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Article ; Online: Beyond O&P Times Three.

Mohapatra, Sonmoon / Singh, Dhruv Pratap / Alcid, David / Pitchumoni, Capecomorin S

The American journal of gastroenterology

2018 Volume 113, Issue 6, Page(s) 805–818

Abstract: Although examination of the stool for ova and parasites times three (O&P ×3) is routinely performed ... either with O&P or with other diagnostic tests, followed by the recommended treatment, is quite rewarding ...

Abstract	Although examination of the stool for ova and parasites times three (O&P ×3) is routinely performed in the United States (US) for the evaluation of persistent and/or chronic diarrhea, the result is almost always negative. This has contributed to the perception that parasitic diseases are nearly non-existent in the country unless there is a history of travel to an endemic area. The increasing number of immigrants from third-world countries, tourists, and students who present with symptoms of parasitic diseases are often misdiagnosed as having irritable bowel syndrome or inflammatory bowel disease. The consequences of such misdiagnosis need no explanation. However, certain parasitic diseases are endemic to the US and other developed nations and affect both immunocompetent and immunocompromised patients. Testing for parasitic diseases either with O&P or with other diagnostic tests, followed by the recommended treatment, is quite rewarding when appropriate. Most parasitic diseases are easily treatable and should not be confused with other chronic gastrointestinal (GI) disorders. In this review, we critically evaluate the symptomatology of luminal parasitic diseases, their differential diagnoses, appropriate diagnostic tests, and management.
MeSH term(s)	Antiprotozoal Agents/therapeutic use ; Diagnosis, Differential ; Diagnostic Errors ; Diarrhea/diagnosis ; Diarrhea/drug therapy ; Diarrhea/epidemiology ; Diarrhea/parasitology ; Feces/parasitology ; Helminthiasis/diagnosis ; Helminthiasis/drug therapy ; Helminthiasis/epidemiology ; Helminthiasis/parasitology ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Intestinal Diseases, Parasitic/diagnosis ; Intestinal Diseases, Parasitic/drug therapy ; Intestinal Diseases, Parasitic/epidemiology ; Intestinal Diseases, Parasitic/parasitology ; Irritable Bowel Syndrome/diagnosis ; United States/epidemiology
Chemical Substances	Antiprotozoal Agents
Language	English
Publishing date	2018-06-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.1038/s41395-018-0083-y
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Article ; Online: Phosphorylation of arenes, heteroarenes, alkenes, carbonyls and imines by dehydrogenative cross-coupling of P(O)-H and P(R)-H.

Hore, Soumyadip / Singh, Ravi P

Organic & biomolecular chemistry

2022 Volume 20, Issue 3, Page(s) 498–537

Abstract: ... without metal catalysts. Over the past few decades, the addition of P-H bonds to alkenes, alkynes, arenes ...

Abstract	Organophosphorous compounds have recently emerged as a powerful class of compounds with widespread applications, such as in bioactive natural products, pharmaceuticals, agrochemicals and organic materials, and as ligands in catalysis. The preparation of these compounds requires synthetic techniques with novel catalytic systems varying from transition metal, photo- and electrochemical catalysis to transformations without metal catalysts. Over the past few decades, the addition of P-H bonds to alkenes, alkynes, arenes, heteroarenes and other unsaturated substrates in hydrophosphination and other related reactions
Language	English
Publishing date	2022-01-19
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d1ob02003j
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Article: p-Silylation of Arenes via Organic Photoredox Catalysis: Use of p-Silylated Arenes for Exclusive o-Silylation, o-Acylation, and o-Alkylation Reactions

Pandey, Ganesh / Tiwari, Sandip Kumar / Singh, Pushpendra / Mondal, Pradip Kumar

Organic letters. 2021 Oct. 06, v. 23, no. 20

2021

Abstract: ... DMA•⁺). p-Silyl arenes, thus formed, are further utilized for exclusive o-silylation reaction and ... Photocatalytic regiospecific p-silylation of arenes has been achieved by the coupling of in situ ... for regiospecific o-acylation as well as o-alkylation reaction. ...

