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Article ; Online: Da-Yuan-Yin decoction polyphenol fraction attenuates acute lung injury induced by lipopolysaccharide.

Guo, Lengqiu / Yang, Yun / Yuan, Jie / Ren, Huiling / Huang, Xiaolei / Li, Meng / Xia, Long / Jiang, Xiaogang / Chen, Daofeng / Zhang, Jian

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 228–240

Abstract: Context: Da-Yuan-Yin is a Chinese traditional prescription.: Objective: This study explores ... the therapeutic effects of the Da-Yuan-Yin decoction polyphenol fraction (DYY-4) on acute lung injury (ALI ...

Abstract	Context: Da-Yuan-Yin is a Chinese traditional prescription. Objective: This study explores the therapeutic effects of the Da-Yuan-Yin decoction polyphenol fraction (DYY-4) on acute lung injury (ALI) in mice induced by lipopolysaccharide (LPS). Materials and methods: The mice ( Results: DYY-4 (30, 60 mg/kg, Discussion and conclusions: Network pharmacology combined with animal experiments revealed the targets of DYY-4 alleviating ALI.
MeSH term(s)	Mice ; Animals ; NF-kappa B/metabolism ; Lipopolysaccharides/toxicity ; Polyphenols/adverse effects ; Cyclooxygenase 2/genetics ; Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/prevention & control ; Lung ; Superoxide Dismutase ; RNA, Messenger
Chemical Substances	NF-kappa B ; Lipopolysaccharides ; Polyphenols ; Cyclooxygenase 2 (EC 1.14.99.1) ; Superoxide Dismutase (EC 1.15.1.1) ; RNA, Messenger
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2166085
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Article: Protective Effect of the Eluting Fraction of Da-Yuan-Yin Decoction on Acute Lung Injury.

Yang, Yun / Chen, Jinglei / Ren, Huiling / Wei, Lan / Huang, Xiaolei / Li, Meng / Yuan, Jie / Wang, Lu / Jiang, Xiaogang / Guo, Lengqiu / Zhang, Jian

Alternative therapies in health and medicine

2023 Volume 29, Issue 5, Page(s) 242–254

Abstract: Context: The Da-yuan-yin (DYY) decoction is a classical prescription ...

Abstract	Context: The Da-yuan-yin (DYY) decoction is a classical prescription of traditional Chinese medicine that has antipyretic and anti-inflammatory effects. Network Pharmacology (NP) is an emerging discipline based on system-biology theory and biosystem network analysis that researchers can use to predict drug-action targets and mechanisms. Objective: The study intended to use NP evaluate the protective effects of the fifth eluting fraction of the supernatant of the DYY decoction (DYY-5) for mice induced with acute lung injury (ALI) using lipopolysaccharide (LPS) and to explore DYY-5's mechanisms. Design: The research team performed an animal study. Setting: The study took place at the College of Pharmaceutical Science at Soochow University in Suzhou, China. Animals: The animals were 42 male Balb/c mice, about 20 to 25 g in weight. Intervention: The research team: instilled 2 mg/kg of LPS intratracheally (i.t.) to induce ALI. The team divided the mice into seven groups of six mice: (1) a control group; (2) a negative control group-the DYY-5 group with mice treated only with a high dosage, 60 mg/kg, of DYY-5 to investigate the effects of DYY-5 on normal mice; (3) the positive control group, the LPS group, with induced ALI but no treatments; (4) the LPS+60 mg/kg-DYY-5 group with induced ALI treated with a high dosage of DYY-5; (5) the LPS+30 mg/kg-DYY-5 group with induced ALI treated with a medium dosage of DYY-5; (6) the LPS+15 mg/kg-DYY-5 group with induced ALI treated with a low dosage of DYY-5; and (7) a reference drug control group, the LPS+DXM group, with induced ALI treated with 5 mg/kg of dexamethasone (DXM). Outcome measures: The research team: (1) determined the chemical components of DYY; (2) identified the anticomplementary activities of DYY-5; (3) took lung specimens, serum, and bronchoalveolar lavage fluid (BALF) from the mice for histopathological examination, Western blot, and biochemical analysis; (4) measured total protein concentrations and lung W/D ratios; (5) measured the expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) using quantitative real-time polymerase chain reaction (PCR); (6) measured the levels of pro-inflammatory and anti-inflammatory factors, the activity of myeloperoxidase (MPO) and superoxide dismutase (SOD), and the levels of complements, including complements 3 (C3), C3c, C5a, C5aR1, and C5b-9, using kits; (7) analyzed the levels of nuclear factor-kappa B (NF-κB) and IkB kinase (IKK) using Western blot; and (8) used network pharmacology (NP) to predict DYY-5's mechanisms and potential targets. Results: The study's results were consistent with the NP analysis, which reflected the multitarget and multipathway characteristics of DYY-5 in alleviating ALI. The LPS+30 mg/kg-DYY-5 group had significantly lower lung wet-to-dry (W/D) ratios and total protein concentrations in BALF than the LPS group did, with P < .01 and P < .0001, respectively as did the LPS+60 mg/kg-DYY-5 group (both P < .0001). The 60 mg/kg of DYY-5 compared to the LPS group: (1) regulated the levels tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and interleukin-1 beta (IL-1β), with all P < .0001, anti-inflammatory factors-IL-4 (P < .05), IL-10 (P < .001), and IL-13 (P < .001); (2) increased the activity of SOD (P < .0001) and decreased the activity of MPO (P < .0001) and the expressions of iNOS and COX-2 mRNA (both P < .01); (3) blocked the activation of NF-κB and IKK; and (4) alleviated the pathological changes in the lung tissue, by reducing the depositions of C3c and decreasing the levels of C3, C5a and C5aR1 (all P < .0001), C5b-9 (P < .001) and C3c (P < .01) in serum. Conclusions: The protective effects of DYY-5 on ALI were related to antioxidation, anti-complementary activities, and regulation of inflammatory factors through the IKK/NF-κB signal pathway. DYY-5 may be useful as a potential therapeutic agent for treating ALI in clinics.
MeSH term(s)	Male ; Mice ; Animals ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Lipopolysaccharides ; Cyclooxygenase 2/adverse effects ; Complement Membrane Attack Complex/adverse effects ; Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Mice, Inbred BALB C ; RNA, Messenger ; Superoxide Dismutase
Chemical Substances	NF-kappa B ; Lipopolysaccharides ; Cyclooxygenase 2 (EC 1.14.99.1) ; Complement Membrane Attack Complex ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents ; RNA, Messenger ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Erratum: SHUO QI, ZHI-TONG LYU, JIAN WANG, YUN-MING MO, ZHAO-CHI ZENG, YANG-JIN ZENG, KE-YUAN DAI, YUAN-QIU LI, L. LEE GRISMER amp; YING-YONG WANG (2022) Three new species of the genus Boulenophrys (Anura, Megophryidae) from southern China. Zootaxa, 5072: 401438.

