glycome changes occurring in COPD and pointed out potential novel markers of the disease progression and severity.
Keywords	N-glycosylation ; COPD ; Biomarkers ; Plasma glycoproteins ; Immunoglobulin G ; Medicine ; R
Subject code	610
Language	English
Publishing date	2018-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Long-term outcome of primary non-responders to tenofovir therapy in HIV/HBV-co-infected patients: impact of HBV genotype G.

Lada, Olivier / Gervais, Anne / Branger, Michel / Peytavin, Gilles / Roquebert, Benedicte / Collin, Gilles / Fraqueiro, Gil / Moucari, Rami / Hamet, Gwen / Martinot-Peignoux, Michelle / Matheron, Sophie / Marcellin, Patrick

Liver international : official journal of the International Association for the Study of the Liver

2012 Volume 32, Issue 1, Page(s) 93–101

Abstract: ... and HBV genotype-G proportion was higher (P = 0.026). No virological breakthrough occurred after ... had genotype G-HBV infection. No resistance was evidenced after 46 months of therapy even in patients ...

Abstract	Aim: To evaluate the early virological response (EVR) to combined tenofovir-lamivudine or emtricitabine regimen in HBV/HIV-co-infected patients and the long-term efficacy of tenofovir. Methods: In this retrospective monocentric study, among the 166 HIV/HBV-co-infected patients regularly followed from 2003 to 2008 at Bichat Claude Bernard Hospital, 61 patients had received, either de novo combination therapy with tenofovir and lamivudine or emtricitabine (group I, n = 15) or add-on tenofovir to lamivudine therapy (group II, n = 46). The HBV polymerase region was sequenced and analysed for all patients with available samples. Results: All 15 group I patients achieved EVR vs 32 (82%) of group II patients (P = 0.15). Seven adherent group II patients met criteria for primary non-response, but achieved delayed response (DR) to therapy. In these seven patients, when compared with the 39 group II patients, there was a trend to longer duration of lamivudine pre-treatment and to higher rate of lamivudine-resistant mutants; and HBV genotype-G proportion was higher (P = 0.026). No virological breakthrough occurred after a median of 46 months follow up. Conclusion: In these HBV/HIV-co-infected patients, first-line HBV therapy with tenofovir and emtricitabine or lamivudine was associated with EVR. However, DR to tenofovir was observed in 15% of patients who added tenofovir to lamivudine therapy, of whom four of seven (57%) had genotype G-HBV infection. No resistance was evidenced after 46 months of therapy even in patients with DR to tenofovir. At last, a good renal safety profile of TDF was observed after a median follow-up of 4 years of therapy.
MeSH term(s)	Adenine/analogs & derivatives ; Adenine/therapeutic use ; Adult ; Anti-HIV Agents/therapeutic use ; Coinfection/drug therapy ; DNA Mutational Analysis ; DNA, Viral/analysis ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/therapeutic use ; Drug Resistance, Viral ; Drug Therapy, Combination ; Emtricitabine ; Female ; Genotype ; HIV/drug effects ; HIV Infections/drug therapy ; Hepatitis B/drug therapy ; Hepatitis B virus/classification ; Hepatitis B virus/drug effects ; Hepatitis B virus/genetics ; Humans ; Lamivudine/therapeutic use ; Male ; Middle Aged ; Mutation ; Organophosphonates/therapeutic use ; Retrospective Studies ; Tenofovir ; Time Factors ; Treatment Outcome
Chemical Substances	Anti-HIV Agents ; DNA, Viral ; Organophosphonates ; Deoxycytidine (0W860991D6) ; Lamivudine (2T8Q726O95) ; Tenofovir (99YXE507IL) ; Emtricitabine (G70B4ETF4S) ; Adenine (JAC85A2161)
Language	English
Publishing date	2012-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/j.1478-3231.2011.02601.x
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Article ; Online: Novel high-affinity binders of human interferon gamma derived from albumin-binding domain of protein G.

