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  1. Article ; Online: Mental health implications of COVID-19 on children with disabilities.

    Patel, Khushboo

    Asian journal of psychiatry

    2020  Volume 54, Page(s) 102273

    MeSH term(s) Adolescent ; Adult ; COVID-19/prevention & control ; Child ; Child, Preschool ; Disabled Children/psychology ; Education, Distance ; Education, Special ; Humans ; Mental Disorders/psychology ; Physical Distancing ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2020.102273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Implicit bias among health care providers and its influence on African Americans - A critical analysis

    Khushboo PATEL

    Journal of Health and Social Sciences, Vol 5, Iss 3, Pp 301-

    2020  Volume 308

    Abstract: The present article reviews implicit bias among health care providers and its influence on African Ameri- cans in the United States and provides critical analysis of the Implicit Association Test (IAT), a commonly used measure to assess implicit bias. ... ...

    Abstract The present article reviews implicit bias among health care providers and its influence on African Ameri- cans in the United States and provides critical analysis of the Implicit Association Test (IAT), a commonly used measure to assess implicit bias. Empirical evidence confirms the widespread presence of implicit bias among health care providers in the United States. African Americans have typically reported a lack of communication, misdiagnoses, and inadequate treatment from their health care providers. It is also revealed that health care providers are likely to favor White patients over Black patients and view Black patients as less cooperative. All the studies discussed in the present article make use of the Implicit Association Test (IAT) in order to measure implicit bias. Due to some loopholes of the measure, the article aimed to provide future directions in order to overcome the limitations of the existing research on implicit bias by proposing alternate methodological considerations.
    Keywords african americans ; implicit association test ; implicit bias ; health care professionals ; Medicine (General) ; R5-920 ; Social sciences (General) ; H1-99
    Subject code 360
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Edizioni FS
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Correction to: Celastrus paniculatus oil ameliorates NF-KB mediated neuroinflammation and synaptic plasticity in the scopolamine-induced cognitive impairment rat model.

    Faldu, Khushboo Govind / Patel, Snehal Sanjay / Shah, Jigna Samir

    Metabolic brain disease

    2023  Volume 38, Issue 5, Page(s) 1685–1687

    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 632824-6
    ISSN 1573-7365 ; 0885-7490
    ISSN (online) 1573-7365
    ISSN 0885-7490
    DOI 10.1007/s11011-023-01215-5
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  5. Article ; Online: Mental health implications of COVID-19 on children with disabilities

    Patel, Khushboo

    Asian Journal of Psychiatry

    2020  Volume 54, Page(s) 102273

    Keywords General Psychology ; Psychiatry and Mental health ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2020.102273
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  6. Article: The structure of the neurotoxin palytoxin determined by MicroED.

    Gillman, Cody / Patel, Khushboo / Unge, Johan / Gonen, Tamir

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Palytoxin (PTX) is a potent neurotoxin found in marine animals that can cause serious symptoms such as muscle contractions, haemolysis of red blood cells and potassium leakage. Despite years of research, very little is known about the mechanism of PTX. ... ...

    Abstract Palytoxin (PTX) is a potent neurotoxin found in marine animals that can cause serious symptoms such as muscle contractions, haemolysis of red blood cells and potassium leakage. Despite years of research, very little is known about the mechanism of PTX. However, recent advances in the field of cryoEM, specifically the use of microcrystal electron diffraction (MicroED), have allowed us to determine the structure of PTX. It was discovered that PTX folds into a hairpin motif and is able to bind to the extracellular gate of Na,K-ATPase, which is responsible for maintaining the electrochemical gradient across the plasma membrane. These findings, along with molecular docking simulations, have provided important insights into the mechanism of PTX and can potentially aid in the development of molecular agents for treating cases of PTX exposure.
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.31.535166
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  7. Article ; Online: MicroED in drug discovery.

    Danelius, Emma / Patel, Khushboo / Gonzalez, Brenda / Gonen, Tamir

    Current opinion in structural biology

    2023  Volume 79, Page(s) 102549

    Abstract: The cryo-electron microscopy (cryo-EM) method microcrystal electron diffraction (MicroED) was initially described in 2013 and has recently gained attention as an emerging technique for research in drug discovery. As compared to other methods in ... ...

    Abstract The cryo-electron microscopy (cryo-EM) method microcrystal electron diffraction (MicroED) was initially described in 2013 and has recently gained attention as an emerging technique for research in drug discovery. As compared to other methods in structural biology, MicroED provides many advantages deriving from the use of nanocrystalline material for the investigations. Here, we review the recent advancements in the field of MicroED and show important examples of small molecule, peptide and protein structures that has contributed to the current development of this method as an important tool for drug discovery.
    MeSH term(s) Cryoelectron Microscopy/methods ; Electrons ; Models, Molecular ; Proteins/chemistry ; Drug Discovery
    Chemical Substances Proteins
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1068353-7
    ISSN 1879-033X ; 0959-440X
    ISSN (online) 1879-033X
    ISSN 0959-440X
    DOI 10.1016/j.sbi.2023.102549
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3206: Show issues Location:
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  8. Article: NMDA Receptor Encephalitis with Significant Autonomic Instability and PRES like MR Images.

    Syamlal, S / Patel, Khushboo / Haridas, Sarath

    Annals of Indian Academy of Neurology

    2022  Volume 25, Issue 6, Page(s) 1244–1245

    Language English
    Publishing date 2022-12-03
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.aian_449_22
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  9. Article ; Online: Celastrus paniculatus oil ameliorates NF-KB mediated neuroinflammation and synaptic plasticity in the scopolamine-induced cognitive impairment rat model.