Abstract	Photocatalytic regiospecific p-silylation of arenes has been achieved by the coupling of in situ generated silyl radical with arene radical cation. The strategy involves reductive activation of PhSe–SiR₃ and single electron transfer from the electron rich arene to 9,10-dimethoxyanthracene radical cation (DMA•⁺). p-Silyl arenes, thus formed, are further utilized for exclusive o-silylation reaction and for regiospecific o-acylation as well as o-alkylation reaction.
Keywords	acylation ; alkylation ; aromatic hydrocarbons ; cations ; electron transfer ; photocatalysis ; regioselectivity
Language	English
Dates of publication	2021-1006
Size	p. 7730-7734.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021/acs.orglett.1c02672
Database	NAL-Catalogue (AGRICOLA)

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Article: Reactive power compensation using derated power generation mode of modified P&O algorithm in grid-interfaced PV system

Kumar, Vinit / Singh, Mukesh

Renewable energy. 2021 Nov., v. 178

2021

Abstract: ... the reactive power at any time instant, a GIPV system with modified perturb & observe (MP&O) maximum power ...

Abstract	A local load connected with the grid-interfaced photovoltaic (GIPV) system demands reactive power compensation at the distribution level. The compensation either fulfilled by the PV inverter or grid side arrangements such as capacitor bank, static VAR compensator or tap-changing transformers. Amongst both, the inverter has merit to compensate reactive power without using an additional compensator or oversizing the inverter rating. However, it always depends upon the availability of irradiance and especially when the inverter transfers power with full capacity has no margin to generate the reactive power. Therefore, to make the system flexible according to the demand of the local loads and to create a margin to generate the reactive power at any time instant, a GIPV system with modified perturb & observe (MP&O) maximum power point tracking (MPPT) technique has been proposed. This proposed technique with an intermediate boost converter extracts maximum power more efficiently as compared to the traditional MPPT technique. On the other hand, it curtails the generated active power and provides margin for the PV inverter to generate the reactive power. Further, the PV inverter generates active and reactive power to the local loads as well as transfer power to the grid using inverter control. The inverter control comprises of decoupled instantaneous active and reactive power control. In this control scheme, it maintains the DC-link voltage and power flow between the GIPV system and the grid under all available irradiance conditions. In this respect, a 30 kW GIPV system is simulated and performance of the system is validated using real-time OP4510 hardware-in-loop (HIL) setup.
Keywords	algorithms ; capacitors ; electric potential difference ; light intensity ; power generation ; renewable energy sources ; solar collectors
Language	English
Dates of publication	2021-11
Size	p. 108-117.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2001449-1
ISSN	1879-0682 ; 0960-1481
ISSN (online)	1879-0682
ISSN	0960-1481
DOI	10.1016/j.renene.2021.06.035
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Article ; Online: Hierarchical Nanoflowers of MgFe 2 O 4 , Bentonite and B-,P- Co-Doped Graphene Oxide as Adsorbent and Photocatalyst

Manpreet Kaur Ubhi / Manpreet Kaur / Dhanwinder Singh / Mohammed Javed / Aderbal C. Oliveira / Vijayendra Kumar Garg / Virender K. Sharma

International Journal of Molecular Sciences, Vol 23, Iss 9678, p

Optimization of Parameters by Box–Behnken Methodology

2022 Volume 9678

Abstract: ... synthesized by ultra-sonication approach. HNFs were ternary composite of MgFe 2 O 4 and bentonite with boron ... on the MgFe 2 O 4 -bentonite surface, resulting in a porous flower-like morphology. The red-shift in XPS ... binding energies of HNFs as compared to MgFe 2 O 4 -bentoniteand BPGO revealed the presence of strong ...

Abstract	In the present study, nanocomposites having hierarchical nanoflowers (HNFs) -like morphology were synthesized by ultra-sonication approach. HNFs were ternary composite of MgFe 2 O 4 and bentonite with boron-, phosphorous- co-doped graphene oxide (BPGO). The HNFs were fully characterized using different analytical tools viz . X-ray photoelectron spectroscopy, scanning electron microscopy, energy dispersion spectroscopy, transmission electron microscopy, X-ray diffraction, vibrating sample magnetometry and Mössbauer analysis. Transmission electron micrographs showed that chiffon-like BPGO nanosheets were wrapped on the MgFe 2 O 4 -bentonite surface, resulting in a porous flower-like morphology. The red-shift in XPS binding energies of HNFs as compared to MgFe 2 O 4 -bentoniteand BPGO revealed the presence of strong interactions between the two materials. Box–Behnken statistical methodology was employed to optimize adsorptive and photocatalytic parameters using Pb(II) and malathion as model pollutants, respectively. HNFs exhibited excellent adsorption ability for Pb(II) ions, with the Langmuir adsorption capacity of 654 mg g −1 at optimized pH 6.0 and 96% photocatalytic degradation of malathion at pH 9.0 as compared to MgFe 2 O 4 -bentonite and BPGO. Results obtained in this study clearly indicate that HNFs are promising nanocomposite for the removal of inorganic and organic contaminants from the aqueous solutions.
Keywords	hierarchical nanoflower ; nanocomposite ; boron and phosphorus doped GO ; magnesium ferrite-bentonite ; adsorbent ; photocatalyst ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	669
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: 3-O-(E)-p-Coumaroyl betulinic acid possess anticancer activity and inhibit Notch signaling pathway in breast cancer cells and mammosphere.

