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  1. Article ; Online: Role of behavioural problems in carer burden in young onset dementia.

    Velayudhan, Latha

    International psychogeriatrics

    2024  , Page(s) 1–7

    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610224000127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Relationship between neuropsychiatric symptoms, cognition, and neuroimaging in mild cognitive impairment: Are we there yet?

    Velayudhan, Latha

    International psychogeriatrics

    2023  Volume 35, Issue 11, Page(s) 595–597

    MeSH term(s) Humans ; Cognitive Dysfunction/diagnosis ; Cognition ; Neuroimaging ; Neuropsychological Tests
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610223000182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Apathy and depression as risk factors for dementia conversion in mild cognitive impairment.

    Velayudhan, Latha

    International psychogeriatrics

    2023  Volume 35, Issue 11, Page(s) 598–600

    MeSH term(s) Humans ; Apathy ; Depression/psychology ; Cognitive Dysfunction/psychology ; Dementia/psychology ; Risk Factors ; Neuropsychological Tests
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610223000042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Diagnostic challenges and disparities in young-onset dementia: insights from a Southeast London memory clinic study.

    Velayudhan, Latha / Mueller, Christoph

    International psychogeriatrics

    2024  , Page(s) 1–3

    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610224000073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cannabidiol for behavior symptoms in Alzheimer's disease (CANBiS-AD): a randomized, double-blind, placebo-controlled trial.

    Velayudhan, Latha / Dugonjic, Marta / Pisani, Sara / Harborow, Lucy / Aarsland, Dag / Bassett, Paul / Bhattacharyya, Sagnik

    International psychogeriatrics

    2024  , Page(s) 1–3

    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610224000516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clinical characteristics of early-onset versus late-onset Alzheimer's disease: a systematic review and meta-analysis.

    Seath, Paige / Macedo-Orrego, Luis Enrique / Velayudhan, Latha

    International psychogeriatrics

    2023  , Page(s) 1–17

    Abstract: Objectives: A number of studies have compared Alzheimer's disease (AD), the commonest form of dementia, based on their age of onset, i.e. before the age of 65 years (early-onset AD, EO-AD) to those developing after 65 years of age (late-onset AD, LO-AD), ...

    Abstract Objectives: A number of studies have compared Alzheimer's disease (AD), the commonest form of dementia, based on their age of onset, i.e. before the age of 65 years (early-onset AD, EO-AD) to those developing after 65 years of age (late-onset AD, LO-AD), but the differences are not clear. We performed a systematic review and meta-analysis to compare clinical characteristics between EO-AD and LO-AD.
    Design, measurements, and participants: Medline, Embase, PsycINFO, and CINAHL databases were systematically searched for studies comparing time to diagnosis, cognitive scores, annual cognitive decline, activities of daily living (ADLs), neuropsychiatric symptoms (NPS), quality of life (QoL), and survival time for EO-AD and LO-AD patients.
    Results: Forty-two studies were included (EO-AD participants
    Conclusions: Our findings suggest that EO-AD differs from LO-AD in baseline cognition, cognitive decline, and survival time but otherwise has similar clinical characteristics to LO-AD. Larger studies using standardized questionnaires focusing on the clinical presentations are needed to better understand the impact of age of onset in AD.
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610223000509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cognitive and executive impairments in Parkinson's disease psychosis: a Bayesian meta-analysis.

    Pisani, Sara / Gosse, Luca / Wieretilo, Rita / Ffytche, Dominic / Velayudhan, Latha / Bhattacharyya, Sagnik

    Journal of neurology, neurosurgery, and psychiatry

    2024  Volume 95, Issue 3, Page(s) 277–287

    Abstract: Background: Cognitive and executive deficits lead to worsening of quality of life and are a risk factor for developing dementia in people with Parkinson's disease (PD) with psychosis (PDP). However, which key cognitive domains are differentially ... ...

    Abstract Background: Cognitive and executive deficits lead to worsening of quality of life and are a risk factor for developing dementia in people with Parkinson's disease (PD) with psychosis (PDP). However, which key cognitive domains are differentially affected in PDP compared with those without (PDnP), remains unclear. Here, we examined this using a Bayesian meta-analytical approach.
    Methods: Searches were conducted on PubMed, Web of Science, SCOPUS, Medline and PsycINFO. Hedges' g effect-size estimates were extracted from eligible studies as a measure of standard mean differences between PDP and PDnP participants. Meta-analyses were conducted separately for each cognitive domain and subdomain, we examined the effect of age, PD medications, PD duration and severity, depression and psychosis severity for all major domains with meta-regressions.
    Results: Effect-size estimates suggest worse performance on all major domains (k=105 studies) in PDP compared with PDnP participants, with global cognition (k=103 studies, g=-0.57), processing speed (k=29 studies, g=-0.58), executive functions (k=33, g=-0.56), episodic memory (k=30 studies, g=-0.58) and perception (k=34 studies, g=-0.55) as the most likely affected domains. Age, depression and PD duration had moderating effects on task-related performance across most of the major nine domains.
    Conclusions: We report extensive deficits across nine domains as well as subdomains in PD psychosis, with global cognition, processing speed and executive functions as the most likely impaired. The presence of depression may influence task-related performance in PDP, alongside age and PD duration, but not dose of dopamine replacement treatments.
    MeSH term(s) Humans ; Parkinson Disease/complications ; Parkinson Disease/psychology ; Quality of Life ; Bayes Theorem ; Cognition ; Executive Function ; Psychotic Disorders/complications ; Cognitive Dysfunction/etiology ; Organophosphorus Compounds
    Chemical Substances phenyl di-n-pentylphosphinate (14656-17-8) ; Organophosphorus Compounds
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2022-331028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A retrospective analysis of patient flow in mental health services for older adults in South London during the COVID-19 pandemic.

