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  1. Article ; Online: Are immune checkpoint inhibitors safe and effective in lung cancer patients with pre-existing interstitial lung disease?

    Zhu, Lin / Gao, Rong / Li, Han / Zheng, Yahui / Yang, Junling

    Immunotherapy

    2024  Volume 16, Issue 7, Page(s) 465–480

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; Lung Neoplasms ; Immune Checkpoint Inhibitors/adverse effects ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Diseases, Interstitial/drug therapy ; Lung Diseases, Interstitial/etiology ; Pneumonia ; Retrospective Studies
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2023-0147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Meditative practice and behavioral neuroscience.

    Gao, Junling / Chang, Chunqi / Zou, Liye / Tsang, Eric W

    Frontiers in behavioral neuroscience

    2023  Volume 17, Page(s) 1304210

    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2023.1304210
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  3. Article ; Online: Efficacy and safety of abrocitinib and upadacitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis

    Qin Gao / Yanxia Zhao / Junling Zhang

    Heliyon, Vol 9, Iss 6, Pp e16704- (2023)

    A systematic review and meta-analysis

    2023  

    Abstract: Background: The sparsity of head-to-head trials for medications used as in atopic dermatitis (AD) treatment makes therapy options difficult. Objective: To better compare the efficacy and safety of abrocitinib and upadacitinib with dupilumab in patients ... ...

    Abstract Background: The sparsity of head-to-head trials for medications used as in atopic dermatitis (AD) treatment makes therapy options difficult. Objective: To better compare the efficacy and safety of abrocitinib and upadacitinib with dupilumab in patients with moderate-to-severe AD. Methods: We systematically searched MEDLINE, EMBASE, and the Cochrane Library database for head-to-head trials. Results: Three studies with 2256 patients were included. The analysis revealed that improvement of EASI-75 was rapidly registered with abrocitinib/upadacitinib as compared to the dupilumab, even as early as week 2 of treatment. The proportions of patients who reached the endpoint of EASI-75 at week 12 and end of therapy were also higher in the abrocitinib/upadacitinib group. Significant improvement in EASI-90 scores was demonstrated with abrocitinib/upadacitinib at week 2 and at all subsequent time points. The administration of abrocitinib/upadacitinib provided a faster onset of IGA response at week 2. The differences in IGA response remained significant at week 12 and end of therapy. Compared with dupilumab, a larger proportion of patients treated with abrocitinib/upadacitinib achieved early itch relief at 2 weeks. Better results were found later during treatment, in between the 12 weeks to the end of study in abrocitinib/upadacitinib group. The only observed significant result of adverse events were severe adverse events between the abrocitinib/upadacitinib group (n = 40) and the dupilumab group (n = 24) (p = 0.043). TEAEs of any causality that led to treatment discontinuation and serious adverse events have not shown special risks in the patients treated with abrocitinib/upadacitinib. Conclusions: This study demonstrated that anti-JAK therapy, particularly abrocitinib and upadacitinib, exhibited superiority over dupilumab in achieving fast relief of disease signs with an acceptable safety profile in patients with moderate-to-severe atopic dermatitis.
    Keywords Abrocitinib ; Upadacitinib ; Dupilumab ; Moderate-to-severe atopic dermatitis ; Randomized controlled trials ; Meta-analysis ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Efficacy and safety of abrocitinib and upadacitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: A systematic review and meta-analysis.

    Gao, Qin / Zhao, Yanxia / Zhang, Junling

    Heliyon

    2023  Volume 9, Issue 6, Page(s) e16704

    Abstract: Background: The sparsity of head-to-head trials for medications used as in atopic dermatitis (AD) treatment makes therapy options difficult.: Objective: To better compare the efficacy and safety of abrocitinib and upadacitinib with dupilumab in ... ...

    Abstract Background: The sparsity of head-to-head trials for medications used as in atopic dermatitis (AD) treatment makes therapy options difficult.
    Objective: To better compare the efficacy and safety of abrocitinib and upadacitinib with dupilumab in patients with moderate-to-severe AD.
    Methods: We systematically searched MEDLINE, EMBASE, and the Cochrane Library database for head-to-head trials.
    Results: Three studies with 2256 patients were included. The analysis revealed that improvement of EASI-75 was rapidly registered with abrocitinib/upadacitinib as compared to the dupilumab, even as early as week 2 of treatment. The proportions of patients who reached the endpoint of EASI-75 at week 12 and end of therapy were also higher in the abrocitinib/upadacitinib group. Significant improvement in EASI-90 scores was demonstrated with abrocitinib/upadacitinib at week 2 and at all subsequent time points. The administration of abrocitinib/upadacitinib provided a faster onset of IGA response at week 2. The differences in IGA response remained significant at week 12 and end of therapy. Compared with dupilumab, a larger proportion of patients treated with abrocitinib/upadacitinib achieved early itch relief at 2 weeks. Better results were found later during treatment, in between the 12 weeks to the end of study in abrocitinib/upadacitinib group. The only observed significant result of adverse events were severe adverse events between the abrocitinib/upadacitinib group (n = 40) and the dupilumab group (n = 24) (p = 0.043). TEAEs of any causality that led to treatment discontinuation and serious adverse events have not shown special risks in the patients treated with abrocitinib/upadacitinib.
    Conclusions: This study demonstrated that
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16704
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  5. Article ; Online: Incremental learning for an evolving stream of medical ultrasound images via counterfactual thinking.