Kushwaha, Prem Prakash / Singh, Atul Kumar / Shuaib, Mohd / Prajapati, Kumari Sunita / Vardhan, Pothabathula Seshu / Gupta, Sanjay / Kumar, Shashank

Chemico-biological interactions

2020 Volume 328, Page(s) 109200

Abstract: ... a better strategy for anticancer drug development. We identified 3-O-(E)-p-Coumaroylbetulinic acid (CB ...

Abstract	Activation of Notch signaling is associated with tumor aggressiveness, poor clinical outcome and drug resistance in breast cancer patients. Targeting Notch signaling with small molecule inhibitors may be a better strategy for anticancer drug development. We identified 3-O-(E)-p-Coumaroylbetulinic acid (CB) as a lead compound and potent inhibitor of Notch signaling pathway. Treatment of human breast cancer MBA-MD-231 and T47D cells with CB resulted in a dose- and time-dependent inhibition of cell viability and G0/G1-phase cell cycle arrest. This effect was associated with a marked decrease in the expression of cyclin D1 and its activating partner, cyclin-dependent kinase 2 with concomitant increase in cyclin kinase inhibitor p21, operative in G1-phase of the cell cycle. CB treatment induced early apoptosis in breast cancer cells as evident by increase in cleaved caspase-3, decrease in Bcl2 and survivin, surge in reactive oxygen species and disruption of mitochondrial membrane potential. CB treatment altered Notch target genes viz. Hes1, Hey1 and E-cadherin at mRNA and protein level in time-dependent manner along with decrease in Notch promoter activity at IC
MeSH term(s)	Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Cell Cycle Checkpoints/drug effects ; Cell Line ; Cell Line, Tumor ; Female ; HEK293 Cells ; Humans ; MCF-7 Cells ; Membrane Potential, Mitochondrial/drug effects ; Reactive Oxygen Species/metabolism ; Receptors, Notch/antagonists & inhibitors ; Receptors, Notch/metabolism ; Signal Transduction/drug effects ; Triterpenes/pharmacology
Chemical Substances	Antineoplastic Agents ; Reactive Oxygen Species ; Receptors, Notch ; Triterpenes ; betulinic acid (4G6A18707N)
Language	English
Publishing date	2020-07-21
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2020.109200
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Book ; Online: A Finite Memory Interacting P\'{o}lya Contagion Network and its Approximating Dynamical Systems

Singh, Somya / Alajaji, Fady / Gharesifard, Bahman

2020

Abstract: ... color P\'{o}lya urns, which we refer to as the finite memory interacting P\'{o}lya contagion network ... dynamical system for the finite memory interacting P\'{o}lya contagion network. Interestingly ...

Abstract	We introduce a new model for contagion spread using a network of interacting finite memory two-color P\'{o}lya urns, which we refer to as the finite memory interacting P\'{o}lya contagion network. The urns interact in the sense that the probability of drawing a red ball (which represents an infection state) for a given urn, not only depends on the ratio of red balls in that urn but also on the ratio of red balls in the other urns in the network, hence accounting for the effect of spatial contagion. The resulting network-wide contagion process is a discrete-time finite-memory Markov process, whose transition probability matrix is determined. The stochastic properties of the network contagion Markov process are analytically examined, and in the particular case of memory one with homogeneous urns, we characterize the limiting state of infection in each urn. Given the complexity of this stochastic process, and in the same spirit as the well-studied SIS models, we use a mean-field type approximation to obtain a discrete-time dynamical system for the finite memory interacting P\'{o}lya contagion network. Interestingly, this dynamical system is linear in the memory one case, and is nonlinear for the general memory case. Furthermore, noting that the latter case dynamical system admits a linear variant (realized by retaining its leading linear terms), we study the asymptotic behavior of the linear systems for both memory modes and characterize their equilibrium. Finally, we present simulations to assess the quality of the approximation purveyed by the linear and non-linear dynamical systems, which illustrate the key role that memory plays in improving its accuracy.
Keywords	Mathematics - Dynamical Systems ; Computer Science - Information Theory ; Computer Science - Social and Information Networks ; Mathematics - Probability
Subject code	519
Publishing date	2020-10-01
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Finite Memory Interacting P\'{o}lya Contagion Network and its Approximating Dynamical Systems