Ahmad, Jawid N / Li, Jingjing / Biedermannová, Lada / Kuchař, Milan / Sípová, Hana / Semerádtová, Alena / Cerný, Jiří / Petroková, Hana / Mikulecký, Pavel / Polínek, Jiří / Staněk, Ondřej / Vondrášek, Jiří / Homola, Jiří / Malý, Jan / Osička, Radim / Sebo, Peter / Malý, Petr

Proteins

2012 Volume 80, Issue 3, Page(s) 774–789

Abstract: ... interferon gamma (hIFNγ) from the three helix bundle scaffold of the albumin-binding domain (ABD) of protein G ...

Abstract	Recombinant ligands derived from small protein scaffolds show promise as robust research and diagnostic reagents and next generation protein therapeutics. Here, we derived high-affinity binders of human interferon gamma (hIFNγ) from the three helix bundle scaffold of the albumin-binding domain (ABD) of protein G from Streptococcus G148. Computational interaction energy mapping, solvent accessibility assessment, and in silico alanine scanning identified 11 residues from the albumin-binding surface of ABD as suitable for randomization. A corresponding combinatorial ABD scaffold library was synthesized and screened for hIFNγ binders using in vitro ribosome display selection, to yield recombinant ligands that exhibited K(d) values for hIFNγ from 0.2 to 10 nM. Molecular modeling, computational docking onto hIFNγ, and in vitro competition for hIFNγ binding revealed that four of the best ABD-derived ligands shared a common binding surface on hIFNγ, which differed from the site of human IFNγ receptor 1 binding. Thus, these hIFNγ ligands provide a proof of concept for design of novel recombinant binding proteins derived from the ABD scaffold.
MeSH term(s)	Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Catalytic Domain ; Gene Library ; Humans ; Interferon-gamma/metabolism ; Models, Molecular ; Mutation ; Protein Binding ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Serum Albumin/metabolism ; Streptococcus/chemistry ; Streptococcus/genetics ; Streptococcus/metabolism
Chemical Substances	Bacterial Proteins ; IgG Fc-binding protein, Streptococcus ; Recombinant Proteins ; Serum Albumin ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2012-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	806683-8
ISSN	1097-0134 ; 0887-3585
ISSN (online)	1097-0134
ISSN	0887-3585
DOI	10.1002/prot.23234
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Zs.A 2291: Show issues

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Article ; Online: The role of family and individual factors in going through adolescence having a disabled sibling - analysis of a healthy child's functioning. A case-control study protocol.

Łada-Maśko, Ariadna B / Sajewicz-Radtke, Urszula / Radtke, Bartosz M / Lipowska, Małgorzata

Health psychology report

2024 Volume 12, Issue 2, Page(s) 173–181

Abstract: ... both on the difficulties associated with having a disabled sibling (e.g. possible occurrence of disorders) and resources (e ... g. higher quality of relationships in the family, especially in the sibling subsystem ...

Abstract	Background: Having a disabled sibling can be a source of extremely important and enriching experiences that foster the development of social and emotional competences, as well as broadening the child's perspective and knowledge. On the other hand, it also poses many challenges for the siblings, especially in adolescence. Thus, the aim of the proposed project is to investigate the specificity of the growing up process in young people with disabled siblings. Participants and procedure: A total of 160 dyads (320 participants) - an adolescent and one of his/her parents - will take part in this cross-sectional case-control study. Participants will be assigned to four groups, having a sibling with: 1) intellectual disability, 2) motor disability, 3) chronic somatic disease, and 4) the control group - having a sibling without any disability. Both the healthy adolescent and one of the parents will fill out a set of questionnaires regarding the study variables: Questionnaire of Relationships with Siblings, Parental Attitude Scale-2, KidScreen-27, Parentification Questionnaire for Youth, Teenage Rebellion Questionnaire, Child Behavior Checklist 6-18. Results: The primary outcomes include investigating the healthy adolescent functioning in three environments: family, peers and school. The proposed research model focuses both on the difficulties associated with having a disabled sibling (e.g. possible occurrence of disorders) and resources (e.g. higher quality of relationships in the family, especially in the sibling subsystem). Conclusions: The proposed comprehensive approach to the issue of disability in the family from the perspective of a healthy child will allow for a better understanding of the mechanisms underlying the process of growing up with disabled siblings.
Language	English
Publishing date	2024-03-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	3031358-2
ISSN	2353-5571 ; 2353-4184
ISSN (online)	2353-5571
ISSN	2353-4184
DOI	10.5114/hpr/183546
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Article ; Online: Association of hsp70-2 (+1267A/G), hsp70-hom (+2437T/C), HMOX-1 (number of GT repeats) and TNF-alpha (+489G/A) polymorphisms with COPD in Croatian population.