    Gao, Junling / Xu, Lei / Wan, Mingxi

    Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society

    2023  Volume 109, Page(s) 102290

    Abstract: Despite the fact that traditional deep learning (DL) approaches provide promising accuracy and efficiency in medical ultrasound image analysis, they cannot replace the physician in making a diagnosis since the DL model is only appropriate in static ... ...

    Abstract Despite the fact that traditional deep learning (DL) approaches provide promising accuracy and efficiency in medical ultrasound image analysis, they cannot replace the physician in making a diagnosis since the DL model is only appropriate in static application scenarios. Currently, most DL-based models are incapable of learning new tasks in the dynamic clinical environments due to the catastrophic forgetting of old tasks. To address the above problem, we propose an incremental classifier that is sequentially trained on evolving tasks for medical ultrasound images by counterfactual thinking. Specifically, the proposed model consists of a feature extractor and a classifier that can add new classes at any time during training. Toward a more discriminative model in the continual learning setting, a contrastive strategy is designed to leverage fine-grained information by generating a series of counterfactual regions. For model optimization, we design a multi-task loss made up of a knowledge distillation loss, a cross-entropy loss, and a contrasting loss. This objective jointly enjoys the merits of less forgetting, better accuracy, and fine-grained information utilization. A newly collected dataset with 52 medical ultrasound classification tasks is used to demonstrate the effectiveness of our method. The proposed approach achieves 76.59%, 11.67%, and 7.93% in terms of the average incremental accuracy, forgetting rate, and feature retention, respectively.
    MeSH term(s) Ultrasonography ; Deep Learning ; Image Processing, Computer-Assisted
    Language English
    Publishing date 2023-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639451-6
    ISSN 1879-0771 ; 0895-6111
    ISSN (online) 1879-0771
    ISSN 0895-6111
    DOI 10.1016/j.compmedimag.2023.102290
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The Impact of Harvesting Mechanization on Oolong Tea Quality.

    Zhou, Junling / Gao, Shuilian / Du, Zhenghua / Xu, Tongda / Zheng, Chao / Liu, Ying

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: Mechanization is the inevitable future of tea harvesting, but its impact on tea chemistry and quality remains uncertain. Our study examines untargeted metabolomic data from 185 oolong tea products (Tieguanyin) made from leaves harvested by hand or ... ...

    Abstract Mechanization is the inevitable future of tea harvesting, but its impact on tea chemistry and quality remains uncertain. Our study examines untargeted metabolomic data from 185 oolong tea products (Tieguanyin) made from leaves harvested by hand or machine based on UPLC-QToF-MS analysis. The data revealed a minimum 50% loss for over half of the chemicals in the machine-harvested group, including catechins, theaflavin, gallic acid, chlorogenic acid, and kaempferol-3-gluocside. Integrating sensory evaluation, OPLS-DA identified the six most important metabolites as significant contributors to sensory decline caused by harvesting mechanization. Furthermore, our research validates the possibility of using DD-SIMCA modelling with untargeted metabolomic data for distinguishing handpicked from machine-harvested tea products. The model was able to achieve 93% accuracy. This study provides crucial insights into the chemical and sensory shifts during mechanization, along with tools to manage and monitor these changes.
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13040552
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  7. Article ; Online: Mediating effect of sleep quality on the association between job stress and health-related productivity loss among workers in R&D enterprises in Shanghai.

    Sun, Yixuan / Wei, Minqi / Zhao, Qiuwen / Yang, Jinfeng / Gao, Junling / Dai, Junming

    Frontiers in public health

    2024  Volume 12, Page(s) 1331458

    Abstract: Background: Past research indicates that occupational stress negatively predicts health-related productivity. Simultaneously, sleep problem among workers may stem from job stress, subsequently leading to a decline in sleep quality and resulting in ... ...

