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  1. Article: Wartime dermatovenereology during the military conflict in Ukraine.

    Szepietowski, Jacek C

    Postepy dermatologii i alergologii

    2023  Volume 40, Issue 3, Page(s) 467–469

    Language English
    Publishing date 2023-05-11
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2596142-1
    ISSN 1642-395X
    ISSN 1642-395X
    DOI 10.5114/ada.2023.127196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Itch-management in clinical practice

    Szepietowski, Jacek C. / Weisshaar, Elke

    (Current problems in dermatology ; 50)

    2016  

    Author's details volume editors Jacek C. Szepietowski (Wrocław), Elke Weisshaar (Heidelberg)
    Series title Current problems in dermatology ; 50
    Collection
    Keywords Pruritus / therapy ; Dermatology ; Allergy ; Internal Medicine ; Nephrology ; Epidemiology ; Public Health ; Jucken
    Subject Hautjucken ; Juckreiz ; Pruritus
    Language English
    Size VII, 209 Seiten, Illustrationen, 26 cm
    Edition [1. Auflage]
    Publisher Karger
    Publishing place Basel ; Freiburg Breisgau ; Paris ; London ; New York ; Chennai ; New Delhi ; Bangkok ; Beijing ; Shanghai ; Tokyo ; Kuala Lumpur ; Singapore ; Sydney
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019106369
    ISBN 978-3-318-05888-8 ; 3-318-05888-2 ; 9783318058895 ; 3318058890
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 2141 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Blue-brownish Nodule in the Umbilical Area: A Quiz.

    Krajewski, Piotr K / Szepietowski, Jacek C

    Acta dermato-venereologica

    2023  Volume 103, Page(s) adv18368

    Language English
    Publishing date 2023-09-28
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/actadv.v103.18368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Psoriasis: An inflammatory skin disease affecting the mind.

    Szepietowski, Jacek C / Krajewski, Piotr K / Pacan, Przemysław

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2024  Volume 38, Issue 3, Page(s) 460–461

    MeSH term(s) Humans ; Psoriasis ; Dermatitis ; Skin
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Secukinumab for the treatment of moderate-to-severe plaque psoriasis in paediatric patients aged six years and older.

    Krajewski, Piotr K / Szepietowski, Jacek C

    Expert review of clinical immunology

    2023  Volume 19, Issue 7, Page(s) 711–716

    Abstract: Introduction: Psoriasis (PSO) is a chronic, recurrent, inflammatory skin disorder that significantly influences patients' quality of life. The prevalence of PSO among children varies depending on the age and ranges from 0.12% at one year to 2% at 18 ... ...

    Abstract Introduction: Psoriasis (PSO) is a chronic, recurrent, inflammatory skin disorder that significantly influences patients' quality of life. The prevalence of PSO among children varies depending on the age and ranges from 0.12% at one year to 2% at 18 years. Due to systemic inflammation, PSO is associated with obesity, hypertension, inflammatory bowel disease, and cardiovascular incidences.Secukinumab is a fully human monoclonal antibody selectively targeting IL-17A. The drug has been approved for children aged 6-18 with moderate to severe plaque psoriasis. Nevertheless, only a few reports thoroughly describe its efficacy and safety in the pediatric population.
    Areas covered: This review aims to describe the efficacy and safety of secukinumab for the treatment of moderate-to-severe plaque PSO in pediatric patients aged six years and older.
    Expert opinion: Although there are only two clinical trials assessing the efficacy and safety of secukinumab in the pediatric population with plaque PSO, this therapy seems to be a significant advancement in managing those patients. Both dose regimens (depending on the weight, low-dose, 75/75/150 mg, and high-dose 75/150/300 mg) of secukinumab were more effective in achieving significant clinical improvement (PASI 75/90 and IGA response) than placebo or active-comparator. Both regimens showed good safety and tolerability profiles, with mostly mild AEs and no SAEs observed.
    MeSH term(s) Humans ; Child ; Quality of Life ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal/adverse effects ; Psoriasis/drug therapy ; Chronic Disease ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances secukinumab (DLG4EML025) ; Antibodies, Monoclonal, Humanized ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-05-23
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2023.2214365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6661: Show issues Location:
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  6. Article ; Online: Topical and systemic JAK inhibitors in hand eczema - a narrative review.