Singh, Somya / Alajaji, Fady / Gharesifard, Bahman

Abstract	We introduce a new model for contagion spread using a network of interacting finite memory two-color P\'{o}lya urns, which we refer to as the finite memory interacting P\'{o}lya contagion network. The urns interact in the sense that the probability of drawing a red ball (which represents an infection state) for a given urn, not only depends on the ratio of red balls in that urn but also on the ratio of red balls in the other urns in the network, hence accounting for the effect of spatial contagion. The resulting network-wide contagion process is a discrete-time finite-memory Markov process, whose transition probability matrix is determined. The stochastic properties of the network contagion Markov process are analytically examined, and in the particular case of memory one with homogeneous urns, we characterize the limiting state of infection in each urn. Given the complexity of this stochastic process, and in the same spirit as the well-studied SIS models, we use a mean-field type approximation to obtain a discrete-time dynamical system for the finite memory interacting P\'{o}lya contagion network. Interestingly, this dynamical system is linear in the memory one case, and is nonlinear for the general memory case. Furthermore, noting that the latter case dynamical system admits a linear variant (realized by retaining its leading linear terms), we study the asymptotic behavior of the linear systems for both memory modes and characterize their equilibrium. Finally, we present simulations to assess the quality of the approximation purveyed by the linear and non-linear dynamical systems, which illustrate the key role that memory plays in improving its accuracy.
Keywords	covid19
Publisher	ArXiv
Document type	Article
Database	COVID19

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Article: Protective Role of Maternal P.VAL158MET Catechol-O-Methyltransferase Polymorphism against Early-Onset Preeclampsia and its Complications.

Krnjeta, Tijana / Mirković, Ljiljana / Ignjatović, Svetlana / Tomašević, Dragana / Lukić, Jelena / Topalov, Drina / Soldatović, Ivan / Majkić-Singh, Nada

Journal of medical biochemistry

2016 Volume 35, Issue 3, Page(s) 312–318

Abstract: Background: Up until now there have been contradictory data about the association between p ... Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal ... of this study was to assess the potential correlation between p.Val158Met : Methods: The study included 47 ...

Abstract	Background: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal of this study was to assess the potential correlation between p.Val158Met Methods: The study included 47 early-onset PE patients and 47 control cases. Forty-seven early-onset PE patients were grouped by disease severity (33 patients with a severe form and 14 patients without severe features) and secondly by size for gestational age (12 patients with appropriate-for-gestational-age (AGA) and 35 patients with SGA size). p.Val158Met polymorphism was genotyped by PCR-RFLP analysis. Results: Allele analysis showed significant difference in Conclusions: COMT
Language	English
Publishing date	2016-07-06
Publishing country	Serbia
Document type	Journal Article
ZDB-ID	2387367-X
ISSN	1452-8258
ISSN	1452-8258
DOI	10.1515/jomb-2016-0013
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Article ; Online: Protective Role of Maternal P.VAL158MET Catechol-O-methyltransferase Polymorphism against Early-Onset Preeclampsia and its Complications

Krnjeta Tijana / Mirković Ljiljana / Ignjatović Svetlana / Tomašević Dragana / Lukić Jelena / Topalov Drina / Soldatović Ivan / Majkić-Singh Nada

Journal of Medical Biochemistry, Vol 35, Iss 3, Pp 312-

2016 Volume 318

Abstract	Background: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestationalage (SGA) complicating PE.
Keywords	COMT ; polymorphism ; early-onset preeclampsia ; severe ; SGA ; Medicine ; R ; Medicine (General) ; R5-920 ; Biochemistry ; QD415-436
Language	English
Publishing date	2016-09-01T00:00:00Z
Publisher	De Gruyter Open
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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