Matokanović, Mirela / Rumora, Lada / Popović-Grle, Sanja / Čepelak, Ivana / Čulić, Ognjen / Barišić, Karmela

Clinical biochemistry

2012 Volume 45, Issue 10-11, Page(s) 770–774

Abstract: Objective: To test for possible association of hsp70-2 (+1267A/G), hsp70-hom (+2437T/C), HMOX-1 ... tested using χ(2) test.: Results: hsp70-2 (+1267A/G) polymorphism was significantly associated ... with COPD. Results of genotyping analysis indicated that a genotype carrying G allele was preferentially ...

Abstract	Objective: To test for possible association of hsp70-2 (+1267A/G), hsp70-hom (+2437T/C), HMOX-1 (number of GT repeats) and TNF-α (+489G/A) polymorphisms with chronic obstructive pulmonary disease (COPD) in Croatian population. Methods: Genotyping of DNA isolated from whole blood of 130 COPD patients (as defined by spirometry) and 95 healthy controls was performed. Fragment size analysis upon restriction enzyme digestion and/or sequencing was used for genotype/allele definition. Significance of findings was tested using χ(2) test. Results: hsp70-2 (+1267A/G) polymorphism was significantly associated with COPD. Results of genotyping analysis indicated that a genotype carrying G allele was preferentially associated with COPD; odds ratio (OR)=1.50, 95% confidence interval (CI)=1.00-2.24 and P=0.061. OR for the GG genotype was 3.47 with CI=1.26-9.56 and P=0.04. No association for hsp70-hom (+2437T/C), TNF-α (+489G/A) and HMOX-1 (number of GT repeats) polymorphisms were found. In addition, comparison of genotype frequencies among different stages of disease severity (GOLD II-IV) revealed no discrimination for any of the tested polymorphisms. Conclusion: This study is supporting the association of hsp70-2 (+1267A/G) polymorphism and COPD. Higher frequency of G allele and GG genotype in Croatian COPD patients was observed. There was no evidence for the association of hsp70-hom (+2437T/C), TNF-α (+489G/A) SNPs and HMOX-1 (number of GT repeats) polymorphism with COPD. Allele and genotype frequencies for all of the tested polymorphisms show no association with disease severity (GOLD II-IV).
MeSH term(s)	Adult ; Aged ; Alleles ; Croatia ; Dinucleotide Repeats/genetics ; Female ; Gene Frequency ; Genetic Predisposition to Disease/genetics ; Genotype ; HSP70 Heat-Shock Proteins/genetics ; Heme Oxygenase-1/genetics ; Humans ; Male ; Middle Aged ; Odds Ratio ; Polymorphism, Genetic ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/pathology ; Severity of Illness Index ; Tumor Necrosis Factor-alpha/genetics
Chemical Substances	HSP70 Heat-Shock Proteins ; Tumor Necrosis Factor-alpha ; HMOX1 protein, human (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18)
Language	English
Publishing date	2012-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390372-2
ISSN	1873-2933 ; 0009-9120
ISSN (online)	1873-2933
ISSN	0009-9120
DOI	10.1016/j.clinbiochem.2012.04.003
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Zs.A 624: Show issues

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Article ; Online: Polymorphism of

Zhuk, Anna S / Lada, Artem G / Pavlov, Youri I

International journal of molecular sciences

2023 Volume 24, Issue 9

Abstract: Baker's yeast, ...