    Abstract Background: Past research indicates that occupational stress negatively predicts health-related productivity. Simultaneously, sleep problem among workers may stem from job stress, subsequently leading to a decline in sleep quality and resulting in reduced health productivity. Therefore, this study aims to idenitify whether the sleep quality of employees functions as a mediator in the process through which job stress impacts health productivity.
    Objectives: This study aimed to assess the status and analyze differences in quality of sleep, job stress, and health-related productivity loss (HRPL) among workers in research and development (R&D) enterprises in Minhang District, Shanghai. We also assessed the mediating effect of sleep quality on the relationship between job stress and HRPL.
    Methods: A total of 3,216 workers in R&D firms aged between 18 and 60 years participated in this study (mean age 35.15 years; standard deviation 8.44; male-to-female ratio≈2:1). The Nakata Insomnia Questionnaire, the Chinese version of the Brief Job Stress Questionnaire revised edition, and the Chinese version of the Work Productivity and Activity Impairment Questionnaire were used in this study. And the Kruskal-Wallis test, Hierarchical Multiple Regression Analysis, and Path Analysis were utilized for data analysis in this study.
    Results: There were significant differences in the positive detection rate of insomnia among participants according to age, educational level, marital status, position, length of service, and level of financial difficulties (all
    Conclusions: Occupational health professionals must pay particular attention to job stress, sleep quality, and their influencing factors to positively influence the wellbeing of workers while improving productivity.
    MeSH term(s) Humans ; Male ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Sleep Quality ; Sleep Initiation and Maintenance Disorders/epidemiology ; Cross-Sectional Studies ; China/epidemiology ; Occupational Stress/epidemiology
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1331458
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  8. Article ; Online: JASMONATE ZIM-DOMAIN PROTEIN 3 regulates photo- and thermo-morphogenesis through inhibiting PIF4 in Arabidopsis.

    Huai, Junling / Gao, Nan / Yao, Yuanyuan / Du, Yanxin / Guo, Qiang / Lin, Rongcheng

    Plant physiology

    2024  

    Abstract: Light and temperature are two major environmental factors that affect growth and development of plants during their life cycle. Plants have evolved complex mechanisms to adapt to varying external environments. Here, we show that JASMONATE ZIM-domain ... ...

    Abstract Light and temperature are two major environmental factors that affect growth and development of plants during their life cycle. Plants have evolved complex mechanisms to adapt to varying external environments. Here, we show that JASMONATE ZIM-domain protein 3 (JAZ3), a jasmonic acid signaling component, acts as a factor to integrate light and temperature in regulating seedling morphogenesis. JAZ3 overexpression transgenic lines display short hypocotyls under red, far-red, and blue light and warm temperature (28 °C) conditions compared to the wild type in Arabidopsis (Arabidopsis thaliana). We show that JAZ3 interacts with the transcription factor PHYTOCHROME-INTERACTING FACTOR4 (PIF4). Interestingly, JAZ3 spontaneously undergoes liquid-liquid phase separation (LLPS) in vitro and in vivo and promotes LLPS formation of PIF4. Moreover, transcriptomic analyses indicate that JAZ3 regulates the expression of genes involved in many biological processes, such as response to auxin, auxin-activated signaling pathway, regulation of growth, and response to red light. Finally, JAZ3 inhibits the transcriptional activation activity and binding ability of PIF4. Collectively, our study reveals a function and molecular mechanism of JAZ3 in regulating plant growth in response to environmental light and temperature.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1093/plphys/kiae143
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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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  9. Article ; Online: 18

    Li, Huiqiang / Li, Xiaochen / Sun, Lingyi / He, Yanjie / Wang, Li / Gao, Yongju / Zeng, Dexing / Pang, Xinchang / Xu, Junling

    Bioconjugate chemistry

    2024  

    Abstract: The exploration of pharmaceutically active agents and positron emission tomography (PET) tracers targeting CXCR4 has been a focal point in cancer research given its pivotal role in the development and progression of various cancers. While significant ... ...

    Abstract The exploration of pharmaceutically active agents and positron emission tomography (PET) tracers targeting CXCR4 has been a focal point in cancer research given its pivotal role in the development and progression of various cancers. While significant strides have been made in PET imaging with radiometal-labeled tracers, the landscape of
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.4c00167
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3400: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Social capital, depressive symptomatology, and frailty among older adults in the western areas of China

    Liqun Wang / Shufeng Xie / Xue Hu / Jiangping Li / Shulan He / Junling Gao / Zhizhong Wang

    PLoS ONE, Vol 18, Iss

    2023  Volume 10

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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