    Faldu, Khushboo Govind / Patel, Snehal Sanjay / Shah, Jigna Samir

    Metabolic brain disease

    2023  Volume 38, Issue 4, Page(s) 1405–1419

    Abstract: Background and aim: Traditionally, Celastrus paniculatus Willd. (CP) oil has been utilized as a tranquilizer and memory enhancer. The present study investigated the neuropharmacological activity and efficacy of CP oil in ameliorating scopolamine-induced ...

    Abstract Background and aim: Traditionally, Celastrus paniculatus Willd. (CP) oil has been utilized as a tranquilizer and memory enhancer. The present study investigated the neuropharmacological activity and efficacy of CP oil in ameliorating scopolamine-induced cognitive impairment in rats.
    Experimental procedure: Cognitive deficiency was induced in rats by administration of scopolamine (2 mg/kg intraperitoneal injection) for a period of 15 days. Donepezil served as a reference drug and CP oil was tested as both preventive and curative treatments. Animals' behaviour was assessed through the Morris water maze (MWM), novel object preference (NOR), and conditioned avoidance (CA) tests. Oxidative stress parameters, bioamine concentration (dopamine, noradrenaline, and 5-hydroxytryptamine), nerve growth factor (NGF), interleukin-6 (IL-6), nuclear factor kappa B (NF-кB), and tumor necrosis factor-alpha (TNFα) were estimated. Synaptophysin immunohistochemistry was performed.
    Results: Our results showed that CP oil ameliorated behavioural deficits. It reduced latency to find a hidden platform in MWM. Reduced novel object exploration time and discrimination index (p < 0.05) in the NOR. Reduced step-down latency and normalized conditioned avoidance response (p < 0.001) in the CA test. CP oil increased dopamine, serotonin, norepinephrine, superoxide dismutase (SOD), glutathione, and catalase levels. It decreased malondialdehyde (MDA), acetylcholinesterase activity, IL-6, NF-кB (P < 0.001), TNFα, and NGF levels. Treatment showed approximate typical reactivity to synaptophysin.
    Conclusion: Our data is suggestive that CP oil treatment improves behavioural test outcomes, increases biogenic amine concentration, and decreases acetylcholinesterase activity, and neuroinflammatory biomarkers. It also restores synaptic plasticity. It thus improves cognitive functions against scopolamine-induced amnesia in rats by improving cholinergic function.
    MeSH term(s) Rats ; Animals ; Scopolamine ; NF-kappa B/metabolism ; Acetylcholinesterase/metabolism ; Celastrus/metabolism ; Synaptophysin/metabolism ; Neuroinflammatory Diseases ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-6/metabolism ; Dopamine ; Nerve Growth Factor/metabolism ; Plant Extracts/pharmacology ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/drug therapy ; Oxidative Stress ; Neuronal Plasticity ; Maze Learning
    Chemical Substances Scopolamine (DL48G20X8X) ; NF-kappa B ; Acetylcholinesterase (EC 3.1.1.7) ; Synaptophysin ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Dopamine (VTD58H1Z2X) ; Nerve Growth Factor (9061-61-4) ; Plant Extracts
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632824-6
    ISSN 1573-7365 ; 0885-7490
    ISSN (online) 1573-7365
    ISSN 0885-7490
    DOI 10.1007/s11011-023-01186-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2155: Show issues Location:
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  10. Book ; Online: Aqueous Laponite Dispersions are Attractive Gels, Not Repulsive Wigner Glasses

    Joshi, Yogesh M / Patel, Shrajesh / Suman, Khushboo

    A Critical Commentary

    2024  

    Abstract: An aqueous dispersion of Laponite has been studied in the literature for over the past three decades. Typically, the aqueous dispersion of Laponite undergoes incessant evolution of its microstructure, wherein its elastic modulus and the mean relaxation ... ...

    Abstract An aqueous dispersion of Laponite has been studied in the literature for over the past three decades. Typically, the aqueous dispersion of Laponite undergoes incessant evolution of its microstructure, wherein its elastic modulus and the mean relaxation time show a continuous increase as a function of time. A considerable amount of discussion has revolved around the nature of this dispersion, specifically whether it can be classified as a repulsive Wigner glass state, characterized by disconnected Laponite particles stabilized by electrostatic repulsions, or an attractive gel state, in which the particles form a percolated space-spanning network. The proponents of the Wigner glass state also conjecture that this system experiences a glass-glass transition after a period of two days has elapsed since its preparation. In this commentary, we explore this topic from a rheological point of view analyzing the published literature and performing new experiments. Aided by additional evidence from the literature, we propose that rheological behavior overwhelmingly suggests that an aqueous dispersion of Laponite undergoes sol - attractive gel transition and remains in the attractive gel state over at least up to 7 days without undergoing any additional transition. Importantly, rheology, despite being a macroscopic tool governed by principles of mechanics, offers profound insight into the microstructure of this particular system. The corresponding analysis conclusively determines the state of an aqueous dispersion of Laponite to be an attractive gel.

    Comment: 19 pages, 2 figures, 1 table
    Keywords Condensed Matter - Soft Condensed Matter ; Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Materials Science
    Subject code 541
    Publishing date 2024-01-03
    Publishing country us
    Document type Book ; Online
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