Abstract	Baker's yeast,
MeSH term(s)	Humans ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Polymorphism, Genetic ; Saccharomyces cerevisiae Proteins/metabolism ; Genomic Instability ; DNA/metabolism
Chemical Substances	Saccharomyces cerevisiae Proteins ; DNA (9007-49-2)
Language	English
Publishing date	2023-04-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24097795
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Article ; Online: PRO AND CONTRA ON ADJUVANTS TO NEUROAXIAL ANESTHESIA AND PERIPHERAL NERVE BLOCKS.

Kalagac Fabris, Lada

Acta clinica Croatica

2023 Volume 61, Issue Suppl 2, Page(s) 57–66

Abstract: ... adjuvants group (e.g. adrenaline, alpha adrenergic agonists, steroids, magnesium, midazolam, ketamine etc ...

Abstract	Modern approach in surgical treatment and in managing acute and chronic pain is nowadays more and more based on the implementation of all possible techniques of regional anesthesia (RA). Local anesthetics (LA) are needed to achieve standard regional anesthesia. Local anesthetics are primarily characterized by time constraints and duration of action, and depending on the amount applied, adverse effects on the cardiac and central nervous system may occur. Adjuvants are drugs used together with LA due to their synergistic effect, i.e. they improve start latency and duration of sensory and motor blockade and enable reduction of cumulative dose of LA and reduction of adverse effects on cardiac and nervous system. Nowadays, there is a huge variety of drugs that can be administered in combination with LA, and they, in general, can be divided into opioid and non-opioid adjuvants. The administration of opioids in RA over an extended time period was accompanied by some negative characteristics as respiratory depression, nausea, vomiting. So, their usage is still under a special control. Due to the positive effects shown by drugs from non-opioid adjuvants group (e.g. adrenaline, alpha adrenergic agonists, steroids, magnesium, midazolam, ketamine etc.), indications for their administration broadened. However, there are still some restrains in clinical practice based on the fact that neurotoxicity and demonstration of neurological complications in regional anesthesia haven't been properly researched yet.
MeSH term(s)	Humans ; Anesthetics, Local ; Anesthesia, Conduction/methods ; Adrenergic alpha-Agonists/pharmacology ; Analgesics, Opioid ; Peripheral Nerves
Chemical Substances	Anesthetics, Local ; Adrenergic alpha-Agonists ; Analgesics, Opioid
Language	English
Publishing date	2023-02-20
Publishing country	Croatia
Document type	Journal Article ; Review
ZDB-ID	1478635-7
ISSN	1333-9451 ; 0353-9466
ISSN (online)	1333-9451
ISSN	0353-9466
DOI	10.20471/acc.2022.61.s2.07
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Article: The Role of Brain-Derived Neurotrophic Factor (BDNF) in Diagnosis and Treatment of Epilepsy, Depression, Schizophrenia, Anorexia Nervosa and Alzheimer's Disease as Highly Drug-Resistant Diseases: A Narrative Review.

Gliwińska, Aleksandra / Czubilińska-Łada, Justyna / Więckiewicz, Gniewko / Świętochowska, Elżbieta / Badeński, Andrzej / Dworak, Marta / Szczepańska, Maria

Brain sciences

2023 Volume 13, Issue 2

Abstract: Brain-derived neurotrophic factor (BDNF) belongs to the family of neurotrophins, which are growth factors with trophic effects on neurons. BDNF is the most widely distributed neurotrophin in the central nervous system (CNS) and is highly expressed in the ...

Abstract	Brain-derived neurotrophic factor (BDNF) belongs to the family of neurotrophins, which are growth factors with trophic effects on neurons. BDNF is the most widely distributed neurotrophin in the central nervous system (CNS) and is highly expressed in the prefrontal cortex (PFC) and hippocampus. Its distribution outside the CNS has also been demonstrated, but most studies have focused on its effects in neuropsychiatric disorders. Despite the advances in medicine in recent decades, neurological and psychiatric diseases are still characterized by high drug resistance. This review focuses on the use of BDNF in the developmental assessment, treatment monitoring, and pharmacotherapy of selected diseases, with a particular emphasis on epilepsy, depression, anorexia, obesity, schizophrenia, and Alzheimer's disease. The limitations of using a molecule with such a wide distribution range and inconsistent method of determination are also highlighted.
Language	English
Publishing date	2023-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13020163
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