    Zalewski, Adam / Szepietowski, Jacek C

    Expert review of clinical immunology

    2023  Volume 19, Issue 4, Page(s) 365–373

    Abstract: Introduction: Hand eczema is a chronic inflammatory skin disease characterized by significant prevalence and impact on patients' Quality of Life (QoL). Because of its complex and diverse clinical picture, HE management requires patient-specific ... ...

    Abstract Introduction: Hand eczema is a chronic inflammatory skin disease characterized by significant prevalence and impact on patients' Quality of Life (QoL). Because of its complex and diverse clinical picture, HE management requires patient-specific treatment which may constitute a challenge. First described in the 1990s, Janus kinase inhibitors (JAK inhibitors) state a group of modern therapeuticals, which exhibit good bioavailability and are well tolerated by patients in both - topical and systemic - routes of administration. They are an immunomodulating small molecules, impacting JAKs' enzymatic activity.
    Areas covered: This review provides a summary of available data concerning JAK inhibitors' use in HE patients, regarding also clinical trials for the HE treatment.
    Expert opinion: Recent studies are introducing JAK inhibitors as an alternative for other topical and systemic therapies in HE patients. Treatment targeting specific immune pathways enables precise management and extends range of potential therapeutic options. Despite early promising results, future studies need to evaluate JAK inhibitors' safety, potential risks and benefits resulting from the treatment, as well as impact of the therapy on patients' QoL.
    MeSH term(s) Humans ; Janus Kinase Inhibitors/therapeutic use ; Quality of Life ; Eczema/drug therapy ; Janus Kinases ; Pyrazoles
    Chemical Substances Janus Kinase Inhibitors ; Janus Kinases (EC 2.7.10.2) ; Pyrazoles
    Language English
    Publishing date 2023-02-05
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2023.2174526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The NLRP3 Inflammasome Gene Is Overexpressed in Hidradenitis Suppurativa Lesions: A Preliminary Study on the Role of Pyroptosis in Disease Pathogenesis.

    Krajewski, Piotr K / Szukała, Weronika / Szepietowski, Jacek C

    Current issues in molecular biology

    2024  Volume 46, Issue 3, Page(s) 2544–2552

    Abstract: Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disorder, and its pathogenesis remains incompletely understood. This study aimed to investigate the role of the P2X7 receptor (P2X7R) and NLRP3 inflammasome in HS pathogenesis. RNA ... ...

    Abstract Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disorder, and its pathogenesis remains incompletely understood. This study aimed to investigate the role of the P2X7 receptor (P2X7R) and NLRP3 inflammasome in HS pathogenesis. RNA sequencing and real-time PCR were performed to assess the gene expression levels of P2X7R and NLRP3 in the skin biopsies of HS patients and healthy controls (HC). The results of our study revealed a significantly increased expression of the NLRP3 gene in both the lesional and perilesional skin of HS patients compared to healthy controls. Moreover, the mRNA levels of NLRP3 were significantly higher in lesional skin compared to non-lesional skin in HS patients, indicating the spread of inflammation to adjacent tissues. In contrast, no significant differences in P2X7R gene expression were observed between the three groups. These findings suggest the involvement of NLRP3 inflammasomes in HS pathogenesis, while P2X7R may not play a significant role in the disease. This research sheds light on the complex inflammatory pathways in HS, highlighting the potential of NLRP3 as a therapeutic target. Understanding the molecular mechanisms underlying HS is crucial for the development of targeted treatment modalities for this debilitating condition.
    Language English
    Publishing date 2024-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb46030161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Pathological and Therapeutical Implications of Pyroptosis in Psoriasis and Hidradenitis Suppurativa: A Narrative Review.

    Krajewski, Piotr K / Tsoukas, Maria / Szepietowski, Jacek C

    Current issues in molecular biology

    2024  Volume 46, Issue 1, Page(s) 663–676

    Abstract: This manuscript explores the role of pyroptosis, an inflammatory programmed cell death, in the pathogenesis of two chronic dermatoses, psoriasis and hidradenitis suppurativa (HS). The diseases, though clinically diverse, share common pathogenetic ... ...