Qi, Shuo / Lyu, Zhi-Tong / Wang, Jian / Mo, Yun-Ming / Zeng, Zhao-Chi / Zeng, Yang-Jin / Dai, Ke-Yuan / Li, Yuan-Qiu / Grismer, L Lee / Wang, Ying-Yong

Zootaxa

2022 Volume 5115, Issue 4, Page(s) 600

Language	English
Publishing date	2022-03-16
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5115.4.10
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Article: Protective Effects of Shen-Yuan-Dan Capsule against Ischemia/Reperfusion Injury in Cardiomyocytes by Alleviating Endoplasmic Reticulum Stress.

Tong, Tong / Yang, Zhihai / Chen, Jiaxing / Gong, Tao / Liu, Hongxu

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 7775876

Abstract: ... via the ER stress pathway. We previously found that Shen-Yuan-Dan capsule (SYDC), a widely used ...

Abstract	Objective: Endoplasmic reticulum (ER) stress leads to the accumulation of misfolded proteins and an active unfolded protein response (UPR). If the ER stress is not resolved, the UPR triggers activation of the apoptotic cell death program. It has been shown that ischemia/reperfusion (I/R) injury can induce apoptosis via the ER stress pathway. We previously found that Shen-Yuan-Dan capsule (SYDC), a widely used traditional Chinese medicine, reduces I/R injury. Here, we investigated whether SYDC protects against cardiomyocyte apoptosis by reducing ER stress during I/R injury and. if so, explored its mechanism of action. Methods: We use forty male Wistar rats to prepare the SYDC pharmacological serum. An I/R injury model was established using cultures of neonatal rat ventricular myocytes where cells were exposed to 2 h of reduced oxygenation followed by 4 h of normal oxygenation. After treatment of cultured cells with serum containing SYDC for 4 h, reverse transcription polymerase chain reaction and western blotting were performed to assess the expression levels of target molecules. Results: Ischemia/reperfusion (I/R) clearly decreased cell viability. Treatment of cells with SYDC in serum (5% and 10%) increased cell viability compared with control serum-treated I/R cardiomyocytes. The mRNA levels of glucose-regulated protein 78 (Grp78), C/EBP homologous protein (CHOP), and caspase-12 were significantly upregulated in the I/R group. The mRNA levels of Grp78, CHOP, and caspase-12 were significantly decreased in the 5% and 10% SYDC groups compared to the I/R group. The protein expression levels of Grp78, CHOP, and caspase-12 were significantly upregulated in the I/R group. Treatment of I/R cardiomyocytes with 5% or 10% SYDC reduced the expression levels of CHOP and caspase-12, while the control serum did not show this effect. Conclusions: These findings demonstrate that SYDC alleviates ER stress and prevents ER stress-induced apoptosis via the CHOP-dependent pathway.
Language	English
Publishing date	2022-07-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/7775876
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Article ; Online: Structural characterization of a low-molecular-weight polysaccharide from Angelica pubescens Maxim. f. biserrata Shan et Yuan root and evaluation of its antioxidant activity.

Yuan, Qingxia / Zhang, Jing / Xiao, Chulei / Harqin, Chaligan / Ma, Mingyang / Long, Tao / Li, Zhenghui / Yang, Yanling / Liu, Jikai / Zhao, Longyan

Carbohydrate polymers

2020 Volume 236, Page(s) 116047

Abstract: ... from Angelica pubescens Maxim. f. biserrata Shan et Yuan root, one of the most widely used ...

Abstract	A novel heteropolysaccharide with about twenty sugar residues named DF80-2 was obtained from Angelica pubescens Maxim. f. biserrata Shan et Yuan root, one of the most widely used traditional Chinese medicines for thousands of years in China. The possible structure of DF80-2 was proposed considering the comprehensive results of physicochemical properties, methylation analysis, and 1D/2D NMR spectroscopy, which showed that its main chain was composed of (1→3)-, and (1→4)-linked-α-d-Glcp, (1→4)-linked-β-d-Galp, (1→6)-linked-α-d-Manp, and (1→3)-linked-α-l-Araf, and the branch was present as the α-d-Glcp-(1→3)-β-d-GalpA disaccharides stretched from O-6 position of (1→4)-linked-α-d-Glc moiety in the main chain. Congo red analysis, scanning electron microscopy and atomic force microscopy showed that DF80-2 possessed a triple helical conformation, and its branched monomers were interlaced with one another forming a regular network structure. DF80-2 exhibited antioxidant activity by effectively scavenging DPPH, and hydroxyl radicals, and chelating ferrous ions.
MeSH term(s)	Angelica/chemistry ; Carbohydrate Conformation ; Free Radical Scavengers/chemistry ; Free Radical Scavengers/isolation & purification ; Iron Chelating Agents/chemistry ; Iron Chelating Agents/isolation & purification ; Molecular Weight ; Plant Roots/chemistry ; Polysaccharides/chemistry ; Polysaccharides/isolation & purification
Chemical Substances	Free Radical Scavengers ; Iron Chelating Agents ; Polysaccharides
Language	English
Publishing date	2020-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2020.116047
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Spatial and Temporal Distribution of Bacterioplankton Molecular Ecological Networks in the Yuan River under Different Human Activity Intensity.

Wu, Bobo / Wang, Peng / Devlin, Adam T / Chen, Lu / Xia, Yang / Zhang, Hua / Nie, Minghua / Ding, Mingjun

Microorganisms

2021 Volume 9, Issue 7

Abstract: Bacterioplankton communities play a crucial role in freshwater ecosystem functioning, but it is unknown how co-occurrence networks within these communities respond to human activity disturbances. This represents an important knowledge gap because changes ...

Abstract	Bacterioplankton communities play a crucial role in freshwater ecosystem functioning, but it is unknown how co-occurrence networks within these communities respond to human activity disturbances. This represents an important knowledge gap because changes in microbial networks could have implications for their functionality and vulnerability to future disturbances. Here, we compare the spatiotemporal and biogeographical patterns of bacterioplankton molecular ecological networks using high-throughput sequencing of Illumina HiSeq and multivariate statistical analyses from a subtropical river during wet and dry seasons. Results demonstrated that the lower reaches (high human activity intensity) network had less of an average degree (10.568/18.363), especially during the dry season, when compared with the upper reaches (low human activity intensity) network (10.685/37.552) during the wet and dry seasons, respectively. The latter formed more complexity networks with more modularity (0.622/0.556) than the lower reaches (high human activity intensity) network (0.505/0.41) during the wet and dry seasons, respectively. Bacterioplankton molecular ecological network under high human activity intensity became significantly less robust, which is mainly caused by altering of the environmental conditions and keystone species. Human activity altered the composition of modules but preserved their ecological roles in the network and environmental factors (dissolved organic carbon, temperature, arsenic, oxidation-reduction potential and Chao1 index) were the best parameters for explaining the variations in bacterioplankton molecular ecological network structure and modules.
Language	English
Publishing date	2021-07-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9071532
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Article ; Online: Molecular Biological Mechanisms of Yuan Zhi Powder in the Treatment of Alzheimer’s Disease

Wei-Jie Qiang / Ying Chen / Fu-Yuan He / Mei-Feng Xiao / Wei-Yan Cai / Yi-Fei Dai / Qing Yang / Yu-Jie Li / Xiao-Gang Weng / Qi Li / Ya-Jie Wang / Xiao-Xin Zhu

Digital Chinese Medicine, Vol 1, Iss 1, Pp 90-

an Analysis Based on Network Pharmacology

2018 Volume 101

Abstract: ... mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods ... A database of chemical constituents of Yuan Zhi powder was constructed by using databases and literatures. Potential ... negative regulation of synaptic transmission and so on.Conclusion The fact that Yuan Zhi powder can treat ...

Abstract	ABSTRACT: Objective To predict the main active ingredients, potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan Zhi powder was constructed by using databases and literatures. Potential targets were predicted by reverse molecular docking, and then a component-target network was constructed. The target network of Alzheimer’s disease (AD) was mapped and analyzed to obtain the “active ingredient-AD target” network. The key targets were screened through network analysis. Finally, the rationality of the prediction was analyzed by comparing with the target reported in the literatures.Results There were 180 chemical constituents acting on the AD target, and the targets included three key targets (cyclooxygenase-2, muscarinic acetylcholine receptor M1, and muscarinic acetylcholine receptor M2) and an important target (acetylcholine esterase). Alzheimer’s disease may be treated by regulating the activity of acetylcholine receptors and the binding to β-amyloid protein, and its biological process may be concentrated in the acetylcholine receptor signal pathway, negative regulation of synaptic transmission and so on.Conclusion The fact that Yuan Zhi powder can treat AD is consistent with the characteristics of multi-components-multi-targets-multiple pathways of traditional Chinese medicine. The important targets obtained from network analysis have a large proportion in literature research, so network analysis have some rationality. Keywords: Yuan Zhi powder, Network pharmacology, Active ingredients–AD targets network, Network analysis, Dementia
Keywords	Medicine ; R ; Other systems of medicine ; RZ201-999
Subject code	571
Language	English
Publishing date	2018-03-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Scale effects of multi-medium heavy metals in response to landscape indices in the Yuan River, China

Chen, Liwen / Yang, Yutao / Ding, Mingjun / Zhang, Hua / Zou, Fu / Wang, Peng / Nie, Minghua / Huang, Gaoxiang / Yan, Caixia

Journal of cleaner production. 2022 Aug. 20,

2022

Abstract: ... indices in the riparian zone of the Yuan River. Results show that the most sensitive spatial scales ...

Abstract	Heavy metals in river basins can affect the entire ecosystem through water recycling. Different heavy metals are significantly affected by riparian landscape patterns due to the difference of source and migration processes, while the intensity of impact is directly influenced by the spatial scale of landscape patterns. Here, we employ correlation analyses (CA) and redundancy analyses (RDA) to determine spatial scales for which multi-medium heavy metals (Cr, Mn, Cu, Zn, As, Cd and Pb) are most sensitive landscape indices in the riparian zone of the Yuan River. Results show that the most sensitive spatial scales for dissolved heavy metals were the 300 m line buffer in the wet season and catchments in the dry season. The most sensitive spatial scales for suspended particulate heavy metals were catchments in the wet season, and the 300 m and 500 m line buffers in the dry season. However, correlations between heavy metals in sediment and landscape indices were unclear at all spatial scales. The spatial scales of the 100 m point buffer and catchments showed the highest explained variances for all media. The most important landscape indices for dissolved heavy metals were ENN_MN (Mean Euclidean Nearest Neighbor Distance) and LPI (Largest Patch Index), and SHDI (Shannon's Diversity Index) and ED (Edge Density) for particulate heavy metals. More accurate spatial scale effects of landscape indicators can provide data and reference for similar watershed studies.
Keywords	dry season ; ecosystems ; landscapes ; riparian areas ; rivers ; sediments ; watersheds ; wet season ; China
Language	English
Dates of publication	2022-0820
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ISSN	0959-6526
DOI	10.1016/j.jclepro.2022.133784
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of Zhu-yuan decoction in patients with chronic rhinosinusitis after functional endoscopic sinus surgery.

Li, Jing / Zheng, Chunquan / Lin, Hai / Yang, Chen / Gu, Siyuan / Wang, Yi / Duan, Honggang

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2020 Volume 38, Issue 1, Page(s) 83–88

Abstract: Objective: To investigate the effectiveness and safety of Zhu-yuan decoction (ZYD) in patients ...

Abstract	Objective: To investigate the effectiveness and safety of Zhu-yuan decoction (ZYD) in patients after functional endoscopic sinus surgery (FESS). Methods: A total of 85 patients were randomized into two groups: 44 were treated with intranasal corticosteroids (INC), and 41 were given Chinese herbal medicine (CHM). Patients with chronic rhinosinusitis (CRS) who underwent FESS were prospectively enrolled in the study. Before surgery, they were evaluated by visual analog scale (VAS), nasal endoscopy, computed tomography (CT), and routine blood test. After surgery, they were randomized to take ZYD or INC for 12 weeks and revaluated by VAS; nasal endoscopy at 4, 8, and 12 weeks; and CT at 12 weeks after surgery. Results: In the both groups, VAS and endoscopy scores decreased significantly at 4, 8, and 12 weeks, and CT scores after treatment declined at 12 weeks compared with baseline scores. No significant differences were observed with regard to postoperative VAS, endoscopy, or CT scores between groups. ZYD, combined with surgery, can reduce VAS, nasal endoscopy, and CT scores and has the same efficacy and safety profile as INC in post-FESS management. No fatalities or major adverse events occurred in either group. Conclusion: Our findings suggest that ZYD has similar effects and safety profiles in patients after FESS compared with INC.
Language	English
Publishing date	2020-03-10
Publishing country	China
Document type	Journal Article
ZDB-ID	603186-9
ISSN	2589-451X ; 0254-6272 ; 0255-2922
ISSN (online)	2589-451X ; 0254-6272
ISSN	0255-2922
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Article ; Online: Regularity of Wind-dispelling Medication Prescribed by LI Dong-Yuan

W.A.N.G. Zhao-Yi / H.U.A.N.G. Zheng-De / Y.A.N.G. Ping / R.E.N. Ting / L.I. Xin-Hui

Digital Chinese Medicine, Vol 3, Iss 1, Pp 20-

A Data Mining Technology-based Study

2020 Volume 33

Abstract: ... medication was prescribed by LI Dong-Yuan and many doctors of his school of thought and to provide ... of these medications. Methods: Original data on wind-dispelling medication described in LI Dong-Yuan’s works were ... prescribed by LI Dong-Yuan. Results: A total of 356 prescriptions and 121 flavors of wind-dispelling ...

Abstract	Objective: To extract and analyze information on the regularity with which wind-dispelling medication was prescribed by LI Dong-Yuan and many doctors of his school of thought and to provide theoretical basis and ideas for modern clinical application to facilitate the use, research, and development of these medications. Methods: Original data on wind-dispelling medication described in LI Dong-Yuan’s works were collected, sorted and organized. Data mining and comprehensive analysis were performed by using a series of data processing softwares, such as SPSS 22.0, Modeler 18.0 and xMiner. By reviewing LI Dong-Yuan's writings on wind-dispelling medication, the number of prescriptions for wind-dispelling medication were counted. Frequency of use of wind-dispelling medication was determined, and association rules analysis, factor analysis, and core drug network analysis were used to reveal associations of the symptoms of syndromes and treatment with wind-dispelling medication and to reveal the regularity with which these medications were prescribed by LI Dong-Yuan. Results: A total of 356 prescriptions and 121 flavors of wind-dispelling medication were observed. Among them, five kinds of medicinal properties, seven kinds of medicinal tastes, and 12 kinds of meridians were identified. Furthermore, herbs were divided into 18 categories according to their efficacy. Statistical analysis showed that there were 23 wind-dispelling medications that were prescribed with a frequency of ≥ 60. The mainly used drugs were Saposhnikoviae Radix (Fang Feng, 防风), Bupleuri Radix (Chai Hu, 柴胡), Cimicifugae Rhizoma (Sheng Ma, 升麻), Notopterygii Rhizoma Et Radix (Qiang Huo, 羌活), Puerariae Lobatae Radix (Ge Gen, 葛根), Chuanxiong Rhizoma (Chuan Xiong, 川芎), and Ephedrae Herba (Ma Huang, 麻黄). In addition, we analyzed the association rules wind-dispelling medication and obtained 23 one-to-one drug association rules and 11 multiple-to-one drug association rules. The core drug network analysis data visualization showed core drugs used in the ...
Keywords	Medicine ; R ; Other systems of medicine ; RZ201-999
Subject code	306 ; 551
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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