    Mueller, Christoph / Perera, Gayan / Broadbent, Matthew / Stewart, Robert / Velayudhan, Latha

    International psychogeriatrics

    2022  , Page(s) 1–2

    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610221002775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Distribution and abundance of microplastics in the water column of Vembanad Lake-A Ramsar site in Kerala, India.

    Anagha, Prabhakaran Latha / Viji, Nambrath Velayudhan / Devika, Das / Ramasamy, Eswara Venkatesaperumal

    Marine pollution bulletin

    2023  Volume 194, Issue Pt B, Page(s) 115433

    Abstract: The study focuses on the occurrence, abundance and characteristics of microplastics (MPs) in the subsurface and bottom waters of Vembanad Lake, a Ramsar site in the state of Kerala. Even though several studies elucidate the prevalence of microplastic ... ...

    Abstract The study focuses on the occurrence, abundance and characteristics of microplastics (MPs) in the subsurface and bottom waters of Vembanad Lake, a Ramsar site in the state of Kerala. Even though several studies elucidate the prevalence of microplastic pollution in the surface waters of aquatic ecosystems, a little is known about the vertical distribution of MPs in the water column. Vembanad Lake water is greatly affected by microplastic pollution compared to other Indian lakes as it receive discharges from six rivers; a number of sewage canals and run-off. Ubiquitous distribution of MPs was found in the lake with a mean abundance of 26.79 ± 3.74 items L
    MeSH term(s) Lakes ; Water ; Microplastics ; Plastics ; Ecosystem ; India
    Chemical Substances Water (059QF0KO0R) ; Microplastics ; Plastics
    Language English
    Publishing date 2023-08-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2023.115433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Neuropsychiatric Symptoms in Mild Cognitive Impairment: A Literature Review.

    Martin, Evangelia / Velayudhan, Latha

    Dementia and geriatric cognitive disorders

    2020  Volume 49, Issue 2, Page(s) 146–155

    Abstract: Background: Neuropsychiatric symptoms (NPS) in dementia have received much attention due to their high prevalence and their significant implications. NPS in mild cognitive impairment (MCI), a clinical concept proposed as an intermediate state between ... ...

    Abstract Background: Neuropsychiatric symptoms (NPS) in dementia have received much attention due to their high prevalence and their significant implications. NPS in mild cognitive impairment (MCI), a clinical concept proposed as an intermediate state between normal aging and dementia, is now gradually gaining in interest. We aimed to conduct a selective review to examine the prevalence rate of NPS in MCI and associations of NPS symptoms with disease progression.
    Summary: We searched the PubMed database for articles on NPS in MCI and included articles that fulfilled the inclusion criteria. NPS was present in 35-85% of MCI patients. The most common symptoms were depression, irritability, apathy, anxiety, agitation, and sleep problems. Although the associated risk for disease progression of some symptoms, such as apathy and anxiety, was more consistent across studies, evidence was conflicting for symptoms like depression and sleep problems. NPS tend to co-occur, and certain combinations of NPS had a mutual or cumulative effect on disease progression. Late-onset NPS, even in a mild form (mild behavioural impairment) were found to be associated with an increased risk of dementia, even in the absence of cognitive impairment. Key Messages: NPS are highly prevalent in MCI patients and associated with subsequent cognitive deterioration. Late-onset NPS should raise suspicions of neurodegeneration. Future studies with improvised methodology are required to understand the interrelations of NPS and the role they play in the prognosis for patients with MCI.
    MeSH term(s) Aged ; Aged, 80 and over ; Aging/psychology ; Anxiety/epidemiology ; Apathy ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Disease Progression ; Female ; Humans ; Male ; Neuropsychological Tests ; Prevalence
    Language English
    Publishing date 2020-04-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1026007-9
    ISSN 1421-9824 ; 1013-7424
    ISSN (online) 1421-9824
    ISSN 1013-7424
    DOI 10.1159/000507078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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