    Abstract This manuscript explores the role of pyroptosis, an inflammatory programmed cell death, in the pathogenesis of two chronic dermatoses, psoriasis and hidradenitis suppurativa (HS). The diseases, though clinically diverse, share common pathogenetic pathways involving the unbalanced interaction between the adaptive and innate immune systems. This review focuses on the molecular changes in psoriatic and HS skin, emphasizing the activation of dendritic cells, secretion of interleukins (IL-17, IL-22, and TNF-α), and the involvement of inflammasomes, particularly NLRP3. This manuscript discusses the role of caspases, especially caspase-1, in driving pyroptosis and highlights the family of gasdermins (GSDMs) as key players in the formation of pores leading to cell rupture and the release of proinflammatory signals. This study delves into the potential therapeutic implications of targeting pyroptosis in psoriasis and HS, examining existing medications like biologics and Janus kinase inhibitors. It also reviews the current limitations and challenges in developing therapies that selectively target pyroptosis. Additionally, the manuscript explores the role of pyroptosis in various inflammatory disorders associated with psoriasis and HS, such as inflammatory bowel disease, diabetes mellitus, and cardiovascular disorders. The review concludes by emphasizing the need for further research to fully elucidate the pathomechanisms of these dermatoses and develop effective, targeted therapies.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb46010043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Acne influences life-changing decisions among young adults.

    Bień, Beata / Krajewski, Piotr K / Szepietowski, Jacek C

    Italian journal of dermatology and venereology

    2024  Volume 159, Issue 2, Page(s) 174–181

    Abstract: Background: Acne is a chronic inflammatory disease predominantly affecting young people. This study was undertaken to assess the impact of acne in young adults on their major life-changing decisions (MLCD), paying attention to the relationships between ... ...

    Abstract Background: Acne is a chronic inflammatory disease predominantly affecting young people. This study was undertaken to assess the impact of acne in young adults on their major life-changing decisions (MLCD), paying attention to the relationships between major life-changing decisions profile (MLCDP) and Quality of Life (QoL), feeling of stigmatization and acceptance of the disease.
    Methods: The study was performed on 213 young people diagnosed with acne. A variety of questionnaires were employed to measure the clinical and psychological aspects of acne.
    Results: The majority of patients (N.=148, 73.3%) reported at least one MLCD that acne affected in any way (mean number 2.9±3.2, range: 0-18). The most common MLCD influenced by acne appeared to be a decision of changing eating habits (N.=132, 65.3%), followed by changing habits associated with smoking and alcohol (N.=85, 42.1%) and deciding to be more active physically (N.=61, 30.2%). The total score of MLCDP ranged from 0 to 33 points (mean 5.41±6.23 points). MLCDP total score significantly correlated with clinical acne severity (P=0.006), QoL (P<0.001), stigmatization (P<0.001) and illness acceptance (P<0.001).
    Conclusions: Acne has an important impact on life-changing decisions in young adults. MLCDP correlates with impaired QoL, level of stigmatization and degree of illness acceptance. This should be taken into consideration in the holistic approach to acne patients.
    Language English
    Publishing date 2024-04-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.24.07754-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Deciphering the enigma of itch sensation: insights and impact from a readability study.

    Skrzypczak, Tomasz / Skrzypczak, Anna / Szepietowski, Jacek C

    International journal of dermatology

    2024  

    Abstract: Background: Itch terminology is ambiguous. How itch was described in online materials and how terminology influenced the readability of these materials was previously unknown.: Materials and methods: Two groups of search terms, itch and prurigo, were ...

    Abstract Background: Itch terminology is ambiguous. How itch was described in online materials and how terminology influenced the readability of these materials was previously unknown.
    Materials and methods: Two groups of search terms, itch and prurigo, were translated into five of the most prevalent European Union (EU) languages. The itch group consisted of "itch" and "pruritus." The prurigo group consisted of "prurigo," "prurigo nodularis," and "chronic prurigo". Then, a search of the terms in each language was queried in the Google search engine in the private mode of the Internet browser. The first 50 results generated were assessed for suitability. Patient education was the primary objective of the materials provided, with no barriers or advertisements included. In cases where the terms yielded identical outcomes, any duplicated materials were omitted from the analysis. When translating search terms within a group led to just one shared transcription, the results were attributed to the search term with the most similar syntax. The Lix score was utilized to assess readability.
    Results: 314 articles in English, German, Italian, French, and Spanish were evaluated. The term "pruritus" was the most commonly used description for the sensation of itching, with 142 (45%) articles included. Overall, the mean Lix score was 54 ± 9, classifying all articles as hard to comprehend. Articles in the itch group had significantly (P < 0.001) lower mean Lix score (52 ± 9) than materials in the prurigo group (56 ± 10).
    Conclusions: Despite being more accessible to conceptualize, skin conditions such as prurigo had lower readability compared to information about the itch itself. The distinction between "itch" and "pruritus" was unclear.